product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Mcl-1 (22) Antibody
catalog :
sc-12756
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
22
reactivity :
human
application :
western blot, ELISA, immunoprecipitation
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4f
Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher
  • western blot; human; loading ...; fig 6a
Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher
  • western blot; human; fig 4
De Toni E, Ziesch A, Rizzani A, Török H, Hocke S, Lü S, et al. Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptor-mediated apoptosis. Oncotarget. 2016;7:9477-90 pubmed publisher
  • western blot; human; fig 2
Cui J, Sun W, Hao X, Wei M, Su X, Zhang Y, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int. 2015;15:4 pubmed publisher
  • western blot; human; loading ...; fig 2a
Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, et al. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014;5:e1316 pubmed publisher
  • western blot; human; fig 6
Son J, Varadarajan S, Bratton S. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 2010;17:1288-301 pubmed publisher
Cervia L, Shibue T, Borah A, Gaeta B, He L, Leung L, et al. A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer Discov. 2023;13:766-795 pubmed publisher
Zhu R, Li L, Nguyen B, Seo J, Wu M, Seale T, et al. FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation. Signal Transduct Target Ther. 2021;6:186 pubmed publisher
Gromisch C, Tan G, Pasion K, Moran A, Gromisch M, Grinstaff M, et al. Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis ratnu/nu model. BMC Cancer. 2021;21:407 pubmed publisher
Zhang Q, Zhang Q, Li H, Zhao X, Zhang H. LiCl induces apoptosis via CHOP/NOXA/Mcl-1 axis in human choroidal melanoma cells. Cancer Cell Int. 2021;21:96 pubmed publisher
Yeh C, Bellon M, Wang F, Zhang H, Fu L, Nicot C. Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells. Mol Cancer. 2020;19:139 pubmed publisher
Sriskandarajah P, de Haven Brandon A, MacLeod K, Carragher N, Kirkin V, Kaiser M, et al. Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma. BMC Cancer. 2020;20:269 pubmed publisher
Blake D, Vaseva A, Hodge R, Kline M, Gilbert T, Tyagi V, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal. 2019;12: pubmed publisher
Klenke S, Akdeli N, Stelmach P, Heukamp L, Schulte J, Bachmann H. The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines. BMC Cancer. 2019;19:243 pubmed publisher
Yin J, Li X, Zhang Z, Luo X, Wang L, Liu L. SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM?1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo. Int J Oncol. 2018;53:297-306 pubmed publisher
Xu F, Zhu Y, Lu Y, Yu Z, Zhong J, Li Y, et al. Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells. Oncol Lett. 2018;15:5871-5878 pubmed publisher
Quast S, Berger A, Eberle J. ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis. Cell Death Dis. 2013;4:e839 pubmed publisher
Tan C, Hagen T. mTORC1 dependent regulation of REDD1 protein stability. PLoS ONE. 2013;8:e63970 pubmed publisher
Plötz M, Gillissen B, Quast S, Berger A, Daniel P, Eberle J. The BH3-only protein Bim(L) overrides Bcl-2-mediated apoptosis resistance in melanoma cells. Cancer Lett. 2013;335:100-8 pubmed publisher
Choi H, Jin H, Kim J, Hong S, Kim H, Kim E, et al. Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2013;432:123-8 pubmed publisher
Berger A, Quast S, Plötz M, Kammermeier A, Eberle J. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. Cell Death Dis. 2013;4:e477 pubmed publisher
Rodust P, Fecker L, Stockfleth E, Eberle J. Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w. Exp Dermatol. 2012;21:520-5 pubmed publisher
Jin H, Hong S, Woo S, Lee J, Choe T, Kim E, et al. Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition. Cell Death Dis. 2012;3:e319 pubmed publisher
Macaire H, Riquet A, Moncollin V, Biémont Trescol M, Duc Dodon M, Hermine O, et al. Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells. J Biol Chem. 2012;287:21357-70 pubmed publisher
al Yacoub N, Fecker L, Möbs M, Plötz M, Braun F, Sterry W, et al. Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling. J Invest Dermatol. 2012;132:2263-74 pubmed publisher
Chu R, Terrano D, Chambers T. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochem Pharmacol. 2012;83:199-206 pubmed publisher
Braun F, al Yacoub N, Plötz M, Möbs M, Sterry W, Eberle J. Nonsteroidal anti-inflammatory drugs induce apoptosis in cutaneous T-cell lymphoma cells and enhance their sensitivity for TNF-related apoptosis-inducing ligand. J Invest Dermatol. 2012;132:429-39 pubmed publisher
Ageberg M, Rydström K, Linden O, Linderoth J, Jerkeman M, Drott K. Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines. Exp Cell Res. 2011;317:1179-91 pubmed publisher
Bredholt T, Dimba E, Hagland H, Wergeland L, Skavland J, Fossan K, et al. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer. 2009;8:101 pubmed publisher
Wang L, Chen L, Benincosa J, Fortney J, Gibson L. VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli. Leukemia. 2005;19:344-53 pubmed
product information
Catalog Number :
sc-12756
Product Name :
Mcl-1 (22) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
22
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Mcl-1
Specificity :
human
Uses :
WB, IP, ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA