product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
E-cadherin (67A4) Antibody
catalog :
sc-21791
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
67A4
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 36
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 5a
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5j
Chen G, Liu B, Yin S, Li S, Guo Y, Wang M, et al. Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis. 2020;9:81 pubmed publisher
  • flow cytometry; human; 1:5; loading ...; fig s3a
Ling C, Nishimoto K, Rolfs Z, Smith L, Frey B, Welham N. Differentiated fibrocytes assume a functional mesenchymal phenotype with regenerative potential. Sci Adv. 2019;5:eaav7384 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig s1
Hurtado Alvarado G, Dominguez Salazar E, Velazquez Moctezuma J, Gómez González B. A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction. PLoS ONE. 2016;11:e0167236 pubmed publisher
  • flow cytometry; human; loading ...
Chaudhury A, Cheema S, Fachini J, Kongchan N, Lu G, Simon L, et al. CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT. Nat Commun. 2016;7:13362 pubmed publisher
  • western blot; human; fig 2
Yin K, Yin W, Wang Y, Zhou L, Liu Y, Yang G, et al. MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-? signaling in estrogen receptor positive breast cancer cells. Oncotarget. 2016;7:24537-48 pubmed publisher
  • immunohistochemistry; human; fig 1
Fraveto A, Cardinale V, Bragazzi M, Giuliante F, De Rose A, Grazi G, et al. Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS ONE. 2015;10:e0142124 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; human; loading ...; fig 3
Zhang Y, Fan N, Yang J. Expression and clinical significance of hypoxia-inducible factor 1?, Snail and E-cadherin in human ovarian cancer cell lines. Mol Med Rep. 2015;12:3393-3399 pubmed publisher
  • immunocytochemistry; human
Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
  • immunocytochemistry; human; 1:100
Findlay V, Moretz R, Wang C, Vaena S, Bandurraga S, Ashenafi M, et al. Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer. Mol Carcinog. 2014;53 Suppl 1:E130-9 pubmed publisher
Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed publisher
Liu M, Hancock S, Sultani G, Wilkins B, Ding E, Osborne B, et al. Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells. J Clin Med. 2019;8: pubmed publisher
Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, et al. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 2019;15:886-899 pubmed publisher
Pliatska M, Kapasa M, Kokkalis A, Polyzos A, Thanos D. The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Mol Cell Biol. 2018;38: pubmed publisher
Huo Y, Li Q, Wang X, Jiao X, Zheng J, Li Z, et al. MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2. Oncotarget. 2017;8:46993-47006 pubmed publisher
Yu J, Liang Q, Wang J, Wang K, Gao J, Zhang J, et al. REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype. Oncogene. 2017;36:182-193 pubmed publisher
Liu W, Qiao R, Wang D, Huang X, Li B, Wang D. UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner. Mol Med Rep. 2016;13:315-20 pubmed publisher
Ghafoory S, Mehrabi A, Hafezi M, Cheng X, Breitkopf Heinlein K, Hick M, et al. Nuclear accumulation of CDH1 mRNA in hepatocellular carcinoma cells. Oncogenesis. 2015;4:e152 pubmed publisher
Liu Y, Han X, Gao B. Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion. Exp Ther Med. 2015;9:1460-1464 pubmed
Ai L, Kim W, Alpay M, Tang M, Pardo C, Hatakeyama S, et al. TRIM29 suppresses TWIST1 and invasive breast cancer behavior. Cancer Res. 2014;74:4875-87 pubmed publisher
Weitzenfeld P, Meron N, Leibovich Rivkin T, Meshel T, Ben Baruch A. Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNF? and the hormonal and growth-supporting arms of the tumor microenvironment. Mediators Inflamm. 2013;2013:720536 pubmed publisher
Kim K, Godarova A, Seedle K, Kim M, Ince T, Wells S, et al. Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PLoS ONE. 2013;8:e80590 pubmed publisher
Junk D, Cipriano R, Bryson B, Gilmore H, Jackson M. Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events. Neoplasia. 2013;15:1100-9 pubmed
Yin S, Peng A, Huang L, Wang Y, Lan C, Yang N. The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing. Evid Based Complement Alternat Med. 2013;2013:262796 pubmed publisher
Bhatia S, Pilquil C, Roth Albin I, Draper J. Demarcation of stable subpopulations within the pluripotent hESC compartment. PLoS ONE. 2013;8:e57276 pubmed publisher
de Sá V, Carvalho L, Gomes A, Alarcão A, Silva M, Couceiro P, et al. Role of the extracellular matrix in variations of invasive pathways in lung cancers. Braz J Med Biol Res. 2013;46:21-31 pubmed
Jensen K, Patel A, Hoperia V, Larin A, Bauer A, Vasko V. Dynamic changes in E-cadherin gene promoter methylation during metastatic progression in papillary thyroid cancer. Exp Ther Med. 2010;1:457-462 pubmed
Feng B, Dong T, Wang L, Zhou H, Zhao H, Dong F, et al. Colorectal cancer migration and invasion initiated by microRNA-106a. PLoS ONE. 2012;7:e43452 pubmed publisher
Han J, Gao B, Jin X, Xu Z, Li Z, Sun Y, et al. Small interfering RNA-mediated downregulation of beta-catenin inhibits invasion and migration of colon cancer cells in vitro. Med Sci Monit. 2012;18:BR273-80 pubmed
Richardson F, Young G, Sennello R, Wolf J, Argast G, Mercado P, et al. The evaluation of E-Cadherin and vimentin as biomarkers of clinical outcomes among patients with non-small cell lung cancer treated with erlotinib as second- or third-line therapy. Anticancer Res. 2012;32:537-52 pubmed
Thomson S, Petti F, Sujka Kwok I, Mercado P, Bean J, Monaghan M, et al. A systems view of epithelial-mesenchymal transition signaling states. Clin Exp Metastasis. 2011;28:137-55 pubmed publisher
Masur K, Vetter C, Hinz A, Tomas N, Henrich H, Niggemann B, et al. Diabetogenic glucose and insulin concentrations modulate transcriptome and protein levels involved in tumour cell migration, adhesion and proliferation. Br J Cancer. 2011;104:345-52 pubmed publisher
Dangi Garimella S, Yun J, Eves E, Newman M, Erkeland S, Hammond S, et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009;28:347-58 pubmed publisher
Wang X, Yu D, McCaughan G, Gorrell M. Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Adv Exp Med Biol. 2006;575:213-22 pubmed
Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med. 2006;203:289-95 pubmed
Wang X, Yu D, McCaughan G, Gorrell M. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology. 2005;42:935-45 pubmed
product information
Catalog Number :
sc-21791
Product Name :
E-cadherin (67A4) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
67A4
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
E-cadherin
Specificity :
human
Uses :
WB, IP, IF, FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA