| Published Application/Species/Sample/Dilution | Reference |
|---|
- ELISA; human; 10 ug/ml; fig 3b
| Zhao J, Xu J, Yang T, Yu X, Cheng C, Zhang T, et al. Expression, purification and characterisation of a human anti-CDK4 single-chain variable fragment antibody. BMC Biotechnol. 2021;21:71 pubmed publisher |
- western blot; mouse; 1:300; fig 5a
| Yin Y, Zhou N, Zhang H, Dai X, Lv X, Chen N, et al. Bmi1 regulate tooth and mandible development by inhibiting p16 signal pathway. J Cell Mol Med. 2021;25:4195-4203 pubmed publisher |
- western blot; rat; 1:200; loading ...; fig 5b
| Lin Y, Huang X, Chang K, Liao K, Tsai N. Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood-Brain Barrier and Suppresses Growth of Glioblastoma. Int J Nanomedicine. 2020;15:749-760 pubmed publisher |
- western blot; human; loading ...; fig 5g
| Si J, Ma Y, Bi J, Xiong Y, Lv C, Li S, et al. Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties. J Exp Clin Cancer Res. 2019;38:481 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher |
- western blot; human; 1:200; loading ...; fig 5a
| Graziano A, Cardile V, Avola R, Vicario N, Parenti C, Salvatorelli L, et al. Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget. 2017;8:13917-13931 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 5h
| Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, et al. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nat Commun. 2017;8:13923 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Xu D, Wang J, Zhou Z, He Z, Zhao Q. Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells. Mol Med Rep. 2015;12:7963-70 pubmed publisher |
- western blot; rat; 1:500; fig 3
| Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher |
- western blot; human; fig 7
| Guha G, Lu W, Li S, Liang X, Kulesz Martin M, Mahmud T, et al. Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. PLoS ONE. 2015;10:e0125322 pubmed publisher |
- western blot; human; fig 3
| Bele A, Mirza S, Zhang Y, Ahmad Mir R, Lin S, Kim J, et al. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14:990-1000 pubmed publisher |
| Oliveira C, de Bock C, Molloy T, Sadeqzadeh E, Geng X, Hersey P, et al. Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma. BMC Cancer. 2014;14:630 pubmed publisher |
| Zhang X, Sun Y, Cheng S, Yao Y, Hua X, Shi Y, et al. CDK6 increases glycolysis and suppresses autophagy by mTORC1-HK2 pathway activation in cervical cancer cells. Cell Cycle. 2022;21:984-1002 pubmed publisher |
| Giordano F, Montalto F, Panno M, Ando S, De Amicis F. A Notch inhibitor plus Resveratrol induced blockade of autophagy drives glioblastoma cell death by promoting a switch to apoptosis. Am J Cancer Res. 2021;11:5933-5950 pubmed |
| Lin H, Hsieh M, Wang C, Yu P, Lee M, Chen J. Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration. Antioxidants (Basel). 2021;10: pubmed publisher |
| Li Q, Jiang B, Guo J, Shao H, Del Priore I, Chang Q, et al. INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer Discov. 2021;: pubmed publisher |
| Aboushousha T, Hammam O, Aref A, Kamel A, Badawy M, Abdel Hamid A. Tissue Profile of CDK4 and STAT3 as Possible Innovative Therapeutic Targets in Urinary Bladder Cancer. Asian Pac J Cancer Prev. 2020;21:547-554 pubmed publisher |
| Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis D, Chahine J, et al. Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. Sci Rep. 2019;9:14650 pubmed publisher |
| Costa C, Wang Y, Ly A, Hosono Y, Murchie E, Walmsley C, et al. PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer. Cancer Discov. 2019;: pubmed publisher |
| Sriraman A, Dickmanns A, Najafova Z, Johnsen S, Dobbelstein M. CDK4 inhibition diminishes p53 activation by MDM2 antagonists. Cell Death Dis. 2018;9:918 pubmed publisher |
| Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher |
| Peurala E, Koivunen P, Haapasaari K, Bloigu R, Jukkola Vuorinen A. The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer. Breast Cancer Res. 2013;15:R5 pubmed publisher |
| Vedin L, Gustafsson J, Steffensen K. The oxysterol receptors LXR? and LXR? suppress proliferation in the colon. Mol Carcinog. 2013;52:835-44 pubmed publisher |
| Lin Y, Chiang B. 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem. 2011;59:8625-31 pubmed publisher |
| Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama K, et al. p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol. 2005;168:55-66 pubmed |
