product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ERK 1/2 (MK1) Antibody
catalog :
sc-135900
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MK1
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation
citations: 71
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:3000
Cheng C, Wooten J, Gibbs Z, McGlynn K, Mishra P, Whitehurst A. Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma. elife. 2020;9: pubmed publisher
  • western blot; rat; loading ...; fig 3c
Li J, Liu X, Chen H, Sun Z, Chen H, Wang L, et al. Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis. BMC Complement Altern Med. 2019;19:48 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Li R, Sahu S, Schachner M. Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury. Restor Neurol Neurosci. 2018;36:469-483 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Hegedüs L, Garay T, Molnar E, Varga K, Bilecz A, Torok S, et al. The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells. Int J Cancer. 2017;140:2758-2770 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Li S, Yang B, Teguh D, Zhou L, Xu J, Rong L. Amyloid ? Peptide Enhances RANKL-Induced Osteoclast Activation through NF-?B, ERK, and Calcium Oscillation Signaling. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; 1:1000; fig 2
Jiang Q, Chen S, Hu C, Huang P, Shen H, Zhao W. Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease. Mol Med Rep. 2016;14:2614-24 pubmed publisher
  • western blot; human; loading ...; fig 6b
Madureira P, Bharadwaj A, Bydoun M, Garant K, O Connell P, Lee P, et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget. 2016;7:47720-47737 pubmed publisher
  • western blot; human; 1:200; fig 6A
Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed publisher
  • western blot; human; 1:1000; fig s4
Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Yang Z, Jiang Q, Chen S, Hu C, Shen H, Huang P, et al. Differential changes in Neuregulin-1 signaling in major brain regions in a lipopolysaccharide-induced neuroinflammation mouse model. Mol Med Rep. 2016;14:790-6 pubmed publisher
  • western blot; human; 1:500; fig 3
Maselli A, Capoccia S, Pugliese P, Raggi C, Cirulli F, Fabi A, et al. Autoantibodies specific to estrogen receptor alpha act as estrogen agonists and their levels correlate with breast cancer cell proliferation. Oncoimmunology. 2016;5:e1074375 pubmed
  • western blot; human; 1:200; fig 5
Maugeri G, D Amico A, Rasà D, Reitano R, Saccone S, Federico C, et al. Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells. Genes Cancer. 2016;7:47-58 pubmed
  • western blot; mouse; 1:1000; fig 5
Liu L, Zhu J, Zhou L, Wan L. RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus. Sci Rep. 2016;6:20183 pubmed publisher
  • western blot; human; fig 3
Quintero Barceinas R, García Regalado A, Aréchaga Ocampo E, Villegas Sepúlveda N, González De la Rosa C. All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. Biomed Res Int. 2015;2015:404368 pubmed publisher
  • western blot; human; 1:8000; fig 7
Zhou X, Tao Y, Liang C, Zhang Y, Li H, Chen Q. BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015;16:20344-59 pubmed publisher
  • western blot; mouse
Choi J, Kim J, Kim T, Park J, Lee J, Kim H, et al. TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors. Neuropharmacology. 2015;97:346-56 pubmed publisher
  • western blot; human; loading ...; fig 4d
Chen M, Yen C, Cheng C, Wu R, Huang S, Yu C, et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget. 2015;6:23594-608 pubmed
  • western blot; human
Faggi F, Codenotti S, Poliani P, Cominelli M, Chiarelli N, Colombi M, et al. MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line. PLoS ONE. 2015;10:e0130287 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6
Korotkevych N, Labyntsev A, Kolybo D, Komisarenko S. The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus. PLoS ONE. 2015;10:e0127887 pubmed publisher
  • western blot; mouse
Bargut T, Mandarim de Lacerda C, Aguila M. A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. J Nutr Biochem. 2015;26:960-9 pubmed publisher
  • western blot; human
Wang B, Wu S, Tang S, Lai C, Ou C, Wu M, et al. Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells. Mutat Res. 2015;773:1-8 pubmed publisher
  • western blot; human
Fouladi F, Jehn L, Metzelder S, Hub F, Henkenius K, Burchert A, et al. Sorafenib induces paradoxical phosphorylation of the extracellular signal-regulated kinase pathway in acute myeloid leukemia cells lacking FLT3-ITD mutation. Leuk Lymphoma. 2015;56:2690-8 pubmed publisher
  • western blot; rat; 1:200
Castorina A, Waschek J, Marzagalli R, Cardile V, Drago F. PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. PLoS ONE. 2015;10:e0117799 pubmed publisher
  • western blot; rat; 1:200
Passos E, Pereira C, Gonçalves I, Rocha Rodrigues S, Silva N, Guimarães J, et al. Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis. Life Sci. 2015;123:51-60 pubmed publisher
  • western blot; rat; fig 3
Xu T, Pan Z, Dong M, Yu C, Niu Y. Ferulic acid suppresses activation of hepatic stellate cells through ERK1/2 and Smad signaling pathways in vitro. Biochem Pharmacol. 2015;93:49-58 pubmed publisher
  • western blot; human; 1:1000
Tang D, Yu Y, Zhao X, Schachner M, Zhao W. Single chain fragment variable antibodies developed by using as target the 3rd fibronectin type III homologous repeat fragment of human neural cell adhesion molecule L1 promote cell migration and neuritogenesis. Exp Cell Res. 2015;330:336-45 pubmed publisher
  • western blot; human; 1:1000
Kannike K, Sepp M, Zuccato C, Cattaneo E, Timmusk T. Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop. J Biol Chem. 2014;289:32845-57 pubmed publisher
  • western blot; human; 1:800
Zhou X, Tao Y, Wang J, Liang C, Wang J, Li H, et al. Roles of FGF-2 and TGF-beta/FGF-2 on differentiation of human mesenchymal stem cells towards nucleus pulposus-like phenotype. Growth Factors. 2015;33:23-30 pubmed publisher
  • western blot; human
Castorina A, Giunta S. Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate. Biometals. 2014;27:1149-58 pubmed publisher
  • western blot; mouse
Kapur N, Qiao X, Paruchuri V, Mackey E, Daly G, Ughreja K, et al. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014;3: pubmed publisher
  • western blot; human
Attarha S, Andersson S, Mints M, Souchelnytskyi S. Mammalian sterile-like 1 kinase inhibits TGF? and EGF?dependent regulation of invasiveness, migration and proliferation of HEC-1-A endometrial cancer cells. Int J Oncol. 2014;45:853-60 pubmed publisher
  • western blot; domestic rabbit; 1:1,000
Jiang Y, Kou Z, Wu T, An W, Zhou R, Wang H, et al. Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion. Stem Cells Dev. 2014;23:2283-96 pubmed publisher
  • western blot; rat; 1:200
Castorina A, Scuderi S, D Amico A, Drago F, D Agata V. PACAP and VIP increase the expression of myelin-related proteins in rat schwannoma cells: involvement of PAC1/VPAC2 receptor-mediated activation of PI3K/Akt signaling pathways. Exp Cell Res. 2014;322:108-21 pubmed publisher
  • western blot; human
Lin S, Hoffmann K, Xiao Z, Jin N, Galli U, Mohr E, et al. MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. Cancer Cell Int. 2013;13:3 pubmed publisher
Al Khayal K, Vaali Mohammed M, Elwatidy M, Bin Traiki T, Al Obeed O, Azam M, et al. A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway. BMC Cancer. 2020;20:685 pubmed publisher
Di Nisio V, Rossi G, Iorio R, Pellegrini C, Macchiarelli G, Tiboni G, et al. VEGFR2 Expression Is Differently Modulated by Parity and Nulliparity in Mouse Ovary. Biomed Res Int. 2018;2018:6319414 pubmed publisher
Tome Garcia J, Erfani P, Nudelman G, Tsankov A, Katsyv I, Tejero R, et al. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018;9:4020 pubmed publisher
Nie X, Zheng J, Ricupero C, He L, Jiao K, Mao J. mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018;14:e1007491 pubmed publisher
Zhang Y, Guo Z, Li M, Fong P, Zhang J, Zhang C, et al. Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain. PLoS ONE. 2015;10:e0141142 pubmed publisher
García Pérez D, Laorden M, Milanés M. Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
Attarha S, Saini R, Andersson S, Mints M, Souchelnytskyi S. PKN1 modulates TGFβ and EGF signaling in HEC-1-A endometrial cancer cell line. Onco Targets Ther. 2014;7:1397-408 pubmed publisher
Tome Garcia J, Li D, Ghazaryan S, Shu L, Wu L. ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells. PLoS ONE. 2014;9:e99525 pubmed publisher
Faggi F, Mitola S, Sorci G, Riuzzi F, Donato R, Codenotti S, et al. Phosphocaveolin-1 enforces tumor growth and chemoresistance in rhabdomyosarcoma. PLoS ONE. 2014;9:e84618 pubmed publisher
Cruceru M, Enciu A, Popa A, Albulescu R, Neagu M, Tanase C, et al. Signal transduction molecule patterns indicating potential glioblastoma therapy approaches. Onco Targets Ther. 2013;6:1737-49 pubmed publisher
Li Y, Gao C, Shi Y, Tang Y, Liu L, Xiong T, et al. Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway. Toxicol Appl Pharmacol. 2013;273:53-8 pubmed publisher
Burch T, Watson M, Nyalwidhe J. Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. PLoS ONE. 2013;8:e65005 pubmed publisher
Agrawal V, Smart K, Jilling T, Hirsch E. Surfactant protein (SP)-A suppresses preterm delivery and inflammation via TLR2. PLoS ONE. 2013;8:e63990 pubmed publisher
Callero M, Luzzani G, De Dios D, Bradshaw T, Perez A. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013;114:2392-404 pubmed publisher
Chappell J, Sun Y, Singh A, Dalton S. MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev. 2013;27:725-33 pubmed publisher
Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, et al. Identification of small molecule activators of BMP signaling. PLoS ONE. 2013;8:e59045 pubmed publisher
Du E, Li H, Jin S, Hu X, Qiu M, Han R. Evidence that TMEM67 causes polycystic kidney disease through activation of JNK/ERK-dependent pathways. Cell Biol Int. 2013;37:694-702 pubmed publisher
Chen J, Guo Y, Cheng W, Chen R, Liu T, Chen Z, et al. High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia. BMC Neurosci. 2013;14:24 pubmed publisher
Cheng T, Zhang L, Fu X, Wang W, Xu H, Song H, et al. The potential protective effects of calcitonin involved in coordinating chondrocyte response, extracellular matrix, and subchondral trabecular bone in experimental osteoarthritis. Connect Tissue Res. 2013;54:139-46 pubmed publisher
Nahid M, Yao B, Dominguez Gutierrez P, Kesavalu L, Satoh M, Chan E. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol. 2013;190:1250-63 pubmed publisher
Huang L, Liu Y, Jin W, Ji X, Dong Z. Ketamine potentiates hippocampal neurodegeneration and persistent learning and memory impairment through the PKC?-ERK signaling pathway in the developing brain. Brain Res. 2012;1476:164-71 pubmed publisher
García Navas R, Munder M, Mollinedo F. Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy. 2012;8:1557-76 pubmed publisher
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
Fisher K, Codina J, Petrovic S, Dubose T. Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway. Am J Physiol Renal Physiol. 2012;303:F1353-62 pubmed publisher
Straussman R, Morikawa T, Shee K, Barzily Rokni M, Qian Z, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487:500-4 pubmed publisher
Batista T, Alonso Magdalena P, Vieira E, Amaral M, Cederroth C, Nef S, et al. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS ONE. 2012;7:e33814 pubmed publisher
Stauber R, Knauer S, Habtemichael N, Bier C, Unruhe B, Weisheit S, et al. A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer. Oncotarget. 2012;3:31-43 pubmed
Okamura J, Huang Y, Moon D, Brait M, Chang X, Kim M. Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer. Cancer Biol Ther. 2012;13:148-55 pubmed publisher
Mahmud H, Sillje H, Cannon M, van Gilst W, de Boer R. Regulation of the (pro)renin-renin receptor in cardiac remodelling. J Cell Mol Med. 2012;16:722-9 pubmed publisher
Pancione M, Sabatino L, Fucci A, Carafa V, Nebbioso A, Forte N, et al. Epigenetic silencing of peroxisome proliferator-activated receptor ? is a biomarker for colorectal cancer progression and adverse patients' outcome. PLoS ONE. 2010;5:e14229 pubmed publisher
Tsai F, Liu W, Pai M, Hsieh M, Lin J, Chou C. Downregulation of the integrin ?(v) signaling pathway in uterine leiomyomas. Gynecol Obstet Invest. 2011;71:129-35 pubmed publisher
Zhang J, Luo W, Liu Z, Lin J, Cheng Z. Effects of transfection of ICAP-1? and its mutants on adhesion and migration of 2H-11 cells. J Huazhong Univ Sci Technolog Med Sci. 2010;30:569-74 pubmed publisher
Palozza P, Colangelo M, Simone R, Catalano A, Boninsegna A, Lanza P, et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis. 2010;31:1813-21 pubmed publisher
Alexandru O, Dragutescu L, Tataranu L, Ciubotaru V, Sevastre A, Georgescu A, et al. Helianthin induces antiproliferative effect on human glioblastoma cells in vitro. J Neurooncol. 2011;102:9-18 pubmed publisher
Jadali A, Ghazizadeh S. Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes. J Biol Chem. 2010;285:23387-97 pubmed publisher
Li H, Han M, Bernier M, Zheng B, Sun S, Su M, et al. Krüppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells. J Biol Chem. 2010;285:17846-56 pubmed publisher
Elbaz J, Reizel Y, Nevo N, Galiani D, Dekel N. Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles. Endocrinology. 2010;151:755-65 pubmed publisher
product information
Catalog Number :
sc-135900
Product Name :
ERK 1/2 (MK1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
MK1
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
ERK 1
Specificity :
mouse, rat, human, canine
Uses :
WB, IP, IF
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA