product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Tom20 (F-10) Antibody
catalog :
sc-17764
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F-10
reactivity :
hamsters, African green monkey, human, mouse, rat, chicken, fruit fly , domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 109
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:500; loading ...; fig 6f
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
  • western blot; rat; 1:50; loading ...; fig 5c
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 1a
Hollville E, Joers V, Nakamura A, Swahari V, TANSEY M, Moy S, et al. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease. Sci Rep. 2020;10:16886 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1h
Cheng C, Wooten J, Gibbs Z, McGlynn K, Mishra P, Whitehurst A. Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1g
Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, et al. Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. J Cell Biol. 2020;219: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Alegre Cortés E, Muriel González A, Canales Cortés S, Uribe Carretero E, Martínez Chacón G, Aiastui A, et al. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 1e
Jo D, Park S, Kim A, Park N, Kim J, Bae J, et al. Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Autophagy. 2020;:1-15 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1f
  • western blot; human; loading ...; fig s2f
Oleinik N, Kim J, Roth B, Selvam S, Gooz M, Johnson R, et al. Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019;5:eaax1978 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3g
Grossmann D, Berenguer Escuder C, Bellet M, Scheibner D, Bohler J, Massart F, et al. Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease. Antioxid Redox Signal. 2019;31:1213-1234 pubmed publisher
  • western blot; human; loading ...; fig 2a
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher
  • immunocytochemistry; mouse; 1:250; loading ...; fig s10
  • immunocytochemistry; African green monkey; 1:250; loading ...; fig 7a
  • western blot; human; 1:100; loading ...; fig 6a
Ruiz K, Thaker T, Agnew C, Miller Vedam L, Trenker R, Herrera C, et al. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nat Commun. 2019;10:531 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4e
Ding D, Liu J, Dong K, Melnick A, Latham K, Chen C. Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis. Nucleic Acids Res. 2019;47:2594-2608 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2c
Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
  • immunohistochemistry; fruit fly ; loading ...; fig 3n
Anding A, Wang C, Chang T, Sliter D, Powers C, Hofmann K, et al. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr Biol. 2018;28:287-295.e6 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6a
Ni Z, HE J, Wu Y, Hu C, Dai X, Yan X, et al. AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells. Autophagy. 2018;14:685-701 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Hos N, Ganesan R, Gutierrez S, Hos D, Klimek J, Abdullah Z, et al. Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses. J Cell Biol. 2017;216:4107-4121 pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...; fig 4c
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 7b
  • western blot; human; fig 4
Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
  • immunocytochemistry; hamsters; loading ...; fig 3d
  • western blot; hamsters; loading ...; fig 6c
  • western blot; mouse; loading ...; fig 3b
  • western blot; human; loading ...; fig 6a
Hosoi K, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng E, et al. The VDAC2-BAK axis regulates peroxisomal membrane permeability. J Cell Biol. 2017;216:709-722 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 4a
  • western blot; human; 1:200; loading ...; fig 3a
Wei Y, Chiang W, Sumpter R, Mishra P, Levine B. Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 2017;168:224-238.e10 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 3d
Puschmann A, Fiesel F, Caulfield T, Hudec R, Ando M, Truban D, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain. 2017;140:98-117 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2c
Titov D, Cracan V, Goodman R, Peng J, Grabarek Z, Mootha V. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science. 2016;352:231-5 pubmed publisher
  • immunocytochemistry; human; fig 5
Ackema K, Prescianotto Baschong C, Hench J, Wang S, Chia Z, Mergentaler H, et al. Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites. PLoS ONE. 2016;11:e0154280 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 1b
  • western blot; mouse; loading ...; fig 1d
Gao Y, Bai X, Zhang D, Han C, Yuan J, Liu W, et al. Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. Nat Struct Mol Biol. 2016;23:441-9 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 3c
Kamino H, Nakamura Y, Tsuneki M, Sano H, Miyamoto Y, Kitamura N, et al. Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. Oncogenesis. 2016;4:e181 pubmed publisher
  • western blot; human; 1:500; fig 2
El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed publisher
  • immunocytochemistry; human; fig 1
Ambroise G, Portier A, Roders N, Arnoult D, Vazquez A. Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells. Oncotarget. 2015;6:38181-94 pubmed publisher
  • immunoprecipitation; human
  • western blot; human; 1:1000
Wang Z, Li S, Ren R, Li J, Cui X. Recombinant Buckwheat Trypsin Inhibitor Induces Mitophagy by Directly Targeting Mitochondria and Causes Mitochondrial Dysfunction in Hep G2 Cells. J Agric Food Chem. 2015;63:7795-804 pubmed publisher
  • western blot; human; 1:500; fig 4
Sargsyan A, Cai J, Fandino L, Labasky M, Forostyan T, Colosimo L, et al. Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor. Sci Rep. 2015;5:12397 pubmed publisher
  • immunocytochemistry; human; fig 1
Hamacher Brady A, Brady N. Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation. J Biol Chem. 2015;290:22005-18 pubmed publisher
  • western blot; human
Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed publisher
  • western blot; mouse; fig 1, 6
Mauro Lizcano M, Esteban Martínez L, Seco E, Serrano Puebla A, García Ledo L, Figueiredo Pereira C, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11:833-43 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 3
  • western blot; human; fig 3
Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A. Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. Nat Commun. 2015;6:6580 pubmed publisher
  • western blot; rat
Yang S, Xia C, Li S, Du L, Zhang L, Zhou R. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol. 2014;3:63-71 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Langone F, Cannata S, Fuoco C, Lettieri Barbato D, Testa S, Nardozza A, et al. Metformin protects skeletal muscle from cardiotoxin induced degeneration. PLoS ONE. 2014;9:e114018 pubmed publisher
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:500
El Khattouti A, Sheehan N, Monico J, Drummond H, Haikel Y, Brodell R, et al. CD133⁺ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment. Cancer Lett. 2015;357:83-104 pubmed publisher
  • immunocytochemistry; human; 1:500; fig s2
Fiesel F, Moussaud Lamodière E, Ando M, Springer W. A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently. J Cell Sci. 2014;127:3488-504 pubmed publisher
  • western blot; chicken
Chauss D, Basu S, Rajakaruna S, Ma Z, Gau V, Anastas S, et al. Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. G3 (Bethesda). 2014;4:1515-27 pubmed publisher
  • western blot; rat; 1:250
Yang S, Xia C, Li S, Du L, Zhang L, Hu Y. Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model. Cell Death Dis. 2014;5:e1217 pubmed publisher
  • western blot; mouse
Huang Y, Liu H, Li S, Tang Y, Wei B, Yu H, et al. MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection. PLoS Pathog. 2014;10:e1004020 pubmed publisher
  • western blot; domestic rabbit
Wolff N, Ghio A, Garrick L, Garrick M, Zhao L, Fenton R, et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J. 2014;28:2134-45 pubmed publisher
  • western blot; mouse
Bartolomé A, López Herradón A, Portal Nuñez S, García Aguilar A, Esbrit P, Benito M, et al. Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function. Biochem J. 2013;455:329-37 pubmed publisher
  • western blot; human
Chaudhuri D, Sancak Y, Mootha V, Clapham D. MCU encodes the pore conducting mitochondrial calcium currents. elife. 2013;2:e00704 pubmed publisher
Duan P, Tan J, Miao Y, Zhang Q. PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury. Front Biosci (Landmark Ed). 2022;27:184 pubmed publisher
Lurette O, Guedouari H, Morris J, Martin Jimenez R, Robichaud J, Hamel Côté G, et al. Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology. Cell Mol Life Sci. 2022;79:327 pubmed publisher
Cannino G, Urbani A, Gaspari M, Varano M, Negro A, Filippi A, et al. The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation. Cell Death Differ. 2022;: pubmed publisher
Schwarz L, Fitzgerald J. Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons. Cells. 2022;11: pubmed publisher
Ke P, Chang C, Hsiao Y. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells. 2022;11: pubmed publisher
Cha Y, Kim T, Jeon J, Jang Y, Kim P, Lopes C, et al. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cell Rep. 2021;37:110155 pubmed publisher
Lim Y, Cho I, Rennke H, Cho G. β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep. 2021;11:21477 pubmed publisher
Begum H, Mariano C, Zhou H, Shen K. E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells. Cancers (Basel). 2021;13: pubmed publisher
Núñez Vázquez S, Saura Esteller J, Sánchez Vera I, Guilbaud E, Cosialls A, Pons G, et al. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells. Oncogenesis. 2021;10:64 pubmed publisher
Rossini M, García Casas P, Filadi R, Pizzo P. Loosening ER-Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain. Cells. 2021;10: pubmed publisher
Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman M. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol. 2021;45:102047 pubmed publisher
Du Y, Wang J, Xiong J, Fang N, Ji W. VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Mol Biol Cell. 2021;32:1474-1486 pubmed publisher
Ma K, Fokkens M, Reggiori F, Mari M, Verbeek D. Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. Transl Neurodegener. 2021;10:19 pubmed publisher
Chen K, Yan R, Xiang L, Xu K. Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing. Light Sci Appl. 2021;10:97 pubmed publisher
Zhang X, Shetty M, Clemente V, Linder S, Bazzaro M. Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries. Int J Mol Sci. 2021;22: pubmed publisher
Deng Z, Li X, Blanca Ramírez M, Purtell K, Choi I, Lu J, et al. Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Yin K, Lee J, Liu Z, Kim H, Martin D, Wu D, et al. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell Death Differ. 2021;28:2421-2435 pubmed publisher
Kojima W, Yamano K, Kosako H, Imai K, Kikuchi R, Tanaka K, et al. Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy. 2021;:1-26 pubmed publisher
Scherer K, Manton J, Soh T, Mascheroni L, Connor V, Crump C, et al. A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication. J Biol Chem. 2021;296:100236 pubmed publisher
Choong C, Okuno T, Ikenaka K, Baba K, Hayakawa H, Koike M, et al. Alternative mitochondrial quality control mediated by extracellular release. Autophagy. 2021;17:2962-2974 pubmed publisher
Andersen J, Zhang J, Sun H, Liu X, Liu J, Nie J, et al. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Mol Metab. 2020;42:101055 pubmed publisher
Abrisch R, Gumbin S, Wisniewski B, Lackner L, Voeltz G. Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology. J Cell Biol. 2020;219: pubmed publisher
Mandracchia B, Hua X, Guo C, Son J, Urner T, Jia S. Fast and accurate sCMOS noise correction for fluorescence microscopy. Nat Commun. 2020;11:94 pubmed publisher
Sivalingam V, Latif A, Kitson S, McVey R, Finegan K, Marshall K, et al. Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin. Br J Cancer. 2020;122:62-71 pubmed publisher
Joshi A, Van Wassenhove L, Logas K, Minhas P, Andreasson K, Weinberg K, et al. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. Acta Neuropathol Commun. 2019;7:190 pubmed publisher
Gao J, Qin A, Liu D, Ruan R, Wang Q, Yuan J, et al. Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv. 2019;5:eaaw7215 pubmed publisher
Wang B, Xiao X, Huang F, Liu R. Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis. Antioxidants (Basel). 2019;8: pubmed publisher
Gao L, Zhang Z, Lu J, Pei G. Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. Front Cell Neurosci. 2019;13:316 pubmed publisher
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 2019;:1-13 pubmed publisher
D Acunzo P, Strappazzon F, Caruana I, Meneghetti G, Di Rita A, Simula L, et al. Reversible induction of mitophagy by an optogenetic bimodular system. Nat Commun. 2019;10:1533 pubmed publisher
Li H, Guo C, Kim Holzapfel D, Li W, Altshuller Y, Schroeder B, et al. Fast, volumetric live-cell imaging using high-resolution light-field microscopy. Biomed Opt Express. 2019;10:29-49 pubmed publisher
Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, et al. Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol. 2019;202:1428-1440 pubmed publisher
D Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, et al. The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. Mol Cell. 2019;73:775-787.e10 pubmed publisher
Rawat P, Teodorof Diedrich C, Spector S. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. 2019;67:802-824 pubmed publisher
Lucarelli G, Rutigliano M, Sallustio F, Ribatti D, Giglio A, Lepore Signorile M, et al. Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma. Aging (Albany NY). 2018;10:3957-3985 pubmed publisher
Kochetkova E, Blinova G, Bystrova O, Martynova M, Pospelov V, Pospelova T. Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases. Aging (Albany NY). 2018;10:3574-3589 pubmed publisher
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed publisher
Park H, Liu G, Liu Q, Zhou Y. Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production. Viruses. 2018;10: pubmed publisher
Kim S, Mehta H, Wan J, Kuehnemann C, Chen J, Hu J, et al. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018;10:1239-1256 pubmed publisher
Brennan L, McGreal Estrada R, Logan C, Cvekl A, Menko A, Kantorow M. BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation. Exp Eye Res. 2018;174:173-184 pubmed publisher
Lu Y, Fujioka H, Joshi D, Li Q, Sangwung P, Hsieh P, et al. Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge. Sci Rep. 2018;8:8251 pubmed publisher
Hensen F, Moretton A, van Esveld S, Farge G, Spelbrink J. The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair. Sci Rep. 2018;8:5368 pubmed publisher
Ryan T, Bamm V, Stykel M, Coackley C, Humphries K, Jamieson Williams R, et al. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. 2018;9:817 pubmed publisher
Yoo L, Chung K. The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. J Biol Chem. 2018;293:1286-1297 pubmed publisher
Chen L, Liu C, Gao J, Xie Z, Chan L, Keating D, et al. Inhibition of Miro1 disturbs mitophagy and pancreatic ?-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes. Oncotarget. 2017;8:90693-90705 pubmed publisher
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, et al. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017;68:786-796.e6 pubmed publisher
Aparicio I, Espino J, Bejarano I, Gallardo Soler A, Campo M, Salido G, et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep. 2016;6:33647 pubmed publisher
Knudsen E, Balaji U, Freinkman E, McCue P, Witkiewicz A. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget. 2016;7:78396-78411 pubmed publisher
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, et al. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem. 2016;291:21616-21629 pubmed
Kim S, Guerrero N, Wassef G, Xiao J, Mehta H, Cohen P, et al. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016;7:46899-46912 pubmed publisher
Trapannone R, Mariappa D, Ferenbach A, van Aalten D. Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins. Biochem J. 2016;473:1693-702 pubmed publisher
Byun J, Son S, Cha M, Shong M, Hwang Y, Kim Y, et al. CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease. Cell Death Differ. 2015;22:959-73 pubmed publisher
Wilson W, Hornig Do H, Bruni F, Chang J, Jourdain A, Martinou J, et al. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum Mol Genet. 2014;23:6345-55 pubmed publisher
Qiu F, Chen Y, Liu X, Chu C, Shen L, Xu J, et al. Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal. 2014;7:ra31 pubmed publisher
Gómez Sánchez R, Gegg M, Bravo San Pedro J, Niso Santano M, Alvarez Erviti L, Pizarro Estrella E, et al. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis. 2014;62:426-40 pubmed publisher
Murata H, Sakaguchi M, Kataoka K, Huh N. SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. Mol Biol Cell. 2013;24:2772-84 pubmed publisher
Martinez Outschoorn U, Curry J, Ko Y, Lin Z, Tuluc M, Cognetti D, et al. Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NF?B target stromal MCT4. Cell Cycle. 2013;12:2580-97 pubmed publisher
Selimovic D, Badura H, El Khattouti A, Soell M, Porzig B, Spernger A, et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013;18:980-97 pubmed publisher
Martinez Outschoorn U, Balliet R, Lin Z, Whitaker Menezes D, Birbe R, Bombonati A, et al. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Cell Cycle. 2012;11:4402-13 pubmed publisher
Guido C, Whitaker Menezes D, Lin Z, Pestell R, Howell A, Zimmers T, et al. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget. 2012;3:798-810 pubmed
Sotgia F, Whitaker Menezes D, Martinez Outschoorn U, Flomenberg N, Birbe R, Witkiewicz A, et al. Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle. 2012;11:1445-54 pubmed publisher
Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Kang D, et al. Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice. J Neurosci Res. 2012;90:1200-8 pubmed publisher
Tibaldi E, Venerando A, Zonta F, Bidoia C, Magrin E, Marin O, et al. Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria. Biochem J. 2011;439:505-16 pubmed publisher
Geisler S, Holmström K, Treis A, Skujat D, Weber S, Fiesel F, et al. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy. 2010;6:871-8 pubmed
Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou Y, et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells. 2010;15:887-900 pubmed publisher
Shi Y, Ghosh M, Tong W, Rouault T. Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. Hum Mol Genet. 2009;18:3014-25 pubmed publisher
product information
Product Name :
Tom20 (F-10) Antibody
Gene Name :
TOMM20
Size :
200 µg/ml
Catalog Number :
sc-17764
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Tom20
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-145 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA