product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MRP1 (QCRL-1) Antibody
catalog :
sc-18835
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
QCRL-1
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 6b
  • western blot; human; loading ...; fig 6a
Yan M, Wang J, Ren Y, Li L, He W, Zhang Y, et al. Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization. Cell Death Dis. 2019;10:204 pubmed publisher
  • western blot; human; loading ...; fig s3e
Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed publisher
  • western blot; human; loading ...; fig 2a
Torres A, Vargas Y, Uribe D, Jaramillo C, Gleisner A, Salazar Onfray F, et al. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget. 2016;7:67373-67386 pubmed publisher
  • western blot; human; fig 4
Jiang P, Wang P, Sun X, Yuan Z, Zhan R, Ma X, et al. Knockdown of long noncoding RNA H19 sensitizes human glioma cells to temozolomide therapy. Onco Targets Ther. 2016;9:3501-9 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 1
Kim B, Stephen S, Hanby A, Horgan K, Perry S, Richardson J, et al. Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy. BMC Cancer. 2015;15:634 pubmed publisher
  • western blot; human; 1:200
Zhang H, Patel A, Ma S, Li X, Zhang Y, Yang P, et al. In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1. Br J Pharmacol. 2014;171:5845-57 pubmed publisher
Afrouzian M, Al Lahham R, Patrikeeva S, Xu M, Fokina V, Fischer W, et al. Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin. Biochem Pharmacol. 2018;156:467-478 pubmed publisher
Torres A, Arriagada V, Erices J, Toro M, Rocha J, Niechi I, et al. FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells. Int J Mol Sci. 2018;19: pubmed publisher
Kim B, Fatayer H, Hanby A, Horgan K, Perry S, Valleley E, et al. Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer. PLoS ONE. 2013;8:e62766 pubmed publisher
Markó L, Paragh G, Ugocsai P, Boettcher A, Vogt T, Schling P, et al. Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light. J Photochem Photobiol B. 2012;116:79-88 pubmed publisher
Shi Z, Yang W, Chen L, Yang D, Zhou Q, Zhu J, et al. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Res Treat. 2012;135:737-47 pubmed publisher
Quezada C, Garrido W, Oyarzun C, Fernandez K, Segura R, Melo R, et al. 5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells. J Cell Physiol. 2013;228:602-8 pubmed publisher
Villar V, Vögler O, Martínez Serra J, Ramos R, Calabuig Fariñas S, Gutierrez A, et al. Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas. PLoS ONE. 2012;7:e37735 pubmed publisher
Cheng C, Liu Z, Zhang H, Xie J, Chen X, Zhao X, et al. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Mol Pharm. 2012;9:1971-82 pubmed publisher
Garrido W, Munoz M, San Martin R, Quezada C. FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1. Biochem Biophys Res Commun. 2011;411:62-8 pubmed publisher
Peigñan L, Garrido W, Segura R, Melo R, Rojas D, Cárcamo J, et al. Combined use of anticancer drugs and an inhibitor of multiple drug resistance-associated protein-1 increases sensitivity and decreases survival of glioblastoma multiforme cells in vitro. Neurochem Res. 2011;36:1397-406 pubmed publisher
Mi Y, Liang Y, Huang H, Zhao H, Wu C, Wang F, et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010;70:7981-91 pubmed publisher
Imesch P, Fink D, Fedier A. Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells. Fertil Steril. 2010;94:2838-42 pubmed publisher
Imesch P, Dedes K, Furlato M, Fink D, Fedier A. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. Int J Oncol. 2009;35:631-40 pubmed
Vanpouille C, Le Jeune N, Kryza D, Clotagatide A, Janier M, Dubois F, et al. Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model. Eur J Nucl Med Mol Imaging. 2009;36:1256-64 pubmed publisher
product information
Product Name :
MRP1 (QCRL-1) Antibody
Gene Name :
ABCC1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-18835
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
MRP1
reactive species  :
human
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA