product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
LAMP-1 (E-5) Antibody
catalog :
sc-17768
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E-5
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:400; loading ...; fig s1
Alissafi T, Hatzioannou A, Mintzas K, Barouni R, Banos A, Sormendi S, et al. Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. J Clin Invest. 2018;128:3840-3852 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 9d
Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6f
  • western blot; human; 1:1000; loading ...; fig 6b
Moody H, Lind M, Maher S. MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma. Mol Ther Nucleic Acids. 2017;8:317-329 pubmed publisher
  • western blot; human; loading ...; fig 5g
Liu S, Liu H, Johnston A, Hanna Addams S, Reynoso E, Xiang Y, et al. MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Proc Natl Acad Sci U S A. 2017;114:E7450-E7459 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s1b
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 7e
Luessen D, Hinshaw T, Sun H, Howlett A, MARRS G, McCool B, et al. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016;110:297-307 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4e
O Rourke J, Bogdanik L, Yáñez A, Lall D, Wolf A, Muhammad A, et al. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351:1324-9 pubmed publisher
  • immunohistochemistry; rat; 1:100; fig 4
Boddu R, Hull T, Bolisetty S, Hu X, Moehle M, Daher J, et al. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Hum Mol Genet. 2015;24:4078-93 pubmed publisher
  • western blot; human
Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed publisher
  • western blot; human
Al Zoubi M, Salem A, Martinez Outschoorn U, Whitaker Menezes D, Lamb R, Hulit J, et al. Creating a tumor-resistant microenvironment: cell-mediated delivery of TNF? completely prevents breast cancer tumor formation in vivo. Cell Cycle. 2013;12:480-90 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Salem A, Howell A, Sartini M, Sotgia F, Lisanti M. Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1?, autophagy and ketone body production. Cell Cycle. 2012;11:4167-73 pubmed publisher
  • immunocytochemistry; mouse; 1:250
Clarke J, Emson P, Irvine R. Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. J Comp Neurol. 2009;517:296-312 pubmed publisher
Fischer J, Gutierrez S, Ganesan R, Calabrese C, Ranjan R, Cildir G, et al. Leptin signaling impairs macrophage defenses against Salmonella Typhimurium. Proc Natl Acad Sci U S A. 2019;116:16551-16560 pubmed publisher
Kochetkova E, Blinova G, Bystrova O, Martynova M, Pospelov V, Pospelova T. Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases. Aging (Albany NY). 2018;10:3574-3589 pubmed publisher
Barbero Camps E, Roca Agujetas V, Bartolessis I, de Dios C, Fernandez Checa J, Mari M, et al. Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 2018;14:1129-1154 pubmed publisher
Kochetkova E, Blinova G, Bystrova O, Martynova M, Pospelov V, Pospelova T. Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway. Aging (Albany NY). 2017;9:2352-2375 pubmed publisher
Smith V, Cheng Y, Bryant B, Schorey J. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection. Sci Rep. 2017;7:43578 pubmed publisher
Deruy E, Nassour J, Martin N, Vercamer C, Malaquin N, Bertout J, et al. Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion. Cell Death Dis. 2014;5:e1577 pubmed publisher
Zhang F, Kumano M, Beraldi E, Fazli L, Du C, Moore S, et al. Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival. Nat Commun. 2014;5:5775 pubmed publisher
Hunter M, O Hagan K, Kenyon A, Dhanani K, Prinsloo E, Edkins A. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PLoS ONE. 2014;9:e86842 pubmed publisher
Kim H, Montana V, Jang H, Parpura V, Kim J. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem. 2013;288:22693-705 pubmed publisher
Su L, Cao L, Zhou R, Jiang Z, Xiao K, Kong W, et al. Identification of novel biomarkers for sepsis prognosis via urinary proteomic analysis using iTRAQ labeling and 2D-LC-MS/MS. PLoS ONE. 2013;8:e54237 pubmed publisher
Capparelli C, Chiavarina B, Whitaker Menezes D, Pestell T, Pestell R, Hulit J, et al. CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle. 2012;11:3599-610 pubmed publisher
Carito V, Bonuccelli G, Martinez Outschoorn U, Whitaker Menezes D, Caroleo M, Cione E, et al. Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle. 2012;11:3403-14 pubmed publisher
Salem A, Whitaker Menezes D, Lin Z, Martinez Outschoorn U, Tanowitz H, Al Zoubi M, et al. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle. 2012;11:2545-56 pubmed publisher
Capparelli C, Whitaker Menezes D, Guido C, Balliet R, Pestell T, Howell A, et al. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle. 2012;11:2272-84 pubmed publisher
Capparelli C, Guido C, Whitaker Menezes D, Bonuccelli G, Balliet R, Pestell T, et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle. 2012;11:2285-302 pubmed publisher
Ko Y, Lin Z, Flomenberg N, Pestell R, Howell A, Sotgia F, et al. Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther. 2011;12:1085-97 pubmed publisher
Castello Cros R, Bonuccelli G, Molchansky A, Capozza F, Witkiewicz A, Birbe R, et al. Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis. Cell Cycle. 2011;10:2021-34 pubmed
Jin J, Whittaker R, Glassy M, Barlow S, Gottlieb R, Glembotski C. Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008;294:H337-44 pubmed
Gonzalez Mariscal L, Namorado M, Martin D, Sierra G, Reyes J. The tight junction proteins claudin-7 and -8 display a different subcellular localization at Henle's loops and collecting ducts of rabbit kidney. Nephrol Dial Transplant. 2006;21:2391-8 pubmed
product information
Product Name :
LAMP-1 (E-5) Antibody
Gene Name :
LAMP1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-17768
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
LAMP-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
1-228 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA