product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
survivin (D-8) Antibody
catalog :
sc-17779
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 82
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 6d
Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, et al. Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer. Cell Death Dis. 2021;12:912 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6f
Hsieh M, Weng C, Lin Y, Wu C, Chen L, Cheng K. Inhibition of β-Catenin Activity Abolishes LKB1 Loss-Driven Pancreatic Cystadenoma in Mice. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig 10
Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
  • western blot; human; loading ...; fig 3d
Forte I, Indovina P, Iannuzzi C, Cirillo D, Di Marzo D, Barone D, et al. Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Int J Oncol. 2019;54:2189-2199 pubmed publisher
  • western blot; human; loading ...; fig 5f
Urtishak K, Wang L, Culjkovic Kraljacic B, Davenport J, Porazzi P, Vincent T, et al. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38:2241-2262 pubmed publisher
  • western blot; human; 1:200; loading ...; fig s3
Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher
  • western blot; human; loading ...; fig 2b
Periyasamy M, Singh A, Gemma C, Kranjec C, Farzan R, Leach D, et al. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells. Nucleic Acids Res. 2017;45:11056-11069 pubmed publisher
  • western blot; human; fig 2b
Liu Z, Li H, Liu J, Wu M, Chen X, Liu L, et al. Inactivated Wnt signaling in resveratrol-treated epidermal squamous cancer cells and its biological implication. Oncol Lett. 2017;14:2239-2243 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6b
Sgourdou P, Mishra Gorur K, Saotome I, Henagariu O, Tuysuz B, Campos C, et al. Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Sci Rep. 2017;7:43708 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s3
Abadía Molina F, Morón Calvente V, Baird S, Shamim F, Martin F, MacKenzie A. Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division. Sci Rep. 2017;7:39981 pubmed publisher
  • western blot; human; loading ...; fig 2b
Park S, Jwa E, Shin S, Ju E, Park I, Pak J, et al. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. Int J Biochem Cell Biol. 2017;83:47-55 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 4
  • western blot; human; 1:200
Fotouhi O, Kjellin H, Larsson C, Hashemi J, Barriuso J, Juhlin C, et al. Proteomics Suggests a Role for APC-Survivin in Response to Somatostatin Analog Treatment of Neuroendocrine Tumors. J Clin Endocrinol Metab. 2016;101:3616-3627 pubmed
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Takasaki C, Kobayashi M, Ishibashi H, Akashi T, Okubo K. Expression of hypoxia-inducible factor-1? affects tumor proliferation and antiapoptosis in surgically resected lung cancer. Mol Clin Oncol. 2016;5:295-300 pubmed
  • immunocytochemistry; human; 1:300; fig 1
  • western blot; human; fig 2
Sasai K, Katayama H, Hawke D, Sen S. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS ONE. 2016;11:e0157305 pubmed publisher
  • flow cytometry; human; 1:25; fig 1b
  • immunohistochemistry; human; loading ...; fig 1a
  • western blot; human; 1:50; fig 1d
Venkatesan N, Kanwar J, Deepa P, Navaneethakrishnan S, Joseph C, Krishnakumar S. Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma. Chem Biol Interact. 2016;252:141-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
Andersson E, Arvidsson Y, Swärd C, Hofving T, Wängberg B, Kristiansson E, et al. Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets. Mod Pathol. 2016;29:616-29 pubmed publisher
  • western blot; human; fig 1
Li Y, Lu W, Saini S, Moukha Chafiq O, Pathak V, Ananthan S. Identification of quinazoline compounds as novel potent inhibitors of Wnt/?-catenin signaling in colorectal cancer cells. Oncotarget. 2016;7:11263-70 pubmed publisher
  • western blot; human; fig 5
Vartanian S, Ma T, Lee J, Haverty P, Kirkpatrick D, Yu K, et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics. 2016;15:1220-31 pubmed publisher
  • western blot; human; fig 1
Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016;35:1541-53 pubmed publisher
  • western blot; mouse; loading ...; fig 7d
Raimondi L, De Luca A, Amodio N, Manno M, Raccosta S, Taverna S, et al. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. 2015;6:13772-89 pubmed
  • western blot; human; 1:75
Rogler A, Kendziorra E, Giedl J, Stoehr C, Taubert H, Goebell P, et al. Functional analyses and prognostic significance of SFRP1 expression in bladder cancer. J Cancer Res Clin Oncol. 2015;141:1779-90 pubmed publisher
  • western blot; human
Papanikolaou V, Stefanou N, Dubos S, Papathanasiou I, Palianopoulou M, Valiakou V, et al. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes. Cell Oncol (Dordr). 2015;38:155-64 pubmed publisher
  • western blot; mouse; fig 6
Olayanju A, Copple I, Bryan H, Edge G, Sison R, Wong M, et al. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. Free Radic Biol Med. 2015;78:202-12 pubmed publisher
  • western blot; human
Leiphrakpam P, Rajput A, Mathiesen M, Agarwal E, Lazenby A, Are C, et al. Ezrin expression and cell survival regulation in colorectal cancer. Cell Signal. 2014;26:868-79 pubmed publisher
  • western blot; human
Cheng Y, Holloway M, Nguyen K, McCauley D, Landesman Y, Kauffman M, et al. XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer. Mol Cancer Ther. 2014;13:675-86 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Lauxen I, Oliveira M, Rados P, Lingen M, Nor J, Sant Ana Filho M. Immunoprofiling of oral squamous cell carcinomas reveals high p63 and survivin expression. Oral Dis. 2014;20:e76-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Kobayashi M, Huang C, Sonobe M, Kikuchi R, Ishikawa M, Kitamura J, et al. Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. Exp Ther Med. 2012;3:952-958 pubmed
  • western blot; human; 1:100
Liu D, Kadota K, Ueno M, Nakashima N, Yokomise H, Huang C. Adenoviral vector expressing short hairpin RNA targeting Wnt2B has an effective antitumour activity against Wnt2B2-overexpressing tumours. Eur J Cancer. 2012;48:1208-18 pubmed publisher
  • western blot; mouse
Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, et al. Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol. 2009;182:6744-52 pubmed publisher
Mohammed Salama M. Role of Napsin A and Survivin Immunohistochemical Expression in Bronchogenic Adenocarcinoma. Asian Pac J Cancer Prev. 2020;21:3345-3348 pubmed publisher
Jin L, Zhao K, Xu L, Zhao R, Werle K, Wang Y, et al. LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin. Aging (Albany NY). 2020;12:14341-14354 pubmed publisher
Lee J, Lee H, Ryu K, Kim M, Ko D, Chung K, et al. KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. J Clin Med. 2020;9: pubmed publisher
Carpi S, Fogli S, Giannetti A, Adinolfi B, Tombelli S, Da Pozzo E, et al. Theranostic properties of a survivin-directed molecular beacon in human melanoma cells. PLoS ONE. 2014;9:e114588 pubmed publisher
Macha M, Rachagani S, Gupta S, Pai P, Ponnusamy M, Batra S, et al. Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. Cancer Lett. 2013;341:166-77 pubmed publisher
Lazarova D, Chiaro C, Wong T, Drago E, Rainey A, O Malley S, et al. CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon Cancer Cells. J Cancer. 2013;4:481-90 pubmed publisher
Ly B, Chi H, Yamagishi M, Kano Y, Hara Y, Nakano K, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS ONE. 2013;8:e66378 pubmed publisher
Nair S, Marlow F, ABRAMS E, KAPP L, Mullins M, Pelegri F. The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. PLoS Genet. 2013;9:e1003448 pubmed publisher
Cui C, Wang Y, Wang Y, Zhao M, Peng S. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091 pubmed publisher
Al Dhaheri Y, Eid A, Abuqamar S, Attoub S, Khasawneh M, Aiche G, et al. Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-? and downregulation of survivin and mutant p53. PLoS ONE. 2013;8:e56649 pubmed publisher
Chi H, Ly B, Kano Y, Tojo A, Watanabe T, Sato Y. ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412. Biochem Biophys Res Commun. 2012;429:87-92 pubmed publisher
Li J, Wang H, Ma Z, Fan W, Li Y, Han B, et al. TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression. Exp Ther Med. 2012;3:1033-1038 pubmed
Freiburghaus C, Lindmark Månsson H, Paulsson M, Oredsson S. Reduction of ultraviolet light-induced DNA damage in human colon cancer cells treated with a lactoferrin-derived peptide. J Dairy Sci. 2012;95:5552-60 pubmed publisher
McCarthy B, Yang L, Ding J, Ren M, King W, Elsalanty M, et al. NF-?B2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors. BMC Cancer. 2012;12:203 pubmed publisher
al Yacoub N, Fecker L, Möbs M, Plötz M, Braun F, Sterry W, et al. Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling. J Invest Dermatol. 2012;132:2263-74 pubmed publisher
Yuan B, Xian R, Wu X, Jing J, Chen K, Liu G, et al. Endoplasmic reticulum chaperone glucose regulated protein 170-Pokemon complexes elicit a robust antitumor immune response in vivo. Immunobiology. 2012;217:738-42 pubmed publisher
Glienke W, Maute L, Wicht J, Bergmann L. The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines. Tumour Biol. 2012;33:757-65 pubmed publisher
Ekeblad S, Lejonklou M, Stalberg P, Skogseid B. Prognostic relevance of survivin in pancreatic endocrine tumors. World J Surg. 2012;36:1411-8 pubmed publisher
Wang Z, Zhao J, Zeng J, Wu K, Chen Y, Wang X, et al. Specific survivin dual fluorescence resonance energy transfer molecular beacons for detection of human bladder cancer cells. Acta Pharmacol Sin. 2011;32:1522-8 pubmed publisher
Zhang C, Elkahloun A, Robertson M, Gills J, Tsurutani J, Shih J, et al. Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. PLoS ONE. 2011;6:e23849 pubmed publisher
Morrison D, Hogan L, Condos G, Bhatla T, Germino N, Moskowitz N, et al. Endogenous knockdown of survivin improves chemotherapeutic response in ALL models. Leukemia. 2012;26:271-9 pubmed publisher
Zhou F, Zhang L, van Laar T, van Dam H, Ten Dijke P. GSK3? inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011;22:3533-40 pubmed publisher
Nardiello T, Jungbluth A, Mei A, DiLiberto M, Huang X, Dabrowski A, et al. MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin. Clin Cancer Res. 2011;17:4309-19 pubmed publisher
Jeong J, Jin C, Park C, Hong S, Kim G, Jeong Y, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro. 2011;25:817-24 pubmed publisher
Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, et al. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res. 2011;21:779-92 pubmed publisher
Liu F, Hu X, Zimmerman M, Waller J, Wu P, Hayes Jordan A, et al. TNF? cooperates with IFN-? to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis. PLoS ONE. 2011;6:e16241 pubmed publisher
Glienke W, Hausmann E, Bergmann L. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour Biol. 2011;32:493-500 pubmed publisher
Hoang T, Bui T, Taguchi T, Watanabe T, Sato Y. All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein. J Exp Clin Cancer Res. 2010;29:165 pubmed publisher
Wang H, Gambosova K, Cooper Z, Holloway M, Kassai A, Izquierdo D, et al. EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic ?-cells. BMC Mol Biol. 2010;11:66 pubmed publisher
Zhou J, Gan N, Zhang W, Lu W, Xie X. Proliferation suppression and apoptosis of ovarian carcinoma cells induced by small interfering RNA against vascular endothelial growth factor. J Obstet Gynaecol Res. 2010;36:232-8 pubmed publisher
Zhou S, Qu X, Yu Z, Zhong L, Ruan M, Ma C, et al. Survivin as a potential early marker in the carcinogenesis of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:575-81 pubmed publisher
Wimmershoff J, Polkinghorne A, Grest P, Schade B, Marchal T, Keller S, et al. Immunohistochemical detection of survivin in canine lymphoma. J Comp Pathol. 2010;142:311-22 pubmed publisher
Kim Y, Lee E, Kim Y, Kim S, Park J, Myoung H, et al. Anti-cancer effects of celecoxib in head and neck carcinoma. Mol Cells. 2010;29:185-94 pubmed publisher
Kim Y, Kim S, Kim Y, Hong S, Kim M, Myoung H. Evaluation of survivin as a prognostic marker in oral squamous cell carcinoma. J Oral Pathol Med. 2010;39:368-75 pubmed publisher
Bennett K, Romigh T, Eng C. Disruption of transforming growth factor-beta signaling by five frequently methylated genes leads to head and neck squamous cell carcinoma pathogenesis. Cancer Res. 2009;69:9301-5 pubmed publisher
Yang L, Ma X, Xiao L, Tang M, Weng X, Sun L, et al. Uniquely modified RNA oligonucleotides targeting STAT3 suppress melanoma growth both in vitro and in vivo. Cancer Biol Ther. 2009;8:2065-72 pubmed
Koelink P, Mieremet Ooms M, Corver W, Wolanin K, Hommes D, Lamers C, et al. 5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes. Inflamm Bowel Dis. 2010;16:379-89 pubmed publisher
Chi H, Vu H, Iwasaki R, Thao L, Hara Y, Taguchi T, et al. Green tea (-)-epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells. Cancer Biol Ther. 2009;8:1934-9 pubmed
Bourhis E, Lingel A, Phung Q, Fairbrother W, Cochran A. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry. 2009;48:6783-93 pubmed publisher
Yang L, Xiao L, Ma X, Tang M, Weng X, Chen X, et al. Effect of DNAzymes targeting Akt1 on cell proliferation and apoptosis in nasopharyngeal carcinoma. Cancer Biol Ther. 2009;8:366-71 pubmed
Schünemann H, Castelli M, Muti P. Systematic reviews for the Journal of Experimental & Clinical Cancer Research: going where the science takes us. J Exp Clin Cancer Res. 2007;26:169-74 pubmed
Lukiw W, Cui J, Li Y, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol. 2009;91:27-32 pubmed publisher
Win H, Acevedo Duncan M. Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival. Cancer Lett. 2008;270:302-11 pubmed publisher
Nakano J, Huang C, Liu D, Masuya D, Yokomise H, Ueno M, et al. The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers. Br J Cancer. 2008;98:1109-17 pubmed publisher
Gonzalez S, Aubert S, Kerdraon O, Haddad O, Fantoni J, Biserte J, et al. Prognostic value of combined p53 and survivin in pT1G3 urothelial carcinoma of the bladder. Am J Clin Pathol. 2008;129:232-7 pubmed publisher
Holst C, Johansson V, Alm K, Oredsson S. Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. Cell Biol Int. 2008;32:66-74 pubmed
Bourhis E, Hymowitz S, Cochran A. The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin. J Biol Chem. 2007;282:35018-23 pubmed
Braun F, Fecker L, Schwarz C, Walden P, Assaf C, Dürkop H, et al. Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2007;127:2425-37 pubmed
Vischioni B, Oudejans J, Kruyt F, Giaccone G, Rodriguez J. Immunohistochemical detection of nuclear survivin in NSCLC: a comparison of commercial antibodies. Histopathology. 2007;50:671-5 pubmed
Calviello G, Resci F, Serini S, Piccioni E, Toesca A, Boninsegna A, et al. Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis. 2007;28:1202-9 pubmed
Kurbanov B, Fecker L, Geilen C, Sterry W, Eberle J. Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4. Oncogene. 2007;26:3364-77 pubmed
Shinohara E, Gonzalez A, Massion P, Chen H, Li M, Freyer A, et al. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer. 2005;103:1685-92 pubmed
Lu B, Gonzalez A, Massion P, Shyr Y, Shaktour B, Carbone D, et al. Nuclear survivin as a biomarker for non-small-cell lung cancer. Br J Cancer. 2004;91:537-40 pubmed
product information
Product Name :
survivin (D-8) Antibody
Gene Name :
BIRC5
Size :
200 µg/ml
Catalog Number :
sc-17779
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
survivin
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-142 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA