product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Stat5b (G-2) Antibody
catalog :
sc-1656
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3a
Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 1a
Jallow F, Brockman J, Helzer K, Rugowski D, Goffin V, Alarid E, et al. 17?-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc. 2018;2:293-309 pubmed publisher
  • western blot; mouse; fig 4
Guo L, Costanzo Garvey D, Smith D, Zavorka M, Venable Kang M, MacDonald R, et al. Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2). Sci Rep. 2016;6:32093 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2c
  • immunocytochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 1b
Sumiyoshi H, Matsushita A, Nakamura Y, Matsuda Y, Ishiwata T, Naito Z, et al. Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion. Oncol Rep. 2016;35:3216-26 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; loading ...; fig 2d
Green A, Maciel T, Hospital M, Yin C, Mazed F, Townsend E, et al. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Sci Adv. 2015;1:e1500221 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human
Pinz S, Unser S, Buob D, Fischer P, Jobst B, Rascle A. Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. Nucleic Acids Res. 2015;43:3524-45 pubmed publisher
  • western blot; mouse; 1:4000; fig 5
Wu A, Yang M, Dalvi P, Turinsky A, Wang W, Butcher D, et al. Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland. Am J Physiol Endocrinol Metab. 2014;307:E596-610 pubmed publisher
Pham H, Maurer B, Prchal Murphy M, Grausenburger R, Grundschober E, Javaheri T, et al. STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest. 2017;: pubmed publisher
Pinz S, Unser S, Brueggemann S, Besl E, Al Rifai N, Petkes H, et al. The synthetic ?-bromo-2',3,4,4'-tetramethoxychalcone (?-Br-TMC) inhibits the JAK/STAT signaling pathway. PLoS ONE. 2014;9:e90275 pubmed publisher
Bogazzi F, Raggi F, Russo D, Bohlooly Y M, Sardella C, Urbani C, et al. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. 2013;154:4226-36 pubmed publisher
Honda T, Ishii A, Inui M. Regulation of adipocyte differentiation of 3T3-L1 cells by PDZRN3. Am J Physiol Cell Physiol. 2013;304:C1091-7 pubmed publisher
Wu A, Dalvi P, Lu X, Yang M, Riddick D, Matthews J, et al. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol. 2013;83:377-88 pubmed publisher
Shao M, Hollar S, Chambliss D, Schmitt J, Emerson R, Chelladurai B, et al. Targeting the insulin growth factor and the vascular endothelial growth factor pathways in ovarian cancer. Mol Cancer Ther. 2012;11:1576-86 pubmed publisher
Davoodi Semiromi A, Wasserfall C, Xia C, Cooper Dehoff R, Wabitsch M, Clare Salzler M, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS ONE. 2012;7:e36079 pubmed publisher
Selmi T, Martello A, Vignudelli T, Ferrari E, Grande A, Gemelli C, et al. ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways. Cell Cycle. 2012;11:1977-87 pubmed publisher
Peng S, Lai Y, Huang H, Huang H, Huang Y. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Nucleic Acids Res. 2010;38:7446-57 pubmed publisher
Jinawath N, Vasoontara C, Jinawath A, Fang X, Zhao K, Yap K, et al. Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma. PLoS ONE. 2010;5:e11198 pubmed publisher
Chen Y, Biada J, Sood S, Rabkin R. Uremia attenuates growth hormone-stimulated insulin-like growth factor-1 expression, a process worsened by inflammation. Kidney Int. 2010;78:89-95 pubmed publisher
Miermont A, Parrish A, Furth P. Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis. Carcinogenesis. 2010;31:1124-31 pubmed publisher
Yamashita H, Takahashi S, Ito Y, Yamashita T, Ando Y, Toyama T, et al. Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer. Cancer Sci. 2009;100:2028-33 pubmed publisher
Chen Y, Sood S, Krishnamurthy V, Rotwein P, Rabkin R. Endotoxin-induced growth hormone resistance in skeletal muscle. Endocrinology. 2009;150:3620-6 pubmed publisher
Cheranov S, Wang D, Kundumani Sridharan V, Karpurapu M, Zhang Q, Chava K, et al. The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8. Blood. 2009;113:6023-33 pubmed publisher
Kundumani Sridharan V, Wang D, Karpurapu M, Liu Z, Zhang C, Dronadula N, et al. Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formation. Am J Pathol. 2007;171:1381-94 pubmed
Chen Y, Sun D, Krishnamurthy V, Rabkin R. Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding. Am J Physiol Endocrinol Metab. 2007;292:E1856-62 pubmed
Eidenschenk C, Jouanguy E, Alcais A, Mention J, Pasquier B, Fleckenstein I, et al. Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J Immunol. 2006;177:8835-43 pubmed
Fleenor D, Arumugam R, Freemark M. Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. Horm Res. 2006;66:101-10 pubmed
Champagne F, Weaver I, Diorio J, Dymov S, Szyf M, Meaney M. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology. 2006;147:2909-15 pubmed
Melzner I, Bucur A, Brüderlein S, Dorsch K, Hasel C, Barth T, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood. 2005;105:2535-42 pubmed
Hinz M, Lemke P, Anagnostopoulos I, Hacker C, Krappmann D, Mathas S, et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med. 2002;196:605-17 pubmed
product information
Product Name :
Stat5b (G-2) Antibody
Gene Name :
STAT5B
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-1656
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Stat5b
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA