product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
GATA-3 (HG3-31) Antibody
catalog :
sc-268
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HG3-31
reactivity :
African green monkey, human, mouse, brown rat, bantam
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, ChIP-Seq
citations: 82
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...; fig 2a
Buchrieser J, Degrelle S, Couderc T, Nevers Q, Disson O, Manet C, et al. IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise. Science. 2019;365:176-180 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 4a
Kim J, Villadsen R. Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. J Histochem Cytochem. 2018;66:879-888 pubmed publisher
  • immunoprecipitation; human; fig 4a
Krendl C, Shaposhnikov D, Rishko V, Ori C, Ziegenhain C, Sass S, et al. GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency. Proc Natl Acad Sci U S A. 2017;114:E9579-E9588 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Fell S, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al. Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA. Genes Dev. 2017;31:1036-1053 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s5
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
  • ChIP-Seq; human; fig 7
Van de Walle I, Dolens A, Durinck K, De Mulder K, Van Loocke W, Damle S, et al. GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate. Nat Commun. 2016;7:11171 pubmed publisher
  • immunohistochemistry - paraffin section; African green monkey; 1:50; loading ...; fig 5a
Dewi F, Wood C, Willson C, Register T, Lees C, Howard T, et al. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prev Res (Phila). 2016;9:385-95 pubmed publisher
  • immunohistochemistry; human; 1:25; fig s2
Fridriksdottir A, Kim J, Villadsen R, Klitgaard M, Hopkinson B, Petersen O, et al. Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun. 2015;6:8786 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 7b
O Brien T, Bao K, Dell aringa M, Ang W, Abraham S, Reinhardt R. Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. Mucosal Immunol. 2016;9:597-609 pubmed publisher
  • western blot; human; fig 5
Baraut J, Farge D, Jean Louis F, Masse I, Grigore E, Arruda L, et al. Transforming growth factor-β increases interleukin-13 synthesis via GATA-3 transcription factor in T-lymphocytes from patients with systemic sclerosis. Arthritis Res Ther. 2015;17:196 pubmed publisher
  • western blot; mouse
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16:859-70 pubmed publisher
  • western blot; mouse; 1:200; fig 4
Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, et al. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS ONE. 2015;10:e0128094 pubmed publisher
  • immunohistochemistry; human
Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman M, et al. High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. Mol Oncol. 2015;9:1636-54 pubmed publisher
  • western blot; mouse; fig 1,2,3,4,5,6
Izzo F, Mercogliano F, Venturutti L, Tkach M, Inurrigarro G, Schillaci R, et al. Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. Breast Cancer Res. 2014;16:491 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Nguyen D, Ouyang H, Mao J, Hlatky L, Barcellos Hoff M. Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice. Cancer Res. 2014;74:7149-58 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Prakash A, Udager A, Saenz D, Gumucio D. Roles for Nkx2-5 and Gata3 in the ontogeny of the murine smooth muscle gastric ligaments. Am J Physiol Gastrointest Liver Physiol. 2014;307:G430-6 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Godde N, Sheridan J, Smith L, Pearson H, Britt K, Galea R, et al. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet. 2014;10:e1004323 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
  • western blot; human
Kitagawa K, Shibata K, Matsumoto A, Matsumoto M, Ohhata T, Nakayama K, et al. Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol. 2014;34:2732-44 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
Ordonez N, Sahin A. Diagnostic utility of immunohistochemistry in distinguishing between epithelioid pleural mesotheliomas and breast carcinomas: a comparative study. Hum Pathol. 2014;45:1529-40 pubmed publisher
  • chromatin immunoprecipitation; mouse
Zou M, Cao J, Liu Z, Huh S, Polyak K, Yan Q. Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J Biol Chem. 2014;289:17620-33 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, et al. LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. BMC Biol. 2014;12:25 pubmed publisher
  • immunocytochemistry; human; 1:250
  • immunohistochemistry; human; 1:250
Balk Møller E, Kim J, Hopkinson B, Timmermans Wielenga V, Petersen O, Villadsen R. A marker of endocrine receptor-positive cells, CEACAM6, is shared by two major classes of breast cancer: luminal and HER2-enriched. Am J Pathol. 2014;184:1198-208 pubmed publisher
  • western blot; human
Cyr A, Kulak M, Park J, Bogachek M, Spanheimer P, Woodfield G, et al. TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene. 2015;34:436-44 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunoprecipitation; human
  • western blot; human
Shan L, Li X, Liu L, Ding X, Wang Q, Zheng Y, et al. GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation. Oncogene. 2014;33:3205-16 pubmed publisher
  • chromatin immunoprecipitation; mouse
Schang A, Granger A, Querat B, Bleux C, Cohen Tannoudji J, Laverrière J. GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene. Mol Endocrinol. 2013;27:74-91 pubmed publisher
  • immunohistochemistry - paraffin section; bantam; 1:100
Jones J, Warchol M. Expression of the Gata3 transcription factor in the acoustic ganglion of the developing avian inner ear. J Comp Neurol. 2009;516:507-18 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Albergaria A, Paredes J, Sousa B, Milanezi F, Carneiro V, Bastos J, et al. Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast Cancer Res. 2009;11:R40 pubmed publisher
  • immunohistochemistry; bantam; 1:200
Warchol M, Speck J. Expression of GATA3 and tenascin in the avian vestibular maculae: normative patterns and changes during sensory regeneration. J Comp Neurol. 2007;500:646-57 pubmed
Naik A, Byrd A, Lucander A, Krangel M. Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. J Exp Med. 2019;216:231-243 pubmed publisher
Li H, Zhao C, Xu J, Xu Y, Cheng C, Liu Y, et al. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell. 2019;10:20-30 pubmed publisher
Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou H, Nakajima T, et al. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat Commun. 2018;9:4231 pubmed publisher
Sada A, Jain P, Wang S, Leung E, Tumbar T. Slc1a3-CreER as a Targeting Tool for the K6+ Epithelial Stem Cell Niche and its Precursors during Mouse Hair Follicle Cycle. J Invest Dermatol. 2017;137:1569-1571 pubmed publisher
Tam K, Chan P, Zhang W, Law P, Tian Z, Fung Chan G, et al. Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach. Nucleic Acids Res. 2017;45:115-126 pubmed publisher
Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, et al. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun. 2016;7:13559 pubmed publisher
Kong S, Kim K, Kim J, Kim M, Lee K, Lee J, et al. The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo. Oncotarget. 2016;7:65137-65146 pubmed publisher
Lee J, Tiwari A, Shum V, Mills G, Mancini M, Igoshin O, et al. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014;42:6839-49 pubmed publisher
Achim K, Peltopuro P, Lahti L, Tsai H, Zachariah A, Astrand M, et al. The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors. Biol Open. 2013;2:990-7 pubmed publisher
Francius C, Harris A, Rucchin V, Hendricks T, Stam F, Barber M, et al. Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. PLoS ONE. 2013;8:e70325 pubmed publisher
Gaughan L, Stockley J, Coffey K, O Neill D, Jones D, Wade M, et al. KDM4B is a master regulator of the estrogen receptor signalling cascade. Nucleic Acids Res. 2013;41:6892-904 pubmed publisher
Nautiyal J, Steel J, Mane M, Oduwole O, Poliandri A, Alexi X, et al. The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013;140:1079-89 pubmed publisher
Muroi S, Tanaka H, Miyamoto C, Taniuchi I. Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer. J Immunol. 2013;190:1397-401 pubmed publisher
Lahti L, Achim K, Partanen J. Molecular regulation of GABAergic neuron differentiation and diversity in the developing midbrain. Acta Physiol (Oxf). 2013;207:616-27 pubmed publisher
Virolainen S, Achim K, Peltopuro P, Salminen M, Partanen J. Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development. 2012;139:3795-805 pubmed
Frietze S, Wang R, Yao L, Tak Y, Ye Z, Gaddis M, et al. Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3. Genome Biol. 2012;13:R52 pubmed publisher
Liu H, Shi J, Wilkerson M, Lin F. Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol. 2012;138:57-64 pubmed publisher
Achim K, Peltopuro P, Lahti L, Li J, Salminen M, Partanen J. Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development. 2012;139:2360-70 pubmed publisher
Oliver C, Khaled W, Frend H, Nichols J, Watson C. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012;26:1086-97 pubmed publisher
Zhao X, Malhotra G, Band H, Band V. Derivation of myoepithelial progenitor cells from bipotent mammary stem/progenitor cells. PLoS ONE. 2012;7:e35338 pubmed publisher
Quesne J, Jones J, Warren J, Dawson S, Ali H, Bardwell H, et al. Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue. J Pathol. 2012;227:306-14 pubmed publisher
Sogut A, Yilmaz O, Kirmaz C, Ozbilgin K, Onur E, Celik O, et al. Regulatory-T, T-helper 1, and T-helper 2 cell differentiation in nasal mucosa of allergic rhinitis with olive pollen sensitivity. Int Arch Allergy Immunol. 2012;157:349-53 pubmed publisher
Nakahira M, Nakanishi K. Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells. Int Immunol. 2011;23:761-72 pubmed publisher
Asselin Labat M, Sutherland K, Vaillant F, Gyorki D, Wu D, Holroyd S, et al. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol. 2011;31:4609-22 pubmed publisher
Hwang S, Kim K, Lee G. Defective GATA-3 expression in Th2 LCR-deficient mice. Biochem Biophys Res Commun. 2011;410:866-71 pubmed publisher
Jacob E, Hod Dvorai R, Ben Mordechai O, Boyko Y, Avni O. Dual function of polycomb group proteins in differentiated murine T helper (CD4+) cells. J Mol Signal. 2011;6:5 pubmed publisher
Kirmaz C, Ozenturk Kirgiz O, Bayrak P, Yilmaz O, Vatansever S, Ozbilgin K, et al. Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis. Eur Cytokine Netw. 2011;22:15-23 pubmed publisher
Affara M, Dunmore B, Sanders D, Johnson N, Print C, Charnock Jones D. MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC Genomics. 2011;12:43 pubmed publisher
Yoon N, Maresh E, Shen D, Elshimali Y, Apple S, Horvath S, et al. Higher levels of GATA3 predict better survival in women with breast cancer. Hum Pathol. 2010;41:1794-801 pubmed publisher
Stanelle J, Döring C, Hansmann M, Kuppers R. Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells. Blood. 2010;116:4202-11 pubmed publisher
Hwang S, Lee S, Lee W, Lee G. GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology. 2010;131:50-8 pubmed publisher
Gross J, Stute K, Moller R, Fuchs J, Amarjargal N, Pohl E, et al. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Hear Res. 2010;261:9-21 pubmed publisher
Xu M, Tan C, Zhou J, Huang X, Dai Z, Zhu H, et al. The dynamic changes of T-bet(+)/GATA-3(+) and RORgammat(+)/FOXP3(+) cells in recipient spleens and grafts after rat orthotopic liver transplantation. Transpl Immunol. 2010;22:165-71 pubmed publisher
Bonin F, Molina M, Malet C, Ginestet C, Berthier Vergnes O, Martin M, et al. GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics. 2009;10:417 pubmed publisher
Kakuta Y, Ueki N, Kinouchi Y, Negoro K, Endo K, Nomura E, et al. TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells. Hum Mol Genet. 2009;18:1089-98 pubmed publisher
Ong C, Sedy J, Murphy K, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS ONE. 2008;3:e2823 pubmed publisher
Engelsen I, Stefansson I, Akslen L, Salvesen H. GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. Am J Obstet Gynecol. 2008;199:543.e1-7 pubmed publisher
Sihto H, Lundin J, Lehtimäki T, Sarlomo Rikala M, Butzow R, Holli K, et al. Molecular subtypes of breast cancers detected in mammography screening and outside of screening. Clin Cancer Res. 2008;14:4103-10 pubmed publisher
Thompson M, Lapointe J, Choi Y, Ong D, Higgins J, Brooks J, et al. Identification of candidate prostate cancer genes through comparative expression-profiling of seminal vesicle. Prostate. 2008;68:1248-56 pubmed publisher
Chang W, Lin Z, Kulessa H, Hebert J, Hogan B, Wu D. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet. 2008;4:e1000050 pubmed publisher
Daniel C, Sartory N, Zahn N, Radeke H, Stein J. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther. 2008;324:23-33 pubmed
Zeiser R, Youssef S, Baker J, Kambham N, Steinman L, Negrin R. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood. 2007;110:4588-98 pubmed
Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007;204:1749-55 pubmed
Charafe Jauffret E, Monville F, Bertucci F, Esterni B, Ginestier C, Finetti P, et al. Moesin expression is a marker of basal breast carcinomas. Int J Cancer. 2007;121:1779-85 pubmed
Birmingham N, Parvataneni S, Hassan H, Harkema J, Samineni S, Navuluri L, et al. An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int Arch Allergy Immunol. 2007;144:203-10 pubmed
Lund R, Löytömäki M, Naumanen T, Dixon C, Chen Z, Ahlfors H, et al. Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation. J Immunol. 2007;178:3648-60 pubmed
Layon M, Ackley C, West R, Lowrey C. Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol. 2007;366:737-44 pubmed
Abba M, Nunez M, Colussi A, Croce M, Segal Eiras A, Aldaz C. GATA3 protein as a MUC1 transcriptional regulator in breast cancer cells. Breast Cancer Res. 2006;8:R64 pubmed
Bertucci F, Finetti P, Cervera N, Charafe Jauffret E, Mamessier E, Adélaïde J, et al. Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers. Cancer Res. 2006;66:4636-44 pubmed
Dunn S, Youssef S, Goldstein M, Prod homme T, Weber M, Zamvil S, et al. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med. 2006;203:401-12 pubmed
Yamane H, Zhu J, Paul W. Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment. J Exp Med. 2005;202:793-804 pubmed
Bocek P, Foucras G, Paul W. Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production. J Exp Med. 2004;199:1619-30 pubmed
Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, et al. The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression. J Exp Med. 2003;198:51-61 pubmed
Zhou M, Ouyang W, Gong Q, Katz S, White J, Orkin S, et al. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp Med. 2001;194:1461-71 pubmed
product information
Product Name :
GATA-3 (HG3-31) Antibody
Gene Name :
GATA3
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-268
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
GATA-3
reactive species  :
m, r, h, avian
Application :
WB, IP, IF, IHC(P)
Epitope :
N-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA