This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
GKLF (H-180)
catalog :
sc-20691
conjugate :
nonconjugated
reactivity :
human, mouse, pigs
application :
western blot, chromatin immunoprecipitation, ChIP-Seq
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2b
Periyasamy P, Liao K, Kook Y, Niu F, Callen S, Guo M, et al. Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling. Mol Neurobiol. 2018;55:3196-3210 pubmed publisher
  • western blot; pigs ; loading ...; fig 2c
Genovese N, Domeier T, Telugu B, Roberts R. Enhanced Development of Skeletal Myotubes from Porcine Induced Pluripotent Stem Cells. Sci Rep. 2017;7:41833 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 6f
Cherepanova O, Gomez D, Shankman L, Swiatlowska P, Williams J, Sarmento O, et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med. 2016;22:657-65 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6
Nawandar D, Wang A, Makielski K, Lee D, Ma S, Barlow E, et al. Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog. 2015;11:e1005195 pubmed publisher
  • ChIP-Seq; mouse; fig 5
Shankman L, Gomez D, Cherepanova O, Salmon M, Alencar G, Haskins R, et al. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015;21:628-37 pubmed publisher
  • western blot; human; 1:1000; fig 1b
Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, et al. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Int J Biol Sci. 2022;18:4869-4883 pubmed publisher
Papathanasiou M, Tsiftsoglou S, Polyzos A, Papadopoulou D, Valakos D, Klagkou E, et al. Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. EMBO J. 2021;40:e102236 pubmed publisher
Xiong X, Schober M, Tassone E, Khodadadi Jamayran A, Sastre Perona A, Zhou H, et al. KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Cell Rep. 2018;25:3006-3020.e7 pubmed publisher
Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, et al. KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Cell Commun Signal. 2018;16:53 pubmed publisher
Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, et al. Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. J Exp Clin Cancer Res. 2018;37:176 pubmed publisher
Kim J, Kim J, Lee J, Park M. Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3- and NF‑κB-mediated IL‑24 production. Int J Oncol. 2018;53:47-58 pubmed publisher
Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, et al. DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages. Sci Rep. 2018;8:5723 pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Hsieh M, Chen Y, Chen Y, Lee Y, Lu J, Chien C, et al. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic Acids Res. 2017;45:10492-10503 pubmed publisher
Lee S, Han S, Kim M, Shim S, Shin H, Lee S, et al. Post-irradiation promotes susceptibility to reprogramming to pluripotent state in human fibroblasts. Cell Cycle. 2017;16:2119-2127 pubmed publisher
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed publisher
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
Lee E, Boldo L, Fernandez B, Feelisch M, Harmsen M. Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1. Sci Rep. 2017;7:42487 pubmed publisher
Saini J, Corneo B, Miller J, Kiehl T, Wang Q, Boles N, et al. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell. 2017;20:635-647.e7 pubmed publisher
Hao Z, Sheng Y, Duncan G, Li W, Dominguez C, Sylvester J, et al. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nat Commun. 2017;8:14003 pubmed publisher
Riverso M, Montagnani V, Stecca B. KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. Oncogene. 2017;36:3322-3333 pubmed publisher
Zhou H, Liu Y, Zhu R, Ding F, Wan Y, Li Y, et al. FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation. Oncogene. 2017;36:3312-3321 pubmed publisher
Hu W, Jia Y, Xiao X, Lv K, Chen Y, Wang L, et al. KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth. Oncotarget. 2016;7:52870-52887 pubmed publisher
Adam C, Cyr D. Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat. Biol Reprod. 2016;94:120 pubmed publisher
Chantzoura E, Skylaki S, Menendez S, Kim S, Johnsson A, Linnarsson S, et al. Reprogramming Roadblocks Are System Dependent. Stem Cell Reports. 2015;5:350-64 pubmed publisher
Clark P, Jensen T, Kluger M, Morelock M, Hanidu A, Qi Z, et al. MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells. Microcirculation. 2011;18:102-17 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA