product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Polycystin-1 (7E12) Antibody
catalog :
sc-130554
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7E12
reactivity :
human, mouse, dogs, domestic rabbit
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation
citations: 12
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig s13e
Choudhury M, Li Y, Mistriotis P, Vasconcelos A, DIXON E, Yang J, et al. Kidney epithelial cells are active mechano-biological fluid pumps. Nat Commun. 2022;13:2317 pubmed publisher
  • western blot; domestic rabbit; 1:50; fig 3
Varela A, Piperi C, Sigala F, Agrogiannis G, Davos C, Andri M, et al. Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity. Sci Rep. 2015;5:13461 pubmed publisher
  • western blot; mouse; fig 1
  • western blot; dogs; fig 1
Castelli M, De Pascalis C, Distefano G, Ducano N, Oldani A, Lanzetti L, et al. Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 2015;16:15 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, et al. Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun. 2014;5:5482 pubmed publisher
  • western blot; human
Hogan M, Johnson K, Zenka R, Charlesworth M, Madden B, Mahoney D, et al. Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine. Kidney Int. 2014;85:1225-37 pubmed publisher
Decuypere J, Van Giel D, Janssens P, Dong K, Somlo S, Cai Y, et al. Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death. Int J Mol Sci. 2021;22: pubmed publisher
Lee E, Seo E, Kim J, Nam S, Lee J, Jun J, et al. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 2020;117:29001-29012 pubmed publisher
Bulley S, Fernández Peña C, Hasan R, Leo M, Muralidharan P, MacKay C, et al. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. elife. 2018;7: pubmed publisher
Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates C, et al. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018;128:157-174 pubmed publisher
Besse W, Dong K, Choi J, Punia S, Fedeles S, Choi M, et al. Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest. 2017;127:1772-1785 pubmed publisher
Jerman S, Ward H, Lee R, Lopes C, Fry A, Macdougall M, et al. OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts. PLoS ONE. 2014;9:e106330 pubmed publisher
Dalagiorgou G, Piperi C, Georgopoulou U, Adamopoulos C, Basdra E, Papavassiliou A. Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signaling axis. Cell Mol Life Sci. 2013;70:167-180 pubmed publisher
product information
Catalog Number :
sc-130554
Product Name :
Polycystin-1 (7E12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
7E12
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Polycystin-1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA