product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Bax (6A7) Antibody
catalog :
sc-23959
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6A7
reactivity :
human, mouse, rat, dogs, pigs , rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 39
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 8d
Edwards G, Perkins G, Kim K, Kong Y, Lee Y, Choi S, et al. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020;11:254 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 3b
Moncsek A, Al Suraih M, Trussoni C, O Hara S, Splinter P, Zuber C, et al. Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice. Hepatology. 2017;: pubmed publisher
  • western blot; dogs; loading ...; fig s5b
Zhang K, Myllymäki S, Gao P, Devarajan R, Kytölä V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Xiao F, Zhang J, Zhang C, An W. Hepatic stimulator substance inhibits calcium overflow through the mitochondria-associated membrane compartment during nonalcoholic steatohepatitis. Lab Invest. 2017;97:289-301 pubmed publisher
  • western blot; pigs ; fig 3
Zhao X, Song X, Bai X, Fei N, Huang Y, Zhao Z, et al. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). Peerj. 2016;4:e1635 pubmed publisher
  • western blot; rat; 1:500
Su C, Sun F, Cunningham R, Rybalchenko N, Singh M. ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning. Age (Dordr). 2014;36:9685 pubmed publisher
  • immunoprecipitation; mouse
  • western blot; mouse
Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, et al. BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. PLoS ONE. 2014;9:e99404 pubmed publisher
  • western blot; mouse; fig 4
Ying Y, Kim J, Westphal S, Long K, Padanilam B. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol. 2014;25:2707-16 pubmed publisher
  • western blot; human
Guerzoni C, Amatori S, Giorgi L, Manara M, Landuzzi L, Lollini P, et al. An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas. BMC Cancer. 2014;14:137 pubmed publisher
  • immunoprecipitation; human
Annibaldi A, Heulot M, Martinou J, Widmann C. TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. Apoptosis. 2014;19:719-33 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Faccenda D, Tan C, Seraphim A, Duchen M, Campanella M. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013;20:686-97 pubmed publisher
  • immunocytochemistry; human; 1:500
Cazanave S, Mott J, Bronk S, Werneburg N, Fingas C, Meng X, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 2011;286:39336-48 pubmed publisher
  • immunoprecipitation; rhesus macaque
  • western blot; rhesus macaque
Martin Latil S, Mousson L, Autret A, Colbere Garapin F, Blondel B. Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. J Virol. 2007;81:4457-64 pubmed
Preston A, Rogers A, Sharp M, Mitchell G, Toruno C, Barney B, et al. Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria. Cell Death Discov. 2023;9:66 pubmed publisher
Schmitt H, Fehrman R, Maes M, Yang H, Guo L, Schlamp C, et al. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. Invest Ophthalmol Vis Sci. 2021;62:14 pubmed publisher
Maes M, Grosser J, Fehrman R, Schlamp C, Nickells R. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Sci Rep. 2019;9:16565 pubmed publisher
Robinson E, Aguiar S, Kouwenhoven W, Starmans D, von Oerthel L, Smidt M, et al. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell Death Discov. 2018;4:107 pubmed publisher
Nie X, Zheng J, Ricupero C, He L, Jiao K, Mao J. mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018;14:e1007491 pubmed publisher
Shim M, Kim K, Bu J, Nam H, Jeong S, Park T, et al. Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis. 2018;9:285 pubmed publisher
Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
Zhang L, Wu H, Sun G, Xu X, Sun X, Cao L. Trichloromethane fraction of Incarvillea compacta induces lytic cytotoxicity and apoptosis in Epstein-Barr virus-positive gastric cancer AGS cells. BMC Complement Altern Med. 2016;16:344 pubmed publisher
Strappazzon F, Di Rita A, Cianfanelli V, D Orazio M, Nazio F, Fimia G, et al. Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. Autophagy. 2016;12:963-75 pubmed publisher
Haschka M, Soratroi C, Kirschnek S, Hacker G, Hilbe R, Geley S, et al. The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. Nat Commun. 2015;6:6891 pubmed publisher
Yang C, Matsuura K, Huang N, Robeson A, Huang B, Zhang L, et al. Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Oncogene. 2015;34:3264-72 pubmed publisher
Sizova O, Shinde V, Lenox A, Gorbatyuk M. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cell Signal. 2014;26:665-672 pubmed publisher
Song J, Ryu S, Cho Y, Kim Y, Lee B, Lee S, et al. Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to ?-radiation. Cell Death Dis. 2013;4:e744 pubmed publisher
Song T, Liang F, Zhang Z, Liu Y, Sheng H, Xie M. S1 kills MCF-7/ADR cells more than MCF-7 cells: A protective mechanism of endoplasmic reticulum stress. Biomed Pharmacother. 2013;67:731-6 pubmed publisher
Song T, Xue Z, Zhang Z, Shen X, Li X. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Basic Clin Pharmacol Toxicol. 2013;113:145-51 pubmed publisher
Gwak M, Cao L, Li L, Zuo Z. Isoflurane preconditioning reduces oxygen-glucose deprivation-induced neuronal injury via B-cell lymphoma 2 protein. Environ Toxicol Pharmacol. 2011;31:262-5 pubmed publisher
Zhang Z, Song T, Zhang T, Gao J, Wu G, An L, et al. A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1. Int J Cancer. 2011;128:1724-35 pubmed publisher
Zheng Y, Zhou M, Ye A, Li Q, Bai Y, Zhang Q. The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. World J Surg Oncol. 2010;8:31 pubmed publisher
Jia G, Kwon M, Liang H, Mortensen J, Nilakantan V, Sweeney W, et al. Chronic treatment with lisinopril decreases proliferative and apoptotic pathways in autosomal recessive polycystic kidney disease. Pediatr Nephrol. 2010;25:1139-46 pubmed publisher
Wang X, Viswanath R, Zhao J, Tang S, Hewlett I. Changes in the level of apoptosis-related proteins in Jurkat cells infected with HIV-1 versus HIV-2. Mol Cell Biochem. 2010;337:175-83 pubmed publisher
Liu J, Zhou W, Li S, Sun Z, Lin B, Lang Y, et al. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. Cancer Res. 2008;68:8871-80 pubmed publisher
Chai W, Zhu X, Li S, Fan J, Chen B. Role of Bcl-2 family members in caspase-3/9-dependent apoptosis during Pseudomonas aeruginosa infection in U937 cells. Apoptosis. 2008;13:833-43 pubmed publisher
Xu Q, Ohara N, Liu J, Nakabayashi K, DeManno D, Chwalisz K, et al. Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells. Am J Physiol Endocrinol Metab. 2007;293:E1002-11 pubmed
Autret A, Martin Latil S, Mousson L, Wirotius A, Petit F, Arnoult D, et al. Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase. J Virol. 2007;81:7504-16 pubmed
Shankar S, Srivastava R. Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis. 2007;28:1277-86 pubmed
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol. 2002;156:519-29 pubmed
product information
Catalog Number :
sc-23959
Product Name :
Bax (6A7) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
6A7
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Bax
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA