product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
VDR (D-6) Antibody
catalog :
sc-13133
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry knockout validation
citations: 49
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; fig 3B
  • immunohistochemistry - frozen section; mouse; fig 3B
Zhang T, Yin Y, Liu H, Du W, Ren C, Wang L, et al. Generation of VDR Knock-Out Mice via Zygote Injection of CRISPR/Cas9 System. PLoS ONE. 2016;11:e0163551 pubmed publisher
  • western blot; mouse; 1:1000; fig 5d
Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, et al. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017;8:14570 pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 2A
  • western blot; human; loading ...; fig 1B
Kempińska Podhorodecka A, Milkiewicz M, Wasik U, Ligocka J, Zawadzki M, Krawczyk M, et al. Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway. Int J Mol Sci. 2017;18: pubmed publisher
  • western blot; human; fig 3
Reynolds J, Haque S, Williamson K, Ray D, Alexander M, Bruce I. Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus. Sci Rep. 2016;6:22341 pubmed publisher
  • western blot; human; fig 1
Berge T, Leikfoss I, Brorson I, Bos S, Page C, Gustavsen M, et al. The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells. Genes Immun. 2016;17:118-27 pubmed publisher
  • western blot; human; fig 1
Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
Visconti B, Paolino G, Carotti S, Pendolino A, Morini S, Richetta A, et al. Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin. J Eur Acad Dermatol Venereol. 2015;29:2038-42 pubmed publisher
  • immunohistochemistry; mouse; 1:100
  • western blot; mouse; fig 4
Girgis C, Mokbel N, Cha K, Houweling P, Abboud M, Fraser D, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014;155:3227-37 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Wahler J, So J, Kim Y, Liu F, Maehr H, Uskokovic M, et al. Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog. Cancer Prev Res (Phila). 2014;7:617-26 pubmed publisher
  • western blot; human
Zhong W, Gu B, Gu Y, Groome L, Sun J, Wang Y. Activation of vitamin D receptor promotes VEGF and CuZn-SOD expression in endothelial cells. J Steroid Biochem Mol Biol. 2014;140:56-62 pubmed publisher
  • western blot; mouse
LaPorta E, Welsh J. Modeling vitamin D actions in triple negative/basal-like breast cancer. J Steroid Biochem Mol Biol. 2014;144 Pt A:65-73 pubmed publisher
  • western blot; human; 1:500
Guo L, Chen W, Zhu H, Chen Y, Wan X, Yang N, et al. Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses. Helicobacter. 2014;19:37-47 pubmed publisher
Ricca C, Aillon A, Bergandi L, Alotto D, Castagnoli C, Silvagno F. Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health. Int J Mol Sci. 2018;19: pubmed publisher
He L, Liu T, Shi Y, Tian F, Hu H, Deb D, et al. Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis. Endocrinology. 2018;159:967-979 pubmed publisher
Dimitrov V, Bouttier M, Boukhaled G, Salehi Tabar R, Avramescu R, Memari B, et al. Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice. J Biol Chem. 2017;292:20657-20668 pubmed publisher
Jia X, Xu J, Gu Y, Gu X, Li W, Wang Y. Vitamin D suppresses oxidative stress-induced microparticle release by human umbilical vein endothelial cells. Biol Reprod. 2017;96:199-210 pubmed publisher
Yazdani S, Poosti F, Toro L, Wedel J, Mencke R, Mirković K, et al. Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms. Sci Rep. 2017;7:44403 pubmed publisher
Tavera Mendoza L, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, et al. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017;114:E2186-E2194 pubmed publisher
Engel N, Adamus A, Schauer N, Kuhn J, Nebe B, Seitz G, et al. Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. PLoS ONE. 2017;12:e0169742 pubmed publisher
Zhou R, Park J, Chun R, Lisse T, Garcia A, Zavala K, et al. Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells. Nucleic Acids Res. 2017;45:606-618 pubmed publisher
Jia X, Gu Y, Groome L, Al Kofahi M, Alexander J, Li W, et al. 1,25(OH)2D3 Induces Placental Vascular Smooth Muscle Cell Relaxation by Phosphorylation of Myosin Phosphatase Target Subunit 1Ser507: Potential Beneficial Effects of Vitamin D on Placental Vasculature in Humans. Biol Reprod. 2016;94:116 pubmed publisher
Li F, Zhang A, Shi Y, Ma Y, Du Y. 1α,25-Dihydroxyvitamin D3 prevents the differentiation of human lung fibroblasts via microRNA-27b targeting the vitamin D receptor. Int J Mol Med. 2015;36:967-74 pubmed publisher
Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, et al. Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet. 2013;9:e1003975 pubmed publisher
Maier R, Maier C, Onder K. Cell-based arrays for the identification of interacting polypeptide domains or epitopes. Methods Mol Biol. 2013;1061:211-29 pubmed publisher
Verway M, Bouttier M, Wang T, Carrier M, Calderon M, An B, et al. Vitamin D induces interleukin-1? expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection. PLoS Pathog. 2013;9:e1003407 pubmed publisher
Brosbøl Ravnborg A, Bundgaard B, Höllsberg P. Synergy between vitamin D(3) and Toll-like receptor agonists regulates human dendritic cell response during maturation. Clin Dev Immunol. 2013;2013:807971 pubmed publisher
Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, et al. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS ONE. 2013;8:e53287 pubmed publisher
Grimm M, Shokri B, Alexander D, Munz A, Hoffmann J, Reinert S. Is 1,25-dihydroxyvitamin D3 receptor expression a potential Achilles' heel of CD44+ oral squamous cell carcinoma cells?. Target Oncol. 2013;8:189-201 pubmed publisher
Jørgensen A, Blomberg Jensen M, Nielsen J, Juul A, Rajpert De Meyts E. Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model. J Steroid Biochem Mol Biol. 2013;136:238-46 pubmed publisher
Duque G, Li W, Vidal C, Bermeo S, Rivas D, Henderson J. Pharmacological inhibition of PPAR? increases osteoblastogenesis and bone mass in male C57BL/6 mice. J Bone Miner Res. 2013;28:639-48 pubmed publisher
Gupta G, Agrawal T, Del Core M, Hunter W, Agrawal D. Decreased expression of vitamin D receptors in neointimal lesions following coronary artery angioplasty in atherosclerotic swine. PLoS ONE. 2012;7:e42789 pubmed publisher
Gross H, Hennard C, Masouris I, Cassel C, Barth S, Stober Gr sser U, et al. Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. PLoS ONE. 2012;7:e42106 pubmed publisher
Zhu J, Rao H, Tonelli M, Westler W, Singarapu K, Markley J, et al. Efficient stable isotope labeling and purification of vitamin D receptor from inclusion bodies. Protein Expr Purif. 2012;85:25-31 pubmed publisher
Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, et al. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012;143:799-810.e2 pubmed publisher
Renne C, Benz A, Hansmann M. Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma. BMC Cancer. 2012;12:215 pubmed publisher
Trowbridge R, Sharma P, Hunter W, Agrawal D. Vitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinoma. Exp Mol Pathol. 2012;93:147-53 pubmed publisher
Agrawal T, Gupta G, Agrawal D. Calcitriol decreases expression of importin ?3 and attenuates RelA translocation in human bronchial smooth muscle cells. J Clin Immunol. 2012;32:1093-103 pubmed publisher
Bristol M, Di X, Beckman M, Wilson E, Henderson S, Maiti A, et al. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy. 2012;8:739-53 pubmed publisher
Essa S, Reichrath S, Mahlknecht U, Montenarh M, Vogt T, Reichrath J. Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines. Anticancer Res. 2012;32:383-9 pubmed
Díaz L, Martínez Reza I, García Becerra R, Gonzalez L, Larrea F, Mendez I. Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: breaking paradigms. Cytokine. 2011;55:188-94 pubmed publisher
Lisse T, Liu T, Irmler M, Beckers J, Chen H, Adams J, et al. Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling. FASEB J. 2011;25:937-47 pubmed publisher
Vrzal R, Doricakova A, Novotna A, Bachleda P, Bitman M, Pavek P, et al. Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?. Toxicol Lett. 2011;200:146-53 pubmed publisher
Sharma V, Fretwell D, Crees Z, Kerege A, Klopper J. Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism. Thyroid. 2010;20:1103-11 pubmed publisher
Krajisnik T, Olauson H, Mirza M, Hellman P, Akerstrom G, Westin G, et al. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int. 2010;78:1024-32 pubmed publisher
Fedirko V, Bostick R, Long Q, Flanders W, McCullough M, Sidelnikov E, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev. 2010;19:280-91 pubmed publisher
Stubbs J, Idiculla A, Slusser J, Menard R, Quarles L. Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD. J Am Soc Nephrol. 2010;21:353-61 pubmed publisher
Beildeck M, Islam M, Shah S, Welsh J, Byers S. Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS ONE. 2009;4:e7872 pubmed publisher
Zbytek B, Janjetovic Z, Tuckey R, Zmijewski M, Sweatman T, Jones E, et al. 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol. 2008;128:2271-80 pubmed publisher
Tishkoff D, Nibbelink K, Holmberg K, Dandu L, Simpson R. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology. 2008;149:558-64 pubmed
product information
Product Name :
VDR (D-6) Antibody
Gene Name :
VDR
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-13133
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
VDR
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
344-424 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA