| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 3d
| Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, et al. Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway. Pharmacol Res. 2020;153:104678 pubmed publisher |
- western blot; mouse; loading ...; fig 1b, e1e
| Su L, Zhou L, Chen F, Wang H, Qian H, Sheng Y, et al. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019;38: pubmed publisher |
- western blot; human; loading ...; fig 1c, s5c
| Nakazeki F, Tsuge I, Horie T, Imamura K, Tsukita K, Hotta A, et al. MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons. Clin Sci (Lond). 2019;133:583-595 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Guo J, Fang W, Chen X, Lin Y, Hu G, Wei J, et al. Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. FEBS Lett. 2018;592:2725-2738 pubmed publisher |
- western blot; mouse; fig 2b
| Tong X, Li P, Zhang D, VanDommelen K, Gupta N, Rui L, et al. E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis. J Lipid Res. 2016;57:1219-30 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
- RNA immunoprecipitation; human; 1:50; fig 4
- western blot; human; 1:1000; fig 5
| Yan C, Chen J, Chen N. Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci Rep. 2016;6:22640 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Ochiai A, Miyata S, Shimizu M, Inoue J, Sato R. Piperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins. PLoS ONE. 2015;10:e0139799 pubmed publisher |
- western blot; mouse; fig 7
| Feng D, Youn D, Zhao X, Gao Y, Quinn W, Xiaoli A, et al. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS ONE. 2015;10:e0126240 pubmed publisher |
- western blot; human; fig 2
- western blot; mouse; fig 2
| Li S, Oh Y, Yue P, Khuri F, Sun S. Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene. 2016;35:642-50 pubmed publisher |
- western blot; human; fig s7
| Kirschner K, Samarajiwa S, Cairns J, Menon S, Perez Mancera P, Tomimatsu K, et al. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genet. 2015;11:e1005053 pubmed publisher |
- western blot; human; 1:500
| Caputo M, De Rosa M, Rescigno T, Zirpoli H, Vassallo A, De Tommasi N, et al. Binding of polyunsaturated fatty acids to LXRα and modulation of SREBP-1 interaction with a specific SCD1 promoter element. Cell Biochem Funct. 2014;32:637-46 pubmed publisher |
- western blot; human; loading ...; fig s2b
| Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed publisher |
| Nakakuki M, Kawano H, Notsu T, Imada K, Mizuguchi K, Shimano H. A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. J Biochem. 2014;155:301-13 pubmed publisher |
| Bengoechea Alonso M, Punga T, Ericsson J. Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci U S A. 2005;102:11681-6 pubmed |
| Ding Y, Yang J, Ma Y, Yao T, Chen X, Ge S, et al. MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2. J Exp Clin Cancer Res. 2019;38:498 pubmed publisher |
| Li L, Hua L, Fan H, He Y, Xu W, Zhang L, et al. Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells. J Cancer. 2019;10:6395-6404 pubmed publisher |
| Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al. A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Nat Commun. 2019;10:1152 pubmed publisher |
| Lee S, Kwon S, Kaya P, Lee Y, Lee J, Kim G, et al. Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis. Sci Rep. 2018;8:15711 pubmed publisher |
| Du T, Sikora M, Levine K, Tasdemir N, Riggins R, Wendell S, et al. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018;20:106 pubmed publisher |
| Zhao X, Xiong X, Liu T, Mi L, Peng X, Rui C, et al. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun. 2018;9:2986 pubmed publisher |
| Mohamed A, Viveiros A, Williams K, Posse de Chaves E. Aβ inhibits SREBP-2 activation through Akt inhibition. J Lipid Res. 2018;59:1-13 pubmed publisher |
| Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X, et al. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. Mol Metab. 2017;6:138-147 pubmed publisher |
| Vecchione G, Grasselli E, Voci A, Baldini F, Grattagliano I, Wang D, et al. Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. World J Gastroenterol. 2016;22:6016-26 pubmed publisher |
| Lu H, Gao Z, Zhao Z, Weng J, Ye J. Transient hypoxia reprograms differentiating adipocytes for enhanced insulin sensitivity and triglyceride accumulation. Int J Obes (Lond). 2016;40:121-8 pubmed publisher |
| Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, et al. The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature. 2015;524:243-6 pubmed publisher |
| Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, et al. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci Rep. 2014;4:5312 pubmed publisher |
| Pauter A, Olsson P, Asadi A, Herslöf B, Csikasz R, Zadravec D, et al. Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice. J Lipid Res. 2014;55:718-28 pubmed publisher |
| Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, et al. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013;4:2883 pubmed publisher |
| Hasek B, Boudreau A, Shin J, Feng D, Hulver M, Van N, et al. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes. 2013;62:3362-72 pubmed publisher |
| Henriksen B, Curtis M, Fillmore N, Cardon B, Thomson D, Hancock C. The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetol Metab Syndr. 2013;5:29 pubmed publisher |
| Hashimoto K, Ishida E, Miura A, Ozawa A, Shibusawa N, Satoh T, et al. Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter. Endocrinology. 2013;154:537-49 pubmed publisher |
| Damiano F, Rochira A, Tocci R, Alemanno S, Gnoni A, Siculella L. hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress. Biochem J. 2013;449:543-53 pubmed publisher |
| Oppi Williams C, Suagee J, Corl B. Regulation of lipid synthesis by liver X receptor ? and sterol regulatory element-binding protein 1 in mammary epithelial cells. J Dairy Sci. 2013;96:112-21 pubmed publisher |
| Mukai Y, Kumazawa M, Sato S. Fructose intake during pregnancy up-regulates the expression of maternal and fetal hepatic sterol regulatory element-binding protein-1c in rats. Endocrine. 2013;44:79-86 pubmed publisher |
| Kim G, Lee K, Oh G, Yoon J, Kim H, Kim S. Regulation of hepatic insulin sensitivity by activating signal co-integrator-2. Biochem J. 2012;447:437-47 pubmed publisher |
| Allen R, Marquart T, Albert C, Suchy F, Wang D, Ananthanarayanan M, et al. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. EMBO Mol Med. 2012;4:882-95 pubmed publisher |
| Ma L, Corl B. Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1. J Dairy Sci. 2012;95:3743-55 pubmed publisher |
| Li S, Tse I, Li E. Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring. J Nutr Biochem. 2012;23:1655-60 pubmed publisher |
| Cho H, Kong H, Kim H, Cheong J. Characterization of Paralichthys olivaceus peroxisome proliferator-activated receptor-? gene as a master regulator of flounder lipid metabolism. Gen Comp Endocrinol. 2012;175:39-47 pubmed publisher |
| Damiano F, Mercuri E, Stanca E, Gnoni G, Siculella L. Streptozotocin-induced diabetes affects in rat liver citrate carrier gene expression by transcriptional and posttranscriptional mechanisms. Int J Biochem Cell Biol. 2011;43:1621-9 pubmed publisher |
| Trebicka J, Racz I, Siegmund S, Cara E, Granzow M, Schierwagen R, et al. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. Liver Int. 2011;31:860-70 pubmed publisher |
| Kim G, Kim G, Oh G, Yoon J, Kim H, Kim M, et al. SREBP-1c regulates glucose-stimulated hepatic clusterin expression. Biochem Biophys Res Commun. 2011;408:720-5 pubmed publisher |
| McFadden J, Corl B. Activation of liver X receptor (LXR) enhances de novo fatty acid synthesis in bovine mammary epithelial cells. J Dairy Sci. 2010;93:4651-8 pubmed publisher |
| Ronis M, Badeaux J, Chen Y, Badger T. Rice protein isolate improves lipid and glucose homeostasis in rats fed high fat/high cholesterol diets. Exp Biol Med (Maywood). 2010;235:1102-13 pubmed publisher |
| Xu F, Gao Z, Zhang J, Rivera C, Yin J, Weng J, et al. Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology. 2010;151:2504-14 pubmed publisher |
| Rideout T, Harding S, Jones P. Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. Mol Nutr Food Res. 2010;54 Suppl 1:S7-13 pubmed publisher |
| Obstfeld A, Sugaru E, Thearle M, Francisco A, Gayet C, Ginsberg H, et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 2010;59:916-25 pubmed publisher |
| Kim K, Kim H, Cho H, Kim K, Cheong J. The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells. Carcinogenesis. 2010;31:679-86 pubmed publisher |
| Yellaturu C, Deng X, Park E, Raghow R, Elam M. Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex. J Biol Chem. 2009;284:31726-34 pubmed publisher |
| Ronis M, Chen Y, Badeaux J, Badger T. Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling. J Nutr. 2009;139:1431-8 pubmed publisher |
| Yellaturu C, Deng X, Cagen L, Wilcox H, Mansbach C, Siddiqi S, et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem. 2009;284:7518-32 pubmed publisher |
| Damiano F, Gnoni G, Siculella L. Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids. Biochem J. 2009;417:561-71 pubmed publisher |
| Kim K, Kim K, Kim H, Cheong J. Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochem J. 2008;416:219-30 pubmed publisher |
| Kim K, Shin H, Kim K, Choi H, Rhee S, Moon H, et al. Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology. 2007;132:1955-67 pubmed |
| Kim K, Hong S, Kim K, Park M, Kim K, Cheong J. HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma. Biochem Biophys Res Commun. 2007;355:883-8 pubmed |
| Teran Garcia M, Adamson A, Yu G, Rufo C, Suchankova G, Dreesen T, et al. Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c. Biochem J. 2007;402:591-600 pubmed |
| Qu S, Su D, Altomonte J, Kamagate A, He J, Perdomo G, et al. PPAR{alpha} mediates the hypolipidemic action of fibrates by antagonizing FoxO1. Am J Physiol Endocrinol Metab. 2007;292:E421-34 pubmed |
| Hansmannel F, Mordier S, Iynedjian P. Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor. Biochem J. 2006;399:275-83 pubmed |
| Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, et al. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res. 2006;47:2028-41 pubmed |
| Zhang W, Patil S, Chauhan B, Guo S, Powell D, Le J, et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem. 2006;281:10105-17 pubmed |
| Botolin D, Wang Y, Christian B, Jump D. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. J Lipid Res. 2006;47:181-92 pubmed |
| Zoumi A, Datta S, Liaw L, Wu C, Manthripragada G, Osborne T, et al. Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer. Mol Cell Biol. 2005;25:2946-56 pubmed |
