Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; loading ...; fig 6c
| Lopez V, Park B, Nowak D, Sreelatha A, Zembek P, Fernandez J, et al. A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity. Cell. 2019;179:205-218.e21 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1b
| Stefanius K, Servage K, de Souza Santos M, Gray H, Toombs J, Chimalapati S, et al. Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. elife. 2019;8: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 3a
| Morris K, Corbett A. The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts. Nucleic Acids Res. 2018;46:6561-6575 pubmed publisher
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- RNA immunoprecipitation; human; loading ...; fig s9d
- western blot; mouse; fig 1c
| Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature. 2017;545:500-504 pubmed publisher
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- western blot; human; loading ...; fig 1f
| de la Mare J, Jurgens T, Edkins A. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 2017;17:202 pubmed publisher
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- western blot; human; loading ...; fig 4d
| Voráčová K, Hajek J, Mares J, Urajová P, Kuzma M, Cheel J, et al. The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells. PLoS ONE. 2017;12:e0172850 pubmed publisher
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- western blot; human; loading ...; fig 3b
| Hattori A, McSkimming D, Kannan N, Ito T. RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. Leuk Res. 2017;54:47-54 pubmed publisher
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- western blot; mouse; 1:1000; loading ...
| Chavan R, Preitner N, Okabe T, Strittmatter L, Xu C, Ripperger J, et al. REV-ERB? regulates Fgf21 expression in the liver via hepatic nuclear factor 6. Biol Open. 2017;6:1-7 pubmed publisher
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- western blot; human; loading ...; fig 1h
| Shibata E, Kiran M, Shibata Y, Singh S, Kiran S, Dutta A. Two subunits of human ORC are dispensable for DNA replication and proliferation. elife. 2016;5: pubmed publisher
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- western blot; mouse; fig 2
| Hinds T, Burns K, Hosick P, McBeth L, Nestor Kalinoski A, Drummond H, et al. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. J Biol Chem. 2016;291:25179-25191 pubmed
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- immunoprecipitation; mouse; loading ...; fig 2c
- immunohistochemistry; mouse; 1:50; loading ...; fig 3
- western blot; mouse; 1:1000; loading ...; fig 2c
| Okabe T, Chavan R, Fonseca Costa S, Brenna A, Ripperger J, Albrecht U. REV-ERB? influences the stability and nuclear localization of the glucocorticoid receptor. J Cell Sci. 2016;129:4143-4154 pubmed
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- western blot; mouse; fig 3d
| Myasnikov A, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, et al. Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Nat Commun. 2016;7:12856 pubmed publisher
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- western blot; human; fig 6
| Sasai K, Katayama H, Hawke D, Sen S. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS ONE. 2016;11:e0157305 pubmed publisher
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- western blot; mouse; fig 2
| Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig s1c
| Lee J, Takahama S, Zhang G, Tomarev S, Ye Y. Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells. Nat Cell Biol. 2016;18:765-76 pubmed publisher
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- western blot; mouse; 1:1000; fig 6
| Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nat Commun. 2016;7:10877 pubmed publisher
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- western blot; human; 1:1000
| Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-776 pubmed
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- western blot; human; fig 3
| Hedstrom E, Pederiva C, Farnebo J, Nodin B, Jirstrom K, Brennan D, et al. Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis. 2015;6:e1892 pubmed publisher
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- western blot; human; fig 6
| Brito H, Martins A, Lavrado J, Mendes E, Francisco A, Santos S, et al. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS ONE. 2015;10:e0126891 pubmed publisher
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| Yeh J, Kreimer S, Walker S, Emori M, Krystal H, Richardson A, et al. Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. Genes Cancer. 2015;6:153-68 pubmed
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- western blot; mouse; 1:1000; fig 5
| Sato M, Matsubara T, Adachi J, Hashimoto Y, Fukamizu K, Kishida M, et al. Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS ONE. 2015;10:e0126483 pubmed publisher
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- western blot; human; fig 4a
| Wang Y, Kuramitsu Y, Kitagawa T, Tokuda K, Baron B, Akada J, et al. The Histone Deacetylase Inhibitor Valproic Acid Sensitizes Gemcitabine-Induced Cytotoxicity in Gemcitabine-Resistant Pancreatic Cancer Cells Possibly Through Inhibition of the DNA Repair Protein Gamma-H2AX. Target Oncol. 2015;10:575-81 pubmed publisher
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- western blot; mouse; 1:2000
| López Bernardo E, Anedda A, Sánchez Pérez P, Acosta Iborra B, Cadenas S. 4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes. Free Radic Biol Med. 2015;88:427-438 pubmed publisher
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- western blot; human; fig 5
| Shrestha S, Sun Y, Lufkin T, Kraus P, Or Y, Garcia Y, et al. Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. Int J Biol Sci. 2015;11:434-47 pubmed publisher
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| Tristante E, MartÃnez C, Jiménez S, Mora L, Carballo F, MartÃnez Lacaci I, et al. Association of a characteristic membrane pattern of annexin A2 with high invasiveness and nodal status in colon adenocarcinoma. Transl Res. 2015;166:196-206 pubmed publisher
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| Wnorowski A, Sadowska M, Paul R, Singh N, Boguszewska Czubara A, Jimenez L, et al. Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells. Cell Signal. 2015;27:997-1007 pubmed publisher
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- immunoprecipitation; human; fig 4
| Guo Y, Liu J, Elfenbein S, Ma Y, Zhong M, Qiu C, et al. Characterization of the mammalian miRNA turnover landscape. Nucleic Acids Res. 2015;43:2326-41 pubmed publisher
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| Park S, Park J, Kim Y, Song S, Kwon H, Lee Y. Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells. Cell Stress Chaperones. 2015;20:149-57 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:200
- western blot; human; 1:1000
| Rappa F, Sciume C, Lo Bello M, Bavisotto C, Marino Gammazza A, Barone R, et al. Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel. Anticancer Res. 2014;34:4153-9 pubmed
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- western blot; mouse; fig 5
| Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, et al. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014;25:2260-71 pubmed publisher
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- western blot; human; loading ...; fig 1c
| Zahreddine H, Culjkovic Kraljacic B, Assouline S, Gendron P, Romeo A, Morris S, et al. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014;511:90-3 pubmed publisher
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| Sun Y, Chung H, Woo A, Lin V. Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor ? via distinct mechanisms. Biochim Biophys Acta. 2014;1843:2067-78 pubmed publisher
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| Havel J, Li Z, Cheng D, Peng J, Fu H. Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene. 2015;34:1487-98 pubmed publisher
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- western blot; human; loading ...; fig 5c
| Walker S, Liu S, Xiang M, Nicolais M, Hatzi K, Giannopoulou E, et al. The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene. 2015;34:1073-82 pubmed publisher
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- western blot; human; fig 3
| Liu S, Walker S, Nelson E, Cerulli R, Xiang M, Toniolo P, et al. Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2. Mol Cancer Ther. 2014;13:1194-205 pubmed publisher
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| Marshall K, Edwards M, Krenz M, Davis J, Baines C. Proteomic mapping of proteins released during necrosis and apoptosis from cultured neonatal cardiac myocytes. Am J Physiol Cell Physiol. 2014;306:C639-47 pubmed publisher
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| Lee J, Kim W, Gygi S, Ye Y. Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation. J Biol Chem. 2014;289:3510-7 pubmed publisher
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- western blot; human; 1:1000
| Ipenberg I, Guttmann Raviv N, Khoury H, Kupershmit I, Ayoub N. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem. 2013;288:14681-7 pubmed publisher
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- immunoprecipitation; human
- immunocytochemistry; human
- western blot; human
| Lyko F, Foret S, Kucharski R, Wolf S, Falckenhayn C, Maleszka R. The honey bee epigenomes: differential methylation of brain DNA in queens and workers. PLoS Biol. 2010;8:e1000506 pubmed publisher
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| Yenerall P, Das A, Wang S, Kollipara R, Li L, Villalobos P, et al. RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol. 2019;: pubmed publisher
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| Watanabe D, Nogami A, Okada K, Akiyama H, Umezawa Y, Miura O. FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Cancers (Basel). 2019;11: pubmed publisher
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| Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed publisher
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| Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, et al. Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Sci Adv. 2019;5:eaax2277 pubmed publisher
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| Miao W, Li L, Zhao Y, Dai X, Chen X, Wang Y. HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. Nat Commun. 2019;10:3613 pubmed publisher
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| Bornelöv S, Selmi T, Flad S, Dietmann S, Frye M. Codon usage optimization in pluripotent embryonic stem cells. Genome Biol. 2019;20:119 pubmed publisher
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| Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg M, Gieseler F, et al. RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5. Cancers (Basel). 2019;11: pubmed publisher
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| Woosley A, Dalton A, Hussey G, Howley B, Mohanty B, Grelet S, et al. TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis. Oncogene. 2019;38:3794-3811 pubmed publisher
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| Lambert J, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla Reimand L, et al. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell. 2019;73:621-638.e17 pubmed publisher
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| Nogami A, Okada K, Ishida S, Akiyama H, Umezawa Y, Miura O. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway. Transl Oncol. 2019;12:336-349 pubmed publisher
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| Ventimiglia L, Cuesta Geijo M, Martinelli N, Caballe A, Macheboeuf P, Miguet N, et al. CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope. Dev Cell. 2018;47:547-563.e6 pubmed publisher
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| Ruiz Estévez M, Staats J, Paatela E, Munson D, Katoku Kikyo N, Yuan C, et al. Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization. Cell Rep. 2018;25:2537-2551.e8 pubmed publisher
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| Sustic T, van Wageningen S, Bosdriesz E, Reid R, Dittmar J, Lieftink C, et al. A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers. Genome Med. 2018;10:90 pubmed publisher
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| Niu X, Su L, Qi S, Gao Z, Zhang Q, Zhang S. GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway. Cell Death Dis. 2018;9:971 pubmed publisher
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| Boel N, Hunter M, Edkins A. LRP1 is required for novobiocin-mediated fibronectin turnover. Sci Rep. 2018;8:11438 pubmed publisher
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| Shao H, Li X, Moses M, Gilbert L, Kalyanaraman C, Young Z, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018;61:6163-6177 pubmed publisher
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| Liu X, Main D, Ma Y, He B. Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex. J Virol. 2018;92: pubmed publisher
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| Bai M, Vozdek R, Hnizda A, Jiang C, Wang B, Kuchar L, et al. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nat Commun. 2018;9:897 pubmed publisher
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