product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
OPN (AKm2A1) Antibody
catalog :
sc-21742
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AKm2A1
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 71
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 2a
Kim J, Ahn M, Choi Y, Chun J, Jung K, Tanaka A, et al. Osteopontin is a biomarker for early autoimmune uveoretinitis. Neural Regen Res. 2022;17:1604-1608 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4c
Hirano Y, Kurosu H, Shiizaki K, Iwazu Y, Tsuruoka S, Kuro O M. Interleukin-36α as a potential biomarker for renal tubular damage induced by dietary phosphate load. FEBS Open Bio. 2020;10:894-903 pubmed publisher
  • western blot; mouse; loading ...; fig 7d
  • immunocytochemistry; rat; fig 2c
  • western blot; rat; fig 3b
Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44:760-770 pubmed publisher
  • western blot; rat; loading ...; fig 8a
Jang M, Lee S, Baek S, Park S, Choi Y, Kim C. α-Iso-Cubebene Inhibits PDGF-Induced Vascular Smooth Muscle Cell Proliferation by Suppressing Osteopontin Expression. PLoS ONE. 2017;12:e0170699 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5h
Jin F, Jiang K, Ji S, Wang L, Ni Z, Huang F, et al. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex. Hum Mol Genet. 2017;26:407-419 pubmed publisher
  • immunoprecipitation; mouse; fig 4
  • western blot; mouse; fig 1
Zhao K, Zhang M, Zhang L, Wang P, Song G, Liu B, et al. Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response. Sci Rep. 2016;6:23771 pubmed publisher
  • western blot; mouse; loading ...; fig 8b
Calyjur P, Almeida C, Ayub Guerrieri D, Ribeiro A, Fernandes S, Ishiba R, et al. The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors. PLoS ONE. 2016;11:e0150748 pubmed publisher
  • immunocytochemistry; rat; fig 5
  • western blot; rat; fig 2
He D, Lu Y, Hu H, Zhang J, Qin B, Wang Y, et al. The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation. Int J Mol Sci. 2015;16:16313-29 pubmed publisher
  • western blot; rat; 1:1000; fig 8
Sun J, Li J, Li C, Yu Y. Role of bone morphogenetic protein-2 in osteogenic differentiation of mesenchymal stem cells. Mol Med Rep. 2015;12:4230-4237 pubmed publisher
  • western blot; mouse
Seo K, Lee S, Ye B, Kim Y, Bae S, Kim C. Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1/AP-1 pathways in VSMC. J Mol Cell Cardiol. 2015;85:13-24 pubmed publisher
  • western blot; mouse; fig 5
Li L, Dong Q, Wang Y, Feng Q, Zhou P, Ou X, et al. Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2015;35:1641-50 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 4
Bouet G, Bouleftour W, Juignet L, Linossier M, Thomas M, Vanden Bossche A, et al. The impairment of osteogenesis in bone sialoprotein (BSP) knockout calvaria cell cultures is cell density dependent. PLoS ONE. 2015;10:e0117402 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 7
Harada K, Harada T, Ferdous T, Takenawa T, Ueyama Y. Osteogenic cell fractions isolated from mouse tongue muscle. Mol Med Rep. 2015;12:31-6 pubmed publisher
  • immunocytochemistry; human; 1:100; tbl 1
Johnstone S, Liley M, Dalby M, Barnett S. Comparison of human olfactory and skeletal MSCs using osteogenic nanotopography to demonstrate bone-specific bioactivity of the surfaces. Acta Biomater. 2015;13:266-76 pubmed publisher
  • western blot; rat
Ndisang J, Chibbar R, Lane N. Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension. Eur J Pharmacol. 2014;734:23-34 pubmed publisher
  • immunocytochemistry; mouse
Inoue M, Arikawa T, Chen Y, Moriwaki Y, Price M, Brown M, et al. T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. Proc Natl Acad Sci U S A. 2014;111:5295-300 pubmed publisher
  • western blot; rat; 1:500
Jia Z, Wang S, Tang J, He D, Cui L, Liu Z, et al. Does crystal deposition in genetic hypercalciuric rat kidney tissue share similarities with bone formation?. Urology. 2014;83:509.e7-14 pubmed publisher
  • immunocytochemistry; human; 2 ug/ml
Kaivosoja E, Sariola V, Chen Y, Konttinen Y. The effect of pulsed electromagnetic fields and dehydroepiandrosterone on viability and osteo-induction of human mesenchymal stem cells. J Tissue Eng Regen Med. 2015;9:31-40 pubmed publisher
  • immunohistochemistry; mouse
Walker C, Ito Y, Dangaria S, Luan X, Diekwisch T. RANKL, osteopontin, and osteoclast homeostasis in a hyperocclusion mouse model. Eur J Oral Sci. 2008;116:312-8 pubmed publisher
Jo S, Weon S, Nam B, Jang M, Kang H, Kim T, et al. WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis. Arthritis Res Ther. 2021;23:301 pubmed publisher
Han T, Goswami S, Hu Y, Tang F, Zafra M, Murphy C, et al. Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer Discov. 2020;10:1590-1609 pubmed publisher
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed publisher
Cheng Z, Alba Perez A, González García C, Donnelly H, Llopis Hernández V, Jayawarna V, et al. Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects. Adv Sci (Weinh). 2019;6:1800361 pubmed publisher
Olive J, Qin Y, Decristo M, Laszewski T, Greathouse F, McAllister S. Accounting for tumor heterogeneity when using CRISPR-Cas9 for cancer progression and drug sensitivity studies. PLoS ONE. 2018;13:e0198790 pubmed publisher
Gong L, Manaenko A, Fan R, Huang L, Enkhjargal B, McBride D, et al. Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage. Neuropharmacology. 2018;138:160-169 pubmed publisher
Ruvolo P, Ruvolo V, Burks J, Qiu Y, Wang R, Shpall E, et al. Role of MSC-derived galectin 3 in the AML microenvironment. Biochim Biophys Acta Mol Cell Res. 2018;1865:959-969 pubmed publisher
Reichetzeder C, von Websky K, Tsuprykov O, Mohagheghi Samarin A, Falke L, Dwi Putra S, et al. Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. Br J Pharmacol. 2017;174:2273-2286 pubmed publisher
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, et al. Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. Sci Rep. 2016;6:27354 pubmed publisher
Bhattarai G, Lee Y, Lee M, Park I, Yi H. Insulin-like growth factor binding protein-3 affects osteogenic efficacy on dental implants in rat mandible. Mater Sci Eng C Mater Biol Appl. 2015;55:490-6 pubmed publisher
Hsu K, Tsai H, Lin P, Hsu Y, Lu P, Shan Y. Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors. World J Surg Oncol. 2014;12:189 pubmed publisher
Oliveira Ferrer L, Rosler K, Haustein V, Schroder C, Wicklein D, Maltseva D, et al. c-FOS suppresses ovarian cancer progression by changing adhesion. Br J Cancer. 2014;110:753-63 pubmed publisher
Zhao M, Zang B, Cheng M, Ma Y, Yang Y, Yang N. Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil. PLoS ONE. 2013;8:e78620 pubmed publisher
Guo Y, Zeng Q, Yan Y, Shen L, Liu L, Li R, et al. Proliferative effect and osteoinductive potential of extracellular matrix coated on cell culture plates. Springerplus. 2013;2:303 pubmed publisher
Yamamoto T, Oishi T, Higo N, Murayama S, Sato A, Takashima I, et al. Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery. PLoS ONE. 2013;8:e65701 pubmed publisher
Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader B. Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab. 2013;304:E1140-56 pubmed publisher
Kaivosoja E, Suvanto P, Barreto G, Aura S, Soininen A, Franssila S, et al. Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces. J Biomed Mater Res A. 2013;101:842-52 pubmed publisher
Wang X, Cheng M, Zhao M, Ge A, Guo F, Zhang M, et al. Differential effects of high-fat-diet rich in lard oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats. Eur J Nutr. 2013;52:1181-9 pubmed publisher
Ferro F, Spelat R, D Aurizio F, Puppato E, Pandolfi M, Beltrami A, et al. Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLoS ONE. 2012;7:e41774 pubmed publisher
Soetikno V, Sari F, Sukumaran V, Lakshmanan A, Mito S, Harima M, et al. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sci. 2012;47:604-14 pubmed publisher
Misawa H, Hara M, Tanabe S, Niikura M, Moriwaki Y, Okuda T. Osteopontin is an alpha motor neuron marker in the mouse spinal cord. J Neurosci Res. 2012;90:732-42 pubmed
Sun L, Pan J, Peng L, Fang L, Zhao X, Sun L, et al. Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. Ann Surg Oncol. 2012;19:2411-9 pubmed publisher
Soetikno V, Watanabe K, Sari F, Harima M, Thandavarayan R, Veeraveedu P, et al. Curcumin attenuates diabetic nephropathy by inhibiting PKC-? and PKC-?1 activity in streptozotocin-induced type I diabetic rats. Mol Nutr Food Res. 2011;55:1655-65 pubmed publisher
Frisch B, Ashton J, Xing L, Becker M, Jordan C, Calvi L. Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood. 2012;119:540-50 pubmed publisher
Yuan S, Wang J, Huang H, Jing H. Osteopontin expression and its possible functions in the aortic disorders and coronary artery disease. Rev Bras Cir Cardiovasc. 2011;26:173-82 pubmed
Uhlmann M, Georges R, Boleij A, Eyol E, Kubarenko A, Adwan H, et al. Influence of osteopontin expression on the metastatic growth of CC531 rat colorectal carcinoma cells in rat liver. Cancer Gene Ther. 2011;18:795-805 pubmed publisher
Maier T, Laubender R, Sturm R, Klingenstein A, Korting H, Ruzicka T, et al. Osteopontin expression in plasma of melanoma patients and in melanocytic tumours. J Eur Acad Dermatol Venereol. 2012;26:1084-91 pubmed publisher
Mi J, Duan J, Zhang J, Lu J, Wang H, Wang Z. Evaluation of antiurolithic effect and the possible mechanisms of Desmodium styracifolium and Pyrrosiae petiolosa in rats. Urol Res. 2012;40:151-61 pubmed publisher
Yim H, Ha K, Bae I, Yoo K, Hong Y, Lee J. Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats. J Nutr Biochem. 2012;23:937-45 pubmed publisher
Flajollet S, Tian T, Flourens A, Tomavo N, Villers A, Bonnelye E, et al. Abnormal expression of the ERG transcription factor in prostate cancer cells activates osteopontin. Mol Cancer Res. 2011;9:914-24 pubmed publisher
Peng A, Ye T, Rakheja D, Tu Y, Wang T, Du Y, et al. The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis. Kidney Int. 2011;80:601-11 pubmed publisher
Li R, Li C, Gasbarre L. The vitamin D receptor and inducible nitric oxide synthase associated pathways in acquired resistance to Cooperia oncophora infection in cattle. Vet Res. 2011;42:48 pubmed publisher
Blake C, McCoy G, Hui Y, Lavoie H. Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression. Exp Biol Med (Maywood). 2011;236:445-55 pubmed publisher
Ding Z, Wu C, Chu G, Xiao Y, Ho D, Zhang J, et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011;470:269-73 pubmed publisher
Zhao B, Sun T, Meng F, Qu A, Li C, Shen H, et al. Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancer. J Cancer Res Clin Oncol. 2011;137:1061-70 pubmed publisher
Fu H, He Y, Gao Y, Man Y, Liu W, Hao H. Acupuncture on the Endometrial Morphology, the Serum Estradiol and Progesterone Levels, and the Expression of Endometrial Leukaemia-inhibitor Factor and Osteopontin in Rats. Evid Based Complement Alternat Med. 2011;2011:606514 pubmed publisher
Walker C, Dangaria S, Ito Y, Luan X, Diekwisch T. Osteopontin is required for unloading-induced osteoclast recruitment and modulation of RANKL expression during tooth drift-associated bone remodeling, but not for super-eruption. Bone. 2010;47:1020-9 pubmed publisher
Hsu K, Tsai H, Lin P, Hsu Y, Shan Y, Lu P. Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation. Ann Surg Oncol. 2010;17:3043-52 pubmed publisher
Lu H, Zhen J, Wu T, Peng A, Ye T, Wang T, et al. Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice. Am J Physiol Renal Physiol. 2010;299:F445-52 pubmed publisher
Facca S, Cortez C, Mendoza Palomares C, Messadeq N, Dierich A, Johnston A, et al. Active multilayered capsules for in vivo bone formation. Proc Natl Acad Sci U S A. 2010;107:3406-11 pubmed publisher
Elcin Y, Inanç B, Elcin A. Human embryonic stem cell differentiation on periodontal ligament fibroblasts. Methods Mol Biol. 2010;584:269-81 pubmed publisher
Inanç B, Elcin A, Elcin Y. In vitro differentiation and attachment of human embryonic stem cells on periodontal tooth root surfaces. Tissue Eng Part A. 2009;15:3427-35 pubmed publisher
Kashyap M, Marimuthu A, Kishore C, Peri S, Keerthikumar S, Prasad T, et al. Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biol Ther. 2009;8:36-46 pubmed
Hannan N, Salamonsen L. CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation. Biol Reprod. 2008;79:58-65 pubmed publisher
Toi S, Shibata N, Sawada T, Kobayashi M, Uchiyama S. Activation of the non-receptor tyrosine kinase cSrc in macrophage-rich atherosclerotic plaques of human carotid arteries. Acta Histochem Cytochem. 2007;40:153-61 pubmed publisher
Chen C, Liu H, Tsai C, Yu C, Lin I, Hsiue G. Photoencapsulation of bone morphogenetic protein-2 and periosteal progenitor cells improve tendon graft healing in a bone tunnel. Am J Sports Med. 2008;36:461-73 pubmed publisher
Pavel E, Nadella K, Towns W, Kirschner L. Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A. Mol Endocrinol. 2008;22:430-40 pubmed
Graessmann M, Berg B, Fuchs B, Klein A, Graessmann A. Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. Oncogene. 2007;26:2840-50 pubmed
Shin T, Ahn M, Kim H, Kim H, Matsumoto Y. Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis. J Vet Med Sci. 2006;68:379-82 pubmed
Nishiwaki T, Yamaguchi T, Zhao C, Amano H, Hankenson K, Bornstein P, et al. Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. J Bone Miner Res. 2006;21:596-604 pubmed
Shin T, Ahn M, Kim H, Moon C, Kang T, Lee J, et al. Temporal expression of osteopontin and CD44 in rat brains with experimental cryolesions. Brain Res. 2005;1041:95-101 pubmed
Gross T, King K, Rabaia N, Pathare P, Srinivasan S. Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen. J Bone Miner Res. 2005;20:250-6 pubmed
product information
Catalog Number :
sc-21742
Product Name :
OPN (AKm2A1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
AKm2A1
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
OPN
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA