product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MMP-9 (2C3) Antibody
catalog :
sc-21733
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2C3
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:900; loading ...; fig 7a
Szabo P, Dogra P, Gray J, Wells S, Connors T, Weisberg S, et al. Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19. Immunity. 2021;54:797-814.e6 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5g
Wong J, Wei R, Lyu P, Tong O, Zhang S, Wen Q, et al. Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer. Int J Biol Sci. 2017;13:1373-1386 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4a
Mrowczynski O, Madhankumar A, Slagle Webb B, Lee S, Zacharia B, Connor J. HFE genotype affects exosome phenotype in cancer. Biochim Biophys Acta Gen Subj. 2017;1861:1921-1928 pubmed publisher
  • western blot; human; loading ...; fig 5b
Ren H, Liu F, Huang G, Liu Y, Shen J, Zhou P, et al. Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma. Oncotarget. 2017;8:6718-6729 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 4
  • western blot; human; 1:200; fig 3
Eterno V, Zambelli A, Villani L, Tuscano A, Manera S, Spitaleri A, et al. AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128. Sci Rep. 2016;6:28436 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1500; loading ...; fig 1
  • western blot; human; 1:1500; loading ...; fig 3d
Anunobi C, Koli K, Saxena G, Banjo A, Ogbureke K. Expression of the SIBLINGs and their MMP partners in human benign and malignant prostate neoplasms. Oncotarget. 2016;7:48038-48049 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 4
Cao Y, Liang H, Zhang F, Luan Z, Zhao S, Wang X, et al. Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer. J Exp Clin Cancer Res. 2016;35:68 pubmed publisher
  • western blot; human; fig 5
Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer. 2016;7:746-57 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; tbl 1
Andrade A, Santos E, Carmo A, Freitas R, Galvão H. Analysis of tryptase-positive mast cells and immunoexpression of MMP-9 and MMP-13 in periapical lesions. Int Endod J. 2017;50:446-454 pubmed publisher
  • western blot; human; 1:200; fig 2
Checa M, Hagood J, Velázquez Cruz R, Ruiz V, García de Alba C, Rangel Escareño C, et al. Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells. PLoS ONE. 2016;11:e0150383 pubmed publisher
  • western blot; rat; 1:2000; fig 3
Lin Y, Ma Q, Lin S, Zhou H, Wen Q, Gao S, et al. Inhibitory effects of 90Sr/90Y β-irradiation on alkali burn-induced corneal neovascularization in rats. Exp Ther Med. 2016;11:409-414 pubmed
  • western blot; mouse; loading ...; fig 8a
Qi T, Xu F, Yan X, Li S, Li H. Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway. Int J Mol Med. 2016;37:182-8 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2b
Zhang L, Zou W. Inhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway. Mol Med Rep. 2015;12:7869-76 pubmed publisher
  • western blot; rat; 1:500; fig 8
Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5
  • western blot; human; loading ...; fig 3c
Chang L, Zhao D, Liu H, Wang Q, Zhang P, Li C, et al. Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. Mol Med Rep. 2015;12:6702-10 pubmed publisher
  • immunohistochemistry; mouse; fig 3
Michinaga S, Seno N, Fuka M, Yamamoto Y, Minami S, Kimura A, et al. Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A. Eur J Neurosci. 2015;42:2356-70 pubmed publisher
  • western blot; human; fig 6
Li S, Wu X, Dong C, Xie X, Wu J, Zhang X. The differential expression of OCT4 isoforms in cervical carcinoma. PLoS ONE. 2015;10:e0118033 pubmed publisher
  • western blot; human; fig 2
Dong X, Lin Q, Aihara A, Li Y, Huang C, Chung W, et al. Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype. Oncotarget. 2015;6:1231-48 pubmed
  • immunohistochemistry - paraffin section; human; 1:50
Zeng X, Ou Z, Yu K, Feng L, Yin W, Li J, et al. Absence of multiple atypical chemokine binders (ACBs) and the presence of VEGF and MMP-9 predict axillary lymph node metastasis in early breast carcinomas. Med Oncol. 2014;31:145 pubmed publisher
  • western blot; human
Lin Q, Aihara A, Chung W, Li Y, Chen X, Huang Z, et al. LRH1 promotes pancreatic cancer metastasis. Cancer Lett. 2014;350:15-24 pubmed publisher
  • western blot; domestic rabbit; 1:2000
Wang L, Wang J, Wang Y, Fu Q, Lei Y, Nie Z, et al. Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure. Exp Ther Med. 2014;7:329-334 pubmed
Wang Z, Li Y, Wang K, Wang L, You B, Zhao D, et al. miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling. Aging (Albany NY). 2020;12:14418-14433 pubmed publisher
Yu W, Hua Y, Qiu H, Hao J, Zou K, Li Z, et al. PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer. Cell Death Dis. 2020;11:506 pubmed publisher
Yang H, Shen J, Wang Y, Liu Y, Shen D, Quan S. Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling. Biomed Res Int. 2019;2019:2686340 pubmed publisher
Xu M, Wei P, Suo M, Hu Y, Ding W, Su L, et al. Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231. Biomed Res Int. 2019;2019:6543230 pubmed publisher
Zeng G, Ding W, Li Y, Sun M, Deng L. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018;16:2229-2234 pubmed publisher
Wang W, Wang J. Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation. Med Sci Monit. 2018;24:5588-5597 pubmed publisher
Qiu J, Li X, He Y, Sun D, Li W, Xin Y. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. J Cancer Res Clin Oncol. 2018;144:1869-1886 pubmed publisher
Wei R, Wong J, Lyu P, Xi X, Tong O, Zhang S, et al. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. J Cell Mol Med. 2018;22:4097-4105 pubmed publisher
Yang X, Cui S, Zeng L, Cheng T, Li X, Chi J, et al. Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer. Aging (Albany NY). 2017;9:914-931 pubmed publisher
Wu Y, Shen Z, Wang K, Ha Y, Lei H, Jia Y, et al. High FMNL3 expression promotes nasopharyngeal carcinoma cell metastasis: role in TGF-β1-induced epithelia-to-mesenchymal transition. Sci Rep. 2017;7:42507 pubmed publisher
Zhu H, Chen X, Chen B, Chen B, Song W, Sun D, et al. Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLoS ONE. 2014;9:e103882 pubmed publisher
Wajner S, Capp C, Brasil B, Meurer L, Maia A. Reduced tissue inhibitor of metalloproteinase-2 expression is associated with advanced medullary thyroid carcinoma. Oncol Lett. 2014;7:731-737 pubmed
Yang B, Tang F, Zhang B, Zhao Y, Feng J, Rao Z. Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer. World J Surg Oncol. 2014;12:24 pubmed publisher
Song C, Zhu S, Wu C, Kang J. Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. J Biol Chem. 2013;288:28021-33 pubmed publisher
Ding S, Yang Y, Li X, Michelli Rivera A, Han S, Wang L, et al. Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. Toxicol Appl Pharmacol. 2013;269:61-71 pubmed publisher
Castillo C, López Muñoz R, Duaso J, Galanti N, Jaña F, Ferreira J, et al. Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi. Placenta. 2012;33:991-7 pubmed publisher
Xue H, Sun K, Xie W, Hu G, Kong H, Wang Q, et al. Etanercept attenuates short-term cigarette-smoke-exposure-induced pulmonary arterial remodelling in rats by suppressing the activation of TNF-a/NF-kB signal and the activities of MMP-2 and MMP-9. Pulm Pharmacol Ther. 2012;25:208-15 pubmed
Gu T, Liu S, Zheng P. Cytoplasmic NANOG-positive stromal cells promote human cervical cancer progression. Am J Pathol. 2012;181:652-61 pubmed publisher
Liu X, Lu J, He M, Li Z, Zhang B, Zhou L, et al. Antitumor effects of interferon-alpha on cell growth and metastasis in human nasopharyngeal carcinoma. Curr Cancer Drug Targets. 2012;12:561-70 pubmed
Kim J, Lee Y, Kim H, Yoon S, Kim H, Youn Y, et al. Additive lymph node dissection may be necessary in minute submucosal cancer of the stomach after endoscopic resection. Ann Surg Oncol. 2012;19:779-85 pubmed publisher
Heo S, Cho C, Kim H, Jo Y, Yoon K, Lee J, et al. Plaque rupture is a determinant of vascular events in carotid artery atherosclerotic disease: involvement of matrix metalloproteinases 2 and 9. J Clin Neurol. 2011;7:69-76 pubmed publisher
Niu L, Zhang L, Jiao K, Li F, Ding Y, Wang D, et al. Localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in human coronal dentine. J Dent. 2011;39:536-42 pubmed publisher
Jiang Q, Zhang H, Zhang P. ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro. J Exp Clin Cancer Res. 2011;30:60 pubmed publisher
Awasthi R, Rathore R, Soni P, Sahoo P, Awasthi A, Husain N, et al. Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers. Neuroradiology. 2012;54:205-13 pubmed publisher
Yuan Z, Sanders A, Ye L, Wang Y, Jiang W. Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncol Rep. 2011;26:237-45 pubmed publisher
Mathalone N, Marmor S, Rahat M, Lahat N, Oron Y, Geyer O. MMP expression in leaking filtering blebs and tears after glaucoma filtering surgery. Graefes Arch Clin Exp Ophthalmol. 2011;249:1047-55 pubmed publisher
Fiorelli A, Ricciardi C, Pannone G, Santoro A, Bufo P, Santini M, et al. Interplay between steroid receptors and neoplastic progression in sarcoma tumors. J Cell Physiol. 2011;226:2997-3003 pubmed publisher
Tobón Arroyave S, Mideros Simarra S, Castaño Ramírez L, Flórez Moreno G, Isaza Guzmán D. Overexpression of matrix metalloproteinase (MMP)-1 and -9 in central giant cell lesions of the jaws: implications for clinical behavior. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:755-63 pubmed publisher
Kelly B, Markle L, Vickers J, Petitt M, Raimer S, McNeese C. The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis. J Am Acad Dermatol. 2010;63:483-9 pubmed publisher
Lin H, Zhang L, Liu C, Xu X, Tang M, Lv H, et al. Haemin-enhanced expression of haem oxygenase-1 stabilizes erythrocyte-induced vulnerable atherosclerotic plaques. Br J Pharmacol. 2010;160:1484-95 pubmed publisher
Zhou J, Gan N, Zhang W, Lu W, Xie X. Proliferation suppression and apoptosis of ovarian carcinoma cells induced by small interfering RNA against vascular endothelial growth factor. J Obstet Gynaecol Res. 2010;36:232-8 pubmed publisher
Møller M, Werther K, Nalla A, Stangerup S, Thomsen J, Bøg Hansen T, et al. Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. Laryngoscope. 2010;120:657-62 pubmed publisher
Xing C, Zhu B, Fan X, Liu H, Hou X, Zhao K, et al. Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice. World J Gastroenterol. 2009;15:5044-52 pubmed
Cokakli M, Erdal E, Nart D, Yilmaz F, Sagol O, Kilic M, et al. Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion. BMC Cancer. 2009;9:65 pubmed publisher
Ezhilarasan R, Jadhav U, Mohanam I, Rao J, Gujrati M, Mohanam S. The hemopexin domain of MMP-9 inhibits angiogenesis and retards the growth of intracranial glioblastoma xenograft in nude mice. Int J Cancer. 2009;124:306-15 pubmed publisher
Achilli C, Ciana A, Rossi A, Balduini C, Minetti G. Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes. J Leukoc Biol. 2008;83:181-9 pubmed
Lin H, Xu X, Lu H, Zhang L, Li C, Tang M, et al. Pathological mechanisms and dose dependency of erythrocyte-induced vulnerability of atherosclerotic plaques. J Mol Cell Cardiol. 2007;43:272-80 pubmed
Gu Z, Li J, Li M, Gu J, Shi X, Ke Y, et al. Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma. Am J Gastroenterol. 2005;100:1835-43 pubmed
Qiu W, Bai S, Zhao M, Wu X, Zhao Y, Sang Q, et al. Spatio-temporal expression of matrix metalloproteinase-26 in human placental trophoblasts and fetal red cells during normal placentation. Biol Reprod. 2005;72:954-9 pubmed
product information
Catalog Number :
sc-21733
Product Name :
MMP-9 (2C3) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
2C3
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
MMP-9
Specificity :
human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA