product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p53 (Bp53-12) Antibody
catalog :
sc-263
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BP53-12
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 49
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5b
Andresen V, Erikstein B, Mukherjee H, Sulen A, Popa M, Sørnes S, et al. Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Cell Death Dis. 2016;7:e2497 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; 1:1500; fig s6c
Yan Y, Ollila S, Wong I, Vallenius T, Palvimo J, Vaahtomeri K, et al. SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling. Nat Commun. 2015;6:8979 pubmed publisher
  • western blot; human
Carvalho S, Vítor A, Sridhara S, Martins F, Raposo A, Desterro J, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. elife. 2014;3:e02482 pubmed publisher
  • immunoprecipitation; human; fig 7
  • western blot; human
Bhansali M, Shemshedini L. COP9 subunits 4 and 5 target soluble guanylyl cyclase ?1 and p53 in prostate cancer cells. Mol Endocrinol. 2014;28:834-45 pubmed publisher
  • western blot; human; fig 4c
Lau R, Niu M, Pratt M. cIAP2 represses IKK?/?-mediated activation of MDM2 to prevent p53 degradation. Cell Cycle. 2012;11:4009-19 pubmed publisher
Chen Y, Chang I, Liu H, Ma C, Kuo Y, Shih C, et al. Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem. 2018;293:10158-10171 pubmed publisher
Weyerer V, Schneckenpointner R, Filbeck T, Burger M, Hofstaedter F, Wild P, et al. Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years. J Cancer. 2017;8:323-331 pubmed publisher
Yalamanchili N, Kriete A, Alfego D, Danowski K, Kari C, Rodeck U. Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts. Front Genet. 2016;7:171 pubmed
Leitch C, Osdal T, Andresen V, Molland M, Kristiansen S, Nguyen X, et al. Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. Oncotarget. 2016;7:8105-18 pubmed publisher
Müller S, Chen Y, Ginter T, Schafer C, Buchwald M, Schmitz L, et al. SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells. Oncotarget. 2014;5:3184-96 pubmed
Sapkota D, Costea D, Ibrahim S, Johannessen A, Bruland O. S100A14 interacts with S100A16 and regulates its expression in human cancer cells. PLoS ONE. 2013;8:e76058 pubmed publisher
Lin S, Dolfi S, Amiri S, Li J, Budak Alpdogan T, Lee K, et al. P53 regulates the migration of mesenchymal stromal cells in response to the tumor microenvironment through both CXCL12-dependent and -independent mechanisms. Int J Oncol. 2013;43:1817-23 pubmed publisher
Jeong J, Yang X, Clark R, Choi J, Baek S, Lee S. A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-?B activation. Carcinogenesis. 2013;34:2350-60 pubmed publisher
Silden E, Hjelle S, Wergeland L, Sulen A, Andresen V, Bourdon J, et al. Expression of TP53 isoforms p53? or p53? enhances chemosensitivity in TP53(null) cell lines. PLoS ONE. 2013;8:e56276 pubmed publisher
Wanka C, Steinbach J, Rieger J. Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis. J Biol Chem. 2012;287:33436-46 pubmed
Wanka C, Brucker D, Bähr O, Ronellenfitsch M, Weller M, Steinbach J, et al. Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Oncogene. 2012;31:3764-76 pubmed publisher
Sapkota D, Costea D, Blø M, Bruland O, Lorens J, Vasstrand E, et al. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncol. 2012;48:219-25 pubmed publisher
Bridges K, Hirai H, Buser C, Brooks C, Liu H, Buchholz T, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011;17:5638-48 pubmed publisher
Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan S. TNF-? response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ. 2012;19:274-83 pubmed publisher
Erkekoglu P, Rachidi W, Yüzügüllü O, Giray B, Ozturk M, Favier A, et al. Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds. Food Chem Toxicol. 2011;49:1565-71 pubmed publisher
Kisova A, Zerzankova L, Habtemariam A, Sadler P, Brabec V, Kasparkova J. Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Mol Pharm. 2011;8:949-57 pubmed publisher
Meley D, Spiller D, White M, McDowell H, Pizer B, See V. p53-mediated delayed NF-?B activity enhances etoposide-induced cell death in medulloblastoma. Cell Death Dis. 2010;1:e41 pubmed publisher
Al Rashid S, Harding S, Law C, Coackley C, Bristow R. Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage. Radiat Res. 2011;175:588-98 pubmed publisher
Xia M, Knezevic D, Vassilev L. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. Oncogene. 2011;30:346-55 pubmed publisher
Menezes H, Jucá M, Gomes E, Nunes B, Costa H, Matos D. Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors. Arq Gastroenterol. 2010;47:141-7 pubmed
Erkekoglu P, Rachidi W, Yuzugullu O, Giray B, Favier A, Ozturk M, et al. Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium. Toxicol Appl Pharmacol. 2010;248:52-62 pubmed publisher
Mirza S, Sharma G, Pandya P, Ralhan R. Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents. Mol Cell Biochem. 2010;342:101-9 pubmed publisher
Thompson T, Andreeff M, Studzinski G, Vassilev L. 1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53. Mol Cancer Ther. 2010;9:1158-68 pubmed publisher
Huang B, Vassilev L. Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3. Aging (Albany NY). 2009;1:845-54 pubmed
Meyer S, Vogt T, Landthaler M, Berand A, Reichle A, Bataille F, et al. Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma. PPAR Res. 2009;2009:848645 pubmed publisher
Lukandu O, Bredholt T, Neppelberg E, Gjertsen B, Johannessen A, Vintermyr O, et al. Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. Toxicology. 2009;263:108-16 pubmed publisher
Baunbaek D, Trinkler N, Ferandin Y, Lozach O, Ploypradith P, Rucirawat S, et al. Anticancer alkaloid lamellarins inhibit protein kinases. Mar Drugs. 2008;6:514-27 pubmed publisher
Eltze E, Wild P, Wulfing C, Zwarthoff E, Burger M, Stoehr R, et al. Expression of the endothelin axis in noninvasive and superficially invasive bladder cancer: relation to clinicopathologic and molecular prognostic parameters. Eur Urol. 2009;56:837-45 pubmed publisher
Xia M, Knezevic D, Tovar C, Huang B, Heimbrook D, Vassilev L. Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation. Cell Cycle. 2008;7:1604-12 pubmed
Faniello M, Di Sanzo M, Quaresima B, Baudi F, Di Caro V, Cuda G, et al. p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y. Int J Biochem Cell Biol. 2008;40:2110-9 pubmed publisher
Lukandu O, Costea D, Dimba E, Neppelberg E, Bredholt T, Gjertsen B, et al. Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci. 2008;116:23-30 pubmed publisher
Schwarz S, Ettl T, Kleinsasser N, Hartmann A, Reichert T, Driemel O. Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. Oral Oncol. 2008;44:563-70 pubmed
Funayama R, Saito M, Tanobe H, Ishikawa F. Loss of linker histone H1 in cellular senescence. J Cell Biol. 2006;175:869-80 pubmed
Burger M, Denzinger S, Hammerschmied C, Tannapfel A, Obermann E, Wieland W, et al. Elevated microsatellite alterations at selected tetranucleotides (EMAST) and mismatch repair gene expression in prostate cancer. J Mol Med (Berl). 2006;84:833-41 pubmed
Ribas J, Boix J, Meijer L. (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis. Exp Cell Res. 2006;312:2394-400 pubmed
Burger M, Burger S, Denzinger S, Wild P, Wieland W, Blaszyk H, et al. Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer. Eur Urol. 2006;50:770-5; discussion 776 pubmed
Madrigal Velázquez M, Avilés A, Neri N, Huerta J, Martínez Jaramillo G, Mayani H. Expression of ice, bcl-2, c-myc and p53 in different bone marrow cell populations from patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2006;47:665-73 pubmed
Dunne J, Cullmann C, Ritter M, Soria N, Drescher B, Debernardi S, et al. siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts. Oncogene. 2006;25:6067-78 pubmed
Naumann U, Huang H, Wolburg H, Wischhusen J, Weit S, Ohgaki H, et al. PCTAIRE3: a putative mediator of growth arrest and death induced by CTS-1, a dominant-positive p53-derived synthetic tumor suppressor, in human malignant glioma cells. Cancer Gene Ther. 2006;13:469-78 pubmed
Amatya V, Naumann U, Weller M, Ohgaki H. TP53 promoter methylation in human gliomas. Acta Neuropathol. 2005;110:178-84 pubmed
Duan J, Duan J, Zhang Z, Tong T. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int J Biochem Cell Biol. 2005;37:1407-20 pubmed
Borden L, Clark P, Hall M. Bladder cancer. Curr Opin Oncol. 2005;17:275-80 pubmed
Hussain S, Ganesan R, Hiller L, Murray P, el Magraby M, Young L, et al. Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder. Br J Cancer. 2003;88:586-92 pubmed
product information
Product Name :
p53 (Bp53-12) Antibody
Gene Name :
TP53
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-263
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p53
reactive species  :
human
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
N-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA