Published Application/Species/Sample/Dilution | Reference |
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- immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 4, 5, 7
- western blot; human; 1:250; loading ...; fig 2
| Letkovska K, Babal P, Cierna Z, Schmidtova S, Lišková V, Kalavska K, et al. Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors. Cancers (Basel). 2021;13: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4b
| Signes A, Cerutti R, Dickson A, Benincá C, Hinchy E, Ghezzi D, et al. APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. EMBO Mol Med. 2019;11: pubmed publisher
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- western blot; human; fig 1b
| Sugiura A, Mattie S, Prudent J, McBride H. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 2017;542:251-254 pubmed publisher
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- western blot; human; 1:700; loading ...; fig 4a
| Lu H, Yang X, Tian X, Tang S, Li L, Zhao S, et al. The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells. Oncotarget. 2016;7:56508-56525 pubmed publisher
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- western blot; human; fig 2
| Scott A, Wilkinson A, Wilkinson J. Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells. BMC Cancer. 2016;16:286 pubmed publisher
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- western blot; human; fig s8
| Jiang L, Shestov A, Swain P, Yang C, Parker S, Wang Q, et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016;532:255-8 pubmed publisher
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- other; human; loading ...; fig st1
| Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
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- western blot; mouse; fig 6
- western blot; rat; fig 2
| Sabirzhanov B, Stoica B, Zhao Z, Loane D, Wu J, Dorsey S, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654-68 pubmed publisher
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- western blot; human; 1:1000; fig 5
| Loureiro R, Magalhães Novais S, Mesquita K, Baldeiras I, Sousa I, Tavares L, et al. Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells. Oncotarget. 2015;6:17081-96 pubmed
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- immunocytochemistry; human; tbl 1
- western blot; human; 1:1000; tbl 1
| Vega Naredo I, Cunha Oliveira T, Serafim T, Sardao V, Oliveira P. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods Mol Biol. 2015;1241:163-80 pubmed publisher
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- western blot; human; fig 4
| Iwaniuk A, Jabłońska E, Jabłoński J, Ratajczak Wrona W, Garley M. Expression of selected proteins of the extrinsic and intrinsic pathways of apoptosis in human leukocytes exposed to N-nitrosodimethylamine. Hum Exp Toxicol. 2015;34:591-600 pubmed publisher
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- western blot; human
- western blot; rat
- western blot; mouse
| Sabirzhanov B, Zhao Z, Stoica B, Loane D, Wu J, Borroto C, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055-71 pubmed publisher
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| Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, et al. KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response. Nucleic Acids Res. 2022;50:6313-6331 pubmed publisher
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| Yang L, Li Y, Bhattacharya A, Zhang Y. Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants. Commun Biol. 2021;4:1373 pubmed publisher
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| Ivanova I, Perkins N. Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα. Biosci Rep. 2019;39: pubmed publisher
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| Ding L, Li J, Li W, Fang Z, Li N, Wu S, et al. p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis. J Vet Med Sci. 2018;80:1775-1781 pubmed publisher
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| Scott A, Walker S, Krank J, Wilkinson A, Johnson K, Lewis E, et al. AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization. J Biol Chem. 2018;293:14707-14722 pubmed publisher
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| Wang R, Li C, Qiao P, Xue Y, Zheng X, Chen H, et al. OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos. Cell Death Dis. 2018;9:628 pubmed publisher
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| Grassilli E, Ianzano L, Bonomo S, Missaglia C, Cerrito M, Giovannoni R, et al. GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. PLoS ONE. 2014;9:e100947 pubmed publisher
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| Teng F, Tang B. Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults. Mol Cell Biochem. 2013;384:7-19 pubmed publisher
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| Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, et al. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci. 2014;71:331-48 pubmed publisher
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| Lu J, Yu J, Lim S, Son Y, Kim D, Lee S, et al. Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites ?-zearalenol and ?-zearalenol on RAW264.7 macrophages. Toxicol In Vitro. 2013;27:1007-17 pubmed publisher
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| Lewis E, Wilkinson A, Jackson J, Mehra R, Varambally S, Chinnaiyan A, et al. The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. J Biol Chem. 2012;287:43862-75 pubmed publisher
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| Sabirzhanov B, Stoica B, Hanscom M, Piao C, Faden A. Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem. 2012;123:542-54 pubmed publisher
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| Namkung J, Song J, Jo H, Kim M, Lew Y, Donahoe P, et al. Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis. J Clin Endocrinol Metab. 2012;97:3224-30 pubmed publisher
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| Cotrim C, Fabris V, Doria M, Lindberg K, Gustafsson J, Amado F, et al. Estrogen receptor beta growth-inhibitory effects are repressed through activation of MAPK and PI3K signalling in mammary epithelial and breast cancer cells. Oncogene. 2013;32:2390-402 pubmed publisher
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| Favreau D, Meessen Pinard M, Desforges M, Talbot P. Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable. J Virol. 2012;86:81-93 pubmed publisher
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| An H, Shin H, Jo S, Kim Y, Lee J, Paik S, et al. The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta. 2011;1813:2088-98 pubmed publisher
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| Yu J, Zheng Z, Son Y, Shi X, Jang Y, Lee J. Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages. Toxicol In Vitro. 2011;25:1654-63 pubmed publisher
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| Ryan M, Jackson J, Hao Y, Leonard S, Alway S. Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. Free Radic Biol Med. 2011;51:38-52 pubmed publisher
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| Ballot C, Kluza J, Lancel S, Martoriati A, Hassoun S, Mortier L, et al. Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D. Apoptosis. 2010;15:769-81 pubmed publisher
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| Son Y, Heo J, Kim T, Jeon Y, Kim J, Lee J. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. BMB Rep. 2010;43:57-61 pubmed
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| Levin V, Panchabhai S, Shen L, Kornblau S, Qiu Y, Baggerly K. Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. J Proteome Res. 2010;9:179-91 pubmed publisher
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| Park K, Lim J, Kim H. Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. Ann N Y Acad Sci. 2009;1171:421-7 pubmed publisher
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| Liu L, Yang C, Herzog C, Seth R, Kaushal G. Proteasome inhibitors prevent cisplatin-induced mitochondrial release of apoptosis-inducing factor and markedly ameliorate cisplatin nephrotoxicity. Biochem Pharmacol. 2010;79:137-46 pubmed publisher
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| Son Y, Jang Y, Heo J, Chung W, Choi K, Lee J. Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Apoptosis. 2009;14:796-808 pubmed publisher
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| Joshi A, Bondada V, Geddes J. Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor. Exp Neurol. 2009;218:221-7 pubmed publisher
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| Pontes H, Sousa C, Silva R, Fernandes E, Carmo H, Remião F, et al. Synergistic toxicity of ethanol and MDMA towards primary cultured rat hepatocytes. Toxicology. 2008;254:42-50 pubmed publisher
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| Wang Y, Luo J, Chen X, Chen H, Cramer S, Sun D. Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. Eur J Neurosci. 2008;28:51-61 pubmed publisher
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| Liu Y, Templeton D. Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. J Cell Physiol. 2008;217:307-18 pubmed publisher
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| Castera L, Hatzfeld Charbonnier A, Ballot C, Charbonnel F, Dhuiege E, Velu T, et al. Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities. J Cell Mol Med. 2009;13:1321-35 pubmed publisher
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| Havasi A, Li Z, Wang Z, Martin J, Botla V, Ruchalski K, et al. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2008;283:12305-13 pubmed publisher
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| Gallego M, Ballot C, Kluza J, Hajji N, Martoriati A, Castera L, et al. Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway. Oncogene. 2008;27:1981-92 pubmed
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| Vaishnav R, Getchell M, Huang L, HERSH M, Stromberg A, Getchell T. Cellular and molecular characterization of oxidative stress in olfactory epithelium of Harlequin mutant mouse. J Neurosci Res. 2008;86:165-82 pubmed
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| Ferreira R, Neuparth M, Vitorino R, Appell H, Amado F, Duarte J. Evidences of apoptosis during the early phases of soleus muscle atrophy in hindlimb suspended mice. Physiol Res. 2008;57:601-11 pubmed
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| Kook S, Son Y, Chung S, Lee S, Kim J, Jeon Y, et al. Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. Apoptosis. 2007;12:1289-98 pubmed
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| Yoon Y, Yoon D, Lim I, Yoon S, Chung H, Rojo M, et al. Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol. 2006;209:468-80 pubmed
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| Wang S, Yan Neale Y, Cai R, Alimov I, Cohen D. Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824. Cell Cycle. 2006;5:1662-8 pubmed
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| Parise R, Egorin M, Kanterewicz B, Taimi M, Petkovich M, Lew A, et al. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. Int J Cancer. 2006;119:1819-28 pubmed
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| Strosznajder R, Gajkowska B. Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study. Acta Neurobiol Exp (Wars). 2006;66:15-22 pubmed
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| Ruchalski K, Mao H, Li Z, Wang Z, Gillers S, Wang Y, et al. Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem. 2006;281:7873-80 pubmed
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| Wu Y, Muldoon L, Neuwelt E. The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. J Pharmacol Exp Ther. 2005;312:424-31 pubmed
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