This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SIRT1 (H-300)
catalog :
sc-15404
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, other
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 2d
Zhang M, Hu C, Moses N, Haakenson J, Xiang S, Quan D, et al. HDAC6 regulates DNA damage response via deacetylating MLH1. J Biol Chem. 2019;294:5813-5826 pubmed publisher
  • western blot; human; loading ...; fig 2a
Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...; fig 1e
Klein M, Dickson M, Antonescu C, Qin L, Dooley S, Barlas A, et al. PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence. Oncogene. 2018;37:5066-5078 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s2c
Li T, Song L, Sun Y, Li J, Yi C, Lam S, et al. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018;9:1916 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 2c
  • immunohistochemistry; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 2c
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
  • western blot; mouse; loading ...; fig s4B
Burikhanov R, Hebbar N, Noothi S, Shukla N, Sledziona J, Araujo N, et al. Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Cell Rep. 2017;18:508-519 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s3b
  • western blot; human; loading ...; fig s2f
Bendre S, Rondelet A, Hall C, Schmidt N, Lin Y, Brouhard G, et al. GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK. J Cell Biol. 2016;215:631-647 pubmed
  • immunohistochemistry; human; 1:100; fig 2e, 2f
Yu L, Li J, Xu S, Navia Miranda M, Wang G, Duan Y. An Xp11.2 translocation renal cell carcinoma with SMARCB1 (INI1) inactivation in adult end-stage renal disease: a case report. Diagn Pathol. 2016;11:98 pubmed
  • western blot; mouse; loading ...; fig 1b
Haney S, Upchurch G, Opavska J, Klinkebiel D, Appiah A, Smith L, et al. Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice. Sci Rep. 2016;6:34222 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2a
  • immunocytochemistry; mouse; fig 4b
  • western blot; mouse; loading ...; fig 2b
Maroui M, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, et al. Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. PLoS Pathog. 2016;12:e1005834 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 1a
Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016;477:454-60 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; mouse; loading ...; fig 2
Tuon T, Souza P, Santos M, Pereira F, Pedroso G, Luciano T, et al. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxid Med Cell Longev. 2015;2015:261809 pubmed publisher
Oliveira B, Santos P, Figueiredo A, Rafacho B, Ishikawa L, Zanati S, et al. Influence of Consumption of Orange Juice (Citrus Sinensis) on Cardiac Remodeling of Rats Submitted to Myocardial Infarction. Arq Bras Cardiol. 2021;116:1127-1136 pubmed publisher
Joo H, Ma D, Hwang J, Shin Y. SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. Antioxidants (Basel). 2020;9: pubmed publisher
Lan F, Lin Y, Gao Z, Cacicedo J, Weikel K, Ido Y. Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging. Aging (Albany NY). 2020;12:18942-18956 pubmed publisher
Kim J, Yang J, Kim E. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Anim Cells Syst (Seoul). 2020;24:53-59 pubmed publisher
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, et al. Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function. Aging (Albany NY). 2020;12:650-671 pubmed publisher
Serra M, Marongiu F, Pisu M, Serra M, Laconi E. Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape. Aging (Albany NY). 2019;11:3851-3863 pubmed publisher
Waters M, Gupta A, Mockenhaupt K, Brown L, Biswas D, Kordula T. RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme. Oncogenesis. 2019;8:37 pubmed publisher
Song H, Park J, Choi K, Lee J, Chen J, Park H, et al. Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator-activated receptor gamma in A549 cells. J Ginseng Res. 2019;43:319-325 pubmed publisher
Gupta A, Waters M, Biswas D, Brown L, Surace M, Floros C, et al. RelB controls adaptive responses of astrocytes during sterile inflammation. Glia. 2019;67:1449-1461 pubmed publisher
Laudati G, Mascolo L, Guida N, Sirabella R, Pizzorusso V, Bruzzaniti S, et al. Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway. Neurotoxicology. 2019;71:6-15 pubmed publisher
Krzysiak T, Thomas L, Choi Y, Auclair S, Qian Y, Luan S, et al. An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity. Mol Cell. 2018;72:985-998.e7 pubmed publisher
Lee J, Ko Y, Chung Y, Yun N, Kim M, Kim K, et al. The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons. Sci Rep. 2018;8:13676 pubmed publisher
Li Y, Zhang M, Dorfman R, Pan Y, Tang D, Xu L, et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism. Neoplasia. 2018;20:745-756 pubmed publisher
Kim J, Kim J, Lee J, Park M. Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3- and NF‑κB-mediated IL‑24 production. Int J Oncol. 2018;53:47-58 pubmed publisher
Lai Y, Li J, Li X, Zou C. Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron. J Cell Sci. 2017;130:3578-3587 pubmed publisher
Wen D, Peng Y, Lin F, Singh R, Mahato R. Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer. Cancer Res. 2017;77:3244-3254 pubmed publisher
Srinivasan S, Su M, Ravishankar S, Moore J, Head P, Dixon J, et al. TLR-exosomes exhibit distinct kinetics and effector function. Sci Rep. 2017;7:41623 pubmed publisher
Li W, Du D, Liu Y, Jiang F, Zhang P, Li Y. Long-term nicotine exposure induces dysfunction of mouse endothelial progenitor cells. Exp Ther Med. 2017;13:85-90 pubmed publisher
García Aguilar A, Guillen C, Nellist M, Bartolomé A, Benito M. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. Biochim Biophys Acta. 2016;1863:2658-2667 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA