product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Arc (C-7) Antibody
catalog :
sc-17839
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-7
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - free floating section
citations: 45
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 1i
Rao Ruiz P, Couey J, Marcelo I, Bouwkamp C, Slump D, Matos M, et al. Engram-specific transcriptome profiling of contextual memory consolidation. Nat Commun. 2019;10:2232 pubmed publisher
  • western blot; mouse; loading ...; fig 13
Wang H, Lee K, Pei Z, Khan A, Bakshi K, Burns L. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5f
Zhu J, Cifuentes H, Reynolds J, Lamba D. Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017;20:374-384.e5 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3i
Biever A, Boubaker Vitre J, Cutando L, Gracia Rubio I, Costa Mattioli M, Puighermanal E, et al. Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum. Front Mol Neurosci. 2016;9:165 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Nakayama D, Hashikawa Yamasaki Y, Ikegaya Y, Matsuki N, Nomura H. Late Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories. Sci Rep. 2016;6:21007 pubmed publisher
  • western blot; mouse; 1:200
Chung H, Jacobs C, Huo Y, Yang J, Krumm S, Plemper R, et al. Tunable and reversible drug control of protein production via a self-excising degron. Nat Chem Biol. 2015;11:713-20 pubmed publisher
  • western blot; mouse; fig 2b
Singh P, Konar A, Kumar A, Srivas S, Thakur M. Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment. J Neurochem. 2015;134:642-51 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Gouty Colomer L, Hosseini B, Marcelo I, Schreiber J, Slump D, Yamaguchi S, et al. Arc expression identifies the lateral amygdala fear memory trace. Mol Psychiatry. 2016;21:364-75 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Subbanna S, Nagre N, Umapathy N, Pace B, Basavarajappa B. Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
  • western blot; mouse; 1:1000
Nakayama D, Iwata H, Teshirogi C, Ikegaya Y, Matsuki N, Nomura H. Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. J Neurosci. 2015;35:819-30 pubmed publisher
  • western blot; rat; 1:250
Fletcher B, Hill G, Long J, Gallagher M, Shapiro M, Rapp P. A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging. Neurobiol Learn Mem. 2014;115:58-67 pubmed publisher
  • western blot; mouse; 1:1000
Wang Z, Park S, Zhao H, Peng S, Zuo Z. A critical role of glutamate transporter type 3 in the learning and memory of mice. Neurobiol Learn Mem. 2014;114:70-80 pubmed publisher
  • western blot; mouse; 1:500
Udagawa T, Farny N, Jakovcevski M, Kaphzan H, Alarcon J, Anilkumar S, et al. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med. 2013;19:1473-7 pubmed publisher
  • western blot; mouse; 1:200; fig 5
  • western blot; rat; 1:200; fig 1
Whittington R, Bretteville A, Virag L, Emala C, Maurin T, Marcouiller F, et al. Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation. Sci Rep. 2013;3:1388 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:100
Liu Q, Rubio F, Bossert J, Marchant N, Fanous S, Hou X, et al. Detection of molecular alterations in methamphetamine-activated Fos-expressing neurons from a single rat dorsal striatum using fluorescence-activated cell sorting (FACS). J Neurochem. 2014;128:173-85 pubmed publisher
Klein M, Younts T, Cobo C, Buxbaum A, Aow J, Erdjument Bromage H, et al. Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons. Cell Rep. 2019;29:1789-1799.e6 pubmed publisher
Scarlata M, Lee S, Lee D, Kandigian S, Hiller A, Dishart J, et al. Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization. Sci Rep. 2019;9:6730 pubmed publisher
Penrod R, Kumar J, Smith L, McCalley D, Nentwig T, Hughes B, et al. Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors. Genes Brain Behav. 2019;:e12561 pubmed publisher
Luo F, Zhang J, Burke K, Romito Digiacomo R, Miller R, Yang Y. Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory. Exp Neurol. 2018;306:92-104 pubmed publisher
Pastuzyn E, Day C, Kearns R, Kyrke Smith M, Taibi A, McCormick J, et al. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018;172:275-288.e18 pubmed publisher
Nikolaienko O, Eriksen M, Patil S, Bito H, Bramham C. Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience. 2017;360:68-80 pubmed publisher
Wang W, Ju Y, Zhou Q, Tang J, Li M, Zhang L, et al. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. J Neurosci. 2017;37:7096-7110 pubmed publisher
Dallérac G, Graupner M, Knippenberg J, Martinez R, Tavares T, Tallot L, et al. Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. Nat Commun. 2017;8:13920 pubmed publisher
Jaitner C, Reddy C, Abentung A, Whittle N, Rieder D, Delekate A, et al. Satb2 determines miRNA expression and long-term memory in the adult central nervous system. elife. 2016;5: pubmed publisher
Konar A, Gautam A, Thakur M. Bacopa monniera (CDRI-08) Upregulates the Expression of Neuronal and Glial Plasticity Markers in the Brain of Scopolamine Induced Amnesic Mice. Evid Based Complement Alternat Med. 2015;2015:837012 pubmed publisher
Bojovic O, Panja D, Bittins M, Bramham C, Tjølsen A. Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. PLoS ONE. 2015;10:e0123604 pubmed publisher
Steward O, Farris S, Pirbhoy P, DARNELL J, Driesche S. Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes. Front Mol Neurosci. 2014;7:101 pubmed publisher
Di Prisco G, Huang W, Buffington S, Hsu C, Bonnen P, Placzek A, et al. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2?. Nat Neurosci. 2014;17:1073-82 pubmed publisher
Onoue K, Nakayama D, Ikegaya Y, Matsuki N, Nomura H. Fear extinction requires Arc/Arg3.1 expression in the basolateral amygdala. Mol Brain. 2014;7:30 pubmed publisher
Gautam A, Wadhwa R, Thakur M. Involvement of hippocampal Arc in amnesia and its recovery by alcoholic extract of Ashwagandha leaves. Neurobiol Learn Mem. 2013;106:177-84 pubmed publisher
Ma T, Trinh M, Wexler A, Bourbon C, Gatti E, Pierre P, et al. Suppression of eIF2? kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013;16:1299-305 pubmed publisher
Ljubimova J, Kleinman M, Karabalin N, Inoue S, Konda B, Gangalum P, et al. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol Pathol. 2013;65:1063-71 pubmed publisher
Fanous S, Guez Barber D, Goldart E, Schrama R, Theberge F, Shaham Y, et al. Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking. J Neurochem. 2013;124:100-8 pubmed publisher
Dziembowska M, Milek J, Janusz A, Rejmak E, Romanowska E, Gorkiewicz T, et al. Activity-dependent local translation of matrix metalloproteinase-9. J Neurosci. 2012;32:14538-47 pubmed publisher
Liu Y, Zhou Q, Hou Y, Lu B, Yu C, Chen J, et al. Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. J Neurosci. 2012;32:12005-17 pubmed publisher
Rudinskiy N, Hawkes J, Betensky R, Eguchi M, Yamaguchi S, Spires Jones T, et al. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nat Neurosci. 2012;15:1422-9 pubmed publisher
Wibrand K, Pai B, Siripornmongcolchai T, Bittins M, Berentsen B, Ofte M, et al. MicroRNA regulation of the synaptic plasticity-related gene Arc. PLoS ONE. 2012;7:e41688 pubmed publisher
Soule J, Alme M, Myrum C, Schubert M, Kanhema T, Bramham C. Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. J Biol Chem. 2012;287:22354-66 pubmed publisher
Westmark C, Westmark P, O Riordan K, Ray B, Hervey C, Salamat M, et al. Reversal of fragile X phenotypes by manipulation of A?PP/A? levels in Fmr1KO mice. PLoS ONE. 2011;6:e26549 pubmed publisher
Ploski J, Monsey M, Nguyen T, DiLeone R, Schafe G. The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. PLoS ONE. 2011;6:e23760 pubmed publisher
Guez Barber D, Fanous S, Golden S, Schrama R, Koya E, Stern A, et al. FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. J Neurosci. 2011;31:4251-9 pubmed publisher
Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, et al. Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Brain Res. 2009;1287:136-45 pubmed publisher
Lively S, Brown I. Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus. J Neurochem. 2008;107:1335-46 pubmed publisher
Li L, Carter J, Gao X, Whitehead J, Tourtellotte W. The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol Cell Biol. 2005;25:10286-300 pubmed
product information
Product Name :
Arc (C-7) Antibody
Gene Name :
ARC
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-17839
Type :
Monoclonal
Host :
mouse monoclonal2a
Antigen :
Arc
reactive species  :
m, r, h
Application :
WB, IP, IF, ELISA
Epitope :
1-300 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA