product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Brg-1 (G-7) Antibody
catalog :
sc-17796
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-7
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 68
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 3c
  • western blot; human; 1:1000; loading ...; fig s4r
Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al. Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed publisher
  • western blot; human; loading ...; fig s1e
Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed publisher
  • western blot; human; loading ...; fig 1c
Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed publisher
  • western blot; human; fig 4b
Chen Z, Gao Y, Yao L, Liu Y, Huang L, Yan Z, et al. LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation. Oncogene. 2018;37:3098-3112 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1-s1d
Kelso T, Porter D, Amaral M, Shokhirev M, Benner C, Hargreaves D. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. elife. 2017;6: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4a
Bitler B, Wu S, Park P, Hai Y, Aird K, Wang Y, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017;19:962-973 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 6,7c,7d
Marquez Vilendrer S, Thompson K, Lu L, Reisman D. Mechanism of BRG1 silencing in primary cancers. Oncotarget. 2016;7:56153-56169 pubmed publisher
  • western blot; mouse; 1:1000; fig 1b
Lee H, Dai F, Zhuang L, Xiao Z, Kim J, Zhang Y, et al. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 2016;7:19134-46 pubmed publisher
  • western blot; mouse; fig s6
Flynn R, Do B, Rubin A, Calo E, Lee B, Kuchelmeister H, et al. 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016;23:231-8 pubmed publisher
  • western blot; mouse; fig 8d
Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, et al. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation. Nat Immunol. 2016;17:331-43 pubmed publisher
  • western blot; human; fig 6b
Jamshidi F, Bashashati A, Shumansky K, Dickson B, Gokgoz N, Wunder J, et al. The genomic landscape of epithelioid sarcoma cell lines and tumours. J Pathol. 2016;238:63-73 pubmed publisher
  • immunocytochemistry; human; fig 2
  • chromatin immunoprecipitation; mouse; fig 4
Fillmore C, Xu C, Desai P, Berry J, Rowbotham S, Lin Y, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520:239-42 pubmed publisher
  • western blot; human; fig 1
Smith Roe S, Nakamura J, Holley D, Chastain P, Rosson G, Simpson D, et al. SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget. 2015;6:732-45 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000; tbl 1
Rao Q, Xia Q, Wang Z, Li L, Shen Q, Shi S, et al. Frequent co-inactivation of the SWI/SNF subunits SMARCB1, SMARCA2 and PBRM1 in malignant rhabdoid tumours. Histopathology. 2015;67:121-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Li L, Fan X, Xia Q, Rao Q, Liu B, Yu B, et al. Concurrent loss of INI1, PBRM1, and BRM expression in epithelioid sarcoma: implications for the cocontributions of multiple SWI/SNF complex members to pathogenesis. Hum Pathol. 2014;45:2247-54 pubmed publisher
  • western blot; human
Wei D, Goldfarb D, Song S, Cannon C, Yan F, Sakellariou Thompson D, et al. SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development. Mol Cancer Res. 2014;12:1574-85 pubmed publisher
  • western blot; human; fig 2a
Helming K, Wang X, WILSON B, Vazquez F, Haswell J, Manchester H, et al. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nat Med. 2014;20:251-4 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Singh A, Archer T. Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014;42:2958-75 pubmed publisher
  • western blot; human; fig 1
Zhou X, Wang H, Burg M, Ferraris J. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol. 2013;305:F362-9 pubmed publisher
  • immunoprecipitation; human
  • western blot; human; fig 1
Chesi A, Staahl B, Jovicic A, Couthouis J, Fasolino M, Raphael A, et al. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013;16:851-5 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
  • western blot; mouse
Davis R, Curtis C, Griffin C. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013;140:1272-81 pubmed publisher
  • western blot; mouse
Chandler R, Brennan J, Schisler J, Serber D, Patterson C, Magnuson T. ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013;33:265-80 pubmed publisher
  • immunoprecipitation; human; fig 1
Leung J, Nevins J. E2F6 associates with BRG1 in transcriptional regulation. PLoS ONE. 2012;7:e47967 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Curtis C, Griffin C. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol. 2012;32:1312-20 pubmed publisher
Asha K, Balfe N, Sharma Walia N. Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4. J Virol. 2020;94: pubmed publisher
Imai Sumida M, Dasgupta P, Kulkarni P, Shiina M, Hashimoto Y, Shahryari V, et al. Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer. Cell Physiol Biochem. 2020;54:53-70 pubmed publisher
Bell C, Raffeiner P, Hart J, Vogt P. PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9. Cancers (Basel). 2019;11: pubmed publisher
Witwicka H, Nogami J, Syed S, Maehara K, Padilla Benavides T, Ohkawa Y, et al. Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme. Mol Cell Biol. 2019;39: pubmed publisher
Qu Y, Deng C, Luo Q, Shang X, Wu J, Shi Y, et al. Arid1a regulates insulin sensitivity and lipid metabolism. EBioMedicine. 2019;42:481-493 pubmed publisher
Shorstova T, Marques M, Su J, Johnston J, Kleinman C, Hamel N, et al. SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors. Cancer Res. 2019;79:2761-2774 pubmed publisher
Hong A, Tseng Y, Wala J, Kim W, Kynnap B, Doshi M, et al. Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. elife. 2019;8: pubmed publisher
Kulkarni R, Bak D, Wei D, Bergholtz S, Briney C, Shrimp J, et al. A chemoproteomic portrait of the oncometabolite fumarate. Nat Chem Biol. 2019;15:391-400 pubmed publisher
Gatchalian J, Malik S, Ho J, Lee D, Kelso T, Shokhirev M, et al. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018;9:5139 pubmed publisher
Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 2018;175:1244-1258.e26 pubmed publisher
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, et al. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature. 2018;563:265-269 pubmed publisher
Wu S, Fatkhutdinov N, Fukumoto T, Bitler B, Park P, Kossenkov A, et al. SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. Nat Commun. 2018;9:4116 pubmed publisher
Huang L, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, et al. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018;9:3569 pubmed publisher
Wu C, Lyu J, Yang E, Liu Y, Zhang B, Shim J. Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. Nat Commun. 2018;9:3212 pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Wood C, Veenstra H, Khasnis S, Gunnell A, Webb H, Shannon Lowe C, et al. MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. elife. 2016;5: pubmed publisher
Hohmann A, Martin L, Minder J, Roe J, Shi J, Steurer S, et al. Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nat Chem Biol. 2016;12:672-9 pubmed publisher
Albini S, Coutinho Toto P, Dall Agnese A, Malecova B, Cenciarelli C, Felsani A, et al. Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis. EMBO Rep. 2015;16:1037-50 pubmed publisher
Dubovsky J, Chappell D, Harrington B, Agrawal K, Andritsos L, Flynn J, et al. Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing. Blood. 2013;122:3308-16 pubmed publisher
Bosse T, Ter Haar N, Seeber L, v Diest P, Hes F, Vasen H, et al. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer. Mod Pathol. 2013;26:1525-35 pubmed publisher
Dykhuizen E, Hargreaves D, Miller E, Cui K, Korshunov A, Kool M, et al. BAF complexes facilitate decatenation of DNA by topoisomerase II?. Nature. 2013;497:624-7 pubmed publisher
Zhou X, Wang H, Burg M, Ferraris J. Inhibitory phosphorylation of GSK-3? by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP). Am J Physiol Renal Physiol. 2013;304:F908-17 pubmed publisher
Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, et al. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci. 2013;104:266-73 pubmed publisher
Ranneberg Nilsen T, Rollag H, Slettebakk R, Backe P, Olsen Ø, Luna L, et al. The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44. PLoS ONE. 2012;7:e34119 pubmed publisher
Kim Y, Fedoriw A, Magnuson T. An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis. Development. 2012;139:1133-40 pubmed publisher
Vizlin Hodzic D, Runnberg R, Ryme J, Simonsson S, Simonsson T. SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. PLoS ONE. 2011;6:e28049 pubmed publisher
DelBove J, Rosson G, Strobeck M, Chen J, Archer T, Wang W, et al. Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene. Epigenetics. 2011;6:1444-53 pubmed publisher
Grandy R, Sepulveda H, Aguilar R, Pihan P, Henriquez B, Olate J, et al. The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner. Mol Cell Biol. 2011;31:2997-3008 pubmed publisher
Bock V, Lyons J, Huang X, Jones A, McDonald L, Scolyer R, et al. BRM and BRG1 subunits of the SWI/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours. Br J Dermatol. 2011;164:1221-7 pubmed publisher
Euskirchen G, Auerbach R, Davidov E, Gianoulis T, Zhong G, Rozowsky J, et al. Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches. PLoS Genet. 2011;7:e1002008 pubmed publisher
Schramedei K, Mörbt N, Pfeifer G, Lauter J, Rosolowski M, Tomm J, et al. MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. Oncogene. 2011;30:2975-85 pubmed publisher
Griffin C, Curtis C, Davis R, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A. 2011;108:2282-7 pubmed publisher
Hang C, Yang J, Han P, Cheng H, Shang C, Ashley E, et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature. 2010;466:62-7 pubmed publisher
Tchapyjnikov D, Li Y, Pisitkun T, Hoffert J, Yu M, Knepper M. Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS. Physiol Genomics. 2010;40:167-83 pubmed publisher
Bourgo R, Siddiqui H, Fox S, Solomon D, Sansam C, Yaniv M, et al. SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell. 2009;20:3192-9 pubmed publisher
Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, et al. Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp Cell Res. 2009;315:1779-89 pubmed publisher
Sachs A, Pisitkun T, Hoffert J, Yu M, Knepper M. LC-MS/MS analysis of differential centrifugation fractions from native inner medullary collecting duct of rat. Am J Physiol Renal Physiol. 2008;295:F1799-806 pubmed publisher
Dmitrieva N, Burg M. Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl. Am J Physiol Renal Physiol. 2008;295:F1678-88 pubmed publisher
Zheng J, Xia X, Ding H, Yan A, Hu S, Gong X, et al. Erasure of the paternal transcription program during spermiogenesis: the first step in the reprogramming of sperm chromatin for zygotic development. Dev Dyn. 2008;237:1463-76 pubmed publisher
Glaros S, Cirrincione G, Muchardt C, Kleer C, Michael C, Reisman D. The reversible epigenetic silencing of BRM: implications for clinical targeted therapy. Oncogene. 2007;26:7058-66 pubmed
Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Mol Cell Endocrinol. 2007;270:23-32 pubmed
Wang X, Sun D, Fang J. [Research advances on the relationship of PI3-kinase/Akt/mTOR pathway and epigenetic modification]. Yi Chuan. 2006;28:1585-90 pubmed
Demasi M, Montor W, Ferreira G, Pimenta D, Labriola L, Sogayar M. Differential proteomic analysis of the anti-proliferative effect of glucocorticoid hormones in ST1 rat glioma cells. J Steroid Biochem Mol Biol. 2007;103:137-48 pubmed
Ahmad N, Lingrel J. Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases. Biochemistry. 2005;44:6276-85 pubmed
product information
Product Name :
Brg-1 (G-7) Antibody
Gene Name :
SMARCA4
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-17796
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Brg-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
209-296 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA