product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Na+/K+-ATPase α1 (C464.6) Antibody
catalog :
sc-21712
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C464.6
reactivity :
guinea pig, human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 52
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:250; fig 1e
Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, et al. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021;16:309-323 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
James C, Müller M, Goldberg M, Lenz C, Urlaub H, Kehlenbach R. Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. J Biol Chem. 2019;294:16241-16254 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s1e
Dumortier J, Le Verge Serandour M, Tortorelli A, Mielke A, de Plater L, Turlier H, et al. Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst. Science. 2019;365:465-468 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3a
Ma Q, Wang Y, Zhang T, Zuo W. Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy. Life Sci. 2018;193:104-109 pubmed publisher
  • immunocytochemistry; dogs; loading ...; fig 8a
Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells. J Biol Chem. 2016;291:24787-24799 pubmed
  • western blot; rat; 1:200; fig 2
Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, et al. Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:3755-62 pubmed publisher
  • western blot; human; fig s2
Natarelli L, Ranaldi G, Leoni G, Roselli M, Guantario B, Comitato R, et al. Nanomolar Caffeic Acid Decreases Glucose Uptake and the Effects of High Glucose in Endothelial Cells. PLoS ONE. 2015;10:e0142421 pubmed publisher
  • immunoprecipitation; human; fig 3
Juel C, Hostrup M, Bangsbo J. The effect of exercise and beta2-adrenergic stimulation on glutathionylation and function of the Na,K-ATPase in human skeletal muscle. Physiol Rep. 2015;3: pubmed publisher
  • western blot; mouse; fig 6
Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. FEBS J. 2015;282:3786-98 pubmed publisher
  • western blot; guinea pig; 1:500; fig 3d
Meade M, Hoffmann A, Makley M, Snider T, Schlager J, Gearhart J. Quantitative proteomic analysis of the brainstem following lethal sarin exposure. Brain Res. 2015;1611:101-13 pubmed publisher
  • western blot; human; loading ...; fig 2a
Ferru Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, et al. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS ONE. 2015;10:e0118943 pubmed publisher
  • other; mouse; 1:500; fig 2
HERRERA V, Pasion K, Moran A, Zaninello R, Ortu M, Fresu G, et al. A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population. PLoS ONE. 2015;10:e0116724 pubmed publisher
  • western blot; human; fig 6
Bollu L, Ren J, Blessing A, Katreddy R, Gao G, Xu L, et al. Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. Cell Cycle. 2014;13:2415-30 pubmed publisher
  • western blot; rat
Schuth O, McLean W, Eatock R, Pyott S. Distribution of Na,K-ATPase α subunits in rat vestibular sensory epithelia. J Assoc Res Otolaryngol. 2014;15:739-54 pubmed publisher
  • western blot; mouse; fig 2a
Cragle F, Baldini G. Mild lipid stress induces profound loss of MC4R protein abundance and function. Mol Endocrinol. 2014;28:357-67 pubmed publisher
Park S, Han J, Jeong B, Song J, Jang S, Jeong H, et al. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane. Nat Struct Mol Biol. 2023;30:1695-1706 pubmed publisher
Chu X, Xiao X, Wang G, Uosef A, Lou X, Arnold P, et al. Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells. Cell Death Dis. 2023;14:469 pubmed publisher
Choudhury M, Li Y, Mistriotis P, Vasconcelos A, DIXON E, Yang J, et al. Kidney epithelial cells are active mechano-biological fluid pumps. Nat Commun. 2022;13:2317 pubmed publisher
Bai Z, Feng J, Franken G, Al Saadi N, Cai N, Yu A, et al. CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells. PLoS Biol. 2021;19:e3001496 pubmed publisher
Scheiber I, Wu Y, Morgan S, Zhao N. The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. J Biol Chem. 2019;294:9147-9160 pubmed publisher
Brandenburg S, Pawlowitz J, Fakuade F, Kownatzki Danger D, Kohl T, Mitronova G, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species. Front Physiol. 2018;9:1227 pubmed publisher
Lamothe S, Hogan Cann A, Li W, Guo J, Yang T, Tschirhart J, et al. The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1-S2 linkage. J Biol Chem. 2018;293:15347-15358 pubmed publisher
Xu B, Turner S, Hinton B. Alteration of transporter activities in the epididymides of infertile initial segment-specific Pten knockout mice. Biol Reprod. 2018;99:536-545 pubmed publisher
Jing H, Zhang X, Wisner S, Chen X, Spiegelman N, Linder M, et al. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. elife. 2017;6: pubmed publisher
Long K, Shipman K, Rbaibi Y, Menshikova E, Ritov V, Eshbach M, et al. Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell. 2017;28:2508-2517 pubmed publisher
Nascimbeni A, Giordano F, Dupont N, Grasso D, Vaccaro M, Codogno P, et al. ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. EMBO J. 2017;36:2018-2033 pubmed publisher
Kleczko E, Kim J, Keysar S, Heasley L, Eagles J, Simon M, et al. An Inducible TGF-?2-TGF?R Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PLoS ONE. 2015;10:e0123600 pubmed publisher
Li Q, Muma N. Estradiol potentiates 8-OH-DPAT-induced sumoylation of 5-HT?A receptor: characterization and subcellular distribution of sumoylated 5-HT?A receptors. Psychoneuroendocrinology. 2013;38:2542-53 pubmed publisher
Yamada K, Hayashi M, Madokoro H, Nishida H, Du W, Ohnuma K, et al. Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription. PLoS ONE. 2013;8:e62304 pubmed publisher
Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, et al. Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci. 2013;70:26-33 pubmed publisher
Singleton K, Kim J, Hinz T, Marek L, Casás Selves M, Hatheway C, et al. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head a. Mol Pharmacol. 2013;83:882-93 pubmed publisher
Tripathy S, Jump D. Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res. 2013;54:71-84 pubmed publisher
Marshall M, Hinz T, Kono S, Singleton K, Bichon B, Ware K, et al. Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells. Clin Cancer Res. 2011;17:5016-25 pubmed publisher
Silva E, Soares da Silva P. Long-term regulation of Na+,K+-ATPase in opossum kidney cells by ouabain. J Cell Physiol. 2011;226:2391-7 pubmed publisher
Taub M, Springate J, Cutuli F. Reduced phosphate transport in the renal proximal tubule cells in cystinosis is due to decreased expression of transporters rather than an energy defect. Biochem Biophys Res Commun. 2011;407:355-9 pubmed publisher
Olianas M, Dedoni S, Onali P. ?-Opioid receptors stimulate GLUT1-mediated glucose uptake through Src- and IGF-1 receptor-dependent activation of PI3-kinase signalling in CHO cells. Br J Pharmacol. 2011;163:624-37 pubmed publisher
Ware K, Marshall M, Heasley L, Marek L, Hinz T, Hercule P, et al. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. PLoS ONE. 2010;5:e14117 pubmed publisher
Tajima N, Itokazu Y, Korpi E, Somerharju P, Käkelä R. Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells. J Biol Chem. 2011;286:5624-38 pubmed publisher
Silva E, Pinto V, Simão S, Serrao M, Afonso J, Amaral J, et al. Renal aging in WKY rats: changes in Na+,K+ -ATPase function and oxidative stress. Exp Gerontol. 2010;45:977-83 pubmed publisher
Soltoff S, Asara J, Hedden L. Regulation and identification of Na,K-ATPase alpha1 subunit phosphorylation in rat parotid acinar cells. J Biol Chem. 2010;285:36330-8 pubmed publisher
Herman M, Rajkhowa T, Cutuli F, Springate J, Taub M. Regulation of renal proximal tubule Na-K-ATPase by prostaglandins. Am J Physiol Renal Physiol. 2010;298:F1222-34 pubmed publisher
Silva E, Soares da Silva P. Protein cytoskeleton and overexpression of Na(+),K(+)-ATPase in opossum kidney cells. J Cell Physiol. 2009;221:318-24 pubmed publisher
Eckert G, Muller W. Presenilin 1 modifies lipid raft composition of neuronal membranes. Biochem Biophys Res Commun. 2009;382:673-7 pubmed publisher
Hao J, Wang G, Pisitkun T, Patino Lopez G, Nagashima K, Knepper M, et al. Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells. J Proteome Res. 2008;7:2911-27 pubmed publisher
Grimm M, Grimm H, Tomic I, Beyreuther K, Hartmann T, Bergmann C. Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. J Biol Chem. 2008;283:11302-11 pubmed publisher
Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis M, et al. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol. 2008;9:11 pubmed publisher
Foster D, Rucker J, Marban E. Is Kir6.1 a subunit of mitoK(ATP)?. Biochem Biophys Res Commun. 2008;366:649-56 pubmed
Panfoli I, Ravera S, Fabiano A, Magrassi R, Diaspro A, Morelli A, et al. Localization of the cyclic ADP-ribose-dependent calcium signaling pathway in bovine rod outer segments. Invest Ophthalmol Vis Sci. 2007;48:978-84 pubmed
Meyer dos Santos S, Weber C, Franke C, Muller W, Eckert G. Cholesterol: Coupling between membrane microenvironment and ABC transporter activity. Biochem Biophys Res Commun. 2007;354:216-21 pubmed
Liu G, Badeau R, Tanimura A, Talamo B. Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells. J Neurochem. 2006;96:1591-605 pubmed
Xinmin D, Yunyou D, Chaosheng P, Huasong F, Pingkun Z, Jiguang M, et al. Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits. Pharmacol Res. 2006;53:372-9 pubmed
Plourde D, Soltoff S. Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity. Am J Physiol Cell Physiol. 2006;290:C702-10 pubmed
product information
Catalog Number :
sc-21712
Product Name :
Na+/K+-ATPase α1 (C464.6) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C464.6
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Na+/K+-ATPase alpha1
Specificity :
broad species
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA