product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p27 (F-8) Antibody
catalog :
sc-1641
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 115
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2b
Hsu H, Chen H, Tsai C, Liao P, Chan Y, Lee Y, et al. Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1g
Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, et al. SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth. Adv Sci (Weinh). 2021;8:e2004846 pubmed publisher
  • immunohistochemistry; mouse; 1:600; loading ...
Gualtieri A, Kyprianou N, Gregory L, Vignola M, Nicholson J, Tan R, et al. Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021;12:2028 pubmed publisher
  • western blot; mouse; fig 2e
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
  • western blot; human; loading ...; fig 5c
He D, Ren B, Liu S, Tan L, Cieply K, Tseng G, et al. Oncogenic activity of amplified miniature chromosome maintenance 8 in human malignancies. Oncogene. 2017;36:3629-3639 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Po A, Begalli F, Abballe L, Alfano V, Besharat Z, Catanzaro G, et al. ?-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells Int. 2017;2017:5274171 pubmed publisher
  • western blot; mouse; loading ...; fig 1B
  • western blot; human; loading ...; fig 1B
Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; fig 2c
Kim H, Lee S, Kim C, Kim Y, Ju W, Kim S. Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells. Oncotarget. 2017;8:6608-6622 pubmed publisher
  • western blot; human; loading ...; fig s2c
Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling. J Mol Med (Berl). 2016;94:1167-1179 pubmed
  • western blot; mouse; 1:100; fig 7
  • western blot; human; 1:100; fig 7
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher
  • western blot; rat; 1:500; fig 3
Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed publisher
  • western blot; human; fig s4g
Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  • western blot; human; fig 5
Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:50
Jones L, Tilli M, Assefnia S, Torre K, Halama E, Parrish A, et al. Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene. 2008;27:794-802 pubmed
  • western blot; human
Furumoto H, Ying H, Chandramouli G, Zhao L, Walker R, Meltzer P, et al. An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis. Mol Cell Biol. 2005;25:124-35 pubmed
Nowosad A, Creff J, Jeannot P, Culerrier R, Codogno P, Manenti S, et al. p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation. Cell Death Dis. 2021;12:481 pubmed publisher
Badr El Din N, Shabana S, Abdulmajeed B, Ghoneum M. A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020;20:127 pubmed publisher
Fardoun M, Iratni R, Dehaini H, Eid A, Ghaddar T, El Elimat T, et al. 7-O-methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells. Biomolecules. 2019;9: pubmed publisher
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed publisher
Morelli G, Even A, Gladwyn Ng I, Le Bail R, Shilian M, Godin J, et al. p27Kip1 Modulates Axonal Transport by Regulating ?-Tubulin Acetyltransferase 1 Stability. Cell Rep. 2018;23:2429-2442 pubmed publisher
Beirowski B, Wong K, Babetto E, Milbrandt J. mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells. Proc Natl Acad Sci U S A. 2017;114:E4261-E4270 pubmed publisher
Zhu Z, Zhang D, Lee H, Menon A, Wu J, Hu K, et al. Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222. J Leukoc Biol. 2017;101:1349-1359 pubmed publisher
Xu L, Zhang X, Li Y, Lu S, Lu S, Li J, et al. Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation. Tumour Biol. 2016;37:8721-9 pubmed publisher
Er H, Acar N, Kipmen Korgun D, Celik Ozenci C, Ustunel I, Asar M, et al. Determination of PCNA, cyclin D3, p27, p57 and apoptosis rate in normal and dexamethasone-induced intrauterine growth restricted rat placentas. Acta Histochem. 2015;117:137-47 pubmed publisher
Milkiewicz M, Kopycinska J, Kempińska Podhorodecka A, Haas T, Bogdanos D, Elias E, et al. Ursodeoxycholic acid influences the expression of p27kip1 but not FoxO1 in patients with non-cirrhotic primary biliary cirrhosis. J Immunol Res. 2014;2014:921285 pubmed publisher
Cronin J, Watkins Chow D, Incao A, Hasskamp J, Schönewolf N, Aoude L, et al. SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Res. 2013;73:5709-18 pubmed publisher
Fozzatti L, Park J, Zhao L, Willingham M, Cheng S. Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer. PLoS ONE. 2013;8:e67954 pubmed publisher
Yuan F, Ma Y, You P, Lin W, Lu H, Yu Y, et al. A novel role of proteasomal ?1 subunit in tumorigenesis. Biosci Rep. 2013;33: pubmed publisher
Handy I, Patel R. STAT1 requirement for PKR-induced cell cycle arrest in vascular smooth muscle cells in response to heparin. Gene. 2013;524:15-21 pubmed publisher
Li K, Chen M, Situ J, Huang W, Su Z, He D, et al. Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery. Chin Med J (Engl). 2013;126:82-7 pubmed
Booher K, Lin D, Borrego S, Kaiser P. Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle. 2012;11:4414-23 pubmed publisher
Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson J. Estrogen receptors ?1 and ?2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3. Mol Endocrinol. 2012;26:1991-2003 pubmed publisher
Shiu S, Leung W, Tam C, Liu V, Yao K. Melatonin MT1 receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF-?B): potential implications on prostate cancer chemopreventi. J Pineal Res. 2013;54:69-79 pubmed publisher
Du W, Wright B, Li X, Finke J, Rini B, Zhou M, et al. Tumor-derived macrophage migration inhibitory factor promotes an autocrine loop that enhances renal cell carcinoma. Oncogene. 2013;32:1469-74 pubmed publisher
Tsapakidis K, Vlachostergios P, Voutsadakis I, Befani C, Patrikidou A, Hatzidaki E, et al. Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells. Int J Urol. 2012;19:565-74 pubmed publisher
Van Hove I, Verslegers M, Buyens T, Delorme N, Lemmens K, Stroobants S, et al. An aberrant cerebellar development in mice lacking matrix metalloproteinase-3. Mol Neurobiol. 2012;45:17-29 pubmed publisher
Hong Z, Lee H, Shin D, Kim S, Seo M, Lee E. Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines. Cancer Lett. 2012;314:34-40 pubmed publisher
Yu H, Xie L, Zhu P, Xu C, Wang H. Human tissue kallikrein 1 gene delivery inhibits PDGF-BB-induced vascular smooth muscle cells proliferation and upregulates the expressions of p27Kip1 and p2lCip1. Mol Cell Biochem. 2012;360:363-71 pubmed publisher
Cayli S, Ocakli S, Erdemir F, Tas U, Aslan H, Yener T, et al. Developmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis. Reprod Biol Endocrinol. 2011;9:117 pubmed publisher
Choudhury S, Balasubramanian S, Chew Y, Han B, Marquez V, Eckert R. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis. 2011;32:1525-32 pubmed publisher
Abe K, Naruse C, Kato T, Nishiuchi T, Saitou M, Asano M. Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice. Biol Reprod. 2011;85:1013-24 pubmed publisher
Ling Y, Chen Y, Chen P, Hui H, Song X, Lu Z, et al. Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest. Exp Biol Med (Maywood). 2011;236:851-8 pubmed publisher
Tam C, Shiu S. Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer. J Pineal Res. 2011;51:297-312 pubmed publisher
Musumeci G, Cardile V, Fenga C, Caggia S, Loreto C. Mineral fibre toxicity: expression of retinoblastoma (Rb) and phospho-retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres. Cell Biol Toxicol. 2011;27:217-25 pubmed publisher
Kollmann K, Heller G, Ott R, Scheicher R, Zebedin Brandl E, Schneckenleithner C, et al. c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood. 2011;117:4065-75 pubmed publisher
Furukawa K, Sato T, Katsuno T, Nakagawa T, Noguchi Y, Tokumasa A, et al. Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression. Biochem Biophys Res Commun. 2011;405:521-6 pubmed publisher
Castro J, Ribo M, Navarro S, Nogués M, Vilanova M, Benito A. A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. BMC Cancer. 2011;11:9 pubmed publisher
Ma J, Huang H, Chen S, Chen Y, Xin X, Lin L, et al. PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo. Breast Cancer Res Treat. 2011;130:85-96 pubmed publisher
Wang X, Gocek E, Novik V, Harrison J, Danilenko M, Studzinski G. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3). Cell Cycle. 2010;9:4542-51 pubmed
Ruiz de Almodovar C, Coulon C, Salin P, Knevels E, Chounlamountri N, Poesen K, et al. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010;30:15052-66 pubmed publisher
Shiu S, Pang B, Tam C, Yao K. Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of G?(s) and G?(q) proteins. J Pineal Res. 2010;49:301-11 pubmed publisher
Nakaya R, Takaya J, Onuki T, Moritani M, Nozaki N, Ishimi Y. Identification of proteins that may directly interact with human RPA. J Biochem. 2010;148:539-47 pubmed publisher
Uecker A, Sicker M, Beckers T, Mahboobi S, Hägerstrand D, Ostman A, et al. Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents. Anticancer Drugs. 2010;21:759-65 pubmed publisher
Mineo T, Mineo D, Onorati I, Cufari M, Ambrogi V. New predictors of response to neoadjuvant chemotherapy and survival for invasive thymoma: a retrospective analysis. Ann Surg Oncol. 2010;17:3022-9 pubmed publisher
Wahl M, Guenther R, Yang L, Bergman A, Straehle U, Strack S, et al. Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: Different toxicity and target gene expression. Toxicol Lett. 2010;198:119-26 pubmed publisher
Watanabe R, Andrade I, Telles M, Albuquerque K, Nascimento C, Oyama L, et al. Long-term consumption of fish oil-enriched diet impairs serotonin hypophagia in rats. Cell Mol Neurobiol. 2010;30:1025-33 pubmed publisher
Voutsadakis I, Patrikidou A, Tsapakidis K, Karagiannaki A, Hatzidaki E, Stathakis N, et al. Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis. 2010;25:795-804 pubmed publisher
Mineo T, Ambrogi V, Cufari M, Pompeo E. May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma?. Eur J Cardiothorac Surg. 2010;38:245-52 pubmed publisher
Liu J, Lyon C, Hsueh W, Law R. A Dominant-Negative PPARgamma Mutant Promotes Cell Cycle Progression and Cell Growth in Vascular Smooth Muscle Cells. PPAR Res. 2009;2009:438673 pubmed publisher
Numata Y, Ishihara S, Hasegawa N, Nozaki N, Ishimi Y. Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb. J Biochem. 2010;147:917-27 pubmed publisher
Liu Y, Dai B, Fu L, Jia J, Mei C. Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells. Basic Clin Pharmacol Toxicol. 2010;106:523-30 pubmed publisher
Lee S, Bui Nguyen T, Kovalenko D, Adhikari N, Grindle S, Polster S, et al. Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27. Mol Cell Biochem. 2010;338:255-61 pubmed publisher
Balasubramanian S, Adhikary G, Eckert R. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis. 2010;31:496-503 pubmed publisher
Castro C, Lorenzo A, Gonzalez A, Cruzado M. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: Involvement of cell-cycle inhibitor p27(Kip1) and mitogen-activated protein kinase. Mol Nutr Food Res. 2010;54:781-7 pubmed publisher
Mallakin A, Sugiyama T, Kai F, Taneja P, Kendig R, Frazier D, et al. The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1. Int J Cancer. 2010;126:1403-16 pubmed publisher
Cheung A, Lung H, Ko J, Cheng Y, Stanbridge E, Zabarovsky E, et al. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Proc Natl Acad Sci U S A. 2009;106:14478-83 pubmed publisher
Hartman J, Edvardsson K, Lindberg K, Zhao C, Williams C, Strom A, et al. Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res. 2009;69:6100-6 pubmed publisher
Mineo T, Ambrogi V, Baldi A, Pompeo E, Mineo D. Recurrent intrathoracic thymomas: potential prognostic importance of cell-cycle protein expression. J Thorac Cardiovasc Surg. 2009;138:40-5 pubmed publisher
Li X, Cai L, Chen H, Zhang Q, Zhang S, Wang Y, et al. Inhibitor of growth 4 induces growth suppression and apoptosis in glioma U87MG. Pathobiology. 2009;76:181-92 pubmed publisher
Mizuma M, Katayose Y, Yamamoto K, Shiraso S, Sasaki T, Yabuuchi S, et al. Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells. Anticancer Res. 2008;28:2669-77 pubmed
Zhu C, Li C, Li Y, Zhan Y, Li Y, Xu C, et al. Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. Cell Death Differ. 2009;16:395-405 pubmed publisher
Wang C, Chen P, Jin H, Yan X, Gan L, Li Y, et al. Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest. Acta Biochim Biophys Sin (Shanghai). 2008;40:970-8 pubmed
Li H, Xu L, Masuda K, Raymundo E, McLeod D, Dobi A, et al. A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. J Biol Chem. 2008;283:28988-95 pubmed publisher
Tam C, Chan K, Liu V, Pang B, Yao K, Shiu S. Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance. J Pineal Res. 2008;45:403-12 pubmed publisher
Wahl M, Lahni B, Guenther R, Kuch B, Yang L, Straehle U, et al. A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity. Chemosphere. 2008;73:209-15 pubmed publisher
Chan D, Yu S, Chiu P, Yao K, Liu V, Cheung A, et al. Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis. J Pathol. 2008;215:245-52 pubmed publisher
Cheong J, Gunaratnam L, Hsu S. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. J Biol Chem. 2008;283:11661-76 pubmed publisher
Perez Caro M, Bermejo Rodríguez C, González Herrero I, Sanchez Beato M, Piris M, Sanchez Garcia I. Transcriptomal profiling of the cellular response to DNA damage mediated by Slug (Snai2). Br J Cancer. 2008;98:480-8 pubmed publisher
Kishioka Y, Thomas M, Wakamatsu J, Hattori A, Sharma M, Kambadur R, et al. Decorin enhances the proliferation and differentiation of myogenic cells through suppressing myostatin activity. J Cell Physiol. 2008;215:856-67 pubmed publisher
Mirzayans R, Scott A, Andrais B, Pollock S, Murray D. Ultraviolet light exposure triggers nuclear accumulation of p21(WAF1) and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strains. J Cell Physiol. 2008;215:55-67 pubmed
Furuya F, Lu C, Willingham M, Cheng S. Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. Carcinogenesis. 2007;28:2451-8 pubmed
Pessina A, Bonomi A, Casati S, Collotta A, Croera C, Marafante E, et al. Mitochondrial function, apoptosis and cell cycle delay in the WEHI-3B leukaemia cell line and its variant Ciprofloxacin-resistant WEHI-3B/CPX. Cell Prolif. 2007;40:568-79 pubmed
Jiao J, Wang S, Qiao R, Vivanco I, Watson P, Sawyers C, et al. Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res. 2007;67:6083-91 pubmed
Li X, Amazit L, Long W, Lonard D, Monaco J, O Malley B. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007;26:831-42 pubmed
Gamboa Dominguez A, Seidl S, Reyes Gutierrez E, Hermannstädter C, Quintanilla Martinez L, Busch R, et al. Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer. J Clin Pathol. 2007;60:756-61 pubmed
Kalemi T, Papazisis K, Lambropoulos A, Voyatzi S, Kotsis A, Kortsaris A. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Anticancer Res. 2007;27:913-20 pubmed
Woo C, Tan F, Cassano H, Lee J, Lee K, Thiele C. Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma. Pediatr Blood Cancer. 2008;50:208-12 pubmed
Romano S, Muscella A, Storelli C, Marsigliante S. Angiotensin II does not stimulate proliferation of rat thyroid PC Cl3 cell line. J Endocrinol. 2006;191:727-35 pubmed
Werner N, Weber W, Fussenegger M, Geisse S. A gas-inducible expression system in HEK.EBNA cells applied to controlled proliferation studies by expression of p27(Kip1). Biotechnol Bioeng. 2007;96:1155-66 pubmed
Qiu L, Lai R, Lin Q, Lau E, Thomazy D, Calame D, et al. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood. 2006;108:2407-15 pubmed
Deb Basu D, Aleem E, Kaldis P, Felsher D. CDK2 is required by MYC to induce apoptosis. Cell Cycle. 2006;5:1342-7 pubmed
Leisenfelder S, Moffat J. Varicella-zoster virus infection of human foreskin fibroblast cells results in atypical cyclin expression and cyclin-dependent kinase activity. J Virol. 2006;80:5577-87 pubmed
Kuo Y, Giam C. Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J. 2006;25:1741-52 pubmed
Yamasoba T, Kondo K. Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo. Cell Tissue Res. 2006;325:23-31 pubmed
Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen kyi V, et al. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res. 2006;66:2038-47 pubmed
Ivorra C, Kubicek M, Gonzalez J, Sanz González S, Alvarez Barrientos A, O Connor J, et al. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev. 2006;20:307-20 pubmed
Chemnitz J, Driesen J, Classen S, Riley J, Debey S, Beyer M, et al. Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma. Cancer Res. 2006;66:1114-22 pubmed
White P, Shore A, Clement M, McLaren J, Soeiro I, Lam E, et al. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene. 2006;25:2170-80 pubmed
Iwanaga R, Komori H, Ishida S, Okamura N, Nakayama K, Nakayama K, et al. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Oncogene. 2006;25:1786-98 pubmed
Sanz González S, Melero Fernández de Mera R, Malek N, Andres V. Atheroma development in apolipoprotein E-null mice is not regulated by phosphorylation of p27(Kip1) on threonine 187. J Cell Biochem. 2006;97:735-43 pubmed
Mineo T, Ambrogi V, Mineo D, Baldi A. Long-term disease-free survival of patients with radically resected thymomas: relevance of cell-cycle protein expression. Cancer. 2005;104:2063-71 pubmed
Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N. Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer. 2006;118:1144-53 pubmed
Groth A, Willumsen B. High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27(Kip) Cdk-complexes. Cell Signal. 2005;17:1063-73 pubmed
Esposito V, Baldi A, De Luca A, Tonini G, Vincenzi B, Santini D, et al. Cell cycle related proteins as prognostic parameters in radically resected non-small cell lung cancer. J Clin Pathol. 2005;58:734-9 pubmed
Zambon A, Zhang L, Minovitsky S, Kanter J, Prabhakar S, Salomonis N, et al. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005;102:8561-6 pubmed
Leek R, Stratford I, Harris A. The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway. Cancer Res. 2005;65:4147-52 pubmed
Papazisis K, Kalemi T, Zambouli D, Geromichalos G, Lambropoulos A, Kotsis A, et al. Synergistic effects of protein tyrosine kinase inhibitor genistein with camptothecins against three cell lines in vitro. Cancer Lett. 2006;233:255-64 pubmed
Balasubramanian S, Chandraratna R, Eckert R. A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis. Oncogene. 2005;24:4257-70 pubmed
Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa J, Peters G, et al. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res. 2005;65:2179-85 pubmed
Breslin E, White P, Shore A, Clement M, Brennan P. LY294002 and rapamycin co-operate to inhibit T-cell proliferation. Br J Pharmacol. 2005;144:791-800 pubmed
Chen F, Harrison L. Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. Cell Signal. 2005;17:809-16 pubmed
Fasciano S, Patel R, Handy I, Patel C. Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). J Biol Chem. 2005;280:15682-9 pubmed
Wei Q, Miskimins W, Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J Biol Chem. 2005;280:16284-94 pubmed
McCallum M, Baker C, Gillespie K, Cohen B, Stewart H, Leonard R, et al. A prognostic index for operable, node-negative breast cancer. Br J Cancer. 2004;90:1933-41 pubmed
Rumi M, Sato H, Ishihara S, Kawashima K, Hamamoto S, Kazumori H, et al. Peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma. Br J Cancer. 2001;84:1640-7 pubmed
product information
Product Name :
p27 (F-8) Antibody
Gene Name :
CDKN1B
Size :
200 µg/ml
Catalog Number :
sc-1641
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p27
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
FL (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA