product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Smad2/3 (C-8) Antibody
catalog :
sc-133098
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 4a
  • western blot; rat; 1:500; loading ...; fig 4a
  • western blot; mouse; 1:500; fig 4d
Xu L, Tan B, Huang D, Yuan M, Li T, Wu M, et al. Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Front Pharmacol. 2021;12:626510 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3a
Hreha T, Collins C, Daugherty A, Twentyman J, Paluri N, Hunstad D. TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis. Physiol Rep. 2020;8:e14401 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 4
  • western blot; human; 1:500; fig 6
Ding Z, Jin G, Wang W, Sun Y, Chen W, Chen L, et al. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells. Int J Mol Sci. 2016;17:408 pubmed publisher
  • immunoprecipitation; human; 1:50; fig 3
  • western blot; human; 1:500; fig 3
Wu Y, Ai X, Liu F, Liang H, Zhang B, Chen X. c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma. Mol Med Rep. 2016;13:1345-52 pubmed publisher
  • proximity ligation assay; mouse; fig s12
Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher
  • western blot; rat; fig s2
  • western blot; mouse; fig s3
Yousef H, Conboy M, Morgenthaler A, Schlesinger C, Bugaj L, Paliwal P, et al. Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 2015;6:11959-78 pubmed
  • western blot; human; 1:500
Zhou X, Tao Y, Wang J, Liang C, Wang J, Li H, et al. Roles of FGF-2 and TGF-beta/FGF-2 on differentiation of human mesenchymal stem cells towards nucleus pulposus-like phenotype. Growth Factors. 2015;33:23-30 pubmed publisher
  • western blot; human
Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
Neely A, Zhang Y, Blumensaadt L, Mao H, Brenner B, Sun C, et al. Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers. Commun Biol. 2023;6:1033 pubmed publisher
Bae Y, Hwang J, Shin Y. miR-30c-1 encourages human corneal endothelial cells to regenerate through ameliorating senescence. Aging (Albany NY). 2021;13:9348-9372 pubmed publisher
Zhang Q, Tran T, Wang M, Ranek M, Kokkonen Simon K, Gao J, et al. Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun. 2018;9:5230 pubmed publisher
Wu Y, Wang W, Peng X, He Y, Xiong Y, Liang H, et al. Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-β-Smad2 Dependent Signaling. Front Pharmacol. 2018;9:877 pubmed publisher
Yu S, Li L, Tian W, Nie D, Mu W, Qiu F, et al. PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial-mesenchymal transition. Br J Pharmacol. 2018;175:3111-3130 pubmed publisher
Yamamoto K, Tateishi K, Kudo Y, Hoshikawa M, Tanaka M, Nakatsuka T, et al. Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer. Oncotarget. 2016;7:61469-61484 pubmed publisher
Fenwick M, Mora J, Mansour Y, Baithun C, Franks S, Hardy K. Investigations of TGF-? signaling in preantral follicles of female mice reveal differential roles for bone morphogenetic protein 15. Endocrinology. 2013;154:3423-36 pubmed publisher
Ding Z, Jin G, Liang H, Wang W, Chen W, Datta P, et al. Transforming growth factor ? induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cell Signal. 2013;25:1981-92 pubmed publisher
Zhao W, Wang K. NGX6 expression improves the sensitivity of tamoxifen-resistant MCF-7 cells through modulation of the Smad signaling pathway. Int J Oncol. 2013;42:2060-8 pubmed publisher
Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3. Lab Invest. 2012;92:1686-97 pubmed publisher
Pavone L, Rea S, Trapani F, De Pasquale V, Tafuri S, Papparella S, et al. Role of serotonergic system in the pathogenesis of fibrosis in canine idiopathic inflammatory myopathies. Neuromuscul Disord. 2012;22:549-57 pubmed publisher
Wang L, Ko C, Meyers E, Pedroja B, Pelaez N, Bernstein A. Concentration-dependent effects of transforming growth factor ?1 on corneal wound healing. Mol Vis. 2011;17:2835-46 pubmed
Pavone L, Cattaneo F, Rea S, De Pasquale V, Spina A, Sauchelli E, et al. Intracellular signaling cascades triggered by the NK1 fragment of hepatocyte growth factor in human prostate epithelial cell line PNT1A. Cell Signal. 2011;23:1961-71 pubmed publisher
Pavone L, Spina A, Rea S, Santoro D, Mastellone V, Lombardi P, et al. Serotonin transporter gene deficiency is associated with sudden death of newborn mice through activation of TGF-beta1 signalling. J Mol Cell Cardiol. 2009;47:691-7 pubmed publisher
product information
Catalog Number :
sc-133098
Product Name :
Smad2/3 (C-8) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C-8
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Smad3
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA