product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
CD3-zeta (6B10.2) Antibody
catalog :
sc-1239
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6B10.2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 6c
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  • western blot; human; loading ...; fig s7
Li L, Guo X, Shi X, Li C, Wu W, Yan C, et al. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017;114:E5891-E5899 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; fig 3
Miyan M, Schmidt Mende J, Kiessling R, Poschke I, de Boniface J. Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer. J Transl Med. 2016;14:227 pubmed publisher
  • western blot; human; 1:1000; fig 1a
Moulton V, Gillooly A, Perl M, Markopoulou A, Tsokos G. Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells. PLoS ONE. 2015;10:e0131073 pubmed publisher
  • immunohistochemistry; human
Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki Sakamoto T, et al. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol. 2014;134:622-633.e9 pubmed publisher
Key P, Germino J, Yang L, Piersma S, Tripathy S. Chronic Ly49H Receptor Engagement in vivo Decreases NK Cell Response to Stimulation Through ITAM-Dependent and Independent Pathways Both in vitro and in vivo. Front Immunol. 2019;10:1692 pubmed publisher
Suárez Fueyo A, Bradley S, Katsuyama T, Solomon S, Katsuyama E, Kyttaris V, et al. Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype. J Immunol. 2018;200:3077-3086 pubmed publisher
Wallis A, Wallace E, Hostager B, Yi Z, Houtman J, Bishop G. TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22. Sci Rep. 2017;7:2081 pubmed publisher
Dutta D, Barr V, Akpan I, Mittelstadt P, Singha L, Samelson L, et al. Recruitment of calcineurin to the TCR positively regulates T cell activation. Nat Immunol. 2017;18:196-204 pubmed publisher
Krshnan L, Park S, Im W, Call M, Call M. A conserved ?? transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. Proc Natl Acad Sci U S A. 2016;113:E6649-E6658 pubmed
Wang E, Wang L, Tsai C, Bhoj V, Gershenson Z, Moon E, et al. Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors. Cancer Immunol Res. 2015;3:815-26 pubmed publisher
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, et al. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE. 2014;9:e96695 pubmed publisher
Zha X, Chen S, Yang L, Shi L, Li B, Wu X, et al. Upregulated TCR? enhances interleukin-2 production in T-cells from patients with CML. DNA Cell Biol. 2012;31:1628-35 pubmed publisher
Rovira Clavé X, Angulo Ibáñez M, Noguer O, Espel E, Reina M. Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface. Immunology. 2012;137:214-25 pubmed publisher
Shuh M, Morse B, Heidecker G, Derse D. Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells. J Virol. 2011;85:4623-7 pubmed publisher
Wang Y, Klumpp S, Amin H, Liang H, Li J, Estrov Z, et al. SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability. Oncogene. 2010;29:3044-53 pubmed publisher
Methi T, Berge T, Torgersen K, Tasken K. Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels. Eur J Immunol. 2008;38:2557-63 pubmed publisher
Montgomery J, Hensler H, Jacobson L, Jenkins F. Validation of a low cost computer-based method for quantification of immunohistochemistry-stained sections. Appl Immunohistochem Mol Morphol. 2008;16:400-4 pubmed publisher
Methi T, Ngai J, Vang T, Torgersen K, Tasken K. Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells. Eur J Immunol. 2007;37:2539-48 pubmed
Guo S, Lin D, Li J, Liu R, Zhou C, Wang D, et al. Tumor-associated macrophages and CD3-zeta expression of tumor-infiltrating lymphocytes in human esophageal squamous-cell carcinoma. Dis Esophagus. 2007;20:107-16 pubmed
Rouquette Jazdanian A, Pelassy C, Breittmayer J, Aussel C. Full CD3/TCR activation through cholesterol-depleted lipid rafts. Cell Signal. 2007;19:1404-18 pubmed
Methi T, Ngai J, Mahic M, Amarzguioui M, Vang T, Tasken K. Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses. J Immunol. 2005;175:7398-406 pubmed
Myers M, Dragone L, Weiss A. Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol. 2005;170:285-94 pubmed
Torelli G, Guarini A, Maggio R, Alfieri C, Vitale A, Foa R. Expansion of natural killer cells with lytic activity against autologous blasts from adult and pediatric acute lymphoid leukemia patients in complete hematologic remission. Haematologica. 2005;90:785-92 pubmed
Crotta S, Stilla A, Wack A, D ANDREA A, Nuti S, D Oro U, et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med. 2002;195:35-41 pubmed
Sosinowski T, Pandey A, Dixit V, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med. 2000;191:463-74 pubmed
product information
Product Name :
CD3-zeta (6B10.2) Antibody
Gene Name :
CD247
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-1239
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
CD3-zeta
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
36-54 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA