product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
c-Abl (24-11) Antibody
catalog :
sc-23
quantity :
100 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
24-11
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; mouse; 1:50; loading ...; fig 6a
  • western blot; mouse; 1:100; loading ...; fig 6c
Mohamed M, Gupta K, Goldufsky J, Roy R, Callaghan L, Wetzel D, et al. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022;13:1295 pubmed publisher
  • western blot; mouse; loading ...; fig s2a
Yuan B, Yang J, Dubeau L, Hu Y, Li R. A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021;9:649087 pubmed publisher
  • western blot; human; loading ...; fig 4c
Kim B, Jeong Y, Wong M, Martin L. DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations. Acta Neuropathol Commun. 2020;8:7 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1s1a
Langer L, Ward J, Archer T. Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determination. elife. 2019;8: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5d
Gerlach B, Tubbesing K, Liao G, Rezey A, Wang R, Barroso M, et al. Phosphorylation of GMFγ by c-Abl Coordinates Lamellipodial and Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell Migration. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
  • western blot; human; fig 4
Wang Z, Zhang Y, Pinkas D, Fox A, Luo J, Huang H, et al. Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem. 2018;: pubmed publisher
  • western blot; human; fig 1
Bilal M, Zhang E, Dinkel B, Hardy D, Yankee T, Houtman J. GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Cell Signal. 2015;27:841-50 pubmed publisher
  • western blot; human
Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed publisher
  • immunoprecipitation; rat
  • immunocytochemistry; rat
Vargas L, Leal N, Estrada L, González A, Serrano F, Araya K, et al. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS ONE. 2014;9:e92309 pubmed publisher
García Tuñón I, Hernández Sánchez M, Ordoñez J, Alonso Pérez V, Álamo Quijada M, Benito R, et al. The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Oncotarget. 2017;8:26027-26040 pubmed publisher
Ananthula S, Sinha A, El Gassim M, Batth S, Marshall G, Gardner L, et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget. 2016;7:20869-89 pubmed publisher
Blanchard Z, Mullins N, Ellipeddi P, Lage J, McKinney S, El Etriby R, et al. Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative. PLoS ONE. 2014;9:e95663 pubmed publisher
Salem T, Gomard T, Court F, Moquet Torcy G, Brockly F, Forné T, et al. Chromatin loop organization of the junb locus in mouse dendritic cells. Nucleic Acids Res. 2013;41:8908-25 pubmed publisher
Liu Y, Zheng W, Song Y, Ma W, Yin H. Low expression of miR-196b enhances the expression of BCR-ABL1 and HOXA9 oncogenes in chronic myeloid leukemogenesis. PLoS ONE. 2013;8:e68442 pubmed publisher
Panjarian S, Iacob R, Chen S, Wales T, Engen J, Smithgall T. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. J Biol Chem. 2013;288:6116-29 pubmed publisher
Liu Y, Song Y, Ma W, Zheng W, Yin H. Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia. Leuk Res. 2013;37:349-56 pubmed publisher
Amengual Cladera E, Llado I, Proenza A, Gianotti M. High-fat diet feeding induces a depot-dependent response on the pro-inflammatory state and mitochondrial function of gonadal white adipose tissue. Br J Nutr. 2013;109:413-24 pubmed publisher
Dinis J, Silva V, Gromicho M, Martins C, Laires A, Tavares P, et al. DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells. Leuk Lymphoma. 2012;53:2004-14 pubmed publisher
Schneider S, Carra G, Sahin U, Hoy B, Rieder G, Wessler S. Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells. Infect Immun. 2011;79:2362-71 pubmed publisher
Vilas Zornoza A, Agirre X, Martín Palanco V, Martin Subero J, San Jose Eneriz E, Garate L, et al. Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. PLoS ONE. 2011;6:e17012 pubmed publisher
Khusial P, Vadla B, Krishnan H, Ramlall T, Shen Y, Ichikawa H, et al. Src activates Abl to augment Robo1 expression in order to promote tumor cell migration. Oncotarget. 2010;1:198-209 pubmed
Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, et al. Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun. 2011;2:158 pubmed
Warsch W, Kollmann K, Eckelhart E, Fajmann S, Cerny Reiterer S, Hölbl A, et al. High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood. 2011;117:3409-20 pubmed publisher
Chen J, Wang M, Hung W. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 2011;226:407-13 pubmed publisher
Mizutani T, Kondo T, Darmanin S, Tsuda M, Tanaka S, Tobiume M, et al. A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells. Clin Cancer Res. 2010;16:3964-75 pubmed publisher
Zuniga F, Craft C. Deciphering the structure and function of Als2cr4 in the mouse retina. Invest Ophthalmol Vis Sci. 2010;51:4407-15 pubmed publisher
Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, et al. Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment. Cell Death Differ. 2010;17:1211-20 pubmed publisher
May V, Lutz E, MacKenzie C, Schutz K, Dozark K, Braas K. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. J Biol Chem. 2010;285:9749-61 pubmed publisher
Fulciniti M, Tassone P, Hideshima T, Vallet S, Nanjappa P, Ettenberg S, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood. 2009;114:371-9 pubmed publisher
Qiao F, Gao C, Tripathi B, Zelenka P. Distinct functions of Cdk5(Y15) phosphorylation and Cdk5 activity in stress fiber formation and organization. Exp Cell Res. 2008;314:3542-50 pubmed publisher
Pielage J, Powell K, Kalman D, Engel J. RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization. PLoS Pathog. 2008;4:e1000031 pubmed publisher
Williams R, Roussel M, Sherr C. Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2006;103:6688-93 pubmed
Kurebayashi J, Okubo S, Yamamoto Y, Ikeda M, Tanaka K, Otsuki T, et al. Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. Cancer Chemother Pharmacol. 2006;58:460-70 pubmed
Liu L, D Mello S. Phosphorylation of IkappaB-beta is necessary for neuronal survival. J Biol Chem. 2006;281:1506-15 pubmed
Burchert A, Wang Y, Cai D, von Bubnoff N, Paschka P, Müller Brüsselbach S, et al. Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development. Leukemia. 2005;19:1774-82 pubmed
Simpson L, He X, Pins M, Huang X, Campbell S, Yang X, et al. Renal medullary carcinoma and ABL gene amplification. J Urol. 2005;173:1883-8 pubmed
product information
Catalog Number :
sc-23
Product Name :
c-Abl (24-11) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
24-11
Isotype :
IgG1
Size :
100 µg/ml
List Price :
316 USD
Immunogen :
c-Abl p120
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA