product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Optineurin (C-2) Antibody
catalog :
sc-166576
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-2
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation, immunocytochemistry knockout validation
citations: 9
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; human; loading ...; fig 3c
  • western blot knockout validation; human; loading ...; fig 2d
  • immunohistochemistry; human; 1:100; loading ...; fig 1a
Inokuchi S, Yoshizumi T, Toshima T, Itoh S, Yugawa K, Harada N, et al. Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy. Cancer Med. 2021;10:1501-1514 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 8e
Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
  • western blot; human; loading ...; fig 6a
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
  • immunoprecipitation; human; fig s7
  • immunocytochemistry; human; 1:500; fig s5
  • western blot; human; 1:2000; fig 5
Pourcelot M, Zemirli N, Silva da Costa L, Loyant R, Garcin D, Vitour D, et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. BMC Biol. 2016;14:69 pubmed publisher
  • western blot; mouse
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
Cucarull B, Tutusaus A, Hernáez Alsina T, Garcia de Frutos P, Reig M, Colell A, et al. Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species. Antioxidants (Basel). 2021;10: pubmed publisher
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas Gervais S, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;:1-23 pubmed publisher
Zachari M, Gudmundsson S, Li Z, Manifava M, Shah R, Smith M, et al. Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform. Dev Cell. 2019;50:627-643.e5 pubmed publisher
product information
Catalog Number :
sc-166576
Product Name :
Optineurin (C-2) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C-2
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Optineurin
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA