product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Bax (2D2) Antibody
catalog :
sc-20067
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2D2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 42
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 8d, 8e
Gao L, Meng J, Yue C, Wu X, Su Q, Wu H, et al. Integrative analysis the characterization of peroxiredoxins in pan-cancer. Cancer Cell Int. 2021;21:366 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 3c
Suo L, Chang X, Xu N, Ji H. The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer. Front Endocrinol (Lausanne). 2019;10:370 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Lian W, Zhang L, Yang L, Chen W. AP-2α reverses vincristine-induced multidrug resistance of SGC7901 gastric cancer cells by inhibiting the Notch pathway. Apoptosis. 2017;22:933-941 pubmed publisher
  • western blot; human; loading ...; fig 10a
Abbaspour Babaei M, Zaman Huri H, Kamalidehghan B, Yeap S, Ahmadipour F. Apoptotic induction and inhibition of NF-?B signaling pathway in human prostatic cancer PC3 cells by natural compound 2,2'-oxybis (4-allyl-1-methoxybenzene), biseugenol B, from Litsea costalis: an in vitro study. Onco Targets Ther. 2017;10:277-294 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 4a
Peng Y, Shi X, Li Z, He X, Sun Y. Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. Exp Ther Med. 2016;12:3905-3912 pubmed publisher
  • western blot; human; fig 2
Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016;16:559 pubmed publisher
  • western blot; human; 1:1000; fig 4
Yu X, Sun K, Tang X, Zhou C, Sun H, Yan Z, et al. Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncol Lett. 2016;12:983-988 pubmed
  • western blot; human; loading ...; fig 4a
Amara S, Zheng M, Tiriveedhi V. Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. Cell Biochem Biophys. 2016;74:427-34 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Pires A, Marques C, Encarnação J, Abrantes A, Mamede A, Laranjo M, et al. Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile. Eur J Cell Biol. 2016;95:208-18 pubmed publisher
  • western blot; rat; 1:1000; fig 4
Jeong J, Noh M, Choi J, Lee H, Kim S. Neuroprotective and antioxidant activities of bamboo salt soy sauce against H2O2-induced oxidative stress in rat cortical neurons. Exp Ther Med. 2016;11:1201-1210 pubmed
  • flow cytometry; human; loading ...; fig 3a, 3b, 3c, 3d
Brito A, Ribeiro M, Abrantes A, Mamede A, Laranjo M, Casalta Lopes J, et al. New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin. Nutr Cancer. 2016;68:250-66 pubmed publisher
  • western blot; mouse; fig 1d
Wu M, Ai W, Chen L, Zhao S, Liu E. Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice. Int J Mol Med. 2016;37:565-74 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5a
Wang S, Song T, Leng C, Lan K, Ning J, Chu H. Propofol protects against the neurotoxicity of 1‑methyl‑4‑phenylpyridinium. Mol Med Rep. 2016;13:309-14 pubmed publisher
  • western blot; human; fig 3
Jung S, Li C, Duan J, Lee S, Kim K, Park Y, et al. TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget. 2015;6:29060-75 pubmed publisher
  • western blot; human; fig 2
Zhang L, Dai F, Sheng P, Chen Z, Xu Q, Guo Y. Resveratrol analogue 3,4,4'-trihydroxy-trans-stilbene induces apoptosis and autophagy in human non-small-cell lung cancer cells in vitro. Acta Pharmacol Sin. 2015;36:1256-65 pubmed publisher
  • western blot; human; fig 3
Li C, Jung S, Lee S, Jeong D, Yang Y, Kim K, et al. Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP. Oncotarget. 2015;6:7522-35 pubmed
  • western blot; human
Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher
  • western blot; human
Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed publisher
  • western blot; human; fig 1
Patwardhan G, Hosain S, Liu D, Khiste S, Zhao Y, Bielawski J, et al. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta. 2014;1841:1571-80 pubmed publisher
  • western blot; human
Charan R, Johnson B, Zaganelli S, Nardozzi J, LaVoie M. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis. 2014;5:e1313 pubmed publisher
  • immunocytochemistry; human
Yee K, Wilkinson S, James J, Ryan K, Vousden K. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009;16:1135-45 pubmed publisher
Huang K, Jia Z, Li H, Peng Y, Chen X, Luo N, et al. Proto-oncogene FAM83A contributes to casein kinase 1-mediated mitochondrial maintenance and white adipocyte differentiation. J Biol Chem. 2022;298:102339 pubmed publisher
So B, Park J, Jang J, Lim W, Imdad S, Kang C. Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs. Front Physiol. 2021;12:773539 pubmed publisher
Zheng Y, Ma L, Liu N, Tang X, Guo S, Zhang B, et al. Autophagy and Apoptosis of Porcine Ovarian Granulosa Cells During Follicular Development. Animals (Basel). 2019;9: pubmed publisher
Lee S, Lee W, Kim N, Kang J, Kim K, Kim S, et al. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers (Basel). 2018;10: pubmed publisher
Wang X, Cui X, Zhu C, Li M, Zhao J, Shen Z, et al. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Mol Med Rep. 2018;18:4428-4438 pubmed publisher
Zhao H, Li Q, Pang J, Jin H, Li H, Yang X. Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress. Biol Open. 2017;6:1416-1422 pubmed publisher
Zheng L, Cai Y, Zhou L, Huang P, Ren X, Zuo A, et al. Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-?B pathway via estrogen receptor signaling. Int J Mol Med. 2017;39:39-46 pubmed publisher
Dunnill C, Ibraheem K, Mohamed A, Southgate J, Georgopoulos N. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis. Oncogene. 2017;36:2515-2528 pubmed publisher
Acedo P, Stockert J, Canete M, Villanueva A. Two combined photosensitizers: a goal for more effective photodynamic therapy of cancer. Cell Death Dis. 2014;5:e1122 pubmed publisher
Teng F, Tang B. Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults. Mol Cell Biochem. 2013;384:7-19 pubmed publisher
Silden E, Hjelle S, Wergeland L, Sulen A, Andresen V, Bourdon J, et al. Expression of TP53 isoforms p53? or p53? enhances chemosensitivity in TP53(null) cell lines. PLoS ONE. 2013;8:e56276 pubmed publisher
Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, et al. Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy. 2012;8:1798-810 pubmed publisher
Serra A, Rocha Gonsalves A, Laranjo M, Abrantes A, Gonçalves A, Sarmento Ribeiro A, et al. Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells. Eur J Med Chem. 2012;53:398-402 pubmed publisher
Mantzaris M, Tsianos E, Galaris D. Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells. FEBS J. 2011;278:519-30 pubmed publisher
Wood K, Voss O, Huang Q, Parihar A, Mehta N, Batra S, et al. The small heat shock protein 27 is a key regulator of CD8+ CD57+ lymphocyte survival. J Immunol. 2010;184:5582-8 pubmed publisher
Peirce S, Findley H. High level MycN expression in non-MYCN amplified neuroblastoma is induced by the combination treatment nutlin-3 and doxorubicin and enhances chemosensitivity. Oncol Rep. 2009;22:1443-9 pubmed
Nilsonne G, Olm E, Szulkin A, Mundt F, Stein A, Kocic B, et al. Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure. J Exp Clin Cancer Res. 2009;28:92 pubmed publisher
Peirce S, Findley H. The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73. Int J Oncol. 2009;34:1395-402 pubmed
Almeida G, Duarte T, Farmer P, Steward W, Jones G. Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: implications for predictive testing. Int J Cancer. 2008;122:1810-9 pubmed
Gillissen B, Essmann F, Hemmati P, Richter A, Richter A, Oztop I, et al. Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis. J Cell Biol. 2007;179:701-15 pubmed
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol. 2002;156:519-29 pubmed
product information
Catalog Number :
sc-20067
Product Name :
Bax (2D2) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
2D2
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Bax
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA