product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Pim-1 (12H8) Antibody
catalog :
sc-13513
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
12H8
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 25
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5a
  • western blot; mouse; 1:500; loading ...; fig 5c
Lu Y, Kim N, Jiang Y, Zhang H, Zheng D, Zhu F, et al. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol. 2018;175:1085-1099 pubmed publisher
  • flow cytometry; mouse; fig 5f
  • western blot; mouse; fig 5a
Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1a
Santio N, Salmela M, Arola H, Eerola S, Heino J, Rainio E, et al. The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways. Exp Cell Res. 2016;342:113-24 pubmed publisher
  • immunohistochemistry; human; fig 3h
  • western blot; human; loading ...; fig s3b
Green A, Maciel T, Hospital M, Yin C, Mazed F, Townsend E, et al. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Sci Adv. 2015;1:e1500221 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Van Der Meer R, Song H, Park S, Abdulkadir S, Roh M. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition. Clin Cancer Res. 2014;20:3211-21 pubmed publisher
Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, et al. A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. J Biol Chem. 2017;292:8207-8222 pubmed publisher
Ren C, Cheng X, Lu B, Yang G. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironme. Eur J Cancer. 2013;49:3889-99 pubmed publisher
Yang J, Wang J, Chen K, Guo G, Xi R, Rothman P, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013;73:4898-908 pubmed publisher
Thomas M, Lange Grünweller K, Hartmann D, Golde L, Schlereth J, Streng D, et al. Analysis of transcriptional regulation of the human miR-17-92 cluster; evidence for involvement of Pim-1. Int J Mol Sci. 2013;14:12273-96 pubmed publisher
Kim K, Carroll A, Mashkani B, Cairns M, Small D, Scott R. MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. PLoS ONE. 2012;7:e44546 pubmed publisher
Gomez Abad C, Pisonero H, Blanco Aparicio C, Roncador G, Gonzalez Menchen A, Martinez Climent J, et al. PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma. Blood. 2011;118:5517-27 pubmed publisher
Okamoto R, Delansorne R, Wakimoto N, Doan N, Akagi T, Shen M, et al. Inecalcitol, an analog of 1?,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer. 2012;130:2464-73 pubmed publisher
Guo S, Mao X, Chen J, Huang B, Jin C, Xu Z, et al. Overexpression of Pim-1 in bladder cancer. J Exp Clin Cancer Res. 2010;29:161 pubmed publisher
Morishita D, Takami M, Yoshikawa S, Katayama R, Sato S, Kukimoto Niino M, et al. Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J Biol Chem. 2011;286:2681-8 pubmed publisher
Santio N, Vahakoski R, Rainio E, Sandholm J, Virtanen S, Prudhomme M, et al. Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol Cancer. 2010;9:279 pubmed publisher
Zhang Y, Parsanejad M, Huang E, Qu D, Aleyasin H, Rousseaux M, et al. Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. J Neurochem. 2010;112:497-510 pubmed publisher
Grundler R, Brault L, Gasser C, Bullock A, Dechow T, Woetzel S, et al. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med. 2009;206:1957-70 pubmed publisher
Peltola K, Hollmen M, Maula S, Rainio E, Ristamaki R, Luukkaa M, et al. Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia. 2009;11:629-36 pubmed
Beharry Z, Zemskova M, Mahajan S, Zhang F, Ma J, Xia Z, et al. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol Cancer Ther. 2009;8:1473-83 pubmed publisher
Vu H, Xinh P, Kano Y, Tokunaga K, Sato Y. The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation. Biochem Biophys Res Commun. 2009;383:308-13 pubmed publisher
Andina N, Didichenko S, Schmidt Mende J, Dahinden C, Simon H. Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils. J Allergy Clin Immunol. 2009;123:603-11 pubmed publisher
Aksoy I, Sakabedoyan C, Bourillot P, Malashicheva A, Mancip J, Knoblauch K, et al. Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3. Stem Cells. 2007;25:2996-3004 pubmed
Tschopp C, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow J, et al. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood. 2006;108:2290-9 pubmed
Qiu L, Lai R, Lin Q, Lau E, Thomazy D, Calame D, et al. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood. 2006;108:2407-15 pubmed
Cibull T, Jones T, Li L, Eble J, Ann Baldridge L, Malott S, et al. Overexpression of Pim-1 during progression of prostatic adenocarcinoma. J Clin Pathol. 2006;59:285-8 pubmed
product information
Product Name :
Pim-1 (12H8) Antibody
Gene Name :
PIM1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-13513
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Pim-1
reactive species  :
m, r, h
Application :
WB, IP
Epitope :
FL (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA