product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p53 (DO-1) Antibody
catalog :
sc-126
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DO-1
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq, other, western blot knockout validation, immunocytochemistry knockout validation
citations: 986
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; human; loading ...; fig 2b
  • western blot knockout validation; human; 1:1000; loading ...; fig 2c
Mircetic J, Dietrich A, Paszkowski Rogacz M, Krause M, Buchholz F. Development of a genetic sensor that eliminates p53 deficient cells. Nat Commun. 2017;8:1463 pubmed publisher
  • western blot knockout validation; mouse; fig 4
  • chromatin immunoprecipitation; mouse; fig 4
  • western blot knockout validation; human; fig 1
  • chromatin immunoprecipitation; human; fig 1
Zhou X, Hao Q, Liao P, Luo S, Zhang M, Hu G, et al. Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. elife. 2016;5: pubmed publisher
  • western blot knockout validation; human; 1:2000; loading ...; fig 1a
Jung S, Kim D, Choi Y, Kim S, Park H, Lee H, et al. Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. Sci Rep. 2021;11:19667 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 1f
  • ChIP-Seq; human; loading ...; fig 2c
Malik N, Yan H, Yang H, Ayaz G, DuBois W, Tseng Y, et al. CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PLoS Genet. 2021;17:e1009553 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig s6a
Hsiue E, Wright K, Douglass J, Hwang M, Mog B, Pearlman A, et al. Targeting a neoantigen derived from a common TP53 mutation. Science. 2021;371: pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 1b
Jung J, Lee H, Cao B, Liao P, Zeng S, Lu H. RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53. Oncogene. 2019;: pubmed publisher
  • western blot knockout validation; human; 1:2500; loading ...; fig 1b, 4c, s3c
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher
  • western blot knockout validation; human; loading ...; fig s5b
Tajan M, Hock A, Blagih J, Robertson N, Labuschagne C, Kruiswijk F, et al. A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Cell Metab. 2018;28:721-736.e6 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 2d
Periyasamy M, Singh A, Gemma C, Kranjec C, Farzan R, Leach D, et al. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells. Nucleic Acids Res. 2017;45:11056-11069 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 1f
Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
  • western blot knockout validation; human; fig s1d
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 2D
  • immunoprecipitation; human; loading ...; fig 6D
Castellini L, Moon E, Razorenova O, Krieg A, von Eyben R, Giaccia A. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017;45:3674-3692 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 1b
  • chromatin immunoprecipitation; human; loading ...; fig 2e
Chao T, Zhou X, Cao B, Liao P, Liu H, Chen Y, et al. Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. Nat Commun. 2016;7:13755 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 4f
Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 8c
McKenzie C, D Avino P. Investigating cytokinesis failure as a strategy in cancer therapy. Oncotarget. 2016;7:87323-87341 pubmed publisher
  • western blot knockout validation; human; loading ...; fig s3c
  • western blot; mouse; loading ...; fig 4j
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 4a
  • immunoprecipitation; human; loading ...; fig 5a
  • immunocytochemistry; human; loading ...; fig s5h, s5i
  • western blot; human; loading ...; fig 3c
  • western blot knockout validation; mouse; loading ...; fig 3e
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed publisher
  • western blot knockout validation; human; fig 3
Shin M, He Y, Marrogi E, Piperdi S, Ren L, Khanna C, et al. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS Genet. 2016;12:e1005884 pubmed publisher
  • western blot knockout validation; human; fig 5f
Ramlee M, Yan T, Cheung A, Chuah C, Li S. High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis. Sci Rep. 2015;5:15587 pubmed publisher
  • western blot knockout validation; human; fig 4
Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher
  • western blot knockout validation; human; fig 2
  • immunoprecipitation; human; fig 3
  • immunocytochemistry; human; fig 4
Ye M, Tang Y, Tang S, Liu J, Wu K, Yao S, et al. STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation. Oncotarget. 2015;6:34718-31 pubmed publisher
  • western blot knockout validation; human; fig 2a
Yoon K, Byun S, Kwon E, Hwang S, Chu K, Hiraki M, et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015;349:1261669 pubmed publisher
  • western blot knockout validation; human; loading ...; fig s7c
Coutts A, La Thangue N. Actin nucleation by WH2 domains at the autophagosome. Nat Commun. 2015;6:7888 pubmed publisher
  • western blot knockout validation; human; fig 6
García Cano J, Ambroise G, Pascual Serra R, Carrión M, Serrano Oviedo L, Ortega Muelas M, et al. Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance. Oncotarget. 2015;6:15551-65 pubmed
  • western blot knockout validation; human; fig 5
Isogai T, van der Kammen R, Innocenti M. SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep. 2015;5:9802 pubmed publisher
  • western blot knockout validation; human; fig 2
Drost J, van Jaarsveld R, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 2015;521:43-7 pubmed publisher
  • western blot knockout validation; human; fig 1
Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Abd Alla J, Jamous Y, Quitterer U. Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig 5a
Chiang C, Hong Y. In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy. Sci Rep. 2021;11:18172 pubmed publisher
  • western blot; human; loading ...; fig 5f
Lee J, Hong J, Zhang Z, de la Peña Avalos B, Proietti C, Deamicis A, et al. Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A). Sci Adv. 2021;7: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1c
Prekovic S, Schuurman K, Mayayo Peralta I, Manjón A, Buijs M, Yavuz S, et al. Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. Nat Commun. 2021;12:4360 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 7f
Bruce J, To K, Lui V, Chung G, Chan Y, Tsang C, et al. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2021;12:4193 pubmed publisher
  • western blot; mouse; loading ...; fig 1i
Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed publisher
  • western blot; human; loading ...; fig 5b
Lin C, Tsai M, Chen Y, Liu W, Lin C, Hsu K, et al. Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Biomol Ther (Seoul). 2021;29:551-561 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2d
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Li H, Liu Y, Jiang W, Xue J, Cheng Y, Wang J, et al. Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma. BMC Cancer. 2021;21:318 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1a
  • western blot; human; loading ...; fig 1d
Ma S, McGuire M, Mangala L, Lee S, Stur E, Hu W, et al. Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Rep. 2021;34:108726 pubmed publisher
  • western blot; human; 1:1000; fig 2s2i
Chen X, Yao H, Kashif M, Revêchon G, Eriksson M, Hu J, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. elife. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 2d
Singh S, Abu Zaid A, Lin W, Low J, Abdolvahabi A, Jin H, et al. 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma. iScience. 2021;24:101996 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 10
Blanden A, Yu X, Blayney A, Demas C, Ha J, Liu Y, et al. Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants. elife. 2020;9: pubmed publisher
  • western blot; human; 1:500; loading ...; fig s3-2c
Hao Q, Zong X, Sun Q, Lin Y, Song Y, Hashemikhabir S, et al. The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. elife. 2020;9: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1b
Capaci V, Bascetta L, Fantuz M, Beznoussenko G, Sommaggio R, Cancila V, et al. Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome. Nat Commun. 2020;11:3945 pubmed publisher
  • western blot; human; loading ...; fig 5d
Varela Eirin M, Carpintero Fernández P, Sánchez Temprano A, Varela Vazquez A, Paíno C, Casado Diaz A, et al. Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis. Aging (Albany NY). 2020;12:15882-15905 pubmed publisher
  • western blot; human; loading ...; fig 4
Lee S, Hong K, Seong Y, Kwak S. Ectopic Overexpression of Coiled-Coil Domain Containing 110 Delays G2/M Entry in U2-OS Cells. Dev Reprod. 2020;24:101-111 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Hastings J, González Rajal A, Latham S, Han J, McCloy R, O Donnell Y, et al. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1s1a
Arai S, Varkaris A, Nouri M, Chen S, Xie L, Balk S. MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 0.4 ug/ml; fig s2a
  • western blot; human; 0.4 ug/ml; loading ...; fig 7c
Sola M, Magrin C, Pedrioli G, Pinton S, Salvade A, Papin S, et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol. 2020;3:245 pubmed publisher
  • western blot; human; 1:2500; loading ...; fig 5d
Wu P, Hong S, Starenki D, Oshima K, Shao H, Gestwicki J, et al. Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene. 2020;39:4257-4270 pubmed publisher
  • western blot; human; loading ...; fig 5d
Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone M, et al. Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s11c
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11:1310 pubmed publisher
  • western blot; mouse; 1:1000; fig 5c
Che H, Li J, Li Y, Ma C, Liu H, Qin J, et al. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 4i
Pothuraju R, Rachagani S, Krishn S, Chaudhary S, Nimmakayala R, Siddiqui J, et al. Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Mol Cancer. 2020;19:37 pubmed publisher
  • western blot; human; loading ...; fig 1c
Gain C, Malik S, Bhattacharjee S, Ghosh A, Robertson E, Das B, et al. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. PLoS Pathog. 2020;16:e1008105 pubmed publisher
  • western blot; mouse; 1:200; loading ...
Ailiken G, Kitamura K, Hoshino T, Satoh M, Tanaka N, Minamoto T, et al. Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer. Oncogenesis. 2020;9:26 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c, 5c
Marin Navarro A, Pronk R, van der Geest A, Oliynyk G, Nordgren A, Arsenian Henriksson M, et al. p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Cell Death Dis. 2020;11:52 pubmed publisher
  • western blot; human; loading ...; fig 2d
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 4h
Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
  • western blot; human; loading ...; fig 2a
Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt M, Hermanns H, et al. IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression. J Exp Clin Cancer Res. 2019;38:397 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5a
El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed publisher
  • western blot; human; loading ...; fig 3s2d
Kabir S, Cidado J, Andersen C, Dick C, Lin P, Mitros T, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s2c
Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3g
Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 3i
Benyelles M, Episkopou H, O Donohue M, Kermasson L, Frange P, Poulain F, et al. Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019;: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1a
  • western blot; human; loading ...; fig 3a
Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix F, et al. Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence. Aging Cell. 2019;18:e12981 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2
Shin Y, Kim Y, Wen X, Cho N, Lee S, Kim W, et al. Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer. Clin Epigenetics. 2019;11:77 pubmed publisher
  • western blot; human; loading ...; fig 1e
Forte I, Indovina P, Iannuzzi C, Cirillo D, Di Marzo D, Barone D, et al. Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Int J Oncol. 2019;54:2189-2199 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig s5b
Goodman D, Pretto C, Krepostman T, Carnahan K, Spindler K. Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). MBio. 2019;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s8a
Pillay N, Tighe A, Nelson L, Littler S, Coulson Gilmer C, Bah N, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35:519-533.e8 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 5b
Dong H, Ye X, Zhong L, Xu J, Qiu J, Wang J, et al. Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis. Front Neurosci. 2019;13:44 pubmed publisher
  • western blot; human; loading ...; fig 4a
Chen H, Poran A, Unni A, Huang S, Elemento O, Snoeck H, et al. Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells. J Exp Med. 2019;216:674-687 pubmed publisher
  • western blot; human; loading ...; fig ev2h
Zhao Y, Ding L, Wang D, Ye Z, He Y, Ma L, et al. EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. EMBO J. 2019;38: pubmed publisher
  • western blot; human; loading ...; fig 3d
Wu Y, Li X, Yu J, Bjorkholm M, Xu D. ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. Cell Death Dis. 2019;10:76 pubmed publisher
  • immunocytochemistry; human; loading ...; fig e8a
  • western blot; human; loading ...; fig e1b, e1d, e1e
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 3a
Sachs N, Papaspyropoulos A, Zomer van Ommen D, Heo I, Böttinger L, Klay D, et al. Long-term expanding human airway organoids for disease modeling. EMBO J. 2019;38: pubmed publisher
  • western blot; human; loading ...; fig s3f
Mohni K, Wessel S, Zhao R, Wojciechowski A, Luzwick J, Layden H, et al. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. 2019;176:144-153.e13 pubmed publisher
  • western blot; human; loading ...; fig 3g
Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, et al. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner. Oncogene. 2019;38:2501-2515 pubmed publisher
  • western blot; human; loading ...; fig 4d
Kim S, Jin H, Seo H, Lee H, Lee Y. Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death Differ. 2019;26:812-825 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 4j
  • western blot; human; 1:100; loading ...; fig 4d
Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher
  • western blot; human; loading ...; fig 3k
Tan P, Ye Y, He L, Xie J, Jing J, Ma G, et al. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 2018;16:e3000051 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Ivanyi Nagy R, Ahmed S, Peter S, Ramani P, Ong P, Dreesen O, et al. The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis. elife. 2018;7: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a
Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, et al. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018;9:4394 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2j
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20:1181-1192 pubmed publisher
  • western blot; human; loading ...; fig 5c
Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford A, et al. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018;8:8438 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s11c
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1a
Gong L, Pan X, Lim C, de Polo A, Little J, Yuan Z. A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene. 2018;37:2150-2164 pubmed publisher
  • western blot; human; loading ...; fig 1e
Tanaka N, Zhao M, Tang L, Patel A, Xi Q, Van H, et al. Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1. Oncogene. 2018;37:1279-1292 pubmed publisher
  • western blot; human; loading ...; fig 7a
Wu J, Xiang S, Zhang M, Fang B, Huang H, Kwon O, et al. Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem. 2018;293:1976-1993 pubmed publisher
  • western blot; human; loading ...; fig 1c
Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed publisher
  • western blot; human; loading ...; fig 1c
Thaler S, Schmidt M, Roβwag S, Thiede G, Schad A, Sleeman J. Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget. 2017;8:72281-72301 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3e
  • western blot; human; 1:1000; loading ...; fig 3a
Huang C, Wu S, Ji H, Yan X, Xie Y, Murai S, et al. Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library. Sci Adv. 2017;3:e1701383 pubmed publisher
  • western blot; human; loading ...; fig 5a
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
  • western blot; human; loading ...; fig 1a
Giono L, Resnick Silverman L, Carvajal L, St Clair S, Manfredi J. Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase. Oncogene. 2017;36:6762-6773 pubmed publisher
  • western blot; human; loading ...; fig s2b
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
  • western blot; human; 1:1000; fig 3e
Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Read M, Fong J, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson R, et al. Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene. 2017;36:5296-5308 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed publisher
  • western blot; human; loading ...; fig 7a
He L, Luo L, Zhu H, Yang H, Zhang Y, Wu H, et al. FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer. Mol Oncol. 2017;11:640-654 pubmed publisher
  • western blot; human; loading ...; fig s1b
Fumagalli A, Drost J, Suijkerbuijk S, van Boxtel R, de Ligt J, Offerhaus G, et al. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proc Natl Acad Sci U S A. 2017;114:E2357-E2364 pubmed publisher
  • western blot; human; loading ...; fig 1b
Yan H, Zhang Y, Zhang Y, Ren X, Shen Y, Cheng M, et al. CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. Biochim Biophys Acta Gene Regul Mech. 2017;1860:516-522 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Singh V, Katta S, Kumar S. WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice. BMC Cancer. 2017;17:148 pubmed publisher
  • western blot; human; fig 2a
Shin S, Song J, Hwang B, Noh D, Park S, Kim W, et al. HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation. PLoS ONE. 2017;12:e0171860 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
  • immunoprecipitation; human; fig 3a
  • immunocytochemistry; human; 1:200
  • western blot; human; fig 1a
Liu T, Krysiak K, Shirai C, Kim S, Shao J, Ndonwi M, et al. Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells. PLoS ONE. 2017;12:e0170470 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 6a
  • western blot; human; fig 5a
Coaxum S, Tiedeken J, Garrett Mayer E, Myers J, Rosenzweig S, Neskey D. The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer. Oncotarget. 2017;8:22991-23007 pubmed publisher
  • western blot; human; loading ...; fig 8a
Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone M, et al. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017;232:3454-3467 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed publisher
  • western blot; human; loading ...; fig 5f
Riverso M, Montagnani V, Stecca B. KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. Oncogene. 2017;36:3322-3333 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 4h-s
  • immunocytochemistry; human; fig 4a-f
  • western blot; human; fig 2a
De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, et al. Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation. J Pathol. 2017;242:24-38 pubmed publisher
  • western blot; human; loading ...; fig 2d
Wamsley J, Issaeva N, An H, Lu X, Donehower L, Yarbrough W. LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle. 2017;16:213-223 pubmed publisher
  • western blot; human; 1:250; loading ...; fig 1a
Marmisolle I, Martínez J, Liu J, Mastrogiovanni M, Fergusson M, Rovira I, et al. Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Arch Biochem Biophys. 2017;613:12-22 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5a
  • western blot; human; loading ...; fig 1a
Bhagirath D, Zhao X, Mirza S, West W, Band H, Band V. Mutant PIK3CA Induces EMT in a Cell Type Specific Manner. PLoS ONE. 2016;11:e0167064 pubmed publisher
  • western blot; human; fig 6e
Chhabra A, Mukherji B, Batra D. Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. Expert Opin Ther Targets. 2017;21:117-129 pubmed publisher
  • western blot; human; loading ...; fig 1
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher
  • western blot; human; loading ...; fig 1a
Gotoh T, Kim J, Liu J, Vila Caballer M, Stauffer P, Tyson J, et al. Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A. 2016;113:13516-13521 pubmed
  • immunocytochemistry; human; loading ...; fig 2d
  • western blot; human; loading ...; fig 1b
Tian X, Dai S, Sun J, Jiang S, Sui C, Meng F, et al. Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53. Cell Physiol Biochem. 2016;39:2088-2098 pubmed
  • chromatin immunoprecipitation; human; loading ...; fig 4
Alfano L, Costa C, Caporaso A, Antonini D, Giordano A, Pentimalli F. HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget. 2016;7:78127-78139 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1d
  • immunohistochemistry; human; 1:2000; loading ...; fig 4e
  • western blot; human; 1:3000; loading ...; fig s8
Parrales A, Ranjan A, Iyer S, Padhye S, Weir S, Roy A, et al. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016;18:1233-1243 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2b
  • western blot; human; 1:1000; loading ...; fig 2a
Dong P, Xiong Y, Watari H, Hanley S, Konno Y, Ihira K, et al. Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124. Sci Rep. 2016;6:35480 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2a
Qi D, Cobrinik D. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation. Oncogene. 2017;36:1760-1769 pubmed publisher
  • western blot; human; loading ...; fig 3b
Lu F, Wu X, Yin F, Chia Fang Lee C, Yu M, Mihaylov I, et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open. 2016;5:1449-1460 pubmed publisher
  • western blot; human; loading ...; fig 2c
Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 2b
Barillari G, Palladino C, Bacigalupo I, Leone P, Falchi M, Ensoli B. Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels. Oncol Lett. 2016;12:2389-2394 pubmed
  • western blot; mouse; loading ...; fig 1e
Zhuang J, Kamp W, Li J, Liu C, Kang J, Wang P, et al. Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise. J Biol Chem. 2016;291:24819-24827 pubmed
  • western blot; human; 1:500; loading ...; fig 4a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • western blot; human; loading ...; fig 5f
Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, et al. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016;76:6950-6963 pubmed
  • western blot; human; fig 3
Wu H, Li S, Hu J, Yu X, Xu H, Chen Z, et al. Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells. J Exp Clin Cancer Res. 2016;35:145 pubmed publisher
  • western blot; human; loading ...; fig 5
Minemura H, Takagi K, Sato A, Takahashi H, Miki Y, Shibahara Y, et al. CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance. Cancer Sci. 2016;107:1898-1908 pubmed publisher
  • western blot; human; loading ...; fig 3
Kozakai Y, Kamada R, Furuta J, Kiyota Y, Chuman Y, Sakaguchi K. PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin. Sci Rep. 2016;6:33272 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, et al. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016;22:1180-1186 pubmed publisher
  • western blot; human; loading ...; fig 1b
Liu T, Xiong J, Yi S, Zhang H, Zhou S, Gu L, et al. FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene. 2017;36:1678-1686 pubmed publisher
  • western blot; human; loading ...; fig 2a
Weber A, Drobnitzky N, Devery A, Bokobza S, Adams R, Maughan T, et al. Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. Oncotarget. 2016;7:60807-60822 pubmed publisher
  • western blot; human; fig 4
Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14:3777-84 pubmed publisher
  • western blot; human; 1:1000; fig 7
Fern ndez Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
  • western blot; human; loading ...; fig s10
Bauer M, Joerger A, Fersht A. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A. 2016;113:E5271-80 pubmed publisher
  • western blot; human; loading ...; fig 1a
Park J, Yang S, Park J, Ka S, Kim J, Kong Y, et al. Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun. 2016;7:12513 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3b
  • western blot; human; loading ...; fig 2a
Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, et al. Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep. 2016;6:31758 pubmed publisher
  • western blot; human; loading ...; fig 4a
Luo H, Cowen L, Yu G, Jiang W, Tang Y. SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov. 2016;2:15042 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 5
Al Maghrebi M, Renno W. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. Peerj. 2016;4:e2195 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 1a
Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, et al. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 2016;22:861-8 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human; loading ...; fig 1d
Itahana Y, Zhang J, Göke J, Vardy L, Han R, Iwamoto K, et al. Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci Rep. 2016;6:28112 pubmed publisher
  • western blot; human; 1:500; fig s5
Hong A, Tseng Y, Cowley G, Jonas O, Cheah J, Kynnap B, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016;7:11987 pubmed publisher
  • immunocytochemistry; human; fig 7
  • western blot; human; 1:200; fig 10a
Pomo J, Taylor R, Gullapalli R. Influence of TP53 and CDH1 genes in hepatocellular cancer spheroid formation and culture: a model system to understand cancer cell growth mechanics. Cancer Cell Int. 2016;16:44 pubmed publisher
  • western blot; human; fig 1
Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed publisher
  • immunoprecipitation; human; 1:100; fig 5
  • western blot; human; 1:1000; fig 1
Alaee M, Danesh G, Pasdar M. Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53. PLoS ONE. 2016;11:e0154323 pubmed publisher
  • western blot; human; loading ...; fig s4a
Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed publisher
  • immunoprecipitation; human; fig 3
  • western blot; human; fig 1
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed publisher
  • chromatin immunoprecipitation; human
Beard J, Tenga A, Hills J, Hoyer J, Cherian M, Wang Y, et al. The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Sci Rep. 2016;6:25108 pubmed publisher
  • western blot; human; fig 6
Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed publisher
  • western blot; human; fig 4
Xia Z, Huang X, Chen K, Wang H, Xiao J, He K, et al. Proapoptotic Role of Potassium Ions in Liver Cells. Biomed Res Int. 2016;2016:1729135 pubmed publisher
  • western blot; human; fig 4
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3
Perez R, Shen H, Duan L, Kim R, Kim T, Park N, et al. Modeling the Etiology of p53-mutated Cancer Cells. J Biol Chem. 2016;291:10131-47 pubmed publisher
  • western blot; human; fig 2
Dai Y, Wang L, Tang J, Cao P, Luo Z, Sun J, et al. Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress. Oncotarget. 2016;7:25478-92 pubmed publisher
  • western blot; human; loading ...; fig 6a
Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016;415:197-205 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 4a
  • western blot; human; loading ...; fig 1b
D Brot A, Kurtz P, Regan E, Jakubowski B, Abrams J. A platform for interrogating cancer-associated p53 alleles. Oncogene. 2017;36:286-291 pubmed publisher
  • western blot; human; loading ...; fig 7g
Jin H, Lee K, Kim Y, Oh H, Maeng Y, Kim T, et al. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene. 2016;35:5106-18 pubmed publisher
  • western blot; human; fig 1
Mori F, Ferraiuolo M, Santoro R, Sacconi A, Goeman F, Pallocca M, et al. Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget. 2016;7:20532-48 pubmed publisher
  • western blot; human; loading ...; fig s8
Chen S, FORRESTER W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016;351:1204-8 pubmed publisher
  • flow cytometry; human; fig 6f
  • western blot; human; 1:500; loading ...; fig 1a
Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed publisher
  • western blot; human; 1:1000; fig 5
Swetzig W, Wang J, Das G. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 2016;7:16049-69 pubmed publisher
  • western blot; human; fig s2
Talarico C, Dattilo V, D Antona L, Barone A, Amodio N, Belviso S, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016;7:15868-84 pubmed publisher
  • western blot; human; 1:1000; fig 6
Liu R, Li S, Garcia E, Glubrecht D, Poon H, Easaw J, et al. Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma. Glia. 2016;64:963-76 pubmed publisher
  • western blot; human; loading ...; fig 3a
  • western blot; mouse; loading ...; fig ev1f
Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed publisher
  • western blot; human; loading ...; fig 1a
Xie X, Lozano G, Siddik Z. Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene. 2016;35:4798-806 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Mignacca L, Saint Germain E, Benoit A, Bourdeau V, Moro A, Ferbeyre G. Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers. Cytokine. 2016;82:80-6 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig st3
  • western blot; human; 1:1000; loading ...; fig st3
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 9a
Vaughan C, Pearsall I, Singh S, Windle B, Deb S, Grossman S, et al. Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter. Oncotarget. 2016;7:12426-46 pubmed publisher
  • western blot; human; fig 1c
Heo J, Kim W, Choi K, Bae S, Jeong J, Kim K. XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. Oncotarget. 2016;7:5118-30 pubmed publisher
  • western blot; human; fig 4d
Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. J Biol Chem. 2016;291:6281-91 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 6g
  • immunocytochemistry; human; fig 2c
  • western blot; human
Soragni A, Janzen D, Johnson L, Lindgren A, Thai Quynh Nguyen A, Tiourin E, et al. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016;29:90-103 pubmed publisher
  • western blot; human; fig 2
Han M, Lee D, Woo S, Seo B, Min K, Kim S, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep. 2016;6:18642 pubmed publisher
  • western blot; human; loading ...; fig 2a
Berges C, Chatterjee M, Topp M, Einsele H. Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells. Immunol Res. 2016;64:687-98 pubmed publisher
  • western blot; human; fig 1a
Du C, Wu H, Leng R. UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget. 2016;7:2823-36 pubmed publisher
  • immunohistochemistry; human; 1:200; tbl 4
Pages M, Lacroix L, Tauziède Espariat A, Castel D, Daudigeos Dubus E, Ridola V, et al. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Acta Neuropathol Commun. 2015;3:85 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 4
  • western blot; human; 1:500; fig 4
Fleury H, Communal L, Carmona E, Portelance L, Arcand S, Rahimi K, et al. Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease. Genes Cancer. 2015;6:378-398 pubmed
  • immunohistochemistry; human; loading ...; fig 8a
Gravina G, Mancini A, Sanità P, Vitale F, Marampon F, Ventura L, et al. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models. BMC Cancer. 2015;15:941 pubmed publisher
  • western blot; human; 1:5000; fig 3
Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo S, Low D, et al. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth. J Clin Invest. 2016;126:68-84 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 5
Ivanschitz L, Takahashi Y, Jollivet F, Ayrault O, Le Bras M, de Thé H. PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence. Proc Natl Acad Sci U S A. 2015;112:14278-83 pubmed publisher
  • western blot; human; 1:500; fig 4b
Carpentieri A, Cozzoli E, Scimeca M, Bonanno E, Sardanelli A, Gambacurta A. Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. Cell Death Dis. 2015;6:e1974 pubmed publisher
  • western blot; human; fig 4
Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Kanu N, Zhang T, Burrell R, Chakraborty A, Cronshaw J, DaCosta C, et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2016;35:4009-19 pubmed publisher
  • western blot; human; fig s4
Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, et al. Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget. 2015;6:40655-66 pubmed publisher
  • western blot; human; fig 5
Antoniali G, Marcuzzi F, Casarano E, Tell G. Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis. DNA Repair (Amst). 2015;35:90-105 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 1
Chene G, Ouellet V, Rahimi K, Barrès V, Meunier L, de Ladurantaye M, et al. Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma. Biomed Res Int. 2015;2015:808531 pubmed publisher
  • western blot; human; fig 5
Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, et al. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015;4:e173 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 4
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med. 2015;21:1364-71 pubmed publisher
  • western blot; human; loading ...; fig 7a
Xu S, Huang J, Chen M, Zeng M, Zou F, Chen D, et al. Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation. Oncotarget. 2017;8:12705-12716 pubmed publisher
  • western blot; human; fig 3
Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
  • western blot; human; 1:1000; fig 3
Habiger C, Jäger G, Walter M, Iftner T, Stubenrauch F. Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. J Virol. 2016;90:694-704 pubmed publisher
  • immunoprecipitation; human; fig 3
  • western blot; human; fig 1
Laezza C, D Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S, et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. Cell Death Dis. 2015;6:e1909 pubmed publisher
  • western blot; human; 1:1000; fig s6
Hu D, Gur M, Zhou Z, Gamper A, Hung M, Fujita N, et al. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015;6:8419 pubmed publisher
  • western blot; human; fig 11
Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed publisher
  • immunocytochemistry; human; fig s3
O Loghlen A, Brookes S, Martin N, Rapisarda V, Peters G, Gil J. CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). Aging Cell. 2015;14:1113-21 pubmed publisher
  • western blot; human; fig 4
Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, et al. USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene. 2016;35:2902-12 pubmed publisher
  • western blot; human; loading ...; fig 5
Kramer H, Lai C, Patel H, Periyasamy M, Lin M, Feller S, et al. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Res. 2016;44:582-94 pubmed publisher
  • western blot; human; 1:1000; fig 1a
Ho D, Kim H, Kim J, Sim H, Ahn H, Kim J, et al. Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain. 2015;8:54 pubmed publisher
  • western blot; human; fig 6
Lee N, Kwon J, Kim Y, Kim S, Park S, Xu W, et al. Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget. 2015;6:30130-48 pubmed publisher
  • western blot; human; fig 3
Bailey M, Singh T, Mero P, Moffat J, Hieter P. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 2015;201:885-95 pubmed publisher
  • western blot; human; loading ...; fig st2
Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher
  • western blot; mouse; fig 5
Zhao C, Su Y, Zhang J, Feng Q, Qu L, Wang L, et al. Fibrinogen-derived fibrinostatin inhibits tumor growth through anti-angiogenesis. Cancer Sci. 2015;106:1596-606 pubmed publisher
  • western blot; human
Tan B, Mu R, Chang Y, Wang Y, Wu M, Tu H, et al. RNF4 negatively regulates NF-κB signaling by down-regulating TAB2. FEBS Lett. 2015;589:2850-8 pubmed publisher
  • western blot; human; fig 1
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
  • western blot; human; fig 2
Khan I, Zakaria M, Kumar M, Mani P, Chattopadhyay P, Sarkar D, et al. A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting [corrected]. J Transl Med. 2015;13:254 pubmed publisher
  • western blot; human; fig 4
Subbaiah V, Zhang Y, Rajagopalan D, Abdullah L, Yeo Teh N, Tomaić V, et al. E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. Oncogene. 2016;35:2062-74 pubmed publisher
  • western blot; human; loading ...; fig 1a
Shatz M, Shats I, Menendez D, Resnick M. p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget. 2015;6:16963-80 pubmed
  • western blot; human; fig 1
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed publisher
  • western blot; human
Succoio M, Comegna M, D Ambrosio C, Scaloni A, Cimino F, Faraonio R. Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. J Proteomics. 2015;128:18-29 pubmed publisher
  • western blot; human; fig 4
Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS ONE. 2015;10:e0132767 pubmed publisher
  • western blot; human; fig 2b
Zhu J, Zhao C, Zhuang T, Jonsson P, Sinha I, Williams C, et al. RING finger protein 31 promotes p53 degradation in breast cancer cells. Oncogene. 2016;35:1955-64 pubmed publisher
  • western blot; human; fig 6
Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed publisher
  • western blot; human; 1:1000; fig 3
Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher
  • western blot; human; fig 4g
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, et al. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015;14:2090-102 pubmed publisher
  • western blot; human; fig 2
Sadaie M, Dillon C, Narita M, Young A, Cairney C, Godwin L, et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell. 2015;26:2971-85 pubmed publisher
  • western blot; human; fig 1
Seo G, Ho M, Bui N, Kim Y, Koh D, Lim Y, et al. Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci. 2015;22:47 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, et al. PML is required for telomere stability in non-neoplastic human cells. Oncogene. 2016;35:1811-21 pubmed publisher
  • western blot; human; fig s1.
Hayashi M, Cesare A, Rivera T, Karlseder J. Cell death during crisis is mediated by mitotic telomere deprotection. Nature. 2015;522:492-6 pubmed publisher
  • western blot; human; 1:1000
Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher
  • western blot; human; 1:500; fig 2
Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505 pubmed publisher
  • western blot; human; 1:1000; fig s2
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
  • immunohistochemistry; human
Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed publisher
  • western blot; human; fig 3a
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher
  • western blot; human; fig 2A
Amente S, Milazzo G, Sorrentino M, Ambrosio S, Di Palo G, Lania L, et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget. 2015;6:14572-83 pubmed
  • immunocytochemistry; human; 1:50; loading ...; fig 7d
  • western blot; human; 1:1000; loading ...; fig 3a
Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, et al. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol. 2015;85:183-98 pubmed publisher
  • western blot; human
Neo S, Itahana Y, Alagu J, Kitagawa M, Guo A, Lee S, et al. TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification. Mol Cell Biol. 2015;35:2851-63 pubmed publisher
  • western blot; human; 1:1000; fig 1
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
  • western blot; human; 1:1000
Chen B, Zaveri P, Longtine M, Nelson D. N-myc downstream-regulated gene 1 (NDRG1) mediates pomegranate juice protection from apoptosis in hypoxic BeWo cells but not in primary human trophoblasts. Placenta. 2015;36:847-53 pubmed publisher
  • immunocytochemistry; human; 1:500
  • western blot; human; 1:1000
Tembe V, Martino Echarri E, Marzec K, Mok M, Brodie K, Mills K, et al. The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cell Signal. 2015;27:1763-71 pubmed publisher
  • western blot; human; loading ...; fig s7f
Kloet D, Polderman P, Eijkelenboom A, Smits L, van Triest M, van den Berg M, et al. FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Biochem J. 2015;469:289-98 pubmed publisher
  • western blot; human; 1:500; fig 5
Zhou Y, Han C, Li D, Yu Z, Li F, Li F, et al. Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth. Sci Rep. 2015;5:10433 pubmed publisher
  • western blot; human
Li Y, Wang W, Xu X, Sun S, Xu X, Qu X. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. Biomed Res Int. 2015;2015:491205 pubmed publisher
  • immunocytochemistry; human; 1:250
Andries V, Vandepoele K, Staes K, Berx G, Bogaert P, Van Isterdael G, et al. NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest. BMC Cancer. 2015;15:391 pubmed publisher
  • western blot; human; fig 1
Bhagirath D, Zhao X, West W, Qiu F, Band H, Band V. Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes. Oncotarget. 2015;6:9018-30 pubmed
  • western blot; human
Mishra A, Kumar R, Tyagi A, Kohaar I, Hedau S, Bharti A, et al. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015;9:525 pubmed publisher
  • western blot; human; 1:10000
Wright J, Atwan Z, Morris S, Leppard K. The Human Adenovirus Type 5 L4 Promoter Is Negatively Regulated by TFII-I and L4-33K. J Virol. 2015;89:7053-63 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Bian C, Li Z, Xu Y, Wang J, Xu L, Shen H. Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study. World J Surg Oncol. 2015;13:128 pubmed publisher
  • western blot; human; 1:500
Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, et al. HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy. BMC Cancer. 2015;15:230 pubmed publisher
  • western blot; human; fig 4g
Barfeld S, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi K, et al. Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget. 2015;6:12587-602 pubmed
  • western blot; human; fig 1
Cho J, Lee S, Oh A, Yoon M, Woo T, Park B. NF2 blocks Snail-mediated p53 suppression in mesothelioma. Oncotarget. 2015;6:10073-85 pubmed
  • immunohistochemistry - paraffin section; human; fig 1
  • western blot; human; 1:500; fig 5
Zhao W, Chen R, Zhao M, Li L, Fan L, Che X. High glucose promotes gastric cancer chemoresistance in vivo and in vitro. Mol Med Rep. 2015;12:843-50 pubmed publisher
  • western blot; human; 1:1000; fig 6c
Xu T, Fan B, Lv C, Xiao D. Slug mediates nasopharyngeal carcinoma radioresistance via downregulation of PUMA in a p53-dependent and -independent manner. Oncol Rep. 2015;33:2631-8 pubmed publisher
  • western blot; human
Markkanen E, Fischer R, Ledentcova M, Kessler B, Dianov G. Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res. 2015;43:3667-79 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 5g
Aubry S, Shin W, Crary J, Lefort R, Qureshi Y, Lefebvre C, et al. Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. PLoS ONE. 2015;10:e0120352 pubmed publisher
  • western blot; human; fig 1
Khoronenkova S, Dianov G. ATM prevents DSB formation by coordinating SSB repair and cell cycle progression. Proc Natl Acad Sci U S A. 2015;112:3997-4002 pubmed publisher
  • western blot; human; fig 4
Katagiri N, Kuroda T, Kishimoto H, Hayashi Y, Kumazawa T, Kimura K. The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription. Sci Rep. 2015;5:8903 pubmed publisher
  • western blot; human; fig 5
Luo Z, Feng X, Wang H, Xu W, Zhao Y, Ma W, et al. Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. Aging Cell. 2015;14:391-9 pubmed publisher
  • immunocytochemistry; human
Ehm P, Nalaskowski M, Wundenberg T, Jücker M. The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies. Nucleus. 2015;6:154-64 pubmed publisher
  • western blot; human; 1:200
Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
  • western blot; human; fig s1
Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, et al. The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell. 2015;14:274-83 pubmed publisher
  • western blot; human; 1:500
Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, Sikora E, et al. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015;233:227-38 pubmed publisher
  • western blot; human
Laura M, de la Cruz Herrera C, Ferreirós A, Baz Martínez M, Lang V, Vidal A, et al. KSHV latent protein LANA2 inhibits sumo2 modification of p53. Cell Cycle. 2015;14:277-82 pubmed publisher
  • western blot; human; fig 3
Lecona E, Narendra V, Reinberg D. USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol. 2015;35:1157-68 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 9c
  • western blot; human; 1:2000; fig 4c
Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed publisher
  • western blot; human; 1:1000
Stolz A, Ertych N, Bastians H. A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation. Cell Cycle. 2015;14:827-37 pubmed publisher
  • western blot; human; 1:200; fig 8
Pérès E, Gérault A, Valable S, Roussel S, Toutain J, Divoux D, et al. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget. 2015;6:2101-19 pubmed
  • western blot; human; fig 6
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed publisher
  • western blot; human
Ghorbani A, Jeddi Tehrani M, Saidpour A, Safa M, Bayat A, Zand H. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58-66 pubmed publisher
  • western blot; human
Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X. Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. J Biol Chem. 2015;290:2024-33 pubmed publisher
  • western blot; human; 1:1000
Wei Z, Guo H, Liu Z, Zhang X, Liu Q, Qian Y, et al. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free Radic Biol Med. 2015;79:1-13 pubmed publisher
  • western blot; human
Kuo P, Huang C, Lee C, Chang H, Hsieh S, Chung Y, et al. BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability. Br J Cancer. 2015;112:391-402 pubmed publisher
  • western blot; human
Kim H, Jung G. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. FEBS Lett. 2014;588:4413-21 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; 1:1000
Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
  • western blot; human; 1:1000; fig s1
Park J, Lee S, Yang S, Yoo H, Park J, Seong M, et al. Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage. Nat Commun. 2014;5:5483 pubmed publisher
  • immunohistochemistry; human; 1:100
Voorneveld P, Kodach L, Jacobs R, van Noesel C, Peppelenbosch M, Korkmaz K, et al. The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. Br J Cancer. 2015;112:122-30 pubmed publisher
  • western blot; human
Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, et al. PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS ONE. 2014;9:e110296 pubmed publisher
  • western blot; human; fig 3
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed publisher
  • western blot; human; fig 4a
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed publisher
  • western blot; human
Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. 2014;5:7540-8 pubmed
  • western blot; human; fig 1
Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed publisher
  • western blot; human
Fan Y, Meley D, Pizer B, Sée V. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. PLoS ONE. 2014;9:e108514 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5b
  • western blot; human; fig 1a
  • western blot; mouse; fig 1f
Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, et al. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014;5:8107-22 pubmed
  • immunocytochemistry; human; fig 4
Santos J, Gil J. TRIM28/KAP1 regulates senescence. Immunol Lett. 2014;162:281-9 pubmed publisher
  • western blot; human
Alpay K, Farshchian M, Tuomela J, Sandholm J, Aittokallio K, Siljamäki E, et al. Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone. PLoS ONE. 2014;9:e105526 pubmed publisher
  • immunohistochemistry; human; 1:5000
Wennerström A, Lothe I, Sandhu V, Kure E, Myklebost O, Munthe E. Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines. PLoS ONE. 2014;9:e103873 pubmed publisher
  • western blot; human; 0.2 ug/ml
Jacob A, Singh R, Comiskey D, Rouhier M, Mohammad F, Bebee T, et al. Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways. PLoS ONE. 2014;9:e104444 pubmed publisher
  • western blot; human
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
  • western blot; human; 1:2000; fig 5h
Zhang P, Wei Y, Wang L, Debeb B, Yuan Y, Zhang J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16:864-75 pubmed publisher
  • western blot; human; 1:1000
Suico M, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, et al. The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism. J Biol Chem. 2014;289:26143-54 pubmed publisher
  • western blot; human
Clewell R, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen P, et al. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci. 2014;142:56-73 pubmed publisher
  • western blot; human
Watanabe T, Nakamura S, Ono T, Ui S, Yagi S, Kagawa H, et al. Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun. 2014;451:93-100 pubmed publisher
  • western blot; human
Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. elife. 2014;3:e02907 pubmed publisher
  • western blot; human
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, et al. AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation. Biochem Biophys Res Commun. 2014;450:1498-504 pubmed publisher
  • western blot; human; fig 2
Patel A, Burton D, Halvorsen K, Balkan W, Reiner T, Perez Stable C, et al. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015;34:2586-96 pubmed publisher
  • western blot; human
Weilbacher A, Gutekunst M, Oren M, Aulitzky W, van der Kuip H. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell Death Dis. 2014;5:e1318 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Oi N, Yuan J, Malakhova M, Luo K, Ryu J, Zhang L, et al. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. 2015;34:2660-71 pubmed publisher
  • western blot; human
Yang H, Hwangbo K, Zheng M, Cho J, Son J, Kim H, et al. Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts. Arch Pharm Res. 2015;38:876-84 pubmed publisher
  • western blot; human
Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama K. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 2014;34:3321-40 pubmed publisher
  • western blot; human; loading ...; fig 1b
Luo X, Suzuki M, Ghandhi S, Amundson S, Boothman D. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS ONE. 2014;9:e99983 pubmed publisher
  • western blot; human; fig 6
Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, et al. Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol. 2014;234:302-15 pubmed publisher
  • western blot; human
  • western blot; mouse
Mahadevan D, Morales C, Cooke L, Manziello A, Mount D, Persky D, et al. Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2. PLoS ONE. 2014;9:e95184 pubmed publisher
  • western blot; human; 1:1000
Zeng L, Holly J, Perks C. Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells. Front Endocrinol (Lausanne). 2014;5:61 pubmed publisher
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product information
Product Name :
p53 (DO-1) Antibody
Gene Name :
TP53
Size :
200 µg/ml
Catalog Number :
sc-126
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p53
reactive species  :
human
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
11-25 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA