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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PEA3 (16) Antibody
catalog :
sc-113
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
16
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 28
Reference
Giovannone A, Winterstein C, Bhattaram P, Reales E, Low S, Baggs J, et al. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018;293:5478-5491 pubmed publisher
Liu C, Yu T, Huang Y, Cui L, Hong W. ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer. J Biol Chem. 2017;292:9420-9430 pubmed publisher
Li S, Huang X, Zhang D, Huang Q, Pei G, Wang L, et al. Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis. PLoS ONE. 2013;8:e79336 pubmed publisher
Euhus D, Bu D, Xie X, Sarode V, Ashfaq R, Hunt K, et al. Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction. Cancer Prev Res (Phila). 2011;4:1852-62 pubmed publisher
Clementz A, Rogowski A, Pandya K, Miele L, Osipo C. NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. Breast Cancer Res. 2011;13:R63 pubmed publisher
Keld R, Guo B, Downey P, Cummins R, Gulmann C, Ang Y, et al. PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma. Br J Cancer. 2011;105:124-30 pubmed publisher
Huang W, Xie W, Guo X, Li F, Jose P, Chen S. Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-?-induced smooth muscle cell differentiation of neural crest cells. Am J Physiol Cell Physiol. 2011;301:C499-506 pubmed publisher
Guo B, Panagiotaki N, Warwood S, Sharrocks A. Dynamic modification of the ETS transcription factor PEA3 by sumoylation and p300-mediated acetylation. Nucleic Acids Res. 2011;39:6403-13 pubmed publisher
Xu B, Abdel Fattah R, Yang L, Crenshaw S, Black M, Hinton B. Testicular lumicrine factors regulate ERK, STAT, and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis. Biol Reprod. 2011;84:1282-91 pubmed publisher
Chen Y, Chen L, Li J, Mukaida N, Wang Q, Yang C, et al. ERβ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells. Cancer Biol Ther. 2011;11:497-511 pubmed
Keld R, Guo B, Downey P, Gulmann C, Ang Y, Sharrocks A. The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma. Mol Cancer. 2010;9:313 pubmed publisher
Znosko W, Yu S, Thomas K, Molina G, Li C, Tsang W, et al. Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol. 2010;342:11-25 pubmed publisher
Nischan J, Gatalica Z, Curtis M, Lenk G, Tromp G, Kuivaniemi H. Binding sites for ETS family of transcription factors dominate the promoter regions of differentially expressed genes in abdominal aortic aneurysms. Circ Cardiovasc Genet. 2009;2:565-72 pubmed publisher
Sloan K, Marquez H, Li J, Cao Y, Hinds A, O Hara C, et al. Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis. 2009;30:1433-42 pubmed publisher
Guo B, Sharrocks A. Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Mol Cell Biol. 2009;29:3204-18 pubmed publisher
Firlej V, Ladam F, Brysbaert G, Dumont P, Fuks F, De Launoit Y, et al. Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription. J Cell Sci. 2008;121:3393-402 pubmed publisher
Dillon M, Stafford A, Kelly G, Redmond A, McIlroy M, Crotty T, et al. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. Endocr Relat Cancer. 2008;15:745-53 pubmed publisher
Kolb S, Vranckx R, Huisse M, Michel J, Meilhac O. The phosphatidylserine receptor mediates phagocytosis by vascular smooth muscle cells. J Pathol. 2007;212:249-59 pubmed
Jiang J, Wei Y, Liu D, Zhou J, Shen J, Chen X, et al. E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription. Biochem Biophys Res Commun. 2007;358:53-8 pubmed
Myers E, Hill A, Kelly G, McDermott E, O Higgins N, Young L. A positive role for PEA3 in HER2-mediated breast tumour progression. Br J Cancer. 2006;95:1404-9 pubmed
El Tanani M, Campbell F, Crowe P, Erwin P, Harkin D, Pharoah P, et al. BRCA1 suppresses osteopontin-mediated breast cancer. J Biol Chem. 2006;281:26587-601 pubmed
Xia W, Lien H, Wang S, Pan Y, Sahin A, Kuo Y, et al. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. Breast Cancer Res Treat. 2006;98:295-301 pubmed
Yu Z, Xia W, Wang H, Wang S, Pan Y, Kwong K, et al. Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. Mol Carcinog. 2006;45:667-75 pubmed
Menendez J, Papadimitropoulou A, Vellon L, Lupu R. A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes. Eur J Cancer. 2006;42:2425-32 pubmed
Gashaw I, Grummer R, Klein Hitpass L, Dushaj O, Bergmann M, Brehm R, et al. Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. Cell Mol Life Sci. 2005;62:2359-68 pubmed
Menendez J, Vellon L, Lupu R. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Ann Oncol. 2005;16:1253-67 pubmed
Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, et al. Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. J Biol Chem. 2005;280:12503-16 pubmed
Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble M, Aubert J, et al. The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. Biochem J. 2005;386:35-45 pubmed
product information
Catalog Number :
sc-113
Product Name :
PEA3 (16) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
16
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
PEA3
Specificity :
mouse, rat, human
Uses :
WB, IP, IF
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA