product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Thrombin R (ATAP2) Antibody
catalog :
sc-13503
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ATAP2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig st3
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:150; tbl 2
Lidfeldt J, Bendahl P, Forsare C, Malmström P, Fernö M, Belting M. Protease Activated Receptors 1 and 2 Correlate Differently with Breast Cancer Aggressiveness Depending on Tumor ER Status. PLoS ONE. 2015;10:e0134932 pubmed publisher
  • western blot; rat; 1:200
Jin S, Liu Y, Deng S, Liao L, Lin T, Ning Q, et al. Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin prothrombinase and the inhibition of pro-inflammatory cyt. Int J Mol Med. 2015;35:1199-212 pubmed publisher
  • flow cytometry; human; fig 2
  • immunocytochemistry; human; fig 2
Asokananthan N, Lan R, Graham P, Bakker A, Tokanović A, Stewart G. Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts. Physiol Rep. 2015;3: pubmed publisher
  • flow cytometry; human
  • western blot; human
Kurz D, Payeli S, Greutert H, Briand Schumacher S, Luscher T, Tanner F. Epigenetic regulation of tissue factor inducibility in endothelial cell senescence. Mech Ageing Dev. 2014;140:1-9 pubmed publisher
  • immunocytochemistry; human
Wang Y, Guo X, Li S, Zhao Y, Liu Z, Lee W, et al. Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. Biochim Biophys Acta. 2014;1843:1393-401 pubmed publisher
Kim S, Han J, Nam D, Kim G, Lim J, Kim J, et al. PAR-1 is a novel mechano-sensor transducing laminar flow-mediated endothelial signaling. Sci Rep. 2018;8:15172 pubmed publisher
Tekin C, Shi K, Daalhuisen J, Ten Brink M, Bijlsma M, Spek C. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer. Oncotarget. 2018;9:32010-32023 pubmed publisher
Raghavan S, Singh N, Mani A, Rao G. Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3-mediated degradation of the ABCA1 transporter. J Biol Chem. 2018;293:10574-10589 pubmed publisher
Towstyka N, Shiromizu C, Keitelman I, Sabbione F, Salamone G, Geffner J, et al. Modulation of γδ T-cell activation by neutrophil elastase. Immunology. 2018;153:225-237 pubmed publisher
Lin C, Majoor C, Roelofs J, de Kruif M, Horlings H, Borensztajn K, et al. Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer. BMC Cancer. 2017;17:113 pubmed publisher
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed publisher
Tibúrcio M, Costa S, DE Fatima Duarte M, Schmitt F, Longatto Filho A. Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance. Oncol Lett. 2012;4:647-657 pubmed
Tsai C, Lee S, Huang F, Chang Y. Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline. Head Neck. 2013;35:1314-8 pubmed publisher
Cooper D, Pechkovsky D, Hackett T, Knight D, Granville D. Granzyme K activates protease-activated receptor-1. PLoS ONE. 2011;6:e21484 pubmed publisher
Yang Z, Cooper P, Damera G, Mukhopadhyay I, Cho H, Kehrl J, et al. Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness. J Biol Chem. 2011;286:11444-55 pubmed publisher
Veiga C, Carneiro Lobo T, Coelho C, Carvalho S, Maia R, Vasconcelos F, et al. Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias. Blood Cells Mol Dis. 2011;46:230-4 pubmed publisher
de Meis E, Azambuja D, Ayres Silva J, Zamboni M, Pinheiro V, Levy R, et al. Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma. Braz J Med Biol Res. 2010;43:403-8 pubmed publisher
Rydén L, Grabau D, Schaffner F, Jönsson P, Ruf W, Belting M. Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer. Int J Cancer. 2010;126:2330-40 pubmed publisher
Hirano K, Hirano M, Hanada A. Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells. J Cell Biochem. 2009;108:499-507 pubmed publisher
Rosenkranz A, Rauch B, Freidel K, Schror K. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res. 2009;83:778-84 pubmed publisher
Gupta A, Gerlitz B, Richardson M, Bull C, Berg D, Syed S, et al. Distinct functions of activated protein C differentially attenuate acute kidney injury. J Am Soc Nephrol. 2009;20:267-77 pubmed publisher
Depasquale I, Thompson W. Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF. Histopathology. 2008;52:500-9 pubmed publisher
Brueckmann M, Hoffmann U, Engelhardt C, Lang S, Fukudome K, Haase K, et al. Prognostic value of platelet-derived growth factor in patients with severe sepsis. Growth Factors. 2007;25:15-24 pubmed
Kirilak Y, Pavlos N, Willers C, Han R, Feng H, Xu J, et al. Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors. Int J Mol Med. 2006;17:551-8 pubmed
product information
Product Name :
Thrombin R (ATAP2) Antibody
Gene Name :
F2R
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-13503
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Thrombin R
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
42-55 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA