product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Mdr-1 (G-1) Antibody
catalog :
sc-13131
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-1
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; fig 2
Yang Y, Qiu J, Li Y, Di J, Zhang W, Jiang Q, et al. Targeting ABCB1-mediated tumor multidrug resistance by CRISPR/Cas9-based genome editing. Am J Transl Res. 2016;8:3986-3994 pubmed
  • western blot; human; loading ...; fig 1b
Yang K, Chen Y, To K, Wang F, Li D, Chen L, et al. Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo. Exp Mol Med. 2017;49:e303 pubmed publisher
  • western blot; human; fig 5
Bosco D, Kenworthy R, Zorio D, Sang Q. Human mesenchymal stem cells are resistant to Paclitaxel by adopting a non-proliferative fibroblastic state. PLoS ONE. 2015;10:e0128511 pubmed publisher
  • western blot; human; fig 3
Qiu J, Zhang Y, Li Y, Zhao J, Zhang W, Jiang Q, et al. Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter. Oncotarget. 2015;6:15494-509 pubmed
  • western blot; human; 1:1000; fig 2
Hung T, Li Y, Tseng C, Lan Y, Hsu S, Chen Y, et al. Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines. Cancer Gene Ther. 2015;22:262-70 pubmed publisher
  • western blot; human; 1:1000; fig 1
Chong K, Hsu C, Hung T, Hu H, Huang T, Wang T, et al. Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells. Cancer Biol Ther. 2015;16:149-59 pubmed publisher
  • western blot; human
Hung T, Hsu S, Cheng C, Choo K, Tseng C, Chen T, et al. Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget. 2014;5:12273-90 pubmed
  • western blot; human
Liu X, Chen L, Feng B, Liu G. Reversing effect of sorcin in the drug resistance of human nasopharyngeal carcinoma. Anat Rec (Hoboken). 2014;297:215-21 pubmed publisher
Clements K, Schleicher E, Thakar T, Hale A, Dhoonmoon A, Tolman N, et al. Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens. Nat Commun. 2020;11:6118 pubmed publisher
Cheng X, Zhou H, Tang S, Jiang T, Chen Q, Gao R, et al. Intercellular transfer of P-glycoprotein mediates the formation of stable multi-drug resistance in human bladder cancer BIU-87 cells. Biol Open. 2019;8: pubmed publisher
Lv M, Qiu J, Zhang W, Jiang Q, Qin W, Yang Y, et al. Wallichinine reverses ABCB1-mediated cancer multidrug resistance. Am J Transl Res. 2016;8:2969-80 pubmed
Chen L, Zhao Y, Halliday G, Berry P, Rousseau R, Middleton S, et al. Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. Br J Cancer. 2014;111:716-25 pubmed publisher
Li Y, Bi H, Zhong G, Huang L, Li G, Xia Y, et al. Effect of phorbol 12-myristate 13-acetate on function and gene expression of P-glycoprotein in adriamycin-resistant K562/ADM cells. Pharmacology. 2013;92:121-30 pubmed publisher
Ellegaard A, Groth Pedersen L, Oorschot V, Klumperman J, Kirkegaard T, Nylandsted J, et al. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Mol Cancer Ther. 2013;12:2018-30 pubmed publisher
Kretschmer N, Rinner B, Stuendl N, Kaltenegger H, Wolf E, Kunert O, et al. Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012;78:1749-56 pubmed publisher
Xue X, Qu X, Gao Z, Sun C, Liu H, Zhao C, et al. Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II. Invest New Drugs. 2012;30:212-22 pubmed publisher
Imesch P, Fink D, Fedier A. Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells. Fertil Steril. 2010;94:2838-42 pubmed publisher
Kinsella P, Clynes M, Amberger Murphy V. Imatinib and docetaxel in combination can effectively inhibit glioma invasion in an in vitro 3D invasion assay. J Neurooncol. 2011;101:189-98 pubmed publisher
Imesch P, Dedes K, Furlato M, Fink D, Fedier A. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. Int J Oncol. 2009;35:631-40 pubmed
Kugawa F, Suzuki T, Miyata M, Tomono K, Tamanoi F. Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Pharmazie. 2009;64:296-300 pubmed
Rusiecka I, Składanowski A. Induction of the multixenobiotic/multidrug resistance system in various cell lines in response to perfluorinated carboxylic acids. Acta Biochim Pol. 2008;55:329-37 pubmed
Schrader A, Seger M, Konrad L, Olbert P, Hegele A, Hofmann R, et al. Clinical impact of MDR1-expression in testicular germ cell cancer. Exp Oncol. 2007;29:212-6 pubmed
Hu X, Li J, Yang E, Vandervalk S, Xing P. Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways. Br J Cancer. 2007;96:918-27 pubmed
product information
Product Name :
Mdr-1 (G-1) Antibody
Gene Name :
ABCB1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-13131
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Mdr-1
reactive species  :
human
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1040-1280 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA