| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 8a
- western blot; mouse; 1:5000; fig 8c
| Merino B, Casanueva xc1 lvarez E, Quesada I, Gonz xe1 lez Casimiro C, Fern xe1 ndez D xed az C, Postigo Casado T, et al. Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation. Diabetologia. 2022;65:1375-1389 pubmed publisher |
- immunoprecipitation; mouse; loading ...; fig 8d
- immunohistochemistry; mouse; 1:50; loading ...; fig 8c
- western blot; mouse; 1:3000; loading ...; fig 8a
| Zahedi K, Brooks M, Barone S, Rahmati N, Murray Stewart T, Dunworth M, et al. Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia. J Neuroinflammation. 2020;17:301 pubmed publisher |
- western blot; human; 1:4000; loading ...; fig 2c
| Shahnawaz M, Mukherjee A, Pritzkow S, Méndez N, Rabadia P, Liu X, et al. Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy. Nature. 2020;578:273-277 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Dansithong W, Paul S, Scoles D, Pulst S, Huynh D. Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. PLoS ONE. 2015;10:e0136930 pubmed publisher |
- western blot; human; 1:1000
| Mbefo M, Fares M, Paleologou K, Oueslati A, Yin G, Tenreiro S, et al. Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. J Biol Chem. 2015;290:9412-27 pubmed publisher |
- immunohistochemistry - frozen section; rat; 1:2000
| Aldrin Kirk P, Davidsson M, Holmqvist S, Li J, Bjorklund T. Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons. PLoS ONE. 2014;9:e100869 pubmed publisher |
- western blot; human; fig 6
| Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher |
| Ko L, Ko H, Lin W, Kulathingal J, Yen S. Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. J Neuropathol Exp Neurol. 2008;67:1084-96 pubmed publisher |
| Cascella R, Chen S, Bigi A, Camino J, Xu C, Dobson C, et al. The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nat Commun. 2021;12:1814 pubmed publisher |
| Chung E, Choi Y, Park J, Nah W, Park J, Jung Y, et al. Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein. Sci Adv. 2020;6:eaba1193 pubmed publisher |
| Pérez Rodríguez D, Kalyva M, Leija Salazar M, Lashley T, Tarabichi M, Chelban V, et al. Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing. Acta Neuropathol Commun. 2019;7:219 pubmed publisher |
| Chumarina M, Russ K, Azevedo C, Heuer A, Pihl M, Collin A, et al. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene. Acta Neuropathol Commun. 2019;7:208 pubmed publisher |
| Sandhof C, Hoppe S, Druffel Augustin S, Gallrein C, Kirstein J, Voisine C, et al. Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. Autophagy. 2020;16:878-899 pubmed publisher |
| Wu J, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath N, et al. Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. Transl Neurodegener. 2019;8:18 pubmed publisher |
| Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, et al. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019;137:939-960 pubmed publisher |
| Chen Q, Haikal C, Li W, Li M, Wang Z, Li J. Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease. Transl Neurodegener. 2018;7:13 pubmed publisher |
| Jan A, Jansonius B, Delaidelli A, Bhanshali F, An Y, Ferreira N, et al. Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Acta Neuropathol Commun. 2018;6:54 pubmed publisher |
| Patel D, Xu C, Nagarajan S, Liu Z, Hemphill W, Shi R, et al. Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Hum Mol Genet. 2018;27:1514-1532 pubmed publisher |
| Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher |
| Filippini A, Bonini D, Lacoux C, Pacini L, Zingariello M, Sancillo L, et al. Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse. RNA Biol. 2017;14:1580-1591 pubmed publisher |
| de Oliveira R, Vicente Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017;15:e2000374 pubmed publisher |
| Yuan J, Ren J, Wang Y, He X, Zhao Y. Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease. PLoS ONE. 2016;11:e0162696 pubmed publisher |
| Nisar R, Hanson P, He L, Taylor R, Blain P, Morris C. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015;89:1811-25 pubmed publisher |
| Cali T, Ottolini D, Negro A, Brini M. ?-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions. J Biol Chem. 2012;287:17914-29 pubmed publisher |
| Ha Y, Liew H, Park H, Kim K, Suh Y, Churchill D. Interplay of salicylaldehyde, lysine, and M2+ ions on ?-synuclein aggregation: cancellation of aggregation effects and determination of salicylaldehyde neurotoxicity. Neurosci Res. 2011;71:168-77 pubmed publisher |
| Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy A. ?-Synuclein negatively regulates protein kinase C? expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci. 2011;31:2035-51 pubmed publisher |
| Sakurai M, Kawamura T, Nishimura H, Suzuki H, Tezuka F, Abe K. Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits. J Cereb Blood Flow Metab. 2009;29:752-8 pubmed publisher |
| Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem. 2008;283:23542-56 pubmed publisher |
| Fornai F, Schlüter O, Lenzi P, Gesi M, Ruffoli R, Ferrucci M, et al. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A. 2005;102:3413-8 pubmed |
