product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MMP-2 (8B4) Antibody
catalog :
sc-13595
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8B4
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 1f, 2f
  • western blot; rat; 1:200; loading ...; fig 5c
Lin Y, Huang X, Chang K, Liao K, Tsai N. Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood-Brain Barrier and Suppresses Growth of Glioblastoma. Int J Nanomedicine. 2020;15:749-760 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Lee Y, Yeo I, Kim K, Han S, Hong J. Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity. Front Immunol. 2019;10:1379 pubmed publisher
  • western blot; human; loading ...; fig 5a
Guan H, Li N, Wang X, Shan X, Li Z, Lin Z. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019;376:198-209 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Liu Y, Wang T, Zhang R, Fu W, Wang X, Wang F, et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016;213:2473-2488 pubmed
  • western blot; human; fig 5
Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer. 2016;7:746-57 pubmed publisher
  • western blot; rat; 1:1000; fig 2
Lai C, Tsai C, Kuo W, Ho T, Day C, Pai P, et al. Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats. Int J Med Sci. 2016;13:277-85 pubmed publisher
  • western blot; human; 1:500; fig 3
  • western blot; mouse; 1:500; fig 3
Pei S, Yang X, Wang H, Zhang H, Zhou B, Zhang D, et al. Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2. BMC Cancer. 2015;15:965 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 4A
Al Trad B, Ashankyty I, Alaraj M. Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats. Diabetol Metab Syndr. 2015;7:97 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5
  • western blot; human; loading ...; fig 3c
Chang L, Zhao D, Liu H, Wang Q, Zhang P, Li C, et al. Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. Mol Med Rep. 2015;12:6702-10 pubmed publisher
  • western blot; human; 1:800; fig 4
Gan L, Zuo G, Wang T, Min J, Wang Y, Wang Y, et al. Expression of WTH3 in breast cancer tissue and the effects on the biological behavior of breast cancer cells. Exp Ther Med. 2015;10:154-158 pubmed
  • western blot; human; 1:1500
Wang G, Liu G, Ye Y, Fu Y, Zhang X. The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4. Biochem Biophys Res Commun. 2015;459:629-35 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Calabro S, Maczurek A, Morgan A, Tu T, Wen V, Yee C, et al. Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis. PLoS ONE. 2014;9:e90571 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Chen R, Zhang F, Song L, Shu Y, Lin Y, Dong L, et al. Transcriptome profiling reveals that the SM22?-regulated molecular pathways contribute to vascular pathology. J Mol Cell Cardiol. 2014;72:263-72 pubmed publisher
Qiu J, Li X, He Y, Sun D, Li W, Xin Y. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. J Cancer Res Clin Oncol. 2018;144:1869-1886 pubmed publisher
Yun J, Park M, Son D, Nam K, Moon D, Ju J, et al. IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation. Cell Death Dis. 2018;9:306 pubmed publisher
Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, et al. Optical imaging of MMP-12 active form in inflammation and aneurysm. Sci Rep. 2016;6:38345 pubmed publisher
Sun Z, Zhu R, Yang G, Li Y. Neoadjuvant chemotherapy with FOLFOX4 regimen to treat advanced gastric cancer improves survival without increasing adverse events: a retrospective cohort study from a Chinese center. ScientificWorldJournal. 2014;2014:418694 pubmed publisher
Pokrywczynska M, Jundzill A, Bodnar M, Adamowicz J, Tworkiewicz J, Szylberg L, et al. Do mesenchymal stem cells modulate the milieu of reconstructed bladder wall?. Arch Immunol Ther Exp (Warsz). 2013;61:483-93 pubmed publisher
Luo W, Huang B, Li Z, Li H, Sun L, Zhang Q, et al. MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. PLoS ONE. 2013;8:e64759 pubmed publisher
Li H, Huang D, Gao Z, Chen Y, Zhang L, Zheng J. Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and ?v?6 integrin. Int J Oncol. 2013;42:1674-81 pubmed publisher
Li H, Fan H, Wang Z, Zheng J, Cao W. Potentiation of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound. PLoS ONE. 2013;8:e59473 pubmed publisher
Hwang J, Ting W, Wu H, Chen Y, Tsai F, Chen P, et al. KHC-4 anti-cancer effects on human PC3 prostate cancer cell line. Am J Chin Med. 2012;40:1063-71 pubmed publisher
Shin H, Oh H. The Effect of Platelet-rich Plasma on Wounds of OLETF Rats Using Expression of Matrix Metalloproteinase-2 and -9 mRNA. Arch Plast Surg. 2012;39:106-12 pubmed publisher
Kim S, Song J. Therapeutic targeting of oncogenic transforming growth factor-?1 signaling by antisense oligonucleotides in oral squamous cell carcinoma. Oncol Rep. 2012;28:539-44 pubmed publisher
Koo B, Kim Y, Han J, Kim D. Dimerization of matrix metalloproteinase-2 (MMP-2): functional implication in MMP-2 activation. J Biol Chem. 2012;287:22643-53 pubmed publisher
Bi X, Liu J, He H, Ye Y, Han Z, Dai Q, et al. Extracellular matrix metalloproteinase inducer: a novel poor prognostic marker for human seminomas. Clin Transl Oncol. 2012;14:190-6 pubmed
Shukla S, MacLennan G, Fu P, Gupta S. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharm Res. 2012;29:1506-17 pubmed publisher
Monção Ribeiro L, Cagido V, Lima Murad G, Santana P, Riva D, Borojevic R, et al. Lipopolysaccharide-induced lung injury: role of P2X7 receptor. Respir Physiol Neurobiol. 2011;179:314-25 pubmed publisher
Man S, Gao W, Yan Y, Liu Z, Liu C. Inhibition of matrix metalloproteinases related to metastasis by diosgenyl and pennogenyl saponins. J Ethnopharmacol. 2011;137:1221-7 pubmed publisher
Man S, Gao W, Zhang Y, Liu Z, Yan L, Huang L, et al. Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma. Cancer Biol Ther. 2011;11:592-8 pubmed
Huang K, Sui L. The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer. Med Oncol. 2012;29:318-23 pubmed publisher
Peng C, Liu X, Chen C, Liu X, Yang X, Pang D, et al. Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment. Biomaterials. 2011;32:2907-17 pubmed publisher
Peng C, Liu X, Liu X, Li Y. Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance. J Transl Med. 2010;8:101 pubmed publisher
Su H, Du Y, Qian Y, Zong Y, Li J, Zhuang R, et al. Targeted ultrasound contrast imaging of matrix metalloproteinase-2 in ischemia-reperfusion rat model: ex vivo and in vivo studies. Mol Imaging Biol. 2011;13:293-302 pubmed publisher
Møller M, Werther K, Nalla A, Stangerup S, Thomsen J, Bøg Hansen T, et al. Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. Laryngoscope. 2010;120:657-62 pubmed publisher
Xing C, Zhu B, Fan X, Liu H, Hou X, Zhao K, et al. Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice. World J Gastroenterol. 2009;15:5044-52 pubmed
Koo B, Kim H, Park M, Jeon O, Kim D. Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases. FEBS J. 2009;276:6271-84 pubmed publisher
Cokakli M, Erdal E, Nart D, Yilmaz F, Sagol O, Kilic M, et al. Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion. BMC Cancer. 2009;9:65 pubmed publisher
Wang X, Yu D, McCaughan G, Gorrell M. Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Adv Exp Med Biol. 2006;575:213-22 pubmed
Wang X, Yu D, McCaughan G, Gorrell M. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology. 2005;42:935-45 pubmed
Pereira A, Strasberg Rieber M, Rieber M. Invasion-associated MMP-2 and MMP-9 are up-regulated intracellularly in concert with apoptosis linked to melanoma cell detachment. Clin Exp Metastasis. 2005;22:285-95 pubmed
product information
Product Name :
MMP-2 (8B4) Antibody
Gene Name :
MMP2
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-13595
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
MMP-2
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA