product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
α Tubulin (B-5-1-2) Antibody
catalog :
sc-23948
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-5-1-2
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 104
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3c
Ferguson B, Wennersten S, Demos Davies K, Rubino M, Robinson E, Cavasin M, et al. DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2021;321:H382-H389 pubmed publisher
  • western blot; human; 1:1000; fig 4f
Steins A, van Mackelenbergh M, van der Zalm A, Klaassen R, Serrels B, Goris S, et al. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep. 2020;21:e48780 pubmed publisher
  • western blot; mouse; loading ...; fig s3a
Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4b
Bugaj L, Sabnis A, Mitchell A, Garbarino J, Toettcher J, Bivona T, et al. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science. 2018;361: pubmed publisher
  • western blot; human; loading ...; fig 2b
Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
  • western blot; mouse; fig 4
Guo L, Costanzo Garvey D, Smith D, Zavorka M, Venable Kang M, MacDonald R, et al. Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2). Sci Rep. 2016;6:32093 pubmed publisher
  • immunocytochemistry; human; fig 3a
Park Y, Nam H, Do M, Lee J. The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles. Exp Mol Med. 2016;48:e250 pubmed publisher
  • western blot; mouse; 1:1000; fig s1
  • western blot; human; 1:1000; fig s3
Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher
  • western blot; human; fig 3
Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1?. Cancer Res. 2016;76:2231-42 pubmed publisher
  • western blot; human; fig 3
Alquezar C, Salado I, de la Encarnación A, Perez D, Moreno F, Gil C, et al. Targeting TDP-43 phosphorylation by Casein Kinase-1? inhibitors: a novel strategy for the treatment of frontotemporal dementia. Mol Neurodegener. 2016;11:36 pubmed publisher
  • western blot; mouse; fig 4
Tanaka T, Takei Y, Yamanouchi D. Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation. J Am Heart Assoc. 2016;5:e003062 pubmed publisher
  • western blot; human; 1:5000; fig 1
de Lange J, Faramarz A, Oostra A, de Menezes R, van der Meulen I, Rooimans M, et al. Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. Nat Commun. 2015;6:8399 pubmed publisher
  • immunocytochemistry; human; 1:650; fig 2b
Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, et al. The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene. 2016;35:2398-406 pubmed publisher
  • western blot; mouse; fig 6d
Mohankumar K, Currle D, White E, Boulos N, Dapper J, Eden C, et al. An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. Nat Genet. 2015;47:878-87 pubmed publisher
  • western blot; human; fig 3b
Gagnon J, Daou S, Zamorano N, Iannantuono N, Hammond Martel I, Mashtalir N, et al. Undetectable histone O-GlcNAcylation in mammalian cells. Epigenetics. 2015;10:677-91 pubmed publisher
  • western blot; human
Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed publisher
  • western blot; mouse; fig 7
  • western blot; human; fig 1
Li S, Oh Y, Yue P, Khuri F, Sun S. Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene. 2016;35:642-50 pubmed publisher
  • western blot; mouse; fig 5
Wijeweera A, Haj M, Feldman A, Pnueli L, Luo Z, Melamed P. Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin. Biochim Biophys Acta. 2015;1849:328-41 pubmed publisher
  • immunocytochemistry; human; 1:700; fig 3
Stolz A, Ertych N, Bastians H. A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation. Cell Cycle. 2015;14:827-37 pubmed publisher
  • western blot; mouse; 1:5000; fig 1
Sathyamurthy A, Yin D, Barik A, Shen C, Bean J, Figueiredo D, et al. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development. 2015;142:522-32 pubmed publisher
  • western blot; human
Peng H, Kaplan N, Yang W, Getsios S, Lavker R. FIH-1 disrupts an LRRK1/EGFR complex to positively regulate keratinocyte migration. Am J Pathol. 2014;184:3262-71 pubmed publisher
  • western blot; human
Tun A, Chaiyarit S, Kaewsutthi S, Katanyoo W, Chuenkongkaew W, Kuwano M, et al. Profiling the mitochondrial proteome of Leber's Hereditary Optic Neuropathy (LHON) in Thailand: down-regulation of bioenergetics and mitochondrial protein quality control pathways in fibroblasts with the 11778G>A mutation. PLoS ONE. 2014;9:e106779 pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...; fig 2c
Zha Y, Xia Y, Ding J, Choi J, Yang L, Dong Z, et al. MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression. Cell Death Dis. 2014;5:e1417 pubmed publisher
  • western blot; human
Kelso T, Baumgart K, Eickhoff J, Albert T, Antrecht C, Lemcke S, et al. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. Mol Cell Biol. 2014;34:3675-88 pubmed publisher
  • western blot; human; 1:1000; fig 1
Duitman J, Ruela de Sousa R, Shi K, de Boer O, Borensztajn K, Florquin S, et al. Protease activated receptor-1 deficiency diminishes bleomycin-induced skin fibrosis. Mol Med. 2014;20:410-6 pubmed publisher
Zhang S, Yang F, Huang Y, He L, Li Y, Wan Y, et al. ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. Nat Commun. 2023;14:4978 pubmed publisher
Lee H, Ha S, Choi S, Do S, Yoon S, Kim Y, et al. Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells. Int J Mol Sci. 2023;24: pubmed publisher
Boese A, Kang J, Hwang J, Kim J, Eun K, Malin C, et al. Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis. Proc Natl Acad Sci U S A. 2023;120:e2217332120 pubmed publisher
Wang X, Li Y, Qiang G, Wang K, Dai J, McCann M, et al. Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. Nat Commun. 2022;13:7323 pubmed publisher
Tilokani L, Russell F, Hamilton S, Virga D, Segawa M, Paupe V, et al. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. Sci Adv. 2022;8:eabo7956 pubmed publisher
Sun P, Zhang Z, Wang B, Liu C, Chen C, Liu P, et al. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun. 2022;13:6562 pubmed publisher
Kabra U, Moruzzi N, Berggren P, Jastroch M. Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells. Int J Mol Sci. 2022;23: pubmed publisher
Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, et al. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nat Commun. 2022;13:6108 pubmed publisher
Liu X, Yang Y, Wang Y. HSP90 and Aha1 modulate microRNA maturation through promoting the folding of Dicer1. Nucleic Acids Res. 2022;: pubmed publisher
Chen P, Liu Z, Zhang Q, Lin D, Lu S, Liu J, et al. DSCAM deficiency leads to premature spine maturation and autism-like behaviors. J Neurosci. 2021;: pubmed publisher
Jia T, Jacquet T, Dalonneau F, Coudert P, Vaganay E, Exbrayat Héritier C, et al. FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells. BMC Biol. 2021;19:173 pubmed publisher
Kim H, Yim J, Yoo H, Lee S, Oh S, Jung S, et al. EVI1 activates tumor-promoting transcriptional enhancers in pancreatic cancer. NAR Cancer. 2021;3:zcab023 pubmed publisher
Moon B, Yang S, Park S, Lee S, Song K, Jeong E, et al. LAD1 expression is associated with the metastatic potential of colorectal cancer cells. BMC Cancer. 2020;20:1180 pubmed publisher
Sun J, Feng H, Xing W, Han Y, Suo J, Yallowitz A, et al. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv. 2020;6: pubmed publisher
Hartl L, Duitman J, Aberson H, Chen K, Dijk F, Roelofs J, et al. CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel). 2020;12: pubmed publisher
van Schie J, Faramarz A, Balk J, Stewart G, Cantelli E, Oostra A, et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. Nat Commun. 2020;11:4287 pubmed publisher
Mazumdar A, Urdinez J, Boro A, Migliavacca J, Arlt M, Muff R, et al. Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. Int J Mol Sci. 2020;21: pubmed publisher
Beel S, Kolloch L, Apken L, Jürgens L, Bolle A, Sudhof N, et al. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Nat Commun. 2020;11:3409 pubmed publisher
Zaja R, Aydin G, Lippok B, Feederle R, Luscher B, Feijs K. Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. Sci Rep. 2020;10:8286 pubmed publisher
Basit A, Cho M, Kim E, Kwon D, Kang S, Lee J. The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels. Exp Mol Med. 2020;52:643-657 pubmed publisher
Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, et al. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun. 2019;10:5787 pubmed publisher
Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, et al. Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. Nat Commun. 2019;10:4869 pubmed publisher
Zhou J, So K, Li Y, Li Y, Yuan J, Ding Y, et al. Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell. 2019;18:e12996 pubmed publisher
Do H, Kim D, Kang J, Son B, Seo D, Youn H, et al. TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells. Biol Res. 2019;52:35 pubmed publisher
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, et al. The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Rep. 2019;27:3533-3546.e7 pubmed publisher
Ahn J, Cho M, Sohn S, Lee J. Inhibition of PP2A activity by H2O2 during mitosis disrupts nuclear envelope reassembly and alters nuclear shape. Exp Mol Med. 2019;51:64 pubmed publisher
Steurer B, Turkyilmaz Y, van Toorn M, van Leeuwen W, Escudero Ferruz P, Marteijn J. Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair. Nucleic Acids Res. 2019;47:3536-3549 pubmed publisher
Bailey C, Metierre C, Feng Y, Baidya K, Filippova G, Loukinov D, et al. CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer. Int J Mol Sci. 2018;19: pubmed publisher
Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W. H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biol. 2018;16:e2006522 pubmed publisher
Essig K, Kronbeck N, Guimaraes J, Lohs C, Schlundt A, Hoffmann A, et al. Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nat Commun. 2018;9:3810 pubmed publisher
Bagchi R, Ferguson B, Stratton M, Hu T, Cavasin M, Sun L, et al. HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI Insight. 2018;3: pubmed publisher
Romanick S, Ulrich C, Schlauch K, Hostler A, Payne J, Woolsey R, et al. Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry. Biosci Rep. 2018;38: pubmed publisher
Zhang H, Tian J, Qi X, Xiang T, He G, Zhang H, et al. Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation. PLoS Pathog. 2018;14:e1007208 pubmed publisher
Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, et al. Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res. 2018;6:14 pubmed publisher
Li H, Chang H, Shi Z, Leung P. SNAIL Mediates TGF-β1-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells. Endocrinology. 2018;159:1644-1657 pubmed publisher
Wang Y, Liu X, Zhou L, Duong D, Bhuripanyo K, Zhao B, et al. Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nat Commun. 2017;8:2232 pubmed publisher
Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher
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Moreno N, Holsten T, Mertins J, Zhogbi A, Johann P, Kool M, et al. Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors. Oncotarget. 2017;8:84986-84995 pubmed publisher
Kim J, Kim H, Yu D, Kweon H, Huh Y, Kim H. Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field. PLoS ONE. 2017;12:e0186416 pubmed publisher
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Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, et al. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017;8:14570 pubmed publisher
Wang Y, Pan Q, Ding S, Wang Z, Yu J, Finzi A, et al. The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity. J Virol. 2017;91: pubmed publisher
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product information
Catalog Number :
sc-23948
Product Name :
α Tubulin (B-5-1-2) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
B-5-1-2
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
alpha Tubulin
Specificity :
multiple species
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA