product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Rock-1 (G-6) Antibody
catalog :
sc-17794
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-6
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:50; loading ...
Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 3b
Yuan W, Guo Y, Li X, Deng M, Shen Z, Bo C, et al. MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. Oncotarget. 2016;7:60230-60244 pubmed publisher
  • western blot; human; 1:50-500
O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed publisher
Lee S, Lee S. Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells. Animals (Basel). 2021;11: pubmed publisher
Tishchenko A, Azorín D, Vidal Brime L, Muñoz M, Arenas P, Pearce C, et al. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher
Li X, Zhou Q, Wang S, Wang P, Li J, Xie Z, et al. Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype. Aging (Albany NY). 2020;12:16621-16646 pubmed publisher
Takeda Y, Matoba K, Kawanami D, Nagai Y, Akamine T, Ishizawa S, et al. ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Chen Y, Ren Y, Xu W, Rosa R, Kuo L, Hein T. Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase. Invest Ophthalmol Vis Sci. 2018;59:5167-5175 pubmed publisher
Jia X, Xu J, Gu Y, Gu X, Li W, Wang Y. Vitamin D suppresses oxidative stress-induced microparticle release by human umbilical vein endothelial cells. Biol Reprod. 2017;96:199-210 pubmed publisher
Xu J, Jia X, Gu Y, Lewis D, Gu X, Wang Y. Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts. J Clin Endocrinol Metab. 2017;102:2100-2110 pubmed publisher
Kang H, Park J, Choi K, Choi H, Jung C, Kim G, et al. Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome. Aging Cell. 2017;16:541-550 pubmed publisher
Jia X, Gu Y, Groome L, Al Kofahi M, Alexander J, Li W, et al. 1,25(OH)2D3 Induces Placental Vascular Smooth Muscle Cell Relaxation by Phosphorylation of Myosin Phosphatase Target Subunit 1Ser507: Potential Beneficial Effects of Vitamin D on Placental Vasculature in Humans. Biol Reprod. 2016;94:116 pubmed publisher
Pan J, Wang T, Wang L, Chen W, Song M. Cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells via the Rho signaling pathway. PLoS ONE. 2014;9:e91580 pubmed publisher
Arita R, Nakao S, Kita T, Kawahara S, Asato R, Yoshida S, et al. A key role for ROCK in TNF-?-mediated diabetic microvascular damage. Invest Ophthalmol Vis Sci. 2013;54:2373-83 pubmed publisher
Yang Z, Wang J, Liu X, Cheng Y, Deng L, Zhong Y. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Oncol Rep. 2013;29:1140-6 pubmed publisher
Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Doty C, et al. ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. Curr Mol Med. 2013;13:205-19 pubmed
Tan H, Zhong Y, Shen X, Cheng Y, Jiao Q, Deng L. Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA/ROCK signaling pathway. Neuropharmacology. 2012;63:1182-90 pubmed publisher
Escudero Esparza A, Jiang W, Martin T. Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways. J Exp Clin Cancer Res. 2012;31:43 pubmed publisher
Peris B, González Granero S, Ballester Lurbe B, Garcia Verdugo J, Perez Roger I, Guerri C, et al. Neuronal polarization is impaired in mice lacking RhoE expression. J Neurochem. 2012;121:903-14 pubmed publisher
Escudero Esparza A, Jiang W, Martin T. Claudin-5 participates in the regulation of endothelial cell motility. Mol Cell Biochem. 2012;362:71-85 pubmed publisher
Chen Z, Wang X, Shao Y, Shi D, Chen T, Cui D, et al. Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway. Mol Cell Biochem. 2011;358:221-7 pubmed publisher
Xu E, Kantores C, Ivanovska J, Engelberts D, Kavanagh B, McNamara P, et al. Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2010;299:H1854-64 pubmed publisher
Bryan B, Dennstedt E, Mitchell D, Walshe T, Noma K, Loureiro R, et al. RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010;24:3186-95 pubmed publisher
Routhier A, Astuccio M, Lahey D, Monfredo N, Johnson A, Callahan W, et al. Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth. Oncol Rep. 2010;23:861-7 pubmed
Fibbi B, Filippi S, Morelli A, Vignozzi L, Silvestrini E, Chavalmane A, et al. Estrogens regulate humans and rabbit epididymal contractility through the RhoA/Rho-kinase pathway. J Sex Med. 2009;6:2173-86 pubmed publisher
Friel A, Curley M, Ravikumar N, Smith T, Morrison J. Rho A/Rho kinase mRNA and protein levels in human myometrium during pregnancy and labor. J Soc Gynecol Investig. 2005;12:20-7 pubmed
product information
Product Name :
Rock-1 (G-6) Antibody
Gene Name :
ROCK1
Size :
200 µg/ml
Catalog Number :
sc-17794
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Rock-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
755-840 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA