product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
cyclin B1 (GNS1) Antibody
catalog :
sc-245
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GNS1
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 255
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1c
Langhans M, Gao J, Tang Y, Wang B, Alexander P, Tuan R. Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. BMC Dev Biol. 2021;21:10 pubmed publisher
  • western blot; human; 1:500; loading ...
Lou X, Ning J, Liu W, Li K, Qian B, Xu D, et al. YTHDF1 Promotes Cyclin B1 Translation through m6A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation. Cells. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 5e
Fischietti M, Eckerdt F, Blyth G, Arslan A, Mati W, Oku C, et al. Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma. Oncogene. 2021;40:3273-3286 pubmed publisher
  • western blot; human
Xue J, Zhao Y, Aronowitz J, Mai T, Vides A, Qeriqi B, et al. Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Nature. 2020;577:421-425 pubmed publisher
  • western blot; human; loading ...; fig 3c
Singh V, Khalil M, De Benedetti A. The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. Cell Cycle. 2020;19:363-375 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 4a
  • immunocytochemistry; human; loading ...; fig 4b
  • immunohistochemistry; human; loading ...; fig 1g, 1h
  • western blot; human; loading ...; fig 3a
Kwan S, Au Yeung C, Yeung T, Rynne Vidal A, Wong K, Risinger J, et al. Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression. Cancers (Basel). 2020;12: pubmed publisher
  • western blot; human; 1:800; loading ...; fig 4
Horton A, Brooker J, Streitfeld W, Flessa M, Pillai B, Simpson R, et al. Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. Sci Rep. 2019;9:1738 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Lei T, Zhang P, Zhang X, Xiao X, Zhang J, Qiu T, et al. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. Nat Commun. 2018;9:1876 pubmed publisher
  • immunocytochemistry; human; 1:25; loading ...; fig 5a
Ruppert J, Samejima K, Platani M, Molina O, Kimura H, Jeyaprakash A, et al. HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry. EMBO J. 2018;37: pubmed publisher
  • western blot; human; loading ...; fig 1a
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira N, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553:91-95 pubmed publisher
  • western blot; human; 1:300; loading ...; fig s4j
Huang C, Wu S, Ji H, Yan X, Xie Y, Murai S, et al. Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library. Sci Adv. 2017;3:e1701383 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 2a
Giono L, Resnick Silverman L, Carvajal L, St Clair S, Manfredi J. Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase. Oncogene. 2017;36:6762-6773 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s6d
Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2d
Li Z, Li D, Choi E, Lapidus R, Zhang L, Huang S, et al. Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells. J Biol Chem. 2017;292:13890-13901 pubmed publisher
  • western blot; human; loading ...; fig 2e
Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3c
Sandén E, Dyberg C, Krona C, Gallo Oller G, Olsen T, Enríquez Pérez J, et al. Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. Sci Rep. 2017;7:46366 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6e; S6i
Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  • western blot; human; fig 2a
Shin S, Song J, Hwang B, Noh D, Park S, Kim W, et al. HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation. PLoS ONE. 2017;12:e0171860 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 4b
Bot C, Pfeiffer A, Giordano F, Manjeera D, Dantuma N, Ström L. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci. 2017;130:1134-1146 pubmed publisher
  • western blot; mouse; fig 2a
Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  • immunocytochemistry; human; loading ...; fig ms1
Li J, Dang N, Wood D, Huang J. The kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cells. Sci Rep. 2017;7:41072 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5c
Huang Z, Zhou X, He Y, Ke X, Wen Y, Zou F, et al. Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. Sci Rep. 2016;6:38072 pubmed publisher
  • immunocytochemistry; rat; fig 6a
Dubey A, Copeland P. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. PLoS ONE. 2016;11:e0165642 pubmed publisher
  • western blot; human; loading ...; fig 2e
Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2c
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
  • western blot; human; 1:500; fig 3
Feringa F, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, et al. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016;7:12618 pubmed publisher
  • western blot; human; fig 2b
Park Y, Nam H, Do M, Lee J. The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles. Exp Mol Med. 2016;48:e250 pubmed publisher
  • western blot; human; loading ...; fig s2a
Zhang X, Ling Y, Guo Y, Bai Y, Shi X, Gong F, et al. Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. Cell Death Dis. 2016;7:e2292 pubmed publisher
  • western blot; human; loading ...; fig 2j
Gholkar A, Cheung K, Williams K, Lo Y, Hamideh S, Nnebe C, et al. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. J Biol Chem. 2016;291:17001-8 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 2c
Rozo M, Li L, Fan C. Targeting ?1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice. Nat Med. 2016;22:889-96 pubmed publisher
  • western blot; human; loading ...; fig 1c
Chung H, Park J, Lee N, Kim H, Jang C. Phosphorylation of Astrin Regulates Its Kinetochore Function. J Biol Chem. 2016;291:17579-92 pubmed publisher
  • western blot; human; 1:200; fig 3
Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, et al. New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res. 2016;44:4745-62 pubmed publisher
  • western blot; human; 1:1000; fig 2
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed
  • flow cytometry; human; fig 2
  • western blot; human; fig 1
Hasvold G, Lund Andersen C, Lando M, Patzke S, Hauge S, Suo Z, et al. Hypoxia-induced alterations of G2 checkpoint regulators. Mol Oncol. 2016;10:764-73 pubmed publisher
  • western blot; human; 1:1000; fig 5c
O Connor A, Maffini S, Rainey M, Kaczmarczyk A, Gaboriau D, Musacchio A, et al. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open. 2015;5:11-9 pubmed publisher
  • western blot; human; 1:1000; fig s6
Lyu L, Whitcomb E, Jiang S, Chang M, Gu Y, Duncan M, et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB J. 2016;30:1087-95 pubmed publisher
  • western blot; human; fig 3
Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher
  • western blot; human; fig 1
Fuchs M, Luthold C, Guilbert S, Varlet A, Lambert H, Jetté A, et al. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet. 2015;11:e1005582 pubmed publisher
  • western blot; human; 1:1000; fig s3
Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher
  • western blot; mouse; fig 5c
Gao L, Tang H, He H, Liu J, Mao J, Ji H, et al. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats. Front Pharmacol. 2015;6:215 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig s2
Voets E, Marsman J, Demmers J, Beijersbergen R, Wolthuis R. The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Sci Rep. 2015;5:14798 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 7d
Maleszewska M, Vanchin B, Harmsen M, Krenning G. The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence. Angiogenesis. 2016;19:9-24 pubmed publisher
  • western blot; human; 1:500
Seo M, Jang W, Rhee K. Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase. PLoS ONE. 2015;10:e0138905 pubmed publisher
  • western blot; human; fig 2
Bailey M, Singh T, Mero P, Moffat J, Hieter P. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 2015;201:885-95 pubmed publisher
  • western blot; human; fig 5
Kruiswijk F, Hasenfuss S, Sivapatham R, Baar M, Putavet D, Naipal K, et al. Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling. Oncogene. 2016;35:2166-77 pubmed publisher
  • western blot; human; fig 4
Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed publisher
  • immunocytochemistry; human; fig 3b
  • western blot; human; fig 3a
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, et al. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015;14:2090-102 pubmed publisher
  • western blot; human; 1:200; fig 3
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
  • western blot; human; 1:500; fig 1e
Li C, Wu W, Wu W, Liao Y, Chen L, Huang C, et al. The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma. Oncotarget. 2015;6:9220-39 pubmed
  • immunoprecipitation; human
  • western blot; human
Voets E, Wolthuis R. MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C. Biol Open. 2015;4:484-95 pubmed publisher
  • western blot; human; 1:1000
Masuda K, Chiyoda T, Sugiyama N, Segura Cabrera A, Kabe Y, Ueki A, et al. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. PLoS ONE. 2015;10:e0118662 pubmed publisher
  • western blot; human; fig 3
Jeong H, Gil N, Lee H, Cho S, Kim K, Chun K, et al. Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression. J Cell Biochem. 2015;116:1602-12 pubmed publisher
  • western blot; human; 1:500
Hamdi A, Lesnard A, Suzanne P, Robert T, Miteva M, Pellerano M, et al. Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions. Chembiochem. 2015;16:432-9 pubmed publisher
  • western blot; mouse
Rizkallah R, Batsomboon P, Dudley G, Hurt M. Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Oncotarget. 2015;6:1446-61 pubmed
  • western blot; human; 1:200; fig 8
Pérès E, Gérault A, Valable S, Roussel S, Toutain J, Divoux D, et al. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget. 2015;6:2101-19 pubmed
  • western blot; rat; 1:1000; fig 9
Pino M, Verstraeten S. Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression. J Appl Toxicol. 2015;35:952-69 pubmed publisher
  • western blot; human
Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, et al. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA Repair (Amst). 2015;25:72-83 pubmed publisher
  • immunocytochemistry; human; 1:100
Brownlow N, Pike T, Zicha D, Collinson L, Parker P. Mitotic catenation is monitored and resolved by a PKCε-regulated pathway. Nat Commun. 2014;5:5685 pubmed publisher
  • western blot; human
Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, König L, et al. PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry. PLoS Pathog. 2014;10:e1004514 pubmed publisher
  • western blot; human; loading ...; fig 3b
Li Y, Kim B, Cho S, Bang M, Kim S, Park D. 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation. Int J Oncol. 2015;46:578-86 pubmed publisher
  • western blot; human
Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014;5:e1513 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2d
Greve K, Lindgreen J, Terp M, Pedersen C, Schmidt S, Mollenhauer J, et al. Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. Mol Oncol. 2015;9:437-49 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
van der Lelij P, Stocsits R, Ladurner R, Petzold G, Kreidl E, Koch B, et al. SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. EMBO J. 2014;33:2643-58 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Shandilya J, Toska E, Richard D, Medler K, Roberts S. WT1 interacts with MAD2 and regulates mitotic checkpoint function. Nat Commun. 2014;5:4903 pubmed publisher
  • western blot; human
Izumi H, Kaneko Y. Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. Cancer Res. 2014;74:5620-30 pubmed publisher
  • western blot; mouse; 1:1000
Jiao G, Lian H, Gao Y, Sun M, Gong S, Zheng L, et al. Carrying-over effects of GVBD blocking on post-blocking meiotic progression of oocytes: species difference and the signaling pathway leading to MPF activation. PLoS ONE. 2014;9:e103838 pubmed publisher
  • western blot; human; fig 6
Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, et al. Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol. 2014;234:302-15 pubmed publisher
  • western blot; human
Hu K, Liao D, Wu W, Han A, Shi H, Wang F, et al. Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma. Oncotarget. 2014;5:3088-100 pubmed
  • western blot; human; 1:1000
Kuijt T, Omerzu M, Saurin A, Kops G. Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma. 2014;123:471-80 pubmed publisher
  • western blot; human; 1:1000; fig 1
Kitagawa M, Fung S, Hameed U, Goto H, Inagaki M, Lee S. Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis. Cell Rep. 2014;7:166-79 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Hu J, Lu J, Lian G, Zhang J, Hecht J, Sheen V. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS ONE. 2014;9:e89352 pubmed publisher
  • western blot; human
Matthess Y, Raab M, Knecht R, Becker S, Strebhardt K. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. Mol Oncol. 2014;8:596-608 pubmed publisher
  • western blot; human; fig 2
Kim S, Park E, Joo H, Shen Y, Hong S, Kim C, et al. RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress. Cancer Lett. 2014;346:249-56 pubmed publisher
  • western blot; human; fig 2
Xu Q, Zhang Y, Xiong X, Huang Y, Salisbury J, Hu J, et al. PIPKI? targets to the centrosome and restrains centriole duplication. J Cell Sci. 2014;127:1293-305 pubmed publisher
  • western blot; human; 1:1000; fig 8
Myatt S, Kongsema M, Man C, Kelly D, Gomes A, Khongkow P, et al. SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene. 2014;33:4316-29 pubmed publisher
  • western blot; human; fig 7
Liu X, Xiao W, Wang X, Li Y, Han J, Li Y. The p38-interacting protein (p38IP) regulates G2/M progression by promoting ?-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013;288:36648-61 pubmed publisher
  • western blot; human
Maier B, Kirsch M, Anderhub S, Zentgraf H, Krämer A. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle. 2013;12:1457-71 pubmed publisher
  • western blot; human
Gao D, Inuzuka H, Tseng A, Chin R, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009;11:397-408 pubmed publisher
  • western blot; human
Bengoechea Alonso M, Punga T, Ericsson J. Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci U S A. 2005;102:11681-6 pubmed
  • immunoprecipitation; human
  • western blot; human
Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005;280:27998-8006 pubmed
Morgan E, Patterson M, Ryder E, Lee S, Wasson C, Harper K, et al. MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer. PLoS Pathog. 2020;16:e1008624 pubmed publisher
Bobkov G, Huang A, van den Berg S, Mitra S, Anselm E, Lazou V, et al. Spt6 is a maintenance factor for centromeric CENP-A. Nat Commun. 2020;11:2919 pubmed publisher
Odle R, Walker S, Oxley D, Kidger A, Balmanno K, Gilley R, et al. An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis. Mol Cell. 2019;: pubmed publisher
Stauffer S, Zeng Y, Santos M, Zhou J, Chen Y, Dong J. Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression. J Cell Sci. 2019;132: pubmed publisher
Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
Roman M, Lopez I, Guruceaga E, Baraibar I, Ecay M, Collantes M, et al. Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network. Cancer Res. 2019;79:625-638 pubmed publisher
Kim S, Jin H, Seo H, Lee H, Lee Y. Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death Differ. 2019;26:812-825 pubmed publisher
Zhou Y, Chu L, Wang Q, Dai W, Zhang X, Chen J, et al. CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair. Cell Death Dis. 2018;9:887 pubmed publisher
Hayashi Y, Fujimura A, Kato K, Udagawa R, Hirota T, Kimura K. Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry. Sci Adv. 2018;4:eaap7777 pubmed publisher
Noguchi A, Adachi S, Yokota N, Hatta T, Natsume T, Kawahara H. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Biol Open. 2018;7: pubmed publisher
Misiak M, Heldt M, Szeligowska M, Mazzini S, Scaglioni L, Grabe G, et al. Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7. Oncotarget. 2017;8:105137-105154 pubmed publisher
Zhuge W, Chen R, Vladimir K, Dong X, Zia K, Sun X, et al. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. Cancer Lett. 2018;412:46-58 pubmed publisher
Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
Nechemia Arbely Y, Fachinetti D, Miga K, Sekulic N, Soni G, Kim D, et al. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017;216:607-621 pubmed publisher
Zhang T, Zhou Y, Li L, Wang Z, Shen W, Schatten H, et al. CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Development. 2017;144:305-312 pubmed publisher
Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier Hayes L, et al. Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017;36:2704-2714 pubmed publisher
Uematsu K, Okumura F, Tonogai S, Joo Okumura A, Alemayehu D, Nishikimi A, et al. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. J Cell Biol. 2016;215:95-106 pubmed
Lv C, Zhao G, Sun X, Wang P, Xie N, Luo J, et al. Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulation. Oncotarget. 2016;7:60366-60382 pubmed publisher
Müssnich P, Raverot G, Jaffrain Rea M, Fraggetta F, Wierinckx A, Trouillas J, et al. Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors. Cell Cycle. 2015;14:2590-7 pubmed publisher
Müllers E, Silva Cascales H, Jaiswal H, Saurin A, Lindqvist A. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle. 2014;13:2733-43 pubmed publisher
Eichhorn J, Kothari A, Chambers T. Cyclin B1 overexpression induces cell death independent of mitotic arrest. PLoS ONE. 2014;9:e113283 pubmed publisher
Park S, Yu S, Chai Y, Jang Y. CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Nucleic Acids Res. 2014;42:6196-207 pubmed publisher
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product information
Product Name :
cyclin B1 (GNS1) Antibody
Gene Name :
CCNB1
Size :
200 µg/ml
Catalog Number :
sc-245
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
cyclin B1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA