product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PI 3-kinase p85alpha (B-9) Antibody
catalog :
sc-1637
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-9
reactivity :
human, mouse, rat, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 44
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 6A
Chung C, Chang C, Hsu C, Lin K, Peng H, Huang T. Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1. Sci Rep. 2017;7:43612 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Sheen M, Marotti J, Allegrezza M, Rutkowski M, Conejo Garcia J, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016;5:e267 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed publisher
  • western blot; human; 1:200; fig 4
Song G, Li Y, Lin L, Cao Y. Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways. Mol Med Rep. 2015;12:7615-22 pubmed publisher
  • western blot; chicken
Ito Y, Hart J, Ueno L, Vogt P. Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K). Proc Natl Acad Sci U S A. 2014;111:16826-9 pubmed publisher
  • western blot; mouse
Ren W, Duan J, Yin J, Liu G, Cao Z, Xiong X, et al. Dietary L-glutamine supplementation modulates microbial community and activates innate immunity in the mouse intestine. Amino Acids. 2014;46:2403-13 pubmed publisher
  • western blot; human
Kim K, Lee S, Ryu S, Han D. Efficient isolation and elution of cellular proteins using aptamer-mediated protein precipitation assay. Biochem Biophys Res Commun. 2014;448:114-9 pubmed publisher
  • western blot; mouse; fig 9
Wu J, Akkuratov E, Bai Y, Gaskill C, Askari A, Liu L. Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry. 2013;52:9059-67 pubmed publisher
  • western blot; human
Luo J, Xu T, Li C, Ba X, Wang X, Jiang Y, et al. p85-RhoGDI2, a novel complex, is required for PSGL-1-induced ?1 integrin-mediated lymphocyte adhesion to VCAM-1. Int J Biochem Cell Biol. 2013;45:2764-73 pubmed publisher
  • western blot; human
Sollome J, Thavathiru E, Camenisch T, Vaillancourt R. HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal. 2014;26:70-82 pubmed publisher
  • western blot; human; fig 3
Chang C, Chen C, Wu M, Chen Y, Chen C, Sheu S, et al. Active Component of Antrodia cinnamomea Mycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death. Evid Based Complement Alternat Med. 2013;2013:946451 pubmed publisher
  • western blot; human
Shibata K, Kajiyama H, Ino K, Nawa A, Nomura S, Mizutani S, et al. P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling. BMC Cancer. 2007;7:15 pubmed
  • western blot; human
Coffey J, Wang J, Smith M, Laing A, Bouchier Hayes D, Cotter T, et al. Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy. J Biol Chem. 2005;280:20968-77 pubmed
Pedros C, Zhang Y, Hu J, Choi Y, Canonigo Balancio A, Yates J, et al. A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. Nat Immunol. 2016;17:825-33 pubmed publisher
Di Zazzo E, Feola A, Zuchegna C, Romano A, Donini C, Bartollino S, et al. The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility. ScientificWorldJournal. 2014;2014:565839 pubmed publisher
Zhang J, Guo H, Zhu J, Yang Y, Chen W, Chen N. Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1? expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells. Oncol Lett. 2014;7:1401-1408 pubmed
Oliveira Junior S, Martinez P, Guizoni D, Campos D, Fernandes T, Oliveira E, et al. AT1 receptor blockade attenuates insulin resistance and myocardial remodeling in rats with diet-induced obesity. PLoS ONE. 2014;9:e86447 pubmed publisher
Wang L, Xu S, Lee J, Baldridge A, Grullon S, Peng W, et al. Histone H3K9 methyltransferase G9a represses PPAR? expression and adipogenesis. EMBO J. 2013;32:45-59 pubmed publisher
Nadal Casellas A, Bauzá Thorbrügge M, Proenza A, Gianotti M, Llado I. Sex-dependent differences in rat brown adipose tissue mitochondrial biogenesis and insulin signaling parameters in response to an obesogenic diet. Mol Cell Biochem. 2013;373:125-35 pubmed publisher
Korkolopoulou P, Levidou G, Trigka E, Prekete N, Karlou M, Thymara I, et al. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma. BJU Int. 2012;110:E1237-48 pubmed publisher
Gupta R, Palchaudhuri S, Chattopadhyay D. Glutamate induces neutrophil cell migration by activating class I metabotropic glutamate receptors. Amino Acids. 2013;44:757-67 pubmed publisher
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
D Cruz S, Jubendradass R, Jayakanthan M, Rani S, Mathur P. Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study. Food Chem Toxicol. 2012;50:1124-33 pubmed publisher
Jubendradass R, D cruz S, Mathur P. Long-term exposure to nonylphenol affects insulin signaling in the liver of adult male rats. Hum Exp Toxicol. 2012;31:868-76 pubmed
Negri T, Brich S, Conca E, Bozzi F, Orsenigo M, Stacchiotti S, et al. Receptor tyrosine kinase pathway analysis sheds light on similarities between clear-cell sarcoma and metastatic melanoma. Genes Chromosomes Cancer. 2012;51:111-26 pubmed publisher
Caggia S, Libra M, Malaponte G, Cardile V. Modulation of YY1 and p53 expression by transforming growth factor-?3 in prostate cell lines. Cytokine. 2011;56:403-10 pubmed publisher
Gurney S, Forster P, Just U, Schwanbeck R. Suppression of the PI3K subunit p85? delays embryoid body development and inhibits cell adhesion. J Cell Biochem. 2011;112:3573-81 pubmed publisher
Padmanabhan R, Nirmala L, Murali M, Laloraya M. CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer. Mol Endocrinol. 2011;25:1499-512 pubmed publisher
Fortin C, Cloutier A, Ear T, Sylvain Prévost S, Mayer T, Bouchelaghem R, et al. A class IA PI3K controls inflammatory cytokine production in human neutrophils. Eur J Immunol. 2011;41:1709-19 pubmed publisher
Abou Youssif T, Fahmy M, Koumakpayi I, Ayala F, Al Marzooqi S, Chen G, et al. The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases. Cancer. 2011;117:290-300 pubmed publisher
Wang L, Jin Q, Lee J, Su I, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A. 2010;107:7317-22 pubmed publisher
Tamborini E, Virdis E, Negri T, Orsenigo M, Brich S, Conca E, et al. Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas. Neuro Oncol. 2010;12:776-89 pubmed publisher
Moreno M, Ordonez P, Alonso A, Diaz F, Tolivia J, Gonzalez C. Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Age (Dordr). 2010;32:1-13 pubmed publisher
Torres V, Mielgo A, Barilà D, Anderson D, Stupack D. Caspase 8 promotes peripheral localization and activation of Rab5. J Biol Chem. 2008;283:36280-9 pubmed publisher
Raskopf E, Vogt A, Sauerbruch T, Schmitz V. siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo. J Hepatol. 2008;49:977-84 pubmed publisher
Yano N, Suzuki D, Endoh M, Tseng A, Stabila J, McGonnigal B, et al. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. 2008;149:6449-61 pubmed publisher
Derin D, Eralp Y, Ozluk Y, Yavuz E, Guney N, Saip P, et al. Lower level of MAPK expression is associated with anthracycline resistance and decreased survival in patients with hormone receptor negative breast cancer. Cancer Invest. 2008;26:671-9 pubmed publisher
Sato Y, Heuckeroth R. Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Dev Biol. 2008;320:185-98 pubmed publisher
He A, Zhu L, Gupta N, Chang Y, Fang F. Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol. 2007;21:2785-94 pubmed
Furuya F, Guigon C, Zhao L, Lu C, Hanover J, Cheng S. Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. Mol Cell Biol. 2007;27:6116-26 pubmed
Liu C, Yu I, Pan H, Lin S, Hsu H. L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. J Biol Chem. 2007;282:1109-18 pubmed
Nakamura T, Terajima T, Ogata T, Ueno K, Hashimoto N, Ono K, et al. Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide. Biol Pharm Bull. 2006;29:1167-74 pubmed
Liu C, Lin S, Chen Y, Chang K, Chang K. Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Mol Carcinog. 2006;45:721-31 pubmed
Noyce R, Collins S, Mossman K. Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. J Virol. 2006;80:226-35 pubmed
product information
Product Name :
PI 3-kinase p85alpha (B-9) Antibody
Gene Name :
PIK3R1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-1637
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
PI 3-kinase p85alpha
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
333-430 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA