product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
cyclin E (HE12) Antibody
catalog :
sc-247
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HE12
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, reverse phase protein lysate microarray, other, western blot knockout validation
citations: 119
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1a
  • western blot knockout validation; mouse; loading ...; fig s2b
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira N, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553:91-95 pubmed publisher
  • western blot; human; loading ...; fig 1e
Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; human; loading ...; fig 7c
Fan Y, Mok C, Chan M, Zhang Y, Nal B, Kien F, et al. Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection. J Biol Chem. 2017;292:5070-5088 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  • western blot; human; loading ...; fig 3d
Shimizu K, Fukushima H, Ogura K, Lien E, Nihira N, Zhang J, et al. The SCF?-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017;10: pubmed publisher
  • western blot; human; loading ...
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  • western blot; human; loading ...; fig 3b
Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 2
Cizkova K, Steigerova J, Gursky J, Ehrmann J. Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning. Lipids Health Dis. 2016;15:164 pubmed
  • western blot; human; loading ...; fig 6a
Cao L, Zhang L, Zhao X, Zhang Y. A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PLoS ONE. 2016;11:e0161025 pubmed publisher
  • western blot; human; fig 1
Hossain M, Stillman B. Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. elife. 2016;5: pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2a
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
  • western blot; human; fig 1
Podmirseg S, Jäkel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed publisher
  • immunoprecipitation; human; fig 5
  • western blot; human; fig 5
Sakurikar N, Thompson R, Montano R, Eastman A. A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase. Oncotarget. 2016;7:1380-94 pubmed publisher
  • western blot; human; 1:2000; fig 7a,d
Leve F, Peres Moreira R, Binato R, Abdelhay E, Morgado Díaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 7d
Maleszewska M, Vanchin B, Harmsen M, Krenning G. The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence. Angiogenesis. 2016;19:9-24 pubmed publisher
  • western blot; human; loading ...; fig 6e
Kumarasamy V, Shin Y, White J, Sun D. Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine. BMC Cancer. 2015;15:599 pubmed publisher
  • immunocytochemistry; human; 1:150; loading ...; fig 4b
Restall I, Parolin D, Daneshmand M, Hanson J, Simard M, Fitzpatrick M, et al. PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma. Cell Cycle. 2015;14:2938-48 pubmed publisher
  • western blot; human; fig 1
Seo G, Ho M, Bui N, Kim Y, Koh D, Lim Y, et al. Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci. 2015;22:47 pubmed publisher
  • western blot; human; fig 5
Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, et al. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015;6:12697-709 pubmed
  • western blot; human; fig 5
Kratz A, Bärenz F, Richter K, Hoffmann I. Plk4-dependent phosphorylation of STIL is required for centriole duplication. Biol Open. 2015;4:370-7 pubmed publisher
  • western blot; human; 1:500; fig 1
Susanto J, Colvin E, Pinese M, Chang D, Pajic M, Mawson A, et al. The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo. Int J Oncol. 2015;46:2223-30 pubmed publisher
  • western blot; human; fig 1
Vosper J, Masuccio A, Kullmann M, Ploner C, Geley S, Hengst L. Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation. Oncotarget. 2015;6:2889-902 pubmed
  • western blot; mouse; fig 1,2,3,4,5,6
Izzo F, Mercogliano F, Venturutti L, Tkach M, Inurrigarro G, Schillaci R, et al. Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. Breast Cancer Res. 2014;16:491 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2d
Greve K, Lindgreen J, Terp M, Pedersen C, Schmidt S, Mollenhauer J, et al. Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. Mol Oncol. 2015;9:437-49 pubmed publisher
  • western blot; human
Caraballo J, Acosta J, Cortés M, Albajar M, Gomez Casares M, Batlle López A, et al. High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. 2014;5:4694-708 pubmed
  • western blot; human; fig 4d
Dai X, North B, Inuzuka H. Negative regulation of DAB2IP by Akt and SCFFbw7 pathways. Oncotarget. 2014;5:3307-15 pubmed
  • western blot; human
Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, et al. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer. 2014;13:94 pubmed publisher
  • western blot; mouse
Kumar V, Palermo R, Talora C, Campese A, Checquolo S, Bellavia D, et al. Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia. Leukemia. 2014;28:2324-35 pubmed publisher
  • flow cytometry; human
Prinz P, Mendler A, Brech D, Masouris I, Oberneder R, Noessner E. NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention. Int J Cancer. 2014;135:1832-41 pubmed publisher
  • western blot; mouse
Jackson D, Li H, Mitchell K, Joshi A, Elferink C. Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression. Mol Pharmacol. 2014;85:533-41 pubmed publisher
  • western blot; human
Lin Q, Aihara A, Chung W, Li Y, Huang Z, Chen X, et al. LRH1 as a driving factor in pancreatic cancer growth. Cancer Lett. 2014;345:85-90 pubmed publisher
  • western blot; human
Kalyuga M, Gallego Ortega D, Lee H, Roden D, Cowley M, Caldon C, et al. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biol. 2012;10:e1001461 pubmed publisher
  • western blot; human
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed publisher
  • western blot; human; fig 3
Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher
  • western blot; human
Gao D, Inuzuka H, Tseng A, Chin R, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009;11:397-408 pubmed publisher
  • western blot; human
Sahin O, Frohlich H, Löbke C, Korf U, Burmester S, Majety M, et al. Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol. 2009;3:1 pubmed publisher
Barger C, Branick C, Chee L, Karpf A. Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer. Cancers (Basel). 2019;11: pubmed publisher
Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough M, Dhir S, et al. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. elife. 2018;7: pubmed publisher
Huang L, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, et al. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018;9:3569 pubmed publisher
Geng Y, Michowski W, Chick J, Wang Y, Jecrois M, Sweeney K, et al. Kinase-independent function of E-type cyclins in liver cancer. Proc Natl Acad Sci U S A. 2018;115:1015-1020 pubmed publisher
Yuan Y, Gaither K, Kim E, Liu E, Hu M, Lengel K, et al. SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome. J Biol Chem. 2018;293:2939-2948 pubmed publisher
Misiak M, Heldt M, Szeligowska M, Mazzini S, Scaglioni L, Grabe G, et al. Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7. Oncotarget. 2017;8:105137-105154 pubmed publisher
Conde M, Michen S, Wiedemuth R, Klink B, Schrock E, Schackert G, et al. Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. BMC Cancer. 2017;17:889 pubmed publisher
Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
Kresoja Rakic J, Kapaklikaya E, Ziltener G, Dalcher D, Santoro R, Christensen B, et al. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. Oncotarget. 2016;7:21272-86 pubmed publisher
Lv H, Shi Y, Zhang L, Zhang D, Liu G, Yang Z, et al. Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor. BMC Cancer. 2014;14:576 pubmed publisher
Yen Y, Shiah S, Chu H, Hsu Y, Hsiao J, Chang J, et al. Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol Cancer. 2014;13:6 pubmed publisher
Feldstein O, Nizri T, Doniger T, Jacob J, Rechavi G, Ginsberg D. The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer. 2013;12:131 pubmed publisher
Redon S, Zemp I, Lingner J. A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res. 2013;41:9117-28 pubmed publisher
Fridman A, Saha A, Chan A, Casteel D, Pilz R, Boss G. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013;454:91-9 pubmed publisher
Doroshow J, Gaur S, Markel S, Lu J, van Balgooy J, Synold T, et al. Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts. Free Radic Biol Med. 2013;57:162-75 pubmed publisher
Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson J. Estrogen receptors ?1 and ?2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3. Mol Endocrinol. 2012;26:1991-2003 pubmed publisher
Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, et al. DNA damage-induced activation of ATM promotes ?-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012;3:1026-35 pubmed
Kamel D, Brady B, Tabchy A, Mills G, Hennessy B. Proteomic classification of breast cancer. Curr Drug Targets. 2012;13:1495-509 pubmed
Freiburghaus C, Lindmark Månsson H, Paulsson M, Oredsson S. Reduction of ultraviolet light-induced DNA damage in human colon cancer cells treated with a lactoferrin-derived peptide. J Dairy Sci. 2012;95:5552-60 pubmed publisher
Feldstein O, Ben Hamo R, Bashari D, Efroni S, Ginsberg D. RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation. Mol Cancer Res. 2012;10:1169-77 pubmed
Hashimoto T, Juso K, Nakano M, Nagano T, Kambayashi S, Nakashima A, et al. Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death. Cell Death Dis. 2012;3:e313 pubmed publisher
Vedin L, Gustafsson J, Steffensen K. The oxysterol receptors LXR? and LXR? suppress proliferation in the colon. Mol Carcinog. 2013;52:835-44 pubmed publisher
Kong Y, Bai P, Sun H, Nan K. Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients. J Mol Neurosci. 2012;47:207-18 pubmed publisher
Kang K, Oh S, Yun J, Jho E, Kang J, Batsuren D, et al. A novel topoisomerase inhibitor, daurinol, suppresses growth of HCT116 cells with low hematological toxicity compared to etoposide. Neoplasia. 2011;13:1043-57 pubmed
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Zhong W, Sit W, Wan J, Yu A. Sonoporation induces apoptosis and cell cycle arrest in human promyelocytic leukemia cells. Ultrasound Med Biol. 2011;37:2149-59 pubmed publisher
Knobel P, Kotov I, Felley Bosco E, Stahel R, Marti T. Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells. Neoplasia. 2011;13:961-70 pubmed
Xiao D, Dai B, Chen J, Luo Q, Liu X, Lin Q, et al. Loss of macrophage migration inhibitory factor impairs the growth properties of human HeLa cervical cancer cells. Cell Prolif. 2011;44:582-90 pubmed publisher
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Ugland H, Naderi S, Brech A, Collas P, Blomhoff H. cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1. Autophagy. 2011;7:1199-211 pubmed publisher
Lin Y, Chiang B. 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem. 2011;59:8625-31 pubmed publisher
Hennessy B, Lu Y, Gonzalez Angulo A, Carey M, Myhre S, Ju Z, et al. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics. 2010;6:129-51 pubmed publisher
Hashimoto T, Kikkawa U, Kamada S. Contribution of caspase(s) to the cell cycle regulation at mitotic phase. PLoS ONE. 2011;6:e18449 pubmed publisher
Ofir M, Hacohen D, Ginsberg D. MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res. 2011;9:440-7 pubmed publisher
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser R, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011;471:104-9 pubmed publisher
Nadalutti C, Viiri K, Kaukinen K, Maki M, Lindfors K. Extracellular transglutaminase 2 has a role in cell adhesion, whereas intracellular transglutaminase 2 is involved in regulation of endothelial cell proliferation and apoptosis. Cell Prolif. 2011;44:49-58 pubmed publisher
Munkley J, Copeland N, Moignard V, Knight J, Greaves E, Ramsbottom S, et al. Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Res. 2011;39:2671-7 pubmed publisher
Choi Y, Yin H, Suh H, Lee Y, Park S, Lee B. Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts. Environ Mol Mutagen. 2011;52:145-52 pubmed publisher
Durgan J, Parker P. Regulation of the tumour suppressor Fbw7? by PKC-dependent phosphorylation and cancer-associated mutations. Biochem J. 2010;432:77-87 pubmed publisher
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Freiburghaus C, Welinder C, Tjörnstad U, Lindmark Månsson H, Paulsson M, Oredsson S. Identification of ubiquitin in bovine milk and its growth inhibitory effects on human cancer cell lines. J Dairy Sci. 2010;93:3442-52 pubmed publisher
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Ray J, Garcia J, Jurisicova A, Caniggia I. Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia. Cell Death Differ. 2010;17:846-59 pubmed publisher
Levin V, Panchabhai S, Shen L, Kornblau S, Qiu Y, Baggerly K. Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. J Proteome Res. 2010;9:179-91 pubmed publisher
Ma H, Tsang Y, Marxer M, Poon R. Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis. Mol Cell Biol. 2009;29:6500-14 pubmed publisher
Mull B, Cox J, Bui T, Keyomarsi K. Post-translational modification and stability of low molecular weight cyclin E. Oncogene. 2009;28:3167-76 pubmed publisher
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Freiburghaus C, Janicke B, Lindmark Månsson H, Oredsson S, Paulsson M. Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line. J Dairy Sci. 2009;92:2477-84 pubmed publisher
Wang H, Zhang X, Geng L, Teng L, Legerski R. Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. J Biol Chem. 2009;284:18236-43 pubmed publisher
Bertz J, Zang C, Liu H, Wächter M, Possinger K, Koeffler H, et al. Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib. Leuk Res. 2009;33:686-92 pubmed publisher
McAndrew C, Gastwirt R, Donoghue D. The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis. Cell Cycle. 2009;8:66-75 pubmed
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Kim E, Kim J, Choi M, Hong S, Bae Y. Effects of excretory/secretory products from Clonorchis sinensis and the carcinogen dimethylnitrosamine on the proliferation and cell cycle modulation of human epithelial HEK293T cells. Korean J Parasitol. 2008;46:127-32 pubmed publisher
Liu H, Zang C, Emde A, Planas Silva M, Rosche M, Kühnl A, et al. Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. Eur J Pharmacol. 2008;591:43-51 pubmed publisher
Cheung K, Khor T, Yu S, Kong A. PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. AAPS J. 2008;10:277-81 pubmed publisher
Milne A, Carvalho R, Jansen M, Kranenbarg E, van de Velde C, Morsink F, et al. Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival. J Clin Pathol. 2008;61:311-6 pubmed publisher
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Kim Y, Choi M, Hong S, Bae Y. Proliferative effects of excretory/secretory products from Clonorchis sinensis on the human epithelial cell line HEK293 via regulation of the transcription factor E2F1. Parasitol Res. 2008;102:411-7 pubmed
Tian Z, Shen J, Moseman A, Yang Q, Yang J, Xiao P, et al. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer. 2008;122:31-8 pubmed
McAndrew C, Gastwirt R, Meyer A, Porter L, Donoghue D. Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27. Cell Cycle. 2007;6:1937-45 pubmed
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Seabra L, Warenius H. Proteomic co-expression of cyclin-dependent kinases 1 and 4 in human cancer cells. Eur J Cancer. 2007;43:1483-92 pubmed
Gu Z, Inomata K, Ishizawa K, Horii A. The FBXW7 beta-form is suppressed in human glioma cells. Biochem Biophys Res Commun. 2007;354:992-8 pubmed
Alagbala A, McRiner A, Borstnik K, Labonte T, Chang W, D Angelo J, et al. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. J Med Chem. 2006;49:7836-42 pubmed
Morris E, Michaud W, Ji J, Moon N, Rocco J, Dyson N. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006;2:e196 pubmed
He G, Kuang J, Huang Z, Koomen J, Kobayashi R, Khokhar A, et al. Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer. 2006;95:1514-24 pubmed
Sivertsen E, Hystad M, Gutzkow K, Døsen G, Smeland E, Blomhoff H, et al. PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. Br J Haematol. 2006;135:117-28 pubmed
Yang G, Rosen D, Colacino J, Mercado Uribe I, Liu J. Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene. 2007;26:1492-8 pubmed
Fujii Y, Yada M, Nishiyama M, Kamura T, Takahashi H, Tsunematsu R, et al. Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci. 2006;97:729-36 pubmed
Miyoshi Y, Nakayama S, Torikoshi Y, Tanaka S, Ishihara H, Taguchi T, et al. High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci. 2006;97:523-9 pubmed
Pasder O, Shpungin S, Salem Y, Makovsky A, Vilchick S, Michaeli S, et al. Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006;25:4194-206 pubmed
Alam S, Sen E, Brashear H, Meyers C. Adeno-associated virus type 2 increases proteosome-dependent degradation of p21WAF1 in a human papillomavirus type 31b-positive cervical carcinoma line. J Virol. 2006;80:4927-39 pubmed
Orlando J, Astor T, Rundle S, Schaffer P. The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells. J Virol. 2006;80:4005-16 pubmed
Marshall R, Salerno D, Garriga J, Grana X. Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes. J Immunol. 2005;175:6402-11 pubmed
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product information
Product Name :
cyclin E (HE12) Antibody
Gene Name :
CCNE1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-247
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
cyclin E
reactive species  :
human
Application :
WB, IP, IF, IHC(P)
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA