product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Smo (E-5) Antibody
catalog :
sc-166685
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E-5
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 5f, s5g
Liu J, Qian B, Zhou L, Shen G, Tan Y, Liu S, et al. IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1. Front Immunol. 2022;13:837262 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 3i
Qiu H, Fujisawa S, Nozaki S, Katoh Y, Nakayama K. Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry. Biol Open. 2021;10: pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 6a
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 10e
Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed publisher
  • western blot; human; loading ...; fig 4b, 4e
Tan Y, Hu Y, Xiao Q, Tang Y, Chen H, He J, et al. Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway. Int J Biol Sci. 2020;16:228-238 pubmed publisher
  • immunocytochemistry; human; fig 2a
Choe C, Shin Y, Kim C, Choi S, Lee J, Kim S, et al. Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition. Onco Targets Ther. 2015;8:3665-78 pubmed publisher
  • immunocytochemistry; mouse; fig 3
Jiang S, Du J, Kong Q, Li C, Li Y, Sun H, et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation. PLoS ONE. 2015;10:e0139830 pubmed publisher
  • immunocytochemistry; mouse
Brown J, Santra T, Owens P, Morrison A, Barry F. Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia. Stem Cell Res. 2014;13:284-99 pubmed publisher
  • western blot; human; loading ...; fig 8a
Zahreddine H, Culjkovic Kraljacic B, Assouline S, Gendron P, Romeo A, Morris S, et al. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014;511:90-3 pubmed publisher
Mu xf1 oz Estrada J, Nguyen A, Goetz S. TTBK2 mutations associated with spinocerebellar ataxia type 11 disrupt peroxisome dynamics and ciliary localization of SHH signaling proteins. bioRxiv. 2023;: pubmed publisher
Pietrobono S, Franci L, Imperatore F, Zanini C, Stecca B, Chiariello M. MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis. Cancers (Basel). 2021;13: pubmed publisher
May E, Kalocsay M, D Auriac I, Schuster P, Gygi S, Nachury M, et al. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol. 2021;220: pubmed publisher
Kozielewicz P, Turku A, Bowin C, Petersen J, Valnohova J, Canizal M, et al. Structural insight into small molecule action on Frizzleds. Nat Commun. 2020;11:414 pubmed publisher
Frikstad K, Molinari E, Thoresen M, Ramsbottom S, Hughes F, Letteboer S, et al. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28:1907-1922.e6 pubmed publisher
Guo L, Wei X, Zhang Z, Wang X, Wang C, Li P, et al. Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway. Arthritis Res Ther. 2019;21:109 pubmed publisher
Kiseleva A, Korobeynikov V, Nikonova A, Zhang P, Makhov P, Deneka A, et al. Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs. Clin Cancer Res. 2019;: pubmed publisher
Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernová I, Fafilek B, et al. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Wang L, Hou S, Han Y. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci. 2016;19:888-96 pubmed publisher
product information
Catalog Number :
sc-166685
Product Name :
Smo (E-5) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
E-5
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Smo
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA