product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
E2F-1 (KH95) Antibody
catalog :
sc-251
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
KH95
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 132
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 5j
Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed publisher
  • western blot; human; loading ...; fig 5a
Fischietti M, Eckerdt F, Blyth G, Arslan A, Mati W, Oku C, et al. Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma. Oncogene. 2021;40:3273-3286 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4g
Malvi P, Janostiak R, Nagarajan A, Zhang X, Wajapeyee N. N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production. Mol Metab. 2021;48:101217 pubmed publisher
  • flow cytometry; human; 1:100; loading ...; fig s5e
Zatulovskiy E, Zhang S, Berenson D, Topacio B, Skotheim J. Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division. Science. 2020;369:466-471 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2d
  • immunoprecipitation; human; loading ...; fig 1a
  • immunocytochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 2a
Goody D, Gupta S, Engelmann D, Spitschak A, Marquardt S, Mikkat S, et al. Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers. Theranostics. 2019;9:1490-1509 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6f
Barger C, Branick C, Chee L, Karpf A. Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer. Cancers (Basel). 2019;11: pubmed publisher
  • western blot; human; loading ...; fig 4e
Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, et al. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019;442:310-319 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 2b
Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford A, et al. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018;8:8438 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; mouse; 1:750; fig s14d
Martín Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion Poll L, et al. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Development. 2017;144:1566-1577 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Swartz K, Wood S, Murthy T, Ramirez O, Qin G, Pillai M, et al. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 6b
Cao L, Zhang L, Zhao X, Zhang Y. A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PLoS ONE. 2016;11:e0161025 pubmed publisher
  • western blot; human; 1:200; fig 5c
Fiedor E, Gregoraszczuk E. The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol. 2016;78:611-22 pubmed publisher
  • western blot; human; fig 1
Hossain M, Stillman B. Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. elife. 2016;5: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2a
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
  • western blot; mouse; 1:500; fig 6
Wang Y, Wang X, Flores E, Yu J, Chang S. Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell. 2016;15:646-60 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 4b
Wang C, Chen Y, Wang C, Yu J, Chang Y, Yu C. mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells. Oncotarget. 2016;7:25432-42 pubmed publisher
  • western blot; human; 1:500; fig s2
Tambe M, Pruikkonen S, Mäki Jouppila J, Chen P, Elgaaen B, Straume A, et al. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel. Oncotarget. 2016;7:12267-85 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; fig 2
Cataldo A, Cheung D, Balsari A, Tagliabue E, Coppola V, Iorio M, et al. miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response. Oncotarget. 2016;7:786-97 pubmed publisher
  • immunohistochemistry; human; 1:25; fig 7
  • immunohistochemistry; mouse; 1:25; fig 2
Wang B, Ma A, Zhang L, Jin W, Qian Y, Xu G, et al. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun. 2015;6:8704 pubmed publisher
  • western blot; human; fig 5
Mahanic C, Budhavarapu V, Graves J, Li G, Lin W. Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37. J Biol Chem. 2015;290:26508-22 pubmed publisher
  • chromatin immunoprecipitation; human; fig S2
Bida O, Gidoni M, Ideses D, Efroni S, Ginsberg D. A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel. Oncotarget. 2015;6:27880-90 pubmed publisher
  • western blot; human; 1:500; fig 6
Barger C, Zhang W, Hillman J, Stablewski A, Higgins M, Vanderhyden B, et al. Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. Oncotarget. 2015;6:27613-27 pubmed publisher
  • western blot; mouse; fig 1
Ma Q, Hu Q, Xu R, Zhen X, Wang G. Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1. Acta Pharmacol Sin. 2015;36:966-75 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 3a
Wang Y, Deng O, Feng Z, Du Z, Xiong X, Lai J, et al. RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. Oncogene. 2016;35:1363-72 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5b
  • immunoprecipitation; human; fig 7d
  • western blot; human; fig 6b
Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, et al. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014;5:8107-22 pubmed
  • western blot; human
Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, et al. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. 2014;16:R53 pubmed publisher
  • western blot; human
Wojdyla L, Stone A, Sethakorn N, Uppada S, Devito J, Bissonnette M, et al. T-oligo as an anticancer agent in colorectal cancer. Biochem Biophys Res Commun. 2014;446:596-601 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunoprecipitation; human
  • western blot; human
Zhang W, Ji W, Liu X, Ouyang G, Xiao W. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1. Mol Cell Biol. 2014;34:765-75 pubmed publisher
  • chromatin immunoprecipitation; human
Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed publisher
  • chromatin immunoprecipitation; human; fig 2
  • EMSA; human; fig 2
  • western blot; human; fig s3
Docquier A, Augereau P, Lapierre M, Harmand P, Badia E, Annicotte J, et al. The RIP140 gene is a transcriptional target of E2F1. PLoS ONE. 2012;7:e35839 pubmed publisher
  • chromatin immunoprecipitation; human
Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, et al. CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. Mol Cell Biol. 2009;29:570-81 pubmed publisher
  • western blot; human
Solier S, Sordet O, Kohn K, Pommier Y. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol. 2009;29:68-82 pubmed publisher
  • western blot; human
Britschgi A, Trinh E, Rizzi M, Jenal M, Ress A, Tobler A, et al. DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function. Oncogene. 2008;27:5706-16 pubmed publisher
  • western blot; human
Xu X, Bieda M, Jin V, Rabinovich A, Oberley M, Green R, et al. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res. 2007;17:1550-61 pubmed
  • chromatin immunoprecipitation; human
Denissov S, van Driel M, Voit R, Hekkelman M, Hulsen T, Hernandez N, et al. Identification of novel functional TBP-binding sites and general factor repertoires. EMBO J. 2007;26:944-54 pubmed
Zhao Y, Jin L, Zhang X. Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1. Aging (Albany NY). 2021;13:18498-18514 pubmed publisher
Schwartz R, Shokhirev M, Andrade L, Gutkind J, Iglesias Bartolomé R, Shadel G. Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes. Aging (Albany NY). 2021;13:4747-4777 pubmed publisher
Lü J, Zhang C, Han J, Xu Z, Li Y, Zhen L, et al. Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation. BMC Cancer. 2020;20:627 pubmed publisher
Sharma S, Munger K. KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. J Virol. 2020;94: pubmed publisher
Shats I, Williams J, Liu J, Makarov M, Wu X, Lih F, et al. Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Cell Metab. 2020;31:564-579.e7 pubmed publisher
Schaal C, Bora Singhal N, Kumar D, Chellappan S. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Mol Cancer. 2018;17:149 pubmed publisher
Qiao L, Zhang Q, Zhang W, Chen J. The lysine acetyltransferase GCN5 contributes to human papillomavirus oncoprotein E7-induced cell proliferation via up-regulating E2F1. J Cell Mol Med. 2018;22:5333-5345 pubmed publisher
Wang T, Chen X, Qiao W, Kong L, Sun D, Li Z. Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer. BMC Cancer. 2017;17:719 pubmed publisher
Cornella N, Tebaldi T, Gasperini L, Singh J, Padgett R, Rossi A, et al. The hnRNP RALY regulates transcription and cell proliferation by modulating the expression of specific factors including the proliferation marker E2F1. J Biol Chem. 2017;292:19674-19692 pubmed publisher
Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed publisher
Lv D, Wu H, Xing R, Shu F, Lei B, Lei C, et al. HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways. Oncotarget. 2017;8:13586-13599 pubmed publisher
Pan J, Yang Q, Shao J, Zhang L, Ma J, Wang Y, et al. Cyclooxygenase-2 induced ?1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway. Sci Rep. 2016;6:33823 pubmed publisher
Ankers J, Awais R, Jones N, Boyd J, Ryan S, Adamson A, et al. Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. elife. 2016;5: pubmed publisher
Wang Y, Alla V, Goody D, Gupta S, Spitschak A, Wolkenhauer O, et al. Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures. Nucleic Acids Res. 2016;44:117-33 pubmed publisher
Yeo S, Ha S, Yu E, Lee K, Kim J, Kim S. ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma. Oncotarget. 2014;5:12260-72 pubmed
McGirt L, Adams C, Baerenwald D, Zwerner J, Zic J, Eischen C. miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma. J Invest Dermatol. 2014;134:1101-1107 pubmed publisher
Feldstein O, Nizri T, Doniger T, Jacob J, Rechavi G, Ginsberg D. The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer. 2013;12:131 pubmed publisher
Zalmas L, Coutts A, Helleday T, La Thangue N. E2F-7 couples DNA damage-dependent transcription with the DNA repair process. Cell Cycle. 2013;12:3037-51 pubmed publisher
Coe B, Thu K, Aviel Ronen S, Vucic E, Gazdar A, Lam S, et al. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS ONE. 2013;8:e71670 pubmed publisher
Jiang W, Wang Q, Chen S, Gao S, Song L, Liu P, et al. Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein. J Virol. 2013;87:3039-52 pubmed publisher
Cai N, Wang Y, Zheng P. The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. RNA. 2013;19:85-95 pubmed publisher
Brant K, Leikauf G. Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells. Mol Carcinog. 2014;53:192-200 pubmed publisher
Okada K, Fujiwara Y, Takahashi T, Nakamura Y, Takiguchi S, Nakajima K, et al. Overexpression of forkhead box M1 transcription factor (FOXM1) is a potential prognostic marker and enhances chemoresistance for docetaxel in gastric cancer. Ann Surg Oncol. 2013;20:1035-43 pubmed publisher
Lee I, Lee S, Kang W, Park C. Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo. Mol Cancer Ther. 2012;11:2342-51 pubmed publisher
Garcia Garcia A, Rodriguez Rocha H, Tseng M, Montes de Oca Luna R, Zhou H, McMasters K, et al. E2F-1 lacking the transcriptional activity domain induces autophagy. Cancer Biol Ther. 2012;13:1091-101 pubmed publisher
Feldstein O, Ben Hamo R, Bashari D, Efroni S, Ginsberg D. RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation. Mol Cancer Res. 2012;10:1169-77 pubmed
Piovan C, Palmieri D, Di Leva G, Braccioli L, Casalini P, Nuovo G, et al. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Mol Oncol. 2012;6:458-72 pubmed publisher
Taura M, Suico M, Koyama K, Komatsu K, Miyakita R, Matsumoto C, et al. Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol. 2012;32:1581-90 pubmed publisher
Boreström C, Forsman A, Ruetschi U, Rymo L. E2F1, ARID3A/Bright and Oct-2 factors bind to the Epstein-Barr virus C promoter, EBNA1 and oriP, participating in long-distance promoter-enhancer interactions. J Gen Virol. 2012;93:1065-75 pubmed publisher
Fragliasso V, Chiodo Y, Ferrari Amorotti G, Soliera A, Manzotti G, Cattelani S, et al. Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBP? in K562 cells. J Cell Biochem. 2012;113:1704-13 pubmed publisher
Lal A, Thomas M, Altschuler G, Navarro F, O Day E, Li X, et al. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011;7:e1002363 pubmed publisher
Gorski J, Savage K, Mulligan J, McDade S, Blayney J, Ge Z, et al. Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis. Nucleic Acids Res. 2011;39:9536-48 pubmed publisher
Hruba E, Vondracek J, Libalova H, Topinka J, Bryja V, Soucek K, et al. Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011;206:178-88 pubmed publisher
Carcagno A, Marazita M, Ogara M, Ceruti J, Sonzogni S, Scassa M, et al. E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. PLoS ONE. 2011;6:e21938 pubmed publisher
Kim S, Rane S. The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. Development. 2011;138:1903-12 pubmed publisher
Niu J, Chen T, Han L, Wang P, Li N, Tong T. Transcriptional activation of the senescence regulator Lsh by E2F1. Mech Ageing Dev. 2011;132:180-6 pubmed publisher
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed publisher
Ji W, Zhang W, Xiao W. E2F-1 directly regulates thrombospondin 1 expression. PLoS ONE. 2010;5:e13442 pubmed publisher
Onnis A, De Falco G, Antonicelli G, Onorati M, Bellan C, Sherman O, et al. Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma. PLoS ONE. 2010;5: pubmed publisher
Bashari D, Hacohen D, Ginsberg D. JNK activation is regulated by E2F and promotes E2F1-induced apoptosis. Cell Signal. 2011;23:65-70 pubmed publisher
Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, et al. Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. Br J Cancer. 2010;102:1753-61 pubmed publisher
Karimi Busheri F, Rasouli Nia A, Mackey J, Weinfeld M. Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res. 2010;12:R31 pubmed publisher
Haller F, Agaimy A, Cameron S, Beyer M, Gunawan B, Happel N, et al. Expression of p16INK4A in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis. Histopathology. 2010;56:305-18 pubmed publisher
Stravopodis D, Karkoulis P, Konstantakou E, Melachroinou S, Thanasopoulou A, Aravantinos G, et al. Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells. J Cancer Res Clin Oncol. 2011;137:359-74 pubmed publisher
Pulikkan J, Dengler V, Peer Zada A, Kawasaki A, Geletu M, Pasalic Z, et al. Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. Leukemia. 2010;24:914-23 pubmed publisher
Zhou X, Sumazin P, Rajbhandari P, Califano A. A systems biology approach to transcription factor binding site prediction. PLoS ONE. 2010;5:e9878 pubmed publisher
He S, Yang S, Deng G, Liu M, Zhu H, Zhang W, et al. Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor. Cell Mol Life Sci. 2010;67:2069-76 pubmed publisher
Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 2010;9:59 pubmed publisher
Ben Shachar B, Feldstein O, Hacohen D, Ginsberg D. The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy. Mol Cancer Res. 2010;8:363-72 pubmed publisher
Ma Y, Chen L, Wright G, Pillai S, Chellappan S, Cress W. CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem. 2010;285:9813-22 pubmed publisher
Nonne N, Ameyar Zazoua M, Souidi M, Harel Bellan A. Tandem affinity purification of miRNA target mRNAs (TAP-Tar). Nucleic Acids Res. 2010;38:e20 pubmed publisher
Hartman J, Lam E, Gustafsson J, Strom A. Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast Cancer Res. 2009;11:R79 pubmed publisher
Everly D, Mainou B, Raab Traub N. Transcriptional downregulation of p27KIP1 through regulation of E2F function during LMP1-mediated transformation. J Virol. 2009;83:12671-9 pubmed publisher
Cassimere E, Pyndiah S, Sakamuro D. The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. Cell Death Differ. 2009;16:1641-53 pubmed publisher
Jenal M, Trinh E, Britschgi C, Britschgi A, Roh V, Vorburger S, et al. The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res. 2009;7:916-22 pubmed publisher
Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, et al. Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. Biochem Pharmacol. 2009;78:33-44 pubmed publisher
Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A. Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation. J Cell Biochem. 2009;106:580-8 pubmed publisher
Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, et al. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A. 2008;105:20734-9 pubmed publisher
Kumagai T, Akagi T, Desmond J, Kawamata N, Gery S, Imai Y, et al. Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. Int J Cancer. 2009;124:827-33 pubmed publisher
Rousseau E, Kojima R, Hoffner G, Djian P, Bertolotti A. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. J Biol Chem. 2009;284:1917-29 pubmed publisher
Pelegri C, Duran Vilaregut J, del Valle J, Crespo Biel N, Ferrer I, Pallas M, et al. Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. Int J Dev Neurosci. 2008;26:665-71 pubmed publisher
Hsieh M, Das D, Sambandam N, Zhang M, Nahle Z. Regulation of the PDK4 isozyme by the Rb-E2F1 complex. J Biol Chem. 2008;283:27410-7 pubmed publisher
Tategu M, Nakagawa H, Sasaki K, Yamauchi R, Sekimachi S, Suita Y, et al. Transcriptional regulation of human polo-like kinases and early mitotic inhibitor. J Genet Genomics. 2008;35:215-24 pubmed publisher
Polager S, Ofir M, Ginsberg D. E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene. 2008;27:4860-4 pubmed publisher
Korotayev K, Chaussepied M, Ginsberg D. ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry. Cell Signal. 2008;20:1221-6 pubmed publisher
Eelen G, Vanden Bempt I, Verlinden L, Drijkoningen M, Smeets A, Neven P, et al. Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy. Oncogene. 2008;27:4233-41 pubmed publisher
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, et al. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008;365:149-53 pubmed
Dirlam A, Spike B, Macleod K. Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007;27:8713-28 pubmed
Crawford E, Blomquist T, Mullins D, Yoon Y, Hernandez D, Al Bagdhadi M, et al. CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions. Carcinogenesis. 2007;28:2552-9 pubmed
Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, et al. Suppression of polyploidy by the BRCA2 protein. Cancer Lett. 2007;257:65-72 pubmed
Giangrande P, Zhang J, Tanner A, Eckhart A, Rempel R, Andrechek E, et al. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. Proc Natl Acad Sci U S A. 2007;104:12988-93 pubmed
Woo C, Tan F, Cassano H, Lee J, Lee K, Thiele C. Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma. Pediatr Blood Cancer. 2008;50:208-12 pubmed
Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K. Transcriptional regulation of human chromatin assembly factor ASF1. DNA Cell Biol. 2007;26:91-9 pubmed
Hao H, Dong Y, Bowling M, Gomez Gutierrez J, Zhou H, McMasters K. E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. BMC Cancer. 2007;7:24 pubmed
Ma Y, Cress W. Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity. Oncogene. 2007;26:3532-40 pubmed
Krieger S, Gauduchon J, Roussel M, Troussard X, Sola B. Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma. BMC Cancer. 2006;6:238 pubmed
Hayashi R, Goto Y, Ikeda R, Yokoyama K, Yoshida K. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem. 2006;281:35633-48 pubmed
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product information
Product Name :
E2F-1 (KH95) Antibody
Gene Name :
E2F1
Size :
200 µg/ml
Catalog Number :
sc-251
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
E2F-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
342-386 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA