product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Cox-2 (29) Antibody
catalog :
sc-19999
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
29
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 44
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 5a
Yang C, Chen Y, Chi P, Lin C, Hsiao L. Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-?B in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 2017;132:77-91 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Yun C, Jung Y, Chun W, Yang B, Ryu J, Lim C, et al. Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo. Mediators Inflamm. 2016;2016:8027537 pubmed publisher
  • western blot; human; fig 1D
Lu S, Yang Y, Du Y, Cao L, Li M, Shen C, et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. Oncotarget. 2015;6:34704-17 pubmed publisher
  • western blot; human; fig 3
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
  • western blot; rat; fig 6
Giunta S, Castorina A, Marzagalli R, Szychlinska M, Pichler K, Mobasheri A, et al. Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis. Int J Mol Sci. 2015;16:5922-44 pubmed publisher
  • western blot; human
Hamdollah Zadeh M, Amin E, Hoareau Aveilla C, Domingo E, Symonds K, Ye X, et al. Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance. Mol Oncol. 2015;9:167-78 pubmed publisher
  • western blot; human
Ramyaa P, Krishnaswamy R, Padma V. Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-?B and COX-2. Biochim Biophys Acta. 2014;1840:681-92 pubmed publisher
Kim M, Kim J, Yang H, Choe J, Hwang I. Nepetoidin B from Salvia plebeia R. Br. Inhibits Inflammation by Modulating the NF-κB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells. Antioxidants (Basel). 2021;10: pubmed publisher
Wu P, Lin T, Hou C, Chang Q, Wen K, Lin C, et al. 1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo. Antioxidants (Basel). 2019;8: pubmed publisher
Popovic D, Kocic G, Katic V, Zarubica A, Velickovic L, Ničković V, et al. Anthocyanins Protect Hepatocytes against CCl4-Induced Acute Liver Injury in Rats by Inhibiting Pro-inflammatory mediators, Polyamine Catabolism, Lipocalin-2, and Excessive Proliferation of Kupffer Cells. Antioxidants (Basel). 2019;8: pubmed publisher
Xiang G, Fan M, Ma Y, Wang M, Gao J, Chen J, et al. Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator. Biochem Pharmacol. 2018;150:150-159 pubmed publisher
Liu W, Guo W, Shen L, Chen Z, Luo Q, Luo X, et al. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. 2017;8:7586-7597 pubmed publisher
Cannavà C, Tommasini S, Stancanelli R, Cardile V, Cilurzo F, Giannone I, et al. Celecoxib-loaded PLGA/cyclodextrin microspheres: characterization and evaluation of anti-inflammatory activity on human chondrocyte cultures. Colloids Surf B Biointerfaces. 2013;111:289-96 pubmed publisher
Puglia C, Cardile V, Panico A, Crascì L, Offerta A, Caggia S, et al. Evaluation of monooleine aqueous dispersions as tools for topical administration of curcumin: characterization, in vitro and ex-vivo studies. J Pharm Sci. 2013;102:2349-61 pubmed publisher
Xu C, Long A, Fang X, Wood S, Slater D, Ni X, et al. Effects of PGF2? on the expression of uterine activation proteins in pregnant human myometrial cells from upper and lower segment. J Clin Endocrinol Metab. 2013;98:2975-83 pubmed publisher
Kalaiselvi P, Rajashree K, Bharathi Priya L, Padma V. Cytoprotective effect of epigallocatechin-3-gallate against deoxynivalenol-induced toxicity through anti-oxidative and anti-inflammatory mechanisms in HT-29 cells. Food Chem Toxicol. 2013;56:110-8 pubmed publisher
Jayaram B, Pan W, Wang Y, Hsuchou H, Macé A, Cornelissen Guillaume G, et al. Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity. J Appl Physiol (1985). 2013;114:734-41 pubmed publisher
Huang W, Sala Newby G, Susana A, Johnson J, Newby A. Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-?B. PLoS ONE. 2012;7:e42507 pubmed publisher
Zheng Y, Liu X, Guo S. Therapeutic potential of andrographolide for treating endometriosis. Hum Reprod. 2012;27:1300-13 pubmed publisher
Rossi A, Coccia M, Trotta E, Angelini M, Santoro M. Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells. PLoS ONE. 2012;7:e31304 pubmed publisher
Liu L, Cao Z, Chen J, Li R, Cao Y, Zhu C, et al. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. J Biol Chem. 2012;287:11899-910 pubmed publisher
Srivastava R, Srivastava S, Singh M, Bajpai V, Ghosh J. Consequences of alteration in leucine zipper sequence of melittin in its neutralization of lipopolysaccharide-induced proinflammatory response in macrophage cells and interaction with lipopolysaccharide. J Biol Chem. 2012;287:1980-95 pubmed publisher
Russo A, Caggia S, Piovano M, Garbarino J, Cardile V. Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chem Biol Interact. 2012;195:1-10 pubmed publisher
Liu Q, Xi Y, Terry T, So S, Mohite A, Zhang J, et al. Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. J Cell Physiol. 2012;227:2907-16 pubmed publisher
Liu Y, Zhang W, Zhang X, Qi Y, Huang D, Zhang Y. Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Exp Biol Med (Maywood). 2011;236:592-7 pubmed publisher
Seo J, Seo J, Chung H, Kim H. Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells. Yonsei Med J. 2011;52:522-6 pubmed publisher
Tung W, Hsieh H, Lee I, Yang C. Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J Cell Biochem. 2011;112:559-70 pubmed publisher
Simmler C, Antheaume C, Lobstein A. Antioxidant biomarkers from Vanda coerulea stems reduce irradiated HaCaT PGE-2 production as a result of COX-2 inhibition. PLoS ONE. 2010;5:e13713 pubmed publisher
Guan S, Fu S, He J, Zhang M. Prevotella intermedia induces prostaglandin E2 via multiple signaling pathways. J Dent Res. 2011;90:121-7 pubmed publisher
LaLone C, Huang N, Rizshsky L, Yum M, Singh N, Hauck C, et al. Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activity. J Agric Food Chem. 2010;58:8573-84 pubmed publisher
Greenhough A, Wallam C, Hicks D, Moorghen M, Williams A, Paraskeva C. The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. Oncogene. 2010;29:3398-410 pubmed publisher
Krishnaswamy R, Devaraj S, Padma V. Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. Free Radic Biol Med. 2010;49:50-60 pubmed publisher
Guo C, Li J, Myatt L, Zhu X, Sun K. Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. Mol Endocrinol. 2010;24:1052-61 pubmed publisher
Huang N, Hauck C, Yum M, Rizshsky L, Widrlechner M, McCoy J, et al. Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages. J Agric Food Chem. 2009;57:10579-89 pubmed publisher
Guo C, Zhu X, Ni X, Yang Z, Myatt L, Sun K. Expression of progesterone receptor A form and its role in the interaction of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts. J Clin Endocrinol Metab. 2009;94:5085-92 pubmed publisher
Tanaka A. Identification of the specific binding proteins of bioactive small compound using affinity resins. Methods Mol Biol. 2009;577:181-95 pubmed publisher
Cho S, Lim J, Kim K, Kim H. Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells. Dig Dis Sci. 2010;55:988-96 pubmed publisher
O Kane S, Eagle G, Greenman J, Lind M, Cawkwell L. COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. Lung Cancer. 2010;67:160-5 pubmed publisher
Carli C, Metz C, Al Abed Y, Naccache P, Akoum A. Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. Endocrinology. 2009;150:3128-37 pubmed publisher
Bivol L, Hultström M, Gudbrandsen O, Berge R, Iversen B. Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1866-73 pubmed publisher
Flockhart R, Diffey B, Farr P, Lloyd J, Reynolds N. NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure. FASEB J. 2008;22:4218-27 pubmed publisher
Stolfi C, Fina D, Caruso R, Caprioli F, Sarra M, Fantini M, et al. Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid. Biochem Pharmacol. 2008;75:668-76 pubmed
Mongini P, Inman J, Han H, Fattah R, Abramson S, Attur M. APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2. J Immunol. 2006;176:6736-51 pubmed
Kim G, Romero R, Kuivaniemi H, Tromp G, Haddad R, Kim Y, et al. Expression of bone morphogenetic protein 2 in normal spontaneous labor at term, preterm labor, and preterm premature rupture of membranes. Am J Obstet Gynecol. 2005;193:1137-43 pubmed
product information
Catalog Number :
sc-19999
Product Name :
Cox-2 (29) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
29
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Cox-2
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA