product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Hemoglobin γ (51-7) Antibody
catalog :
sc-21756
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
51-7
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 2c
Grevet J, Lan X, Hamagami N, Edwards C, Sankaranarayanan L, Ji X, et al. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018;361:285-290 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2a
Trakarnsanga K, Griffiths R, Wilson M, Blair A, Satchwell T, Meinders M, et al. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells. Nat Commun. 2017;8:14750 pubmed publisher
  • flow cytometry; human; loading ...; fig s3d
  • western blot; human; fig s7c
Masuda T, Wang X, Maeda M, Canver M, Sher F, Funnell A, et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science. 2016;351:285-9 pubmed publisher
  • western blot; human; fig 3
Boosalis M, Sangerman J, White G, Wolf R, Shen L, Dai Y, et al. Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice. PLoS ONE. 2015;10:e0144660 pubmed publisher
  • western blot; human
Miyazawa M, Tsuji Y. Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene. Mol Biol Cell. 2014;25:2116-27 pubmed publisher
  • western blot; human
Peretti de Albuquerque Wobeto V, Machado Neto J, Zaccariotto T, Ribeiro D, da Silva Santos Duarte A, Saad S, et al. PIPKII? is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells. Mol Cell Biochem. 2014;393:145-53 pubmed publisher
  • immunocytochemistry; human; 1:75
  • western blot; human; 1:100
Emara M, Turner A, Allalunis Turner J. Adult, embryonic and fetal hemoglobin are expressed in human glioblastoma cells. Int J Oncol. 2014;44:514-20 pubmed publisher
Khosravi M, Abbasalipour M, Concordet J, Berg J, Zeinali S, Arashkia A, et al. Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease. Eur J Pharmacol. 2019;854:398-405 pubmed publisher
Starlard Davenport A, Smith A, Vu L, Li B, Pace B. MIR29B mediates epigenetic mechanisms of HBG gene activation. Br J Haematol. 2019;186:91-100 pubmed publisher
Wang H, Georgakopoulou A, Psatha N, Li C, Capsali C, Samal H, et al. In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia. J Clin Invest. 2019;129:598-615 pubmed publisher
Li B, Zhu X, Ward C, Starlard Davenport A, Takezaki M, Berry A, et al. MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease. Exp Hematol. 2019;70:85-96.e5 pubmed publisher
Li C, Psatha N, Gil S, Wang H, Papayannopoulou T, Lieber A. HDAd5/35++ Adenovirus Vector Expressing Anti-CRISPR Peptides Decreases CRISPR/Cas9 Toxicity in Human Hematopoietic Stem Cells. Mol Ther Methods Clin Dev. 2018;9:390-401 pubmed publisher
Shen Y, Bassett M, Gurumurthy A, Nar R, Knudson I, Guy C, et al. Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression. Mol Cell Biol. 2018;38: pubmed publisher
Zhang Y, Paikari A, Sumazin P, Ginter Summarell C, Crosby J, Boerwinkle E, et al. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018;132:321-333 pubmed publisher
Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison T, Naing Z, et al. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018;36:1004-1019 pubmed publisher
Loucari C, Patsali P, van Dijk T, Stephanou C, Papasavva P, Zanti M, et al. Rapid and sensitive assessment of globin chains for gene and cell therapy of haemoglobinopathies. Hum Gene Ther Methods. 2018;: pubmed publisher
Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantù I, van Gent T, et al. Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice. Blood. 2013;121:2553-62 pubmed publisher
Chen A, Kleiboeker S, Qiu J. Productive parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIF?. PLoS Pathog. 2011;7:e1002088 pubmed publisher
Wong S, Keyvanfar K, Wan Z, Kajigaya S, Young N, Zhi N. Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells. Exp Hematol. 2010;38:994-1005.e1-2 pubmed publisher
van Dijk T, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, et al. Fetal globin expression is regulated by Friend of Prmt1. Blood. 2010;116:4349-52 pubmed publisher
Suzuki Y, Takeda Y, Ikuta T. Immunoblotting conditions for human hemoglobin chains. Anal Biochem. 2008;378:218-20 pubmed publisher
product information
Catalog Number :
sc-21756
Product Name :
Hemoglobin γ (51-7) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
51-7
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Hemoglobin gamma
Specificity :
human
Uses :
WB, IP, IF, IHC(P), FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA