product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
A20 (A-12) Antibody
catalog :
sc-166692
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A-12
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 8d, s8
Wang W, Bale S, Wei J, Yalavarthi B, Bhattacharyya D, Yan J, et al. Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs. Nat Commun. 2022;13:6358 pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig s6a
Son M, Wang A, Tu H, Metzig M, Patel P, Husain K, et al. NF-κB responds to absolute differences in cytokine concentrations. Sci Signal. 2021;14: pubmed
  • flow cytometry; human; loading ...; fig 6b
Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  • western blot; human; loading ...; fig 2a
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  • western blot; human; loading ...; fig 4a
Afonina I, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Staal J, et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 2016;17:914-27 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
  • western blot; human; 1:1000; fig 1
Wang Y, Wan M, Zhou Q, Wang H, Wang Z, Zhong X, et al. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. PLoS ONE. 2015;10:e0141165 pubmed publisher
  • immunoprecipitation; mouse; 1:50
  • western blot; mouse; 1:50
Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed publisher
  • western blot; mouse
Kasama Y, Mizukami T, Kusunoki H, Peveling Oberhag J, Nishito Y, Ozawa M, et al. B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-?B signalling. PLoS ONE. 2014;9:e91373 pubmed publisher
Yang M, Yu X, Li X, Luo B, Yang W, Lin Y, et al. TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells. Breast Cancer Res. 2018;20:97 pubmed publisher
Bombassaro B, Ignacio Souza L, Nunez C, Razolli D, Pedro R, Coope A, et al. A20 deubiquitinase controls PGC-1? expression in the adipose tissue. Lipids Health Dis. 2018;17:90 pubmed publisher
Mouton Liger F, Rosazza T, Sepulveda Diaz J, Ieang A, Hassoun S, Claire E, et al. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018;: pubmed publisher
Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J Immunol. 2013;190:2896-903 pubmed publisher
Sun J, Sun L, Zhang N, Lu X, Zhang H. A20 is up-regulated in primary mouse hepatocytes subjected to hypoxia and reperfusion. Cell Biochem Funct. 2012;30:683-6 pubmed publisher
Lippens S, Lefebvre S, Gilbert B, Sze M, Devos M, Verhelst K, et al. Keratinocyte-specific ablation of the NF-?B regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis. Cell Death Differ. 2011;18:1845-53 pubmed publisher
product information
Catalog Number :
sc-166692
Product Name :
A20 (A-12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
A-12
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
A20
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA