product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Fra-1 (C-12) Antibody
catalog :
sc-28310
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-12
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 7c
  • western blot; human; loading ...; fig 1a, 1b
Yun S, Hong H, Yeo S, Kim S, Cho Y, Kim K. Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 Deubiquitinase. Cancers (Basel). 2020;12: pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4c
Na T, Kim G, Oh H, Lee M, Han Y, Kim K, et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017;7:43823 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 1g
  • western blot; human; loading ...; fig 1j
Wu J, Sun Y, Zhang P, Qian M, Zhang H, Chen X, et al. The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. Cell Death Dis. 2016;7:e2384 pubmed publisher
  • immunoprecipitation; human; fig 2d
  • western blot; human; fig 2d
Hanson R, Brown R, Steele M, Grandgenett P, Grunkemeyer J, Hollingsworth M. Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget. 2016;7:39996-40011 pubmed publisher
  • western blot; human; 1:500; fig 5
Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
  • western blot; human; fig 2
Iskit S, Schlicker A, Wessels L, Peeper D. Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. Oncotarget. 2015;6:43146-61 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3c
Delgado Olguín P, Dang L, He D, Thomas S, Chi L, Sukonnik T, et al. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014;141:4610-7 pubmed publisher
Xu C, Kleinschmidt H, Yang J, Leith E, Johnson J, Tan S, et al. Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1. bioRxiv. 2023;: pubmed publisher
McAloney C, Makkawi R, Budhathoki Y, Cannon M, Franz E, Gross A, et al. Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. Cell Oncol (Dordr). 2023;: pubmed publisher
Krause H, Bondarowicz H, Karls A, McClean M, Kreeger P. Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway. APL Bioeng. 2021;5:046101 pubmed publisher
Shetty A, Bhosale S, Tripathi S, Buchacher T, Biradar R, Rasool O, et al. Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells. ACS Omega. 2021;6:24834-24847 pubmed publisher
Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed publisher
Witusik Perkowska M, Zakrzewska M, Sikorska B, Papierz W, Jaskolski D, Szemraj J, et al. Glioblastoma-derived cells in vitro unveil the spectrum of drug resistance capability - comparative study of tumour chemosensitivity in different culture systems. Biosci Rep. 2017;37: pubmed publisher
Witusik Perkowska M, Zakrzewska M, Szybka M, Papierz W, Jaskolski D, Liberski P, et al. Astrocytoma-associated antigens - IL13Rα2, Fra-1, and EphA2 as potential markers to monitor the status of tumour-derived cell cultures in vitro. Cancer Cell Int. 2014;14:82 pubmed publisher
Gray L, Fong K, Pavelitz T, Weiner A. Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans. PLoS Genet. 2012;8:e1002972 pubmed publisher
Wu J, Wu G, Lv L, Ren Y, Zhang X, Xue Y, et al. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis. 2012;33:519-28 pubmed publisher
Logullo A, Stiepcich M, Osório C, Nonogaki S, Pasini F, Rocha R, et al. Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma. Histopathology. 2011;58:617-25 pubmed publisher
Baan B, Pardali E, Ten Dijke P, van Dam H. In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo. Mol Cell Proteomics. 2010;9:1982-90 pubmed publisher
product information
Catalog Number :
sc-28310
Product Name :
Fra-1 (C-12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C-12
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Fra-1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA