product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MCPyV large T-antigen (CM2B4) Antibody
catalog :
sc-136172
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CM2B4
reactivity :
, human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 13
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 3b
La Rosa S, Bonzini M, Sciarra A, Asioli S, Maragliano R, Arrigo M, et al. Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature. Endocr Pathol. 2020;31:392-400 pubmed publisher
  • western blot; human; loading ...; fig 4d
Rasheed K, Abdulsalam I, Fismen S, Grimstad Ø, Sveinbjørnsson B, Moens U. CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget. 2018;9:31432-31447 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6
  • immunocytochemistry; human; 1:50; fig 9b
  • western blot; human; fig 2c
Theiss J, Gunther T, Alawi M, Neumann F, Tessmer U, Fischer N, et al. A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence. PLoS Pathog. 2015;11:e1004974 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Capella C, Marando A, Longhi E, Bernasconi B, Finzi G, Parravicini C, et al. Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma. Hum Pathol. 2014;45:1310-4 pubmed publisher
Yang J, Liu W, You J. Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential. PLoS Pathog. 2023;19:e1011598 pubmed publisher
Rasheed K, Sveinbjørnsson B, Moens U. Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins. Virol J. 2021;18:139 pubmed publisher
Nwogu N, Ortiz L, Kwun H. Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth. Viruses. 2020;12: pubmed publisher
Czech Sioli M, Siebels S, Radau S, Zahedi R, Schmidt C, Dobner T, et al. The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication. J Virol. 2020;94: pubmed publisher
Liu W, Krump N, MacDonald M, You J. Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts. J Virol. 2018;92: pubmed publisher
Stakaityte G, Nwogu N, Dobson S, Knight L, Wasson C, Salguero F, et al. Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation. J Virol. 2018;92: pubmed publisher
Knight L, Stakaityte G, Wood J, Abdul Sada H, Griffiths D, Howell G, et al. Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration. J Virol. 2015;89:35-47 pubmed publisher
Diaz J, Wang X, Tsang S, Jiao J, You J. Phosphorylation of large T antigen regulates merkel cell polyomavirus replication. Cancers (Basel). 2014;6:1464-86 pubmed publisher
Xie H, Lee L, Caramuta S, Höög A, Browaldh N, Björnhagen V, et al. MicroRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma. J Invest Dermatol. 2014;134:507-517 pubmed publisher
product information
Catalog Number :
sc-136172
Product Name :
MCPyV large T-antigen (CM2B4) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
CM2B4
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Merkel Cell Polyomavirus
Specificity :
Merkel cell polyomavirus
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA