product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
cyclin A (BF683) Antibody
catalog :
sc-239
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BF683
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:100; loading ...; fig s2k
  • western blot; human; 1:100; loading ...; fig s2a, 7a
Vaughan C, Singh S, Subler M, Windle J, Inoue K, Fry E, et al. The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3. Nat Commun. 2021;12:704 pubmed publisher
  • western blot; mouse; fig 3
Rao V, Ow J, Shankar S, Bharathy N, Manikandan J, Wang Y, et al. G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation. Nucleic Acids Res. 2016;44:8129-43 pubmed publisher
  • western blot; human; fig 5b
Heo J, Kim W, Choi K, Bae S, Jeong J, Kim K. XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. Oncotarget. 2016;7:5118-30 pubmed publisher
  • western blot; human; fig 8
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
  • western blot; human; fig s9d
Wang P, Alvarez Perez J, Felsenfeld D, Liu H, Sivendran S, Bender A, et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015;21:383-8 pubmed publisher
  • western blot; rat
  • western blot; human
Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher
  • western blot; human
Bengoechea Alonso M, Punga T, Ericsson J. Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci U S A. 2005;102:11681-6 pubmed
García Gutiérrez L, Bretones G, Molina E, Arechaga I, Symonds C, Acosta J, et al. Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27. Sci Rep. 2019;9:18693 pubmed publisher
Phan A, Hua T, Kim M, Vo V, Choi J, Kim H, et al. Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. Oncotarget. 2016;7:54702-54713 pubmed publisher
Yan K, Lee L, Hsieh M, Yan M, Yao C, Chang P, et al. Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells. Oncol Rep. 2013;30:1497-505 pubmed publisher
Kim H, Cho J, Quan H, Kim J. Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway. FEBS Lett. 2011;585:3569-76 pubmed publisher
Song B, Liu X, Davis K, Liu X. Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Mol Cell Biol. 2011;31:4844-56 pubmed publisher
Giles N, Pavey S, Pinder A, Gabrielli B. Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. Br J Dermatol. 2012;166:362-71 pubmed publisher
Scharadin T, Jiang H, Jans R, Rorke E, Eckert R. TIG3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer cells. PLoS ONE. 2011;6:e23230 pubmed publisher
Kuo S, Hsu C, Chen L, Lu Y, Lin C, Yeh P, et al. Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001. Eur J Cancer. 2011;47:1244-57 pubmed publisher
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed publisher
Liu G, Yang G, Chang B, Mercado Uribe I, Huang M, Zheng J, et al. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 2010;102:812-27 pubmed publisher
Sato K, Kusama Y, Tategu M, Yoshida K. FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells. Int J Oncol. 2010;36:479-90 pubmed
Balasubramanian S, Adhikary G, Eckert R. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis. 2010;31:496-503 pubmed publisher
Nelson L, Cool L, Solek C, Haverty M. Cuticular hydrocarbons and soldier defense secretions of Reticulitermes in southern California: a critical analysis of the taxonomy of the genus in North America. J Chem Ecol. 2008;34:1452-75 pubmed publisher
Burd C, Kinyamu H, Miller F, Archer T. UV radiation regulates Mi-2 through protein translation and stability. J Biol Chem. 2008;283:34976-82 pubmed publisher
Zuco V, Zunino F. Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia. 2008;10:587-96 pubmed
Seabra L, Warenius H. Proteomic co-expression of cyclin-dependent kinases 1 and 4 in human cancer cells. Eur J Cancer. 2007;43:1483-92 pubmed
Hayashi R, Goto Y, Ikeda R, Yokoyama K, Yoshida K. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem. 2006;281:35633-48 pubmed
Goto Y, Hayashi R, Kang D, Yoshida K. Acute loss of transcription factor E2F1 induces mitochondrial biogenesis in HeLa cells. J Cell Physiol. 2006;209:923-34 pubmed
Mukhopadhyay I, Sausville E, Doroshow J, Roy K. Molecular mechanism of adaphostin-mediated G1 arrest in prostate cancer (PC-3) cells: signaling events mediated by hepatocyte growth factor receptor, c-Met, and p38 MAPK pathways. J Biol Chem. 2006;281:37330-44 pubmed
Orlando J, Astor T, Rundle S, Schaffer P. The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells. J Virol. 2006;80:4005-16 pubmed
Viola Rhenals M, Rieber M, Rieber M. Suppression of survival in human SKBR3 breast carcinoma in response to metal-chelator complexes is preferential for copper-dithiocarbamate. Biochem Pharmacol. 2006;71:722-34 pubmed
Shen G, Xu C, Chen C, Hebbar V, Kong A. p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Chemother Pharmacol. 2006;57:317-27 pubmed
Schmitz N, Leibundgut K, Hirt A. CDK2 catalytic activity and loss of nuclear tethering of retinoblastoma protein in childhood acute lymphoblastic leukemia. Leukemia. 2005;19:1783-7 pubmed
Yao C, Lai G, Chan C, Cheng A, Yang Y, Chuang S. Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone. Int J Cancer. 2006;118:773-9 pubmed
Soghoian D, Jayaraman V, Silane M, Berenstein A, Jayaraman T. Inositol 1,4,5-trisphosphate receptor phosphorylation in breast cancer. Tumour Biol. 2005;26:207-12 pubmed
Solorzano L, Rieber M, Medina J, Rieber M. Decreased glycolytic metabolism accelerates apoptosis in response to 2-acetyl furanonaphthoquinone in K1735 melanoma irrespective of bcl-2 overexpression. Cancer Biol Ther. 2005;4:329-35 pubmed
Halaban R, Cheng E, Smicun Y, Germino J. Deregulated E2F transcriptional activity in autonomously growing melanoma cells. J Exp Med. 2000;191:1005-16 pubmed
product information
Product Name :
cyclin A (BF683) Antibody
Gene Name :
CCNA2
Size :
200 µg/ml
Catalog Number :
sc-239
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
cyclin A
reactive species  :
m, r, h
Application :
WB, IP, IF, FCM, KA, ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA